Organization
Undergraduate School School of Business Administration Professor
Title
Professor
Homepage
External link
Degree
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Ph.D. of Medicine ( 2004.12 Juntendo University )
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Master of Physical Education ( 1985.3 University of Tsukuba )
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Master of Physical Education ( 1985.3 University of Tsukuba )
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Bachelor of Business Administration ( 1982.3 Meiji University )
Research Areas
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Humanities & social sciences / Home economics, lifestyle science / 生活科学一般(General Life Science)
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Life sciences / Nutrition and health science / 応用健康科学(Applied Health Sciences)
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Life sciences / Immunology / 免疫学(Immunology)
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Life sciences / Sports science / スポーツ科学(Sports Science)
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Life sciences / Healthcare management, medical sociology / 公衆衛生学・健康科学(Public Hygiene Studies/Health Science)
Education
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University of Tsukuba Graduate School, Division of Physical Education
1983.4 - 1985.3
Country/Region： Japan
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Meiji University School of Business Management
1978.4 - 1982.3
Country/Region： Japan
Research History
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Juntendo University Medical School, Atopy Center Researher Postdoc Collabotate Researcher
2023.4
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Juntendo University Medical School, Department of Immunology Researher Postdoc Collaborate Researcher
2001.5 - 2023.3
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Tokyo Metropolitan Institute of Gerontology Part-time researcher for university or other academic organization Part-time Researcher
2000.4 - 2001.3
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Meiji University School of Business Administration Professor
1998.4
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University of Toronto Researher Postdoc Visiting Researcher
1994.4 - 1995.3
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Gunma University Faculty of Education Lecturer Part-time Lecturer
1994.1 - 2004.3
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Meiji University School of Business Administration Associate Professor Assistant Professor
1992.4 - 1998.3
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Meiji University School of Business Administration Lecturer
1989.4 - 1992.3
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Meiji University School of Business Administration Research Assistant Research Assistant.
1986.4 - 1989.3
Committee Memberships
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東洋大学 重点研究推進プログラム外部評価委員
2024.3
Committee type：Academic society
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東洋大学大学院 健康スポーツ研究科外部評価委員
2024.3
Committee type：Academic society
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日本体力医学会 学術委員会称号委員会副委員長
2006.7 - 2009.3
Committee type：Academic society
Papers
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Mobilization of NK cells by exercise : Down modulation of adhesion molecules on NK cells by catecholamines. Reviewed
Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura
American Journal of Physiology 279 ( 4 ) R1251-R1256 - R1256 2000.10
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Natural killer cell lytic activity and CD56(dim) and CD56(bright) cell distributions during and after intensive training
M Suzui, T Kawai, H Kimura, K Takeda, H Yagita, K Okumura, PN Shek, RJ Shephard
JOURNAL OF APPLIED PHYSIOLOGY 96 ( 6 ) 2167 - 2173 2004.6
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NK Cell and Protective Fitness Invited
The Japanese Society of Physical Fitness and Sports MedicineJapanese Journal of Physical Fitness and Sports 56 ( 1 ) 36 - 36 2002.2
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Highly Sensitive Determination of Plasma Cytokines by Time-Resolved Fluoroimmunoassay; Effect of Bicycle Exercise on Plasma Level of Interleukin-1α(IL-1α), Tumor Necrosis Factor α (TNFα), and Interferon γ (INFγ) Reviewed
Hiroko Kimura, Masatoshi Suzui, Fumiko Nagao, Kazuko Matsumoto
The Japan Society for Analytical ChemistryAnalytical Sciences 17 ( 5 ) 593-597 - 597 2001.5
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Indomethacin Inhibits Circulating PGE2 and Reverses Postexercise Suppression of Natutral Killer Cell Activity. Reviewed
Shawn G. Rhind, Greg A. Gannon, Masatoshi Suzui, Pang N. Shek, Roy J. Shephard
American Journal of Physiology 276 ( 5 Pt 2 ) R1496 - R1505 1999.5
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Does Anaerobic Threshold Coincide with the Threshold for Changes in Natural Killer Cell Cytotoxicity During Incremental Exercise? Reviewed
MEIJI LIFE FOUNDATION OF HEALTH AND WELFARE THE 14TH RESEARCH-AID REPORT 76 - 85 1999.3
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beta-Endorphin and natural killer cell cytolytic activity during prolonged exercies. Is there a connection? Reviewed
Gannon, G. A, S. G. Rhind, M. Suzui, J. Zamecnik, B. H. Sabiston, P. N. Shek, R. J. Shephard
American Journal of Physiology 257 ( 6Pt2 ) R1725 - R1734 1998.12
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beta-Endorphin and natural killer cell cytolytic activity during prolonged exercies. Is there a connection? Reviewed
Gannon, G. A., S. G. Rhind, M. Suzui, J. Zamecnik, B. H. Sabiston, P. N. Shek, R. J. Shephard
American Journal of Physiology 257 ( 6Pt2 ) R1725 - R1734 1998.12
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Circulating levels of peripheral blood leucocytes and cytokines following competitive cycling Reviewed
GA Gannon, SG Rhind, M Suzui, PN Shek, RJ Shephard
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE 22 ( 2 ) 133 - 147 1997.4
Books
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ナチュラルキラー細胞、ニュー運動生理学 II 宮村実晴編
（ Role： Joint authorSection 16 運動と免疫 5「ナチュラルキラー細胞」）
2015.1 （ ISBN:9784880038902 ）
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運動と免疫、運動器慢性疾患に対する運動療法 黒澤尚編
（ Role： Joint author第1章 基礎編「6. 運動と免疫」）
金原出版株式会社 2009.9 （ ISBN:9784307251433 ）
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トレーニングと免疫「ナチュラルキラー」、身体トレーニング 宮村実晴編
（ Role： Joint authorセクション8 トレーニングと免疫「ナチュラルキラー」）
真興交易医書出版部 2009.3 （ ISBN:9784880038261 ）
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NK細胞機能、新運動生理学（上巻）宮村実晴編
（ Role： Joint author免疫4「NK細胞機能」）
真興交易医書出版部 2001.11 （ ISBN:9784880036694 ）
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免疫機能と運動、スポーツ医学II-健康と運動-
池上晴夫（ Role： Joint author第9章「免疫機能と運動」）
朝倉書店 2000.1 （ ISBN:9784254695304 ）
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健康とからだの教養
健康とからだの教養研究会（ Role： Joint author第1章第2節「健康のパラダイム」）
学術図書出版 1993.3 （ ISBN:9784873617282 ）
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健康のパラダイム —ヘルスとウエルネス—、健康とからだの教養、健康とからだの教養研究会編
健康とからだの教養研究会（ Role： Joint author第1章第2節「健康のパラダイム」）
学術図書出版 1993.3 （ ISBN:9784873617282 ）
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運動時の蛋白質代謝、図説・運動生化学入門 伊藤朗編
伊藤朗,栗林徹,斉藤篤司, 杉浦崇夫 ,鈴井正敏,鈴木政登,角田聡,田崎洋佑,丹信介,丸山剛生,三上俊夫,山田哲雄（ Role： Joint author4章「運動時の蛋白質代謝」）
医歯薬出版 1987.4 （ ISBN:9784263702352 ）
MISC
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COVID-19 and Exercise
68 23 - 37 2022.3
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Effects of training on NK cell activating receptors
Memoirs of the Institute of Humanities, Meiji University 72 39 - 64 2013.3
Presentations
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Mobilization and Fcγ-Receptor Expression of Six NK Cell Subsets During and After Acute Exercise International conference
Masatoshi Suzui, Masashi Ichinose, Kazuyoshi Takeda, Shek, Roy J. Shephard, Ko Okumura
American College of Sports Medicine 66th Annual Meeting 2019.5 American College of Sports Medicine
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Natural Killer Cells Response to the Muscular Metaboreflex International conference
Masatoshi Suzui, Masashi Ichinose, Kazuyoshi Takeda, Hideo Yagita, Pang N. Shek, Roy J. Shephard, Ko Okumura
American College of Sports Medicine 61th Annual Meeting 2014.5 American College of Sports Medicine
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筋代謝受容器反射が血中免疫細胞動態に及ぼす影響
一之瀬真志,鈴井正敏,竹田和由
第68回日本体力医学会大会 2013.9 日本体力医学会
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炎症・免疫に対する運動の効果 −運動免疫学のこれまでの10年とこれからの10年−
第68回日本体力医学会大会 2013.9 日本体力医学会
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Effects of Acute Exercise on Expressions of Functional Receptors on CD56<SUP>dim</SUP> and CD56<SUP>bright</SUP> Natural Killer Cells International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Pang N. Shek, Roy J. Shephard, Ko Okumura
International Society of Exercise Immunology, The 11th Symposium 2013.9 International Society of Exercise Immunology
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Effect of OLL 1073R-1 Yogurt Intake on NK Cell Receptors during Intense Training International conference
Masatoshi Suzui, Kazuyoshi Takeda, Ryoichi Nagatomi, Hideo Yagita, Ko Okumura, Shuji Ikegami, Hiroyuki Ito, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 60th Annual Meeting 2013.5 American College of Sports Medicine
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運動と免疫 − NK細胞の動態を中心として − Invited
第32回日本登山医学会学術集会 2012.6 日本登山医学会
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Effects of Acute Exercise on Expressions of Natural Killer Cell Receptors International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 59th Annual Meeting 2012.6 American College of Sports Medicine
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Effect of OLL 1073R-1 Yogurt Intake on NK cell Cytolytic Activities during Intense Training. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Shuji Ikegami, Hiroyuki Ito, Hideo Yagita, Pang N. Shek, Roy J. Shephard, Ko Okumura
International Society of Exercise Immunology, The 10th Symposium 2011.7 International Society of Exercise Immunology
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Impact of Acute Exercise on Natural Killer Cell Subset Distributions in Selected Mouse Tissues. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Yoshihiro Hayakawa, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 58th Annual Meeting 2011.6 American College of Sports Medicine 58th Annual Meeting, Denver, Colorado, U.S.A.
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免疫力 運動アプローチ Invited
抗加齢医学の実際2010 2010.9 株式会社メディアプロデュース
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NK細胞の運動時の変化 ?イブニングセッション? 「運動をするとカゼをひきやすくなるのか？ ーオープンウィンドウ仮説への挑戦ー」 Invited
第65回日本体力医学会大会 2010.9 日本体力医学会
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Effect of NKG2D and DNAM-1 Expression on CD56<SUP>dim</SUP> NK Cell and Cytotoxic Activity During Training. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 57th Annual Meeting 2010.6 American College of Sports Medicine
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スポーツと免疫 Invited
第36回香川県スポーツ医学フォーラム 2009.12 香川県スポーツ医科学フォーラム
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Relationship Between Autonomic Nerve Activity and Distribution of Neutrophil and Lymphocyte Subsets during Intensive Training. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
The 9th Symposium of the International Society of Exercise and Immunology 2009.9 The International Society of Exercise and Immunology
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Relationship Between Autonomic Nerve Activity And Distribution Of Leukocyte Subsets During Intensive Training. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 56th Annual Meeting 2009.5 American College of Sports Medicine
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Changes in Adhesion Molecule Expression on Natural Killer Cell Subsets during Incremental Exercise. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 55th Annual Meeting 2008.5 American College of Sports Medicine
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Players of innate immunity; friend or foe? Natural Killer Cell Subsets and Exercise. Invited International conference
The 8th Symposium of the International Society of Exercise and Immunology 2007.10 The International Society of Exercise and Immunology
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Relationship between Natural Killer Cell Cytotoxicity and Overtraining Aspects during Intensive Training. International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 54th Annual Meeting 2007.6 American College of Sports Medicine
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Exercise and NK Cell 10 (Changes In The Proportions Of CD56<SUP>dim</SUP> And CD56<SUP>bright</SUP> Natural Killer Cells During And After Acute Exercise)
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
第36回日本免疫学会総会 2006.12 日本免疫学会
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Changes In The Proportions Of CD56<SUP>dim</SUP> And CD56<SUP>bright</SUP> Natural Killer Cells During And After Acute Exercise International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 53rd Annual Meeting 2006.6 American College of Sports Medicine
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Plasma Glutamine Concentration and Natural Killer Cell Cytotoxicity During Intensive Training International conference
Masatoshi Suzui, Takeshi Kawai, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
The 7th Symposium of the International Society of Exercise and Immunology 2005.9 The International Society of Exercise and Immunology
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Changes In The Proportions Of CD56<SUP>dim</SUP> And CD56<SUP>bright</SUP> Natural Killer Cells During Incremental Exercise International conference
Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 52nd Annual Meeting 2005.6 American College of Sports Medicine
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運動がNK細胞に及ぼす影響9 （トレーニング時の血漿グルタミン濃度とNK細胞活性）
鈴井正敏,川合武司,竹田和由,八木田秀雄,奥村康
第34回日本免疫学会総会 2004.12 日本免疫学会
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一般大学生を対象としたスポーツ活動習慣の有無と免疫疾患に関する意識調査
矢野博巳,鈴木克彦,鈴井正敏,永富良一
第59回日本体力医学会大会 2004.9 日本体力医学会
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スポーツ活動と急性上気道感染症のリスク
牛凱軍,鈴木克彦,矢野博巳,鈴井正敏,永富良一
第59回日本体力医学会大会 2004.9 日本体力医学会
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Changes in Plasma Glutamine Concentration and Natural Killer Cell Cytotoxicity During Intensive Training International conference
Masatoshi Suzui, Takeshi Kawai, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 51st Annual Meeting 2004.6 American College of Sports Medicine
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運動がNK細胞に及ぼす影響8（CD56<SUP>dim</SUP>およびCD56<SUP>bright</SUP>細胞の変化）
鈴井正敏,川合武司,竹田和由,八木田秀雄,奥村康
第33回日本免疫学会総会 2003.12 日本免疫学会
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Changes in Proportions of CD56<SUP>dim</SUP> and CD56<SUP>bright</SUP> Natural Killer Cells During Intensive Training International conference
Masatoshi Suzui, Takeshi Kawai, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 50th Annual Meeting 2003.5 American College of Sports Medicine
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Changes in Adhesion Molecule on Natural Killer Cell Post Exercise International conference
Masatoshi Suzui, Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 49th Annual Meeting 2002.5 American College of Sports Medicine
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運動がNK細胞に及ぼす影響7（運動後の接着分子の変化）
鈴井正敏,長尾夫美子,竹田和由,八木田秀雄,奥村康
第31回日本免疫学会総会 2001.12 日本免疫学会
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シンポジウム あなたの免疫力はどこまでわかる「NK細胞からみた防衛体力」
第56回日本体力医学会大会 2001.9 日本体力医学会
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Natural Killer Cell Cytotoxicity Decreased during Intensive Training in Female Volleyball Players International conference
American College of Sports Medicine 48th Annual Meeting 2001.5 American College of Sports Medicine
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Changes in IL-1α and IFN-γ during Incremental Exercise International conference
The 5th Congress of the International Society of Exercise and Immunology 2001.5 the International Society of Exercise and Immunology
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Exercise and NK cells 6(Changes in Plasma Cytokine Levels during Intensive Training)
Proceedings of the Japanese Society for Immunology 2000.11 The Japanese Society for Immunology
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運動がNK細胞に及ぼす影響5（強いトレーニングの影響）
鈴井正敏,長尾夫美子,川合武司,竹田和由,八木田秀雄,奥村康
第30回日本免疫学会総会 2000.11 日本免疫学会
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時間分解蛍光イムノアッセイによる血清中のサイトカインの測定2；長期の激しい運動が免疫機能に及ぼす影響
木村博子,田嶋美智子,鈴井正敏,向田政博,松本和子
日本分析化学会第49年会 2000.9 日本分析化学会
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Changes In Natural Killer Cell Cytotoxicity and Adhesion Molecule Expression during Incremental Exercise. International conference
Masatoshi Suzui, Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 47th Annual Meeting 2000.5 American College of Sports Medicine
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Exercise and NK cells 4 (Trasition of the concentration of cytokines during and after exercise in serum)
Proceedings of the Japanese Society for Immunology 1999.12 Japanese Society for Immunology
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運動がNK細胞に及ぼす影響3（漸増負荷運動の影響）
鈴井正敏,長尾夫美子,竹田和由,八木田秀雄,奥村康
第29回日本免疫学会総会 1999.12 日本免疫学会総会
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Do Temporary Anaerobic Efforts Open the Window of Natural Killer Cell Cytotoxicity? International conference
Masatoshi Suzui, Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Shawn G. Rhind, Greg A.Gannon, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 46th Annual Meeting 1999.6 American College of Sports Medicine
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Does Anaerobic Threshold Coincide with the Threshold for Changes in Natural Killer Cell Cytotoxicity During Incremental Exercise? International conference
Masatoshi Suzui, Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J. Shephard
The 4th Congress of the International Society of Exercise and Immunology 1999.5 International Society of Exercise and Immunology
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Exercise and NK cell 2(Changes in Adhesion molecules on NK Cell)
Proceedings of the Japanese Society for Immunology 1998.12 The Japanese Society for Immunology
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Exercise and NK cell 1(Effects of Different Exercise Intensities)
1998.12 The Japanese Society for Immunology
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Effects of 2h of Exercise and in Vivo Indomethacin on Circulating PGE2 Levels and NK Cell Activity
Shawn G. Rhind, Greg A.Gannon, Pang N. Shek, Masatoshi Suzui, Roy J. Shephard
American College of Sports Medicine 45th Annual Meeting 1998.6 American College of Sports Medicine
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Is Ventilatory Threshold A Key to Open The Window of Natural Killer CellCytotoxicity?
Masatoshi Suzui, Fumiko Nagao, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Shawn G. Rhind, Greg A.Gannon, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 45th Annual Meeting 1998.6 American College of Sports Medicine
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Exercise-Enhanced Natural Killer-Cell Cytotoxic Capacity of Peripheral Blood is Not Affected by the Opioid Antagonist Naltrexone International conference
Greg A. Gannon, Shawn G. Rhind, Masatoshi Suzui, Pang N. Shek, Roy J. Shephard
American College of Sports Medicine 44th Annual Meeting 1997.5 American College of Sports Medicine
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Determination of Natural killer Cell Activity by Flow Cytometry: Applications in Studies of Exercise Immunology International conference
Shawn G. Rhind, Greg A. Gannon, Masatoshi Suzui, Pang N. Shek, Roy J. Shephard
The 2nd Congress of the International Society of Exercise and Immunology 1995.11 International Society of Exercise and Immunology
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Changes in Selected Cellular and Soluble Mediators of Immunity Following a 250-km Competitive Road-Cycling Race International conference
Greg A. Gannon, Shawn G. Rhind, Masatoshi Suzui, Pang N. Shek, Roy J. Shephard
The 2nd Congress of the International Society of Exercise and Immunology 1995.11 International Society of Exercise and Immunology
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一般大学生のフルマラソン中および回復期の感情の経時的変化
◎斉藤篤司*(助教授), 鈴井正敏(教授), 後藤真二*(助教授), 橋本公雄*(教授)
九州体育学会第42回大会 1993.9 九州体育学会
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Health Promotion vs Karoshi International conference
The 18th Annual Association for Fitness in Business International Conference 1992.9 Association for Fitness in Business
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Examples of Health Promotion Activities at the Worksite in Japan International conference
The 17th Annual Association for Fitness in Business International Conference 1991.9 Association for Fitness in Business
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Health Promotion Activities in Japan Invited
International Symposium on Community Based Fitness and Health 1990.9
Works
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心身の調和を追求する新しい視点～ライフスタイルマネジメントの可能性～
2024.3
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現代人に必要なライフスタイルマネジメント。豊かな人生を送るためのバランスの取り方とは
2023.2
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「楽しみ」がなければ健康を害する？ライフスタイルマネジメントとは
2023.1
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免疫を強くする運動との関係とは?
2021.1
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今だから知りたい免疫と運動の関係
2020.12
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サッカージュニアの免疫力を上げる秘訣
2019.11
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適度な運動こそ強くなれる。戦えるチカラ。
2019.7
Awards
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第14回明治生命厚生事業団 健康医科学研究助成
1998.1 明治生命厚生事業団 無酸素性作業閾値はナチュラルキラー細胞活性の閾値としても考えられるか
鈴井正敏, 長尾夫美子, 竹田和由, 八木田秀雄, 奥村康
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第14回明治生命厚生事業団 健康医科学研究助成
1998.1 明治生命厚生事業団 無酸素性作業閾値はナチュラルキラー細胞活性の閾値としても考えられるか
鈴井正敏,長尾夫美子,竹田和由,八木田秀雄,奥村康
Research Projects
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Relationships of the immune-cells dynamic state in circulatory blood and regulations of cardiovascular, autonomic nerve activity and hormonal secretion during exercise
Grant number：24650450 2012.4 - 2014.3
Japan Society for the Promotion of Science Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
Masashi Ichinose
Authorship：Coinvestigator(s)
Grant amount：\4640000 （ Direct Cost: \3770000 、 Indirect Cost：\870000 ）
In this study, we found that when the muscle metaboreflex activation by forearm muscle ischemia after the handgrip exercise caused increase in sympathetic nerve activity and secretion of catecholamine without large rise in circulatory blood flow, the circulating count of NK cells as well as NK cell cytotoxicity increased. In addition, when passive bicycle exercise induced increase in circulatory blood flow and the fall of catecholamine concentration, we found that the circulating count of helper T cells, killer T cells and B cells increased. These findings advance elucidation of regulatory mechanisms of immune-cells dynamic state in circulatory blood during exercise, and will be a significant academic base in considering the efficacy of the exercise training in promotion of health.
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*
2010.4 - 2012.3
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Effecs of Exercise on Intensities of Expressions of Receptors on NK cell Subsets.
Grant number：21300257 2009.4 - 2013.3
Japan Society for the Promotion of Science The Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
SUZUI Masatoshi
Authorship：Principal investigator
Grant amount：\9120000 （ Direct Cost: \7410000 、 Indirect Cost：\1710000 ）
In these studies，we examined the impacts of acute and chronic exercise on the functional receptors on NK cell in human. The results indicated that both induced changes in the expressions of molecules. These changes were mainly found in CD56dim NK cell. Some of changes in adhesion molecules seemed to contribute to cell mobilization. However, changes in activating/inhibitory receptors did not directly relate to the cell cytotoxicity. We also indicated the possibility that acute exercise stimulated cell turnover in the liver in mice.
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Exercise and Immunology
2009
Authorship：Principal investigator
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*
Grant number：15630009 2003.4 - 2004.3
Japan Society for the Promotion of Science The Grant-in-Aid for Scientific Research (C)
Ryoichi Nagatomi
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Effects of Intensive Training on Natural Killer Cell Function
Grant number：11680058 1999.4 - 2001.3
Japan Society for the Promotion of Science The Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
SUZUI Masatoshi, KAWAI Takeshi
Authorship：Principal investigator
Grant amount：\3100000 （ Direct Cost: \3100000 ）
Purpose : The impact of heavy training in competitive sports on natural killer (NK) cell function in eight female volleyball players of a college team was investigated, in a one-month period during their preparation for the game season. Methods : Subjects performed volleyball drills for five hours per day and six days per week. Four resting blood samples were taken respectively in the morning, pre-training (PRE), on the 10th day of training (DURING), one day before the end of training (END) and one week after training (POST). Data were analyzed using one-factor ANOVA with Bonferroni's post hoc test, Results and Discussion : Epinephrine, norepinephrine and cortisol concentrations remained unchanged from PRE levels, but plasma creatine kinase concentration increased at END (p=0.001). The number and percentage of circulating NK cells did not change throughout the experiment ; neither did other leukocyte subset counts. However, an overall decrease in NK cell cytotoxicity by 20.3±11.8% (p=0.02) was observed from PRE to END, recovering at POST.Lytic units per NK cell followed a similar pattern (p=0.002). The intensity of expression of CD44 on NK cells (CD3^-CD56^+) increased significantly at END (both, p<0.05). The expression of CD62L decreased at DURING and the expression of CD 18 dropped at POST (p<0.05). These results suggest that heavy training can decrease total NK cell cytotoxicity as well as the lytic activity per NK cell that was different response during and after acute exercise.
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Exercise and Immune Function
1996
Authorship：Coinvestigator(s)
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Exercise and Immune Function
1994
Authorship：Coinvestigator(s)
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Lifestyle Management
1986
Authorship：Principal investigator
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Wellness
1986
Authorship：Principal investigator
Teaching Experience
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Contemporary Health Issues
2023.4 Institution：Meiji University, The School of Business Administration
Level：Undergraduate (specialized)
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Lifestyle Management
2003.4 Institution：Meiji University, The School of Business Administration
Level：Undergraduate (specialized)
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Health Science
1989.4 Institution：Meiji University, The School of Business Administration
Level：Undergraduate (liberal arts)
Social Activities
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