Updated on 2026/03/22

写真a

 
TAKAHASHI NAOKI
 
Organization
Undergraduate School School of Agriculture Associate Professor
Title
Associate Professor
External link

Research Interests

  • 植物分子細胞生物学

  • 植物生理学

Research Areas

  • Life sciences / Plants: molecular biology and physiology

Research History

  • Meiji University   School of Agriculture Department of Life Sciences   Associate Professor

    2023.4

    　 More details

  • Nara Institute of Science and Technology   Assistant Professor (non-tenured)

    2012.4 - 2023.3

    　 More details

Professional Memberships

Papers

  • A start codon-targeted genome editing strategy for generating hypomorphic mutants of lethal plant genes.

    Mika Yoshimura, Tsubasa Mamiya, Naoki Takahashi, Takashi Ishida

    Plant biotechnology (Tokyo, Japan)   42 ( 4 )   509 - 512   2025.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    In plants, the functional characterization of essential genes is often hindered by the lethality associated with complete loss-of-function alleles. Here, we present a genome editing-based strategy to generate viable hypomorphic alleles through selective removal of the translation start codon. Using Arabidopsis thaliana NON-SMC ELEMENT 1, which encodes a conserved component of the Structural Maintenance of Chromosomes (SMC) 5/6 complex involved in DNA repair and genome stability, as a model, we generated CRISPR-Cas9-edited alleles lacking the start codon. These homozygous mutants exhibited severe developmental defects, including stunted growth and failure to form true leaves. Moreover, they displayed molecular hallmarks of genome instability, such as increased DNA fragmentation, upregulation of DNA repair and cell cycle checkpoint genes, and root meristem cell death. Complementation assays using wild-type and mutated NSE1 genomic constructs confirmed that these alleles retained partial gene function. Overall, the use of start codon removal as an editing strategy is a robust and broadly applicable approach for generating hypomorphic alleles without relying on transcript-level manipulations, such as RNAi. This work therefore provides a practical demonstration of a novel editing strategy for dissecting the functions of essential genes that are otherwise genetically intractable. Consequently, this approach expands the functional genomics toolkit and opens new avenues for basic plant biology and advanced biotechnological applications.

    DOI： 10.5511/plantbiotechnology.25.0812a

    PubMed

    researchmap

  • The transcriptional repressors IAA5 and IAA29 participate in DNA damage-induced stem cell death in Arabidopsis roots. International journal

    Naoki Takahashi, Nobuo Ogita, Toshiya Koike, Kohei Nishimura, Soichi Inagaki, Ye Zhang, Takumi Higaki, Masaaki Umeda

    Plant physiology   198 ( 3 )   2025.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Plants generate organs continuously during postembryonic development. Thus, their ability to preserve stem cells in changing environments is crucial for their survival. Genotoxic stress threatens genome stability in all somatic cells. However, in the meristem, only the stem cells actively die in response to DNA damage, followed by stem cell replenishment that guarantees genome stability in these cells. Cytokinin biosynthesis-induced inhibition of downward auxin flow participates in DNA damage-induced stem cell death in roots. Without this system, stem cell death occurs at a reduced but significant level, suggesting another mechanism governing the DNA damage response in stem cells. Here, we demonstrate that in response to DNA double-strand breaks, the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) family members IAA5 and IAA29, encoding negative regulators of auxin signaling, are induced in Arabidopsis (Arabidopsis thaliana) roots. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 directly induces their expression as an active response to DNA damage. In the iaa5 iaa29 double mutant, DNA damage-induced stem cell death is greatly suppressed, while it is fully restored by the expression of a stable form of IAA5 in vascular stem cells. Our genetic data reveal that reduced auxin signaling around the stem cell niche, caused by IAA5 and IAA29 induction and enhanced cytokinin biosynthesis, is a prerequisite for cell death induction, thus playing a central role in maintaining genome integrity in root stem cells.

    DOI： 10.1093/plphys/kiaf303

    PubMed

    researchmap

  • SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.

    Toshiki Wada, Ayako N Sakamoto, Masaaki Umeda, Naoki Takahashi

    Journal of plant research   138 ( 4 )   679 - 693   2025.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Living organisms are constantly at the risk of DNA damage caused by factors such as DNA replication errors, reactive oxygen species, and UV radiation. In plants, DNA damage activates the NAC-type transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) that governs DNA damage responses such as cell cycle arrest, stem cell death, and early onset of endoreplication. However, molecular mechanisms underlying the early induction of endoreplication onset in response to DNA damage remain elusive. In this study, we show that CELL CYCLE SWITCH 52 A1 (CCS52A1), an activator of the APC/C E3 ligase, plays a major role in the early onset of endoreplication in response to DNA double-strand breaks (DSBs) in Arabidopsis roots. Upon DSBs, SOG1 directly binds to the CCS52A1 locus, thereby inducing its expression. Moreover, early transition to endoreplication in response to DSBs is suppressed in ccs52a1 knockout roots. Our data propose that increased polyploidy may function as a unique adaptative mechanism to genotoxic stress in plants.

    DOI： 10.1007/s10265-025-01630-y

    PubMed

    researchmap

  • DNA double-strand breaks enhance brassinosteroid signaling to activate quiescent center cell division in Arabidopsis

    Naoki Takahashi, Kazuki Suita, Toshiya Koike, Nobuo Ogita, Ye Zhang, Masaaki Umeda

    Journal of Experimental Botany   75 ( 5 )   1364 - 1375   2023.10

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    In Arabidopsis roots, the quiescent center (QC), a group of slowly dividing cells located at the center of the stem cell niche, functions as an organizing center to maintain the stemness of neighboring cells. Recent studies have shown that they also act as a reservoir for backup cells, which replenish DNA-damaged stem cells by activating cell division. The latter function is essential for maintaining stem cells under stressful conditions, thereby guaranteeing post-embryonic root development in fluctuating environments. In this study, we show that one of the brassinosteroid receptors in Arabidopsis, BRASSINOSTEROID INSENSITIVE1-LIKE3 (BRL3), plays a major role in activating QC division in response to DNA double-strand breaks. SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor governing DNA damage response, directly induces BRL3. DNA damage-induced QC division was completely suppressed in brl3 mutants, whereas QC-specific overexpression of BRL3 activated QC division. Our data also showed that BRL3 is required to induce the AP2-type transcription factor ETHYLENE RESPONSE FACTOR 115, which triggers regenerative cell division. We propose that BRL3-dependent brassinosteroid signaling plays a unique role in activating QC division and replenishing dead stem cells, thereby enabling roots to restart growing after recovery from genotoxic stress.

    DOI： 10.1093/jxb/erad424

    researchmap

    Other Link： https://academic.oup.com/jxb/article-pdf/75/5/1364/56751686/erad424.pdf

  • Cytokinin signaling promotes root hair growth by directly regulating <i>RSL4</i> expression

    Hirotomo Takatsuka, Anna Sasaki, Naoki Takahashi, Michitaro Shibata, Keiko Sugimoto, Maho Tanaka, Motoaki Seki, Masaaki Umeda

    Journal of Experimental Botany   2023.3

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Root hairs are single-celled tubular structures produced from the epidermis, which play an essential role in water and nutrient uptake from the soil. Therefore, root hair formation and elongation are controlled not only by developmental programs but also by environmental factors, enabling plants to survive under fluctuating conditions. Phytohormones are key signals that link environmental cues to developmental programs; indeed, root hair elongation is known to be controlled by auxin and ethylene. Another phytohormone, cytokinin, also affects root hair growth, while whether cytokinin is actively involved in root hair growth and, if so, how it regulates the signaling pathway governing root hair development have remained unknown. In this study, we show that the two-component system of cytokinin, which involves the B-type response regulators ARABIDOPSIS RESPONSE REGULATOR 1 (ARR1) and ARR12, promotes the elongation process of root hairs. They directly upregulate ROOT HAIR DEFECTIVE 6-LIKE 4 (RSL4) encoding a basic helix-loop-helix (bHLH) transcription factor that plays a central role in root hair growth, whereas the ARR1/12-RSL4 pathway does not crosstalk with auxin or ethylene signaling. These results suggest that cytokinin signaling constitutes another input onto the regulatory module governed by RSL4, making it possible to fine-tune root hair growth in changing environments.

    DOI： 10.1093/jxb/erad091

    researchmap

  • Brassinosteroids are required for efficient root tip regeneration in &lt;i&gt;Arabidopsis&lt;/i&gt;

    Naoki Takahashi, Masaaki Umeda

    Plant Biotechnology   39 ( 1 )   73 - 78   2022.3

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Plant Cell and Molecular Biology  

    DOI： 10.5511/plantbiotechnology.21.1103a

    researchmap

  • CFI 25 Subunit of Cleavage Factor I is Important for Maintaining the Diversity of 3MODIFIER LETTER PRIME UTR Lengths in Arabidopsis thaliana (L.) Heynh.

    Xiaojuan Zhang, Mika Nomoto, Marta Garcia-Leon, Naoki Takahashi, Mariko Kato, Kei Yura, Masaaki Umeda, Vicente Rubio, Yasuomi Tada, Tsuyoshi Furumoto, Takashi Aoyama, Tomohiko Tsuge

    PLANT AND CELL PHYSIOLOGY   63 ( 3 )   369 - 383   2022.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/pcp/pcac002

    Web of Science

    researchmap

  • Arabidopsis thaliana subclass I ACTIN DEPOLYMERIZING FACTORs and vegetative ACTIN2/8 are novel regulators of endoreplication.

    Noriko Inada, Naoki Takahashi, Masaaki Umeda

    Journal of plant research   134 ( 6 )   1291 - 1300   2021.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10265-021-01333-0

    Web of Science

    PubMed

    researchmap

  • Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks in Arabidopsis roots

    Naoki Takahashi, Soichi Inagaki, Kohei Nishimura, Hitoshi Sakakibara, Ioanna Antoniadi, Michal Karady, Karin Ljung, Masaaki Umeda

    Science Advances   7 ( 25 )   eabg0993 - eabg0993   2021.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/sciadv.abg0993

    Web of Science

    researchmap

  • ANAC044 is associated with P reutilization in P deficient Arabidopsis thaliana root cell wall in an ethylene dependent manner

    Xiao Long Zhang, Qi Wu, Ye Tao, Xiao Fang Zhu, Naoki Takahashi, Masaaki Umeda, Ren Fang Shen, Jian Feng Ma

    ENVIRONMENTAL AND EXPERIMENTAL BOTANY   185   2021.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.envexpbot.2021.104386

    Web of Science

    researchmap

  • Regulation of the Plant Cell Cycle in Response to Hormones and the Environment. International journal

    Akie Shimotohno, Shiori S Aki, Naoki Takahashi, Masaaki Umeda

    Annual review of plant biology   72   273 - 296   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1146/annurev-arplant-080720-103739

    Web of Science

    PubMed

    researchmap

  • TheArabidopsisNRT1/PTR FAMILY protein NPF7.3/NRT1.5 is an indole-3-butyric acid transporter involved in root gravitropism International journal

    Shunsuke Watanabe, Naoki Takahashi, Yuri Kanno, Hiromi Suzuki, Yuki Aoi, Noriko Takeda-Kamiya, Kiminori Toyooka, Hiroyuki Kasahara, Ken-ichiro Hayashi, Masaaki Umeda, Mitsunori Seo

    Proceedings of the National Academy of Sciences   117 ( 49 )   31500 - 31509   2020.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.2013305117

    Web of Science

    PubMed

    researchmap

  • SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana. Reviewed International journal

    Kaoru Okamoto Yoshiyama, Naoki Aoshima, Naoki Takahashi, Tomoaki Sakamoto, Kei Hiruma, Yusuke Saijo, Jun Hidema, Masaaki Umeda, Seisuke Kimura

    Plant molecular biology   103 ( 3 )   321 - 340   2020.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11103-020-00994-0

    Web of Science

    PubMed

    researchmap

  • ストレスに応答した植物の細胞周期停止機構 Reviewed

    高橋直紀, 梅田正明

    BSJ-review   11   122 - 130   2020.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • Gap 2 phase: making the fundamental decision to divide or not. Reviewed

    Umeda M, Aki SS, Takahashi N

    Current opinion in plant biology   51   1 - 6   2019.10

    　More details

  • A regulatory module controlling stress-induced cell cycle arrest in <i>Arabidopsis</i>. Reviewed

    Takahashi N, Ogita N, Takahashi T, Taniguchi S, Tanaka M, Seki M, Umeda M

    eLife   8   2019.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.7554/eLife.43944

    Web of Science

    PubMed

    researchmap

  • Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Reviewed International journal

    Nobuo Ogita, Yoko Okushima, Mutsutomo Tokizawa, Yoshiharu Y Yamamoto, Maho Tanaka, Motoaki Seki, Yuko Makita, Minami Matsui, Kaoru Okamoto-Yoshiyama, Tomoaki Sakamoto, Tetsuya Kurata, Kei Hiruma, Yusuke Saijo, Naoki Takahashi, Masaaki Umeda

    The Plant journal : for cell and molecular biology   94 ( 3 )   439 - 453   2018.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/tpj.13866

    Web of Science

    PubMed

    researchmap

  • Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage Reviewed

    Poyu Chen, Hirotomo Takatsuka, Naoki Takahashi, Rie Kurata, Yoichiro Fukao, Kosuke Kobayashi, Masaki Ito, Masaaki Umeda

    NATURE COMMUNICATIONS   8 ( 1 )   635   2017.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-017-00676-4

    Web of Science

    PubMed

    researchmap

  • DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana Reviewed

    La Ode Muhammad Muchdar Davis, Nobuo Ogita, Soichi Inagaki, Naoki Takahashi, Masaaki Umeda

    GENES TO CELLS   21 ( 11 )   1195 - 1208   2016.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/gtc.12436

    Web of Science

    PubMed

    researchmap

  • The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis Reviewed

    Annika K. Weimer, Sascha Biedermann, Hirofumi Harashima, Farshad Roodbarkelari, Naoki Takahashi, Julia Foreman, Yonsheng Guan, Gaetan Pochon, Maren Heese, Daniel Van Damme, Keiko Sugimoto, Csaba Koncz, Peter Doerner, Masaaki Umeda, Arp Schnittger

    EMBO JOURNAL   35 ( 19 )   2068 - 2086   2016.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.15252/embj.201593083

    Web of Science

    PubMed

    researchmap

  • 植物のDNA損傷応答 Invited Reviewed

    高橋 直紀, 梅田 正明

    化学と生物   54 ( 2 )   123 - 129   2016.1

    　More details

  • 根端メリステムのサイズ制御機構 Invited Reviewed

    高橋 直紀, 梅田 正明

    BSJ-review   7   201 - 209   2016

    　More details

  • Cytokinins promote onset of endoreplication by controlling cell cycle machinery Reviewed

    Naoki Takahashi, Masaaki Umeda

    Plant Signaling and Behavior   9 ( 8 )   e29396   2014.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4161/psb.29396

    Web of Science

    Scopus

    PubMed

    researchmap

  • Cytokinins promote onset of endoreplication by controlling cell cycle machinery. Reviewed

    Takahashi N, Umeda M

    Plant signaling & behavior   9 ( 8 )   2014.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4161/psb.29396

    Web of Science

    PubMed

    researchmap

  • The Arabidopsis SIAMESE-RELATED Cyclin-Dependent Kinase Inhibitors SMR5 and SMR7 Regulate the DNA Damage Checkpoint in Response to Reactive Oxygen Species Reviewed

    Dalong Yi, Claire Lessa Alvim Kamei, Toon Cools, Sandy Vanderauwera, Naoki Takahashi, Yoko Okushima, Thomas Eekhout, Kaoru Okamoto Yoshiyama, John Larkin, Hilde Van den Daele, Phillip Conklin, Anne Britt, Masaaki Umeda, Lieven De Veylder

    PLANT CELL   26 ( 1 )   296 - 309   2014.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1105/tpc.113.118943

    Web of Science

    PubMed

    researchmap

  • Cytokinins Control Endocycle Onset by Promoting the Expression of an APC/C Activator in Arabidopsis Roots Reviewed

    Naoki Takahashi, Takehiro Kajihara, Chieko Okamura, Yoonhee Kim, Youhei Katagiri, Yoko Okushima, Sachihiro Matsunaga, Ildoo Hwang, Masaaki Umeda

    CURRENT BIOLOGY   23 ( 18 )   1812 - 1817   2013.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cub.2013.07.051

    Web of Science

    PubMed

    researchmap

  • Jasmonate Controls Leaf Growth by Repressing Cell Proliferation and the Onset of Endoreduplication while Maintaining a Potential Stand-By Mode Reviewed

    Sandra Noir, Moritz Boemer, Naoki Takahashi, Takashi Ishida, Tjir-Li Tsui, Virginia Balbi, Hugh Shanahan, Keiko Sugimoto, Alessandra Devoto

    PLANT PHYSIOLOGY   161 ( 4 )   1930 - 1951   2013.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1104/pp.113.214908

    Web of Science

    PubMed

    researchmap

  • Dof transcription factors control the expression of the anaphase promoting complex/cyclosome activator CCS52A1 Reviewed

    Naoki Takahashi, Shanshan Kong, Masaaki Umeda

    Plant Biotechnology   30 ( 4 )   407 - 410   2013

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Plant Cell and Molecular Biology  

    Endoreduplication, a modified cell cycle process in which the cellular DNA level increases without subsequent cell division, is a key component of growth and development of plants. CCS52A1, a substrate-specific activator of the anaphase promoting complex/cyclosome (APC/C), is essential for the transition from mitosis to endoreduplication. Here, we show that DNA-binding with one finger (Dof) transcription factors directly regulate the transcription of the <i>CCS52A1</i> gene. Dof proteins are plant-specific transcription factors involved in plant growth and development processes, such as phytohormone and light signaling, defense response, and seed germination. We performed yeast one-hybrid screening using an <i>Arabidopsis</i> transcription factor library and identified several Dof transcription factors as novel <i>CCS52A1</i> promoter-binding proteins. Protoplast transient assay showed that the Dof proteins, such as CDF1, CDF2, CDF3, and COG1, function as transcriptional repressors of <i>CCS52A1</i>. All of these Dof transcription factors were localized to the nucleus. Our data imply that CDF1, CDF2, CDF3, and COG1 control plant growth and development through the regulation of <i>CCS52A1</i> expression.

    DOI： 10.5511/plantbiotechnology.13.0408a

    CiNii Research

    researchmap

    Other Link： https://jlc.jst.go.jp/DN/JALC/10025638683?from=CiNii

  • Transcriptional repression of the APC/C activator CCS52A1 promotes active termination of cell growth Reviewed

    Christian Breuer, Kengo Morohashi, Ayako Kawamura, Naoki Takahashi, Takashi Ishida, Masaaki Umeda, Erich Grotewold, Keiko Sugimoto

    EMBO JOURNAL   31 ( 24 )   4488 - 4501   2012.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/emboj.2012.294

    Web of Science

    PubMed

    researchmap

  • A Comprehensive Analysis of Interaction and Localization of Arabidopsis SKP1-LIKE (ASK) and F-Box (FBX) Proteins Reviewed

    Hirofumi Kuroda, Yuki Yanagawa, Naoki Takahashi, Yoko Horii, Minami Matsui

    PLOS ONE   7 ( 11 )   e50009   2012.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0050009

    Web of Science

    PubMed

    researchmap

  • SD3, an Arabidopsis thaliana Homolog of TIM21, Affects Intracellular ATP Levels and Seedling Development Reviewed

    Hidefumi Hamasaki, Takeshi Yoshizumi, Naoki Takahashi, Mieko Higuchi, Takashi Kuromori, Yuko Imura, Hiroaki Shimada, Minami Matsui

    MOLECULAR PLANT   5 ( 2 )   461 - 471   2012.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/mp/ssr088

    Web of Science

    PubMed

    researchmap

  • Arabidopsis mitochondrial protein TIM50 affects hypocotyl cell elongation through intracellular ATP level Reviewed

    Shailesh Kumar, Takeshi Yoshizumi, Hiroaki Hongo, Arata Yoneda, Hiroko Hara, Hidefumi Hamasaki, Naoki Takahashi, Noriko Nagata, Hiroaki Shimada, Minami Matsui

    PLANT SCIENCE   183   212 - 217   2012.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.plantsci.2011.08.014

    Web of Science

    PubMed

    researchmap

  • The Arabidopsis thaliana Checkpoint Kinase WEE1 Protects against Premature Vascular Differentiation during Replication Stress Reviewed

    Toon Cools, Anelia Iantcheva, Annika K. Weimer, Shannah Boens, Naoki Takahashi, Sara Maes, Hilde Van den Daele, Gert Van Isterdael, Arp Schnittger, Lieven De Veylder

    PLANT CELL   23 ( 4 )   1435 - 1448   2011.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1105/tpc.110.082768

    Web of Science

    PubMed

    researchmap

  • Normalization using ploidy and genomic DNA copy number allows absolute quantification of transcripts, proteins and metabolites in cells Reviewed

    Hiroshi Shimada, Takeshi Obayashi, Naoki Takahashi, Minami Matsui, Atsushi Sakamoto

    PLANT METHODS   6   29   2010.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1746-4811-6-29

    Web of Science

    PubMed

    researchmap

  • The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair Reviewed

    Naoki Takahashi, Mauricio Quimbaya, Veit Schubert, Tim Lammens, Klaas Vandepoele, Ingo Schubert, Minami Matsui, Dirk Inze, Geert Berx, Lieven De Veylder

    PLOS GENETICS   6 ( 1 )   e1000817   2010.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pgen.1000817

    Web of Science

    PubMed

    researchmap

  • The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1 Reviewed

    Naoki Takahashi, Tim Lammens, Veronique Boudolf, Sara Maes, Takeshi Yoshizumi, Geert De Jaeger, Erwin Witters, Dirk Inze, Lieven De Veylder

    EMBO JOURNAL   27 ( 13 )   1840 - 1851   2008.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/emboj.2008.107

    Web of Science

    PubMed

    researchmap

  • shk1-D, a dwarf Arabidopsis mutant caused by activation of the CYP72C1 gene, has altered brassinosteroid levels Reviewed

    N Takahashi, M Nakazawa, K Shibata, T Yokota, A Ishikawa, K Suzuki, M Kawashima, T Ichikawa, H Shimada, M Matsui

    PLANT JOURNAL   42 ( 1 )   13 - 22   2005.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-313X.2005.02357.x

    Web of Science

    PubMed

    researchmap

  • ydk1-D, an auxin-responsive GH3 mutant that is involved in hypocotyl and root elongation Reviewed

    T Takase, M Nakazawa, A Ishikawa, M Kawashima, T Ichikawa, N Takahashi, H Shimada, K Manabe, M Matsui

    PLANT JOURNAL   37 ( 4 )   471 - 483   2004.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1046/j.1365-313X.2003.01973.x

    Web of Science

    PubMed

    researchmap

  • Expression and interaction analysis of Arabidopsis Skp1-related genes Reviewed

    N Takahashi, H Kuroda, T Kuromori, T Hirayama, M Seki, K Shinozaki, H Shimada, M Matsui

    PLANT AND CELL PHYSIOLOGY   45 ( 1 )   83 - 91   2004.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

    researchmap

  • Expression and interaction analysis of Arabidopsis SKP1-related genes Reviewed

    N Takahashi, H Kuroda, T Kuromori, T Hirayama, M Seki, K Shinozaki, H Shimada, M Matsui

    PLANT AND CELL PHYSIOLOGY   45 ( 1 )   S177 - S177   2004

    　More details

  • Classification and expression analysis of Arabidopsis F-box-containing protein genes Reviewed

    H Kuroda, N Takahashi, H Shimada, M Seki, K Shinozaki, M Matsui

    PLANT AND CELL PHYSIOLOGY   43 ( 10 )   1073 - 1085   2002.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/pcp/pcf151

    Web of Science

    PubMed

    researchmap

▼display all

Books

  • Cell Biology: Cell cycle (S. Assmann, B. Liu, ed.)

    高橋 直紀, 梅田 正明（ Role： Contributorpp. 1-19）

    Springer, New York  2014 

    　More details

MISC

  • シロイヌナズナのSKP1-LIKE(ASK)タンパク質とF-Boxタンパク質との相互作用解析及び局在解析による包括的な理解

    柳川由紀, 黒田浩文, 高橋直紀, 高橋直紀, 堀井陽子, 堀井陽子, 松井南, 松井南

    日本生化学会大会(Web)   85th   2012

    　More details

  • シロイヌナズナのSKP1-LIKE(ASK)タンパク質とF-Boxタンパク質との相互作用解析及び局在解析による包括的な理解

    柳川由紀, 黒田浩文, 高橋直紀, 堀井陽子, 堀井陽子, 松井南, 松井南

    日本分子生物学会年会プログラム・要旨集(Web)   35th   2012

    　More details

  • Mechanism that reaulates plant endoreduplication - Light dependent and independent pathways

    M Matsui, Y Tsumoto, N Takahashi, H Kuroda, N Nagata, Y Yamamoto, M Kawashima, T Ichikawa, M Nakazawa, N Yamamoto, H Shimada, T Yoshizumi

    PLANT AND CELL PHYSIOLOGY   47   S13 - S13   2006

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • ILP5 promotes endoreduplication in Arabidopsis

    N Takahashi, T Yoshizumi, M Nakazawa, T Ichikawa, Y Kondou, A Ishikawa, M Kawashima, H Shimada, M Matsui

    PLANT AND CELL PHYSIOLOGY   47   S186 - S186   2006

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • ILP5 promotes endoreduplication in Arabidopsis

    N Takahashi, T Yoshizumi, M Nakazawa, T Ichikawa, Y Kondou, A Ishikawa, M Kawashima, K Suzuki, H Shimada, M Matsui

    PLANT AND CELL PHYSIOLOGY   46   S221 - S221   2005

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Analysis of regulation of YDK1 gene expression in Arabidopsis

    T Takase, M Nakazawa, A Ishikawa, N Takahashi, H Shimada, K Manabe, M Matsui

    PLANT AND CELL PHYSIOLOGY   45   S39 - S39   2004

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Functional analysis of F-box protein genes in Arabidopsis

    H Kuroda, N Takahashi, H Shimada, M Seki, K Shinozaki, M Matsui

    PLANT AND CELL PHYSIOLOGY   44   S54 - S54   2003

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Functional analysis of Arabidopsis SKP1 homologue genes

    N Takahashi, H Kuroda, M Seki, K Shinozaki, H Shimada, M Matui

    PLANT AND CELL PHYSIOLOGY   44   S54 - S54   2003

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

▼display all

Presentations

  • ストレスに応答した細胞分裂制御 Invited

    高橋 直紀, 梅田 正明

    日本植物学会第83回大会  2019.9 

    　More details

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    researchmap

  • Genome maintenance strategies in stem cells Invited International conference

    Masaaki Umeda, Shiori Aki, Naoki Takahashi

    2019.5 

    　More details

    Language：English   Presentation type：Symposium, workshop panel (public)  

    researchmap

  • ANAC044 and ANAC085 arrest the cell cycle to cope with stresses in Arabidopsis International conference

    Naoki Takahashi

    2019.5 

    　More details

    Language：English   Presentation type：Poster presentation  

    researchmap

  • ストレスに応答した細胞周期停止の制御機構の解明

    高橋直紀, 荻田伸夫, 高橋知伸, 谷口昌司, 梅田正明

    第60回日本植物生理学会  2019.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    researchmap

  • DNA damage responses in Arabidopsis roots Invited

    Masaaki Umeda, 荻田伸夫, Naoki Takahashi

    日本遺伝学会第 90 回大会  2018.9 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：奈良  

    researchmap

  • 植物のストレスに応答した細胞周期停止の分子機構

    高橋 直紀, 荻田伸夫, 梅田 正明

    日本遺伝学会第 90 回大会  2018.9 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：奈良  

    researchmap

  • Molecular analyses of CFI 25 in plant 3’-UTR length determination

    Xiaojuan Zhang, Naoki Takahashi, Masaaki Umeda, Marta Garcia-Le?n, Vicente Rubio, Mika Nomoto, Yasuomi Tada, Tsuyoshi Furumoto, Takashi Aoyama, Tom Tsuge

    日本光生物学協会 第20回年会  2018.7 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：京都  

    researchmap

  • DNA damage activates two distinct signaling pathways controlling DNA repair and cell cycle arrest International conference

    Naoki Takahashi, Nobuo Ogita, Masaaki Umeda

    Plant Genome Stability and Change 2018  2018.6 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Gatersleben, Germany  

    researchmap

  • ANAC044およびANAC085はDNA損傷による細胞周期停止に必要である

    高橋 直紀, 荻田 伸夫, 高橋 知伸, 谷口 昌司, 梅田 正明

    第 59 回日本植物生理学会年会  2018.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌  

    researchmap

  • Comprehending gene expression regulation mediated by pre-mRNA metabolism and proteolysis pre-mRNA

    Tom Tsuge, Xiaojuan Zhang, Shiori Aki, Jun Zhang, Mika Nomoto, Kakeru Goto, Ryo Kuroda, Tomonao Matsushita, Naoki Takahashi, Masaaki Umeda, Yasuomi Tada, Lijia Qu, Tsuyoshi Furumoto, Takashi Aoyama

    第7 回植物RNA 研究ネットワークシンポジウム  2017.12 

    　More details

    Language：English  

    Venue：岡崎  

    researchmap

  • DNA損傷応答における新規NAC転写因子の機能解析

    荻田伸夫, 沢邉翔吾, 大野暢也, 高橋 直紀, 梅田 正明

    第58回日本植物生理学会年会  2017.3 

    　More details

    Language：Japanese   Presentation type：Poster presentation  

    Venue：鹿児島  

    researchmap

  • DNA損傷応答におけるindole-3-butyric acid (IBA)輸送体の機能解析

    吉國早紀, 大野暢也, 渡邊俊介, 笠原博幸, 高橋 直紀, 瀬尾光範, 梅田 正明

    第58回日本植物生理学会年会  2017.3 

    　More details

    Language：Japanese   Presentation type：Poster presentation  

    Venue：鹿児島  

    researchmap

  • Hormonal control of genome integrity in roots Invited International conference

    Masaaki Umeda, Naoki Takahashi

    Plant Organ Growth Symposium 2017  2017.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Elche, Spain  

    researchmap

  • Brassinosteroids are involved in stem cell replenishment in Arabidopsis roots under DNA damage International conference

    Naoki Takahashi, Masaaki Umeda

    Plant Organ Growth Symposium 2017  2017.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Elche, Spain  

    researchmap

  • Phytohormone auxin required for genome maintenance in plant stem cells International conference

    Naoki Takahashi, Masaaki Umeda

    10th 3R International Symposium  2016.11 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：松江  

    researchmap

  • The SOG1 transcription factor regulates distinct sets of target genes and enables continuous organ growth under DNA stress International conference

    Masaaki Umeda, 荻田伸夫, Naoki Takahashi

    Plant Genome Stability and Change  2016.7 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：神奈川県三浦郡葉山町  

    researchmap

  • Comprehensive analysis of target genes of SOG1, a master regulator of DNA damage response International conference

    荻田伸夫, 時澤睦朋, 山本義治, Yoko Okushima, 倉田哲也, 岡本(愿山)郁, Kei Hiruma, Yusuke Saijo, Naoki Takahashi, Masaaki Umeda

    Plant Genome Stability and Change  2016.7 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：神奈川県三浦郡葉山町  

    researchmap

  • DNA double-strand breaks suppress root growth by enhancing cytokinin biosynthesis in Arabidopsis roots International conference

    Naoki Takahashi, Masaaki Umeda

    Plant Genome Stability and Change  2016.7 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：神奈川県三浦郡葉山町  

    researchmap

  • The cyclin-dependent kinase B1 (CDKB1)-cyclin B1 (CYCB1) complex is a major regulator of homologous recombination repair in Arabidopsis International conference

    Poyu Chen, Annika K. Weimer, Sascha Biedermann, Hirofumi Harashima, Naoki Takahashi, Keiko Sugimoto, Masaaki Umeda, Csaba Koncz, Peter Doerner, Arp Schnittger

    Plant Genome Stability and Change  2016.7 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：神奈川県三浦郡葉山町  

    researchmap

  • The cyclin-dependent kinase B1 (CDKB1)-cyclin B1 (CYCB1) complex is a major regulator of homologous recombination repair in Arabidopsis International conference

    Poyu Chen, Annika K. Weimer, Sascha Biedermann, Hirofumi Harashima, Naoki Takahashi, Keiko Sugimoto, Masaaki Umeda, Csaba Koncz, Peter Doerner, Arp Schnittger

    International Conference on Arabidopsis Research  2016.7 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：韓国  

    researchmap

  • DNA損傷応答におけるNAC転写因子の機能解析

    大野暢也, 荻田伸夫, 沢邊翔吾, 高橋 直紀, 梅田 正明

    第57回日本植物生理学会年会  2016.3 

    　More details

    Language：Japanese   Presentation type：Poster presentation  

    Venue：岩手  

    researchmap

  • Maintenance of genome integrity in root stem cells under DNA stress Invited

    Naoki Takahashi, 藤本啓介, Masaaki Umeda

    第57回日本植物生理学会年会  2016.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：岩手  

    researchmap

  • 根端分裂組織のサイズ制御機構 Invited

    高橋 直紀, 丸池 加奈子, 高塚 大知, 梅田 正明

    日本植物学会第79回大会  2015.9 

    　More details

    Language：Japanese  

    Venue：新潟  

    researchmap

  • 植物の幹細胞維持の分子機構

    高橋 直紀

    細胞周期合同セミナー  2015.6 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：蒲群  

    researchmap

  • DNA損傷応答に関わる転写因子SOG1の標的遺伝子の解析

    荻田 伸夫, 奥島 葉子, 倉田 哲也, 時澤 睦朋, 山本 義治, 高橋 直紀, 梅田 正明

    第56回日本植物生理学会年会  2015.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京  

    researchmap

  • Regulation of auxin signaling is essential for stem cell maintenance under DNA stress conditions

    高橋 直紀, 梅田 正明

    第56回日本植物生理学会年会  2015.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京  

    researchmap

  • Stem cell replenishment maintains genome integrity Invited

    Masaaki Umeda, Keisuke Fujimoto, Naoki Takahashi

    第56回日本植物生理学会年会  2015.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：東京  

    researchmap

  • Brassinosteroids are involved in stem cell replenishment in Arabidopsis roots under DNA stress conditions

    藤本 啓介, 高橋 直紀, 梅田 正明

    第56回日本植物生理学会年会  2015.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京  

    researchmap

  • DNA damage response in Arabidopsis roots International conference

    Naoki Takahashi, Poyu Chen, Masaaki Umeda

    Plant Genome Stability and Change  2014.7 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Asilomar  

    researchmap

  • DNA損傷ストレス応答におけるサイトカイニンの役割

    高橋 直紀

    細胞周期合同セミナー  2014.5 

    　More details

    Language：Japanese  

    researchmap

  • Cytokinin signaling is involved in DNA stress response in Arabidopsis roots

    Naoki Takahashi, Masaaki Umeda

    第55回日本植物生理学会年会  2014.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：富山大  

    researchmap

  • The essential function of cytokinin in promoting cell elongation in Arabidopsis roots

    梅田正明, 高塚大知, 高橋 直紀

    第55回日本植物生理学会年会  2014.3 

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：富山大  

    researchmap

  • Cytokinins control two-step transition of root cells in Arabidopsis International conference

    高塚 大知, 高橋 直紀, 梅田 正明

    Annual Main Meeting of Society for Experimental Biology 2013  2013.7 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：バレンシア、スペイン  

    researchmap

  • Cytokinins control endocycle onset by promoting the expression of an APC/C activator in Arabidopsis roots International conference

    高橋 直紀, Y. Kim, I. Hwang, 梅田 正明

    Annual Main Meeting of Society for Experimental Biology 2013  2013.7 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：バレンシア、スペイン  

    researchmap

  • Cell cycle control in Arabidopsis roots by internal and external factors Invited International conference

    高橋 直紀, 梅田 正明

    VIB Seminar  2013.7 

    　More details

    Language：English  

    Venue：ゲント、ベルギー  

    researchmap

  • Cell-cycle control in Arabidopsis roots by internal and extarnal factors Invited International conference

    Naoki Takahashi, Masaaki Umeda

    IBMP-CNRS Seminar  2013.7 

    　More details

    Language：English  

    Venue：ストラスブール、フランス  

    researchmap

  • Functional Role of Cytokinin Signaling in the Transition Zone of Arabidopsis Roots

    Hirotomo Takatsuka, Naoki Takahashi, Masaaki Umeda

    第5４回日本植物生理学会年会  2013.3 

    　More details

    Language：Japanese   Presentation type：Poster presentation  

    Venue：岡山大学 Japan  

    researchmap

  • Cytokinins Control Endocycle Onset by Inducing an APC/C Activator in Arabidopsis Roots

    Naoki Takahashi, Yoonhee Kim, ildoo Hwang, Masaaki Umeda

    第54回日本植物生理学会年会  2013.3 

    　More details

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岡山 Japan  

    researchmap

  • Cytokinin coordinates DNA ploidization and cell differentiation in roots Invited International conference

    M. Umeda, N. Takahashi

    10th International Congress on Plant Molecular Biology  2012.10 

    　More details

    Language：English  

    Venue：Jeju 韓国  

    researchmap

  • Termination of ploidy-dependent cell growth is transcriptionally regulated through an active developmental mechanism during plant cell morphogenesis International conference

    C. Breuer, K. Morohashi, A. Kawamura, N. Takahashi, T. Ishida, M. Umeda, E. Grotewold, K. Sugimoto

    10th International Congress on Plant Molecular Biology  2012.10 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：Jeju 韓国  

    researchmap

  • Cytokinins determine endocycle onset by controlling APC/CCS52A1 activity in Arabidopsis root International conference

    N. Takahashi, Y.H. Kim, I.D. Hwang, M. Umeda

    10th International Congress on Plant Molecular Biology  2012.10 

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：Jeju 韓国  

    researchmap

▼display all

Research Projects

  • Analysis of stem cell induction caused by local DNA damage using microbeam irradiation

    Grant number：24K09509  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    researchmap

  • 植物の組織再生を支える分子基盤の解明

    Grant number：22K06265  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    高橋 直紀

    　 More details

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    researchmap

  • 根の成長を制御する周期と変調の分子基盤の解明

    Grant number：22H04722  2022.4 - 2024.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    高橋 直紀

    　 More details

    Grant amount：\7540000 （ Direct Cost: \5800000 、 Indirect Cost：\1740000 ）

    researchmap

  • ストレスに応答した植物の細胞周期停止を制御する分子基盤の解明

    2019.4 - 2022.3

    日本学術振興会:基盤研究(C) 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 病原菌感染に対する植物の防御システムの分子基盤の解明

    2017.4 - 2019.3

    日本学術振興会  若手研究(B) 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 植物の組織再生を支える分子基盤の解明

    2017.3 - 2018.4

    奈良先端科学技術大学院大学支援財団 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 根の幹細胞再生を支える分子基盤の解明

    2016.4 - 2018.3

    文部科学省  新学術領域研究(研究領域提案型) 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 植物の幹細胞維持機構の分子基盤の解明

    2015.3 - 2016.4

    奈良先端科学技術大学院大学支援財団 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 植物のエンドサイクル制御の分子基盤の解明

    2014.4 - 2017.3

    日本学術振興会  若手研究(B) 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • Studies on the molecular mechanisms underlying the transition from cell division to cell differentiation

    Grant number：26291061  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    UMEDA Masaaki, SEKI Motoaki, FUKAO Yoichiro

    　 More details

    Grant amount：\15730000 （ Direct Cost: \12100000 、 Indirect Cost：\3630000 ）

    In this study, we revealed the mechanisms underlying the transition from cell division to cell differentiation by conducting functional analyses of KRPs, which are involved in degradation of B-type response regulators, and by analyzing the epigenetic regulation in triggering DNA polyploidization in roots. We found that some KRPs are expressed in the transition zone in roots and play an important role in an early onset of cell differentiation in response to DNA damage. Our results also indicated the possibility that auxin controls chromatin structure, thereby being associated with the transition from cell division to cell differentiation.

    researchmap

  • 根の成長プログラムの分子基盤の解明

    2014.4 - 2016.3

    文部科学省  新学術領域研究(研究領域提案型) 

    高橋 直紀

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

▼display all