Updated on 2026/06/17

写真a

 
HASHIMOTO KEI
 
Organization
Undergraduate School School of Agriculture Senior Assistant Professor
Title
Senior Assistant Professor
External link

Degree

  • 博士(理学) ( お茶の水女子大学 )

Research Interests

  • プログラニュリン

  • ミクログリア

  • 神経変性疾患

  • Neurogenesis

  • Brain injury

  • Extracellular matrix

Research Areas

  • Life sciences / Cell biology

  • Life sciences / Neuroscience - general

Education

  • Ochanomizu University   Graduate schoold of Humanities and Sciences   PhD course, Life Sciences

    2015.4 - 2018.3

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  • Ochanomizu University   Graduate schoold of Humanities and Sciences   Master course, Life Sciences

    2013.4 - 2015.3

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  • Ochanomizu University

    2009.4 - 2013.3

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Research History

  • Meiji University   School of Agriculture Department of Life Sciences   Senior Assistant Professor

    2026.4

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  • お茶の水女子大学ヒューマンライフサイエンス研究所   特任講師

    2023.7 - 2026.3

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  • Ochanomizu University   Academic Production

    2021.3 - 2023.6

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  • UCSF   Department of Pathology

    2020.4 - 2021.10

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  • University of California San Francisco   Department of Pathology   Research Fellow

    2018.10 - 2021.10

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  • Ochanomizu University   Institute for Human Life Innovation

    2018.4 - 2019.3

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  • 日本学術振興会   特別研究員DC-2

    2017.4 - 2018.3

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  • 理化学研究所   多細胞システム形成研究センター   細胞外環境研究チーム研修生

    2016.8 - 2017.2

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  • Shimane University   Faculty of Medicine

    2015.12 - 2016.2

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Professional Memberships

Committee Memberships

  •   日本結合組織学会評議員  

    2024.11   

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  •   第11回MatriCellフォーラム事務局長  

    2024.10 - 2025.8   

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  •   第34回神経行動薬理若手研究者の集い 大会長  

    2023.12   

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  •   神経行動薬理若手研究者の集い 世話人  

    2023.9   

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  •   第10回MatriCellフォーラム 事務局  

    2023.9 - 2024.9   

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  • 日本結合組織学会   若手の会 世話人  

    2019.5 - 2024.10   

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Papers

  • Lysophosphatidic acid derivative is a novel candidate of therapeutic agents for a mouse model of frontotemporal dementia with progranulin deficiency Reviewed

    Nami Yamamoto, Rino Takei, Mari Gotoh, Yasunori Miyamoto, Kei Hashimoto

    Neurobiology of Aging   158   39 - 51   2026.2

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.neurobiolaging.2025.11.006

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  • Induction of neurodegeneration in the hippocampus of senescence-accelerated mouse-prone 8 (SAMP8) mice by blood-brain barrier-crossing serum amyloid P component Reviewed

    Fuka Sato, Ai Fujii, Saki Katagiri, Yuri Uchiumi, Mari Gotoh, Yasunori Miyamoto, Masaki Ishikawa, Yusuke Kawashima, Daisuke Nakajima, Ryo Konno, Kei Yura, Keiichi Nakagawa, Toshiaki Ishizuka, Kei Hashimoto

    Journal of Neuroinflammation   2026.1

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1186/s12974-026-03704-7

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  • Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models Reviewed

    Kei Hashimoto, Mari Gotoh, Hiroko Ikeshima-Kataoka

    Frontiers in Cellular Neuroscience   19   2025.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    Neurodegenerative diseases are frequently accompanied by inflammatory responses and alterations in lipid metabolism, both of which are believed to negatively affect neural regeneration in mammals. In addition to immune cells, glial cells such as astrocytes and microglia contribute significantly to these inflammatory processes, and it is now recognized that lipid droplet accumulation and cholesterol metabolism are dysregulated in these glial cells. Consequently, recent studies have examined inflammation and lipid metabolism from the standpoint of glial cell function; however, effective therapeutic strategies remain unestablished. By contrast, in zebrafish, a teleost species, robust neural regeneration occurs within a short period after injury to the telencephalon or spinal cord. In this review, we aimed to identify candidate functional factors by comparing mouse and zebrafish disease models and to explore molecules with potential therapeutic relevance for mammalian neurological disorders.

    DOI： 10.3389/fncel.2025.1708775

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  • Reactive astrocyte-derived neurotoxicity is mitigated by vitronectin in traumatic brain injury mouse model Reviewed

    Minori Yamashita, Nito Nakahira, Kei Hashimoto, Hirono Kobayashi, Mari Nakashima, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

    IBRO Neuroscience Reports   19   300 - 306   2025.12

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ibneur.2025.07.009

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  • Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury Reviewed

    Kei Hashimoto, Mari Nakashima, Yasunori Miyamoto, Hiroko Ikeshima-Kataoka

    Journal of Visualized Experiments   ( 216 )   2025.2

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    Publishing type：Research paper (scientific journal)   Publisher：MyJove Corporation  

    DOI： 10.3791/67797

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  • An <i>eGFP-Col4a2</i> mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis Reviewed

    Duligengaowa Wuergezhen, Eleonore Gindroz, Ritsuko Morita, Kei Hashimoto, Takaya Abe, Hiroshi Kiyonari, Hironobu Fujiwara

    Journal of Cell Biology   224 ( 2 )   2024.12

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    Publishing type：Research paper (scientific journal)   Publisher：Rockefeller University Press  

    Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of developing hair follicles, we reveal a spatial gradient in the turnover rate of COL4A2 that is closely coupled with both the BM expansion rate and the proliferation rate of epithelial progenitors. Epithelial progenitors are displaced with directionally expanding BMs but do not actively migrate on stationary BM. The addition of a matrix metalloproteinase inhibitor delays COL4A2 turnover, restrains BM expansion, and increases perpendicular divisions of epithelial progenitors, altering hair follicle morphology. Our findings highlight the spatially distinct dynamics of BM and their key roles in orchestrating progenitor cell behavior and organ shape during development.

    DOI： 10.1083/jcb.202404003

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  • Vitronectin regulates osteoclastogenesis and bone remodeling in a mouse model of osteoporosis. Reviewed International journal

    Mari Nakashima, Akiko Suzuki, Kei Hashimoto, Mayu Yamashita, Yoko Fujiwara, Yasunori Miyamoto

    Anatomy & cell biology   2024.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    Vitronectin (VN) is an extracellular matrix protein with a crucial role in regulating bone remodeling. In this study, we aimed to investigate the effect of VN deficiency in a mouse model of osteoporosis induced by ovariectomy (OVX). The findings revealed that the absence of VN led to an increase in the activity of tartrate-resistant acid phosphatase (TRAP), a marker for osteoclasts, in the plasma of OVX-operated mice. TRAP staining further demonstrated that VN deficiency resulted in a higher number of osteoclasts within the femurs of OVX-operated mice. X-ray micro-computed tomography analysis of the femurs in OVX-operated mice indicated that VN deficiency significantly suppressed the OVX-induced increase of marrow area and total volume of bone. Additionally, we assessed structural model index (SMI) and degree of anisotropy (DA) as indices of osteoporosis. The results showed that VN deficiency effectively attenuated the OVX-induced increase in SMI and DA among OVX-operated mice. In summary, our study demonstrates the vital role of VN in regulating osteoclastogenesis and bone remodeling in the mouse model of osteoporosis.

    DOI： 10.5115/acb.23.251

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  • 2-Carba cyclic phosphatidic acid regulates blood coagulation and fibrinolysis system for repair after brain injury. Reviewed International journal

    Misaki Endo, Mari Gotoh, Mari Nakashima, Yuka Kawamoto, Shiho Sakai, Kimiko Murakami-Murofushi, Kei Hashimoto, Yasunori Miyamoto

    Brain research   148511 - 148511   2023.7

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Effective blood coagulation prevents inflammation and neuronal loss after brain injury. 2-Carba-cyclic phosphatidic acid (2ccPA), a biotherapeutic for brain injury, inhibits blood extravasation resulting from blood-brain barrier breakdown. However, the hemostasis mechanism of 2ccPA remains unclear. We determined the effects of 2ccPA-injection on blood coagulation and fibrinolysis using a needle-induced brain injury model. 2ccPA suppressed the expression of platelet degranulation-related genes. Immediately after brain injury, 2ccPA increased CD41+ platelet aggregation around the lesions and promoted fibrin aggregation. Additionally, 2ccPA supported fibrinolysis by upregulating plasminogen activator expression. These results suggest the acute effects of 2ccPA on brain hemostasis. (97 words).

    DOI： 10.1016/j.brainres.2023.148511

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  • Syndecan-3 regulates the time of transition from cell cycle exit to initial differentiation stage in mouse cerebellar granule cell precursors. Reviewed International journal

    Hiina Watanabe, Ayaka Fukuda, Natsumi Ikeda, Maoko Sato, Kei Hashimoto, Yasunori Miyamoto

    Brain research   148317 - 148317   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    To analyze the role of syndecan-3 (SDC3), a heparan sulfate proteoglycan, in cerebellum development, we examined the effect of SDC3 on the transition from cell cycle exit to the initial differentiation stage of cerebellar granule cell precursors (CGCPs). First, we examined SDC3 localization in the developing cerebellum. SDC3 was mainly localized to the inner external granule layer where the transition from the cell cycle exit to the initial differentiation of CGCPs occurs. To examine how SDC3 regulates the cell cycle exit of CGCPs, we performed SDC3-knockdown (SDC3-KD) and -overexpression (Myc-SDC3) assays using primary CGCPs. SDC3-KD significantly increased the ratio of p27Kip1+ cells to total cells at day 3 in vitro (DIV3) and 4, but Myc-SDC3 reduced that at DIV3. Regarding the cell cycle exit efficiency using 24 h labelled bromodeoxyuridine (BrdU) and a marker of cell cycling, Ki67, SDC3-KD significantly increased cell cycle exit efficiency (Ki67-; BrdU+ cells/BrdU+ cells) in primary CGCP at DIV4 and 5, but Myc-SDC3 reduced that at DIV4 and 5. However, SDC3-KD and Myc-SDC3 did not affect the efficiency of the final differentiation from CGCPs to granule cells at DIV3-5. Furthermore, the ratio of CGCPs in the cell cycle exiting stage to total cells, identified by initial differentiation markers TAG1 and Ki67 (TAG1+; Ki67+ cells), was considerably decreased by SDC3-KD at DIV4, but increased by Myc-SDC3 at DIV4 and 5. Altogether, these results indicate that SDC3 regulates the timing of the transition from the cell cycle exit stage to the initial differentiation stage of CGCP.

    DOI： 10.1016/j.brainres.2023.148317

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  • 2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype. Reviewed International journal

    Rino Takei, Mari Nakashima, Mari Gotoh, Misaki Endo, Kei Hashimoto, Yasunori Miyamoto, Kimiko Murakami-Murofushi

    Neuroscience letters   797   137063 - 137063   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    2-carba-cyclic phosphatidic acid (2ccPA) suppresses microglial and astrocyte inflammation for neuronal survival following traumatic brain injury. However, it remains unknown how 2ccPA regulates microglial activation. In this study, to elucidate the 2ccPA behavior in glial communication, we collected the astrocyte conditioned media (ACM) from primary astrocyte cultures that were treated by lipopolysaccharide (LPS) and 2ccPA and analyzed the alteration of microglial inflammation caused by the ACM treatment. The addition of the ACM derived from LPS- and 2ccPA-double treated astrocytes to microglia decreased the CD86+ pro-inflammatory M1 microglia, which were upregulated with the ACM collected from astrocytes treated by LPS without 2ccPA, while the direct addition of LPS and 2ccPA to microglia failed to decrease the CD86+ microglia to the basal level. We confirmed that the ACM from LPS- and 2ccPA-treated astrocytes increased the ratio of CD206+ anti-inflammatory M2 microglia to total microglia, whereas direct treatment of microglia with LPS and 2ccPA had no effect on the CD206+ microglia ratio, demonstrating the importance of astrocyte intervention in microglial polarization. In addition, we examined whether astrocytes modulate the 2ccPA-regulated proinflammatory cytokine production derived from microglia. The addition of the ACM from LPS- and 2ccPA-treated astrocytes to microglia remarkably canceled the LPS-induced upregulation of IL-1β, IL-6, and TNF-α secreted from microglia, while the direct addition of LPS and 2ccPA to microglia showed no affect. Therefore, our results indicate that astrocytes mediate the 2ccPA function to shift microglia towards the M2 phenotype by interfering with the polarization of M1 microglia and to suppress cytokine production.

    DOI： 10.1016/j.neulet.2023.137063

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  • Neuroimmune dysfunction in frontotemporal dementia: Insights from progranulin and C9orf72 deficiency Reviewed

    Kei Hashimoto, Naznin Jahan, Zachary A. Miller, Eric J. Huang

    Current Opinion in Neurobiology   76   102599 - 102599   2022.10

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.conb.2022.102599

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  • The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury Reviewed

    Mari Nakashima, Mari Gotoh, Kei Hashimoto, Misaki Endo, Kimiko Murakami-Murofushi, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

    Journal of Neuroimmunology   2021.12

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  • Vitronectin regulates the axon specification of mouse cerebellar granule cell precursors via αvβ5 integrin in the differentiation stage Reviewed

    Yuko Oishi, Kei Hashimoto, Ayaka Abe, Maho Kuroda, Ai Fujii, Yasunori Miyamoto

    Neuroscience Letters   746   135648 - 135648   2021.2

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.neulet.2021.135648

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  • Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency Reviewed

    Jiasheng Zhang, Dmitry Velmeshev, Kei Hashimoto, Yu-Hsin Huang, Jeffrey W. Hofmann, Xiaoyu Shi, Jiapei Chen, Andrew M. Leidal, Julian G. Dishart, Michelle K. Cahill, Kevin W. Kelley, Shane A. Liddelow, William W. Seeley, Bruce L. Miller, Tobias C. Walther, Robert V. Farese, J. Paul Taylor, Erik M. Ullian, Bo Huang, Jayanta Debnath, Torsten Wittmann, Arnold R. Kriegstein, Eric J. Huang

    Nature   588 ( 7838 )   459 - 465   2020.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41586-020-2709-7

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    Other Link： http://www.nature.com/articles/s41586-020-2709-7

  • The effects of coating culture dishes with collagen on fibroblast cell shape and swirling pattern formation Reviewed International journal

    Kei Hashimoto, Kimiko Yamashita, Kanako Enoyoshi, Xavier Dahan, Tatsu Takeuchi, Hiroshi Kori, Mari Gotoh

    Journal of Biological Physics   46 ( 4 )   351 - 369   2020.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>Motile human-skin fibroblasts form macroscopic swirling patterns when grown to confluence on a culture dish. In this paper, we investigate the effect of coating the culture-dish surface with collagen on the resulting pattern, using human-skin fibroblast NB1RGB cells as the model system. The presence of the collagen coating is expected to enhance the adherence of the fibroblasts to the dish surface, and thereby also enhance the traction that the fibroblasts have as they move. We find that, contrary to our initial expectation, the coating does not significantly affect the motility of the fibroblasts. Their eventual number density at confluence is also unaffected. However, the coherence length of cell orientation in the swirling pattern is diminished. We also find that the fibroblasts cultured in collagen-coated dishes are rounder in shape and shorter in perimeter, compared with those cultured in uncoated polystyrene or glass culture dishes. We hypothesise that the rounder cell-shape which weakens the cell–cell nematic contact interaction is responsible for the change in coherence length. A simple mathematical model of the migrating fibroblasts is constructed, which demonstrates that constant motility with weaker nematic interaction strength does indeed lead to the shortening of the coherence length.

    DOI： 10.1007/s10867-020-09556-3

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    Other Link： http://link.springer.com/article/10.1007/s10867-020-09556-3/fulltext.html

  • Frontotemporal dementia nonsense mutation of progranulin rescued by aminoglycosides Reviewed

    Lisha Kuang, Kei Hashimoto, Eric J Huang, Matthew S Gentry, Haining Zhu

    Human Molecular Genetics   2020.1

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  • Vitronectin is Involved in the Morphological Transition of Neurites in Retinoic Acid-Induced Neurogenesis of Neuroblastoma Cell Line Neuro2a Reviewed

    Miyaka Sugahara, Yuri Nakaoki, Ayano Yamaguchi, Kei Hashimoto, Yasunori Miyamoto

    Neurochemical Research   44   1621 - 1635   2019.7

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  • Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model Reviewed

    Momoka Hayashida, Kei Hashimoto, Tomoko Ishikawa, Yasunori Miyamoto

    International Journal of Experimental Pathology   100(2)   72 - 82   2019.4

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  • αvβ5 integrin mediates the effect of vitronectin on the initial stage of differentiation in mouse cerebellar granule cell precursors Reviewed

    Ayaka Abe, Kei Hashimoto, Ayumi Akiyama, Momoe Iida, Natsumi Ikeda, Ayana Hamano, Riho Watanabe, Yokichi Hayashi, Yasunori Miyamoto

    Brain Research   1691   94 - 104   2018.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

    DOI： 10.1016/j.brainres.2018.04.025

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  • Wound healing-related properties detected in an experimental model with a collagen gel contraction assay are affected in the absence of tenascin-X Reviewed

    Kei Hashimoto, Naoyo Kajitani, Yasunori Miyamoto, Ken-ichi Matsumoto

    Experimental Cell Research   363 ( 1 )   102 - 113   2018

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    Authorship：Lead author  

    DOI： 10.1016/j.yexcr.2017.12.025

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  • Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF Reviewed

    Kasumi Higashine, Kei Hashimoto, Emi Tsujimoto, Yuko Oishi, Yokichi Hayashi, Yasunori Miyamoto, ese authors equally contributed to this study

    Neuroscience letter   686   87 - 93   2018

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  • 2-carba cyclic phosphatidic acid suppresses inflammation via regulation of microglial polarisation in the stab-wounded mouse cerebral cortex Reviewed

    Kei Hashimoto*, Mari Nakashima*, Ayana Hamano*, Mari Gotoh, Hiroko Ikeshima-Kataoka, Kimiko Murakami-Murofushi, Yasunori Miyamoto, ese authors equally contributed to this study

    Scientific Reports   8(1)   9715   2018

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  • Vitronectin Regulates the Fibrinolytic System during the Repair of Cerebral Cortex in Stab-Wounded Mice Reviewed

    Kei Hashimoto, Natsumi Ikeda, Mari Nakashima, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

    JOURNAL OF NEUROTRAUMA   34 ( 22 )   3183 - 3191   2017.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1089/neu.2017.5008

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  • Analyzing orientation patterns of human skin fibroblasts using image gradient information Reviewed

    Md. Khayrul Bashar, Kei Hashimoto, Mari Gotoh, Hiroshi Kori

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   600 - 603   2017.9

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    Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：Institute of Electrical and Electronics Engineers Inc.  

    DOI： 10.1109/EMBC.2017.8036896

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  • Vitronectin promotes the progress of the initial differentiation stage in cerebellar granule cells Reviewed

    Kei Hashimoto, Fumi Sakane, Natsumi Ikeda, Ayumi Akiyama, Miyaka Sugahara, Yasunori Miyamoto

    MOLECULAR AND CELLULAR NEUROSCIENCE   70   76 - 85   2016.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.mcn.2015.11.013

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  • N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development Reviewed

    Yasunori Miyamoto, Fumi Sakane, Kei Hashimoto

    CELL ADHESION & MIGRATION   9 ( 3 )   183 - 192   2015.5

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  • Pattern Quantification from Human Skin Fibroblast Images Image quantification for fibroblast chracterization Reviewed

    Md. Khayrul Bashar, Kei Hashimoto, Kanako Enoyoshi, Kimiko Yamashita, Mari Gotoh, Hiroshi Kori

    2015 INTERNATIONAL CONFERENCE ON INTELLIGENT INFORMATICS AND BIOMEDICAL SCIENCES (ICIIBMS)   1   321 - 326   2015

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    Language：English   Publishing type：Research paper (international conference proceedings)  

    Web of Science

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  • Quantification of Interaction between Human Skin Fibroblasts and Collagen by Image Texture Analysis Reviewed

    Md. Khayrul Bashar, Kei Hashimoto, Kanako Enoyoshi, Kimiko Yamashita, Mari Gotoh, Hiroshi Kori

    Journal of Bioinfomatics and Neuroscience   1   31 - 37   2015

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Books

  • ブレインサイエンス・レビュー2025

    （ Role： Contributor）

    アドスリー  2025.4 

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MISC

  • 前頭側頭型変性症モデルマウスにおける肝自己免疫疾患併発メカニズムの解明

    田中千晴, 坂井志穂, 後藤真里, 宮本泰則, 橋本恵

    日本分子生物学会年会プログラム・要旨集(Web)   48th   2025

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  • Effect of lipid mediator cyclic phosphatidic acid on hypoxia and its potential medical applications

    後藤真里, 後藤真里, 橋本恵

    日本解剖学会総会・全国学術集会抄録集(CD-ROM)   130th   2025

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  • An extracellular matrix molecule vitronectin attenuates hepatocyte necrosis and liver fibrosis caused by carbon tetrachloride-induced liver injury

    山下茉佑, 橋本恵, 宮本泰則, 宮本泰則

    日本結合組織学会学術大会抄録集   57th   2025

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  • The role of pleiotrophin in cell cycle regulation of mouse cerebellar granule cell precursors

    高田彩羽, 渡邉雛, 橋本恵, 宮本泰則, 宮本泰則

    日本結合組織学会学術大会抄録集   57th   2025

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  • 脳の老化に関する恒常性維持におけるビトロネクチンの神経細胞やグリア細胞に与える効果

    川本祐華, 高崎真実, 橋本恵, 宮本泰則

    日本生物学的精神医学会(Web)   46th   2024

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  • 環状ホスファチジン酸誘導体の前頭側頭型認知症に対する治療薬効果

    山本菜未, 後藤真理, 宮本泰則, 宮本泰則, 橋本恵

    日本分子生物学会年会プログラム・要旨集(Web)   47th   2024

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  • 小脳発生を制御する細胞外マトリックス

    橋本恵, 宮本泰則

    日本生化学会大会(Web)   97th   2024

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  • 前頭側頭型変性症モデルマウスにおける肝自己免疫疾患発症メカニズムの解明

    田中千晴, 坂井志穂, 後藤真里, 宮本泰則, 宮本泰則, 橋本恵, 橋本恵

    日本分子生物学会年会プログラム・要旨集(Web)   47th   2024

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  • Neuroprotective effects of vitronectin via astrocytes in traumatic brain injury repair.

    宮本泰則, 宮本泰則, 宮本泰則, 山下みのり, 小林寛乃, 橋本恵

    日本結合組織学会学術大会抄録集   54th (Web)   2022

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  • Role of syndecan-3 in the cell cycle exit of cerebellar granule cell precursors

    佐藤真生子, 渡邉雛, 池田夏美, 福田彩華, 橋本恵, 宮本泰則, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   45th   2022

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  • 2-carba-cyclic phosphatidic acid suppresses the apoptosis of neuron mediated by tenascin-C from astrocyte in traumatic brain injury

    NAKASHIMA Mari, GOTOH Mari, HASHIMOTO Kei, ENDO Misaki, MURAKAMI-MUROFUSHI Kimiko, IKESHIMA-KATAOKA Hiroko, MIYAMOTO Yasunori

    日本神経化学会大会抄録集(Web)   64th   2021

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  • The neuroprotective effect of tenascin-C via astrocytes in traumatic brain injury

    中島麻里, 中島麻里, 後藤真里, 後藤真里, 橋本恵, 室伏きみ子, 池島(片岡)宏子, 宮本泰則, 宮本泰則

    日本結合組織学会学術大会抄録集   53rd   2021

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  • Role of heparan sulfate proteoglycan syndecan-3 on the cell cycle of mouse cerebellar granule cell precursors.

    渡邉雛, 池田夏実, 福田彩華, 橋本恵, 宮本泰則, 宮本泰則, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   44th   2021

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  • Role of vitronectin in neuronal polarization during cerebellar formation

    藤井愛, 大石佑子, 橋本恵, 阿部彩香, 黒田真帆, 丸山千秋, 宮本泰則, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   44th   2021

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  • Neuroprotective effect of vitronectin, an extracellular matrix protein, in recovering from traumatic brain injury.

    山下みのり, 山下みのり, 橋本恵, 中島麻里, 中島麻里, 池島(片岡)宏子, 宮本泰則, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   44th   2021

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  • マウス小脳顆粒前駆細胞の軸索決定におけるビトロネクチンの役割

    宮本 泰則, 大石 佑子, 橋本 恵, 阿部 彩香, 黒田 真帆

    日本結合組織学会学術大会プログラム・抄録集   51回   117 - 117   2019.5

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  • テネイシンX欠損による創傷治癒メカニズムの活性化 コラーゲンゲル収縮に着目して

    橋本 恵, 梶谷 尚世, 宮本 泰則, 松本 健一

    日本結合組織学会学術大会プログラム・抄録集   48回   115 - 115   2016.6

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    J-GLOBAL

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  • 穿刺脳損傷修復における生理活性脂質cPA誘導体(2ccPA)の機能解析

    濱野文菜, 濱野文菜, 中島麻里, 中島麻里, 橋本恵, 橋本恵, 後藤真里, 室伏きみ子, 宮本泰則, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   39th   2016

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  • コラーゲンコートが皮膚線維芽細胞の渦状パターン形成に与える影響

    後藤真里, 後藤真里, 橋本恵, 橋本恵, 榎吉奏子, 榎吉奏子, 山下公子, 山下公子, 郡宏, 郡宏

    日本結合組織学会学術大会抄録集   48th   2016

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  • 高血圧ラットの延髄由来培養アストロサイトにおける遺伝子発現プロファイル

    GOURAUD Sabine, 大西真紀子, 橋本恵, 宮本泰則, 山中航, 和気秀文

    体力科学   64 ( 6 )   575 - 575   2015.12

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    Language：Japanese   Publisher：(一社)日本体力医学会  

    J-GLOBAL

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  • 発生中のマウス小脳皮質形成における細胞接着タンパク質ビトロネクチンの機能解析

    橋本恵, 宮本泰則

    日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

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Presentations

  • 細胞外マトリックスが制御する小脳発生メカニズム Invited

    第56回日本結合組織学会学術大会 International Junior Investigators Forum  2024.6 

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  • 認知症モデルマウスから紐解く神経変性疾患発症機構 Invited

    お茶の水女子大学ヒューマンライフイノベーション開発研究機構2023年度研究交流会  2024.2 

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  • 外傷性脳損傷におけるビトロネクチンの神経保護作用

    第9回Matricellフォーラム  2023.9 

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    Presentation type：Oral presentation (general)  

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  • 老化促進マウスSAMP8における認知障害誘発機構の解明

    第41回日本ヒト細胞学会  2023.8 

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  • 前頭側頭型認知症モデルマウスにおけるミクログリア活性を介した神経変性誘発機構の解明 Invited

    第45回日本分子生物学会(ワークショップオーガナイザー兼任)  2022.11 

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  • プログラニュリン欠損マウスにおけるミクログリア活性を介した神経変性誘発機構の解明

    第32回神経行動薬理若手研究者の集い  2022.11 

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  • Blockade of endo-lysosomal pathway promotes progranulin-deficient microglial toxicity via proinflammatory lipids

    NEURO2022 若手道場  2022.7 

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  • プログラニュリン欠損マウスにおけるミクログリア活性を介した神経変性誘発機構の解明 Invited

    第45回日本結合組織学会 若手の会シンポジウム企画  2022.6 

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  • 認知症におけるグリア細胞動態 Invited

    岡山大学国際研究拠点支援授業セミナー: 口腔器官の再構築から器官の発生・再生の統一原理の解明  2022.1 

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  • 細胞外マトリックス・ビトロネクチンによる非アルコール性脂肪肝炎発症制御 Invited

    橋本恵

    第44回日本分子生物学会 (ワークショップオーガナイザー)  2021.12 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • Mechanism of glial pathology in neurodegeneration Invited

    Joint International Research Seminar  2021.6 

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    Presentation type：Oral presentation (invited, special)  

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  • 【博士人材のためのキャリア支援セミナー】思っているより活躍の場は広い ～女性博士のキャリアパス～ Invited

    橋本恵

    2019.9 

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  • 非アルコール性脂肪性肝炎発症機構におけるビトロネクチンの機能

    橋本恵, 林田桃香, 石川朋子, 宮本泰則

    第5回MatriCellフォーラム  2018.9 

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  • 穿刺性マウス大脳皮質損傷時におけるビトロネクチンのアストロサイト活性制御

    橋本恵, 田邉昌子, 池田夏実, 中島麻里, 池島(片岡)宏子, 宮本泰則

    第50回日本結合組織学会学術大会  2018.7 

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  • ライブイメージング技術を用いたマウス毛包発生における基底膜動態メカニズムの解明

    橋本恵, 森田梨律子, 宮本泰則, 藤原裕展

    第49回日本結合組織学会学術大会  2017.6 

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  • 卒業生リレートーク 招待講演 Invited

    橋本恵

    2016年度 安田学園安田女子中学高等学校スーパーサイエンスハイスクール 生徒研究発表会  2016.12 

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  • テネイシンX欠損が線維芽細胞を含むコラーゲンゲル収縮に与える影響

    橋本恵, 梶谷尚世, 宮本泰則, 松本健一

    第4回Matricellフォーラム  2016.9 

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  • テネイシンX欠損による創傷治癒メカニズムの活性化～コラーゲンゲル収縮に着目して～

    橋本恵, 梶谷尚世, 宮本泰則, 松本健一

    第48回日本結合組織学会学術集会  2016.6 

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  • 小脳顆粒細胞の軸索形成を制御する細胞外マトリックス分子ビトロネクチン

    橋本恵, 坂根扶美, 池田夏実, 宮本泰則

    第3回Matricellフォーラム  2015.9 

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  • マウス小脳発生におけるビトロネクチンとその受容体候補αvβ5インテグリンの機能解析

    橋本恵, 宮本泰則

    第2回Matricellフォーラム  2014.9 

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Industrial property rights

  • 損傷治療剤

    宮本泰則, 濱野文菜, 中島麻里, 橋本恵, 後藤真里, 室伏きみ子

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    Application no：特願2016-221422  Date applied：2016.11

    Patent/Registration no：特許6864899  Date registered：2021.4 

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Awards

  • 第41回ヒト細胞学会 優秀賞

    2023.8  

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  • 第16回資生堂女性研究者サイエンスグラント

    2023.6  

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  • 最優秀賞 (一般の部)

    2022.11   第32回神経行動薬理若手研究者の集い  

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  • 2022年度 International Travel Award

    2022.10   日本結合組織学会  

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  • 令和元年度国立大学法人お茶の水女子大学創立120周年記念事業国際交流振興基金・桜蔭会国際交流奨励賞

    2019.8  

    橋本恵

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  • 平成30年度国立大法人お茶の水女子大学創立120周年記念事業国際交流振興基金・桜蔭会国際交流奨励賞

    2018.8  

    橋本恵

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  • Yasui/Kuroda Scholarship Fund

    2017.11   Ochanomizu University  

    Kei Hashimoto

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  • Japan Matrix Club Young Investigator Award

    2016.6   The Japanese Society for Matrix Biology and Medicine   Tenascin-X deficiency stimulates wound healing in an experimental model with collagen gel contraction assay

    Kei Hashimoto

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  • Japan Matrix Club Young Investigator Award

    2013.6   The Japanese Society for Matrix Biology   Role of vitronectin, a cell adhesive protein, during the development of mouse cerebellar cortex

    Kei Hashimoto

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  • Student Award of Excellence in Biology

    2012.12   Ochanomizu University  

    Kei Hashimoto

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Research Projects

  • 脳機能を崩壊させるリピ ドーシス解明機構と認知 症のリンキング

    2024.4 - 2025.3

    三菱財団  自然科学研究助成(若手助成) 

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  • 脂質代謝異常が認知症を誘発するメカニズムの解明

    2023.6 - 2024.6

    資生堂  女性研究者サイエンスグラント 

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  • 多様な認知症マウス系統おミクスデータから探る老化認知障害誘発機構

    2023.4 - 2024.2

    日本科学協会  笹川科学研究助成 

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  • グリア脂質代謝異常が誘発する神経変性機構

    2023.3 - 2024.4

    ブレインサイエンス振興財団  研究助成 

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  • グリア脂質代謝異常が誘発する神経変性機構

    2023.3 - 2024.4

    上原記念生命科学財団  研究奨励金 

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  • リピドーシスが認知症を誘発するメカニズム

    2023.1 - 2024.12

    アステラス病態代謝研究会  研究助成 

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  • ミクログリア脂質代謝異 常が誘発する神経変性機構

    2023.1 - 2024.3

    ライフサイエンス振興財団  研究開発助成 

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  • 認知症と全身性自己免疫疾患のシンクロナイゼーション理解

    2023.1 - 2024.3

    ホクト生物科学振興財団助成 

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  • 脂質代謝異常が神経変性疾患を誘発する機構の解明

    2022.11 - 2027.3

    武田科学振興財団  ライフサイエンス研究助成 

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  • マルチオミクス融合解析による前頭側頭型認知症におけるリピドーシス機構の解明

    2022.11 - 2023.12

    持田記念医学薬学振興財団  持田記念研究助成 

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  • 脂質摂取行動パターンが及ぼす心理・器官変容の解明 -文理融合研究が導く理学基礎研究の心理学的活用-

    2022.8 - 2023.3

    お茶の水女子大学  令和4年度文理融合共同研究 

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  • 老化により認知機能が低下するメカニズムの解明と治療法の創出

    2022.6 - 2023.3

    お茶の水女子大学  髙田弘子若手研究者奨学金 

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  • 細胞外マトリックス・ビトロネクチンによる肝星細胞活性を介したNASH病因の解明

    Grant number：19K16122  2021.11 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • 前頭側頭型認知症発症メカニズムと治療薬探索

    2020.3 - 2023.6

    お茶の水女子大学  株式会社ナガセ研究奨励金 

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  • 細胞外マトリックス・ビトロネクチンによる小脳顆粒神経細胞の軸索決定シグナル解明

    2017.4 - 2019.3

    科学研究費助成事業  特別研究員奨励費 

    橋本恵

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1900000

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Other

  • サイエンス学びラボ 高校生培養実習取材

    2025.7

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    https://science-manabi-lab.com/topics/t-article51/

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  • 科学技術振興機構サイエンスポータル 令和3年版科学技術・イノベーション白書特集インタビュー

    2021.7

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    https://scienceportal.jst.go.jp/gateway/sciencewindow/20210715_w01/

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  • 安田女子中学高等学校ホームページインタビュー"世界で活躍する本校の卒業生"

    2021.5

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