Updated on 2026/04/03

写真a

 
ICHINOSE MASASHI
 
Organization
Undergraduate School School of Business Administration Professor
Title
Professor
External link

Degree

  • Doctor of Philosophy ( 2005.3   University of Tsukuba )

Research Interests

  • Autonomic nervous system

  • Training

  • Blood pressure

  • Cardiovascular regulation

  • Cardiopulmonary baroreflex

  • Orthostatic stress

  • Arterial baroreflex

  • Muscle metaboreflex

  • Health

  • Exercise

  • Active muscle blood flow

  • Orthostatic hypotension

Research Areas

  • Life sciences / Sports science  / スポーツ科学(Sports Science)

Education

  • University of Tsukuba   Institute of Health and Sport Sciences   Sport Science

    2000.4 - 2005.3

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    Country/Region： Japan

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  • Ibaraki University   Faculty of Education   health and physical education

    1996.4 - 2000.3

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    Country/Region： Japan

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Research History

  • Meiji University   Professor

    2017.4

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  • Meiji University   Associate Professor

    2012.4 - 2017.3

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  • Meiji University

    2012.4 - 2017.3

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  • Meiji University   Senior Assistant Professor

    2009.4 - 2012.3

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  • Wayne State University   Department of Physiology, School of Medicine   Researher Postdoc   Research Associate

    2008.4 - 2009.3

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  • Wayne State University   Department of Physiology, School of Medicine   Researher Postdoc   Visiting Fellow

    2006.8 - 2008.2

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  • Japan Society for the Promotion of Science   Special researcher of the Japan Society for the Promotion of Science   Fellow

    2005.4 - 2008.3

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Professional Memberships

Papers

  • Muscle metaboreflex activation via postexercise ischemia increases intercostal muscle blood flow index without evidence of local vasoconstriction in humans. Reviewed International journal

    Masashi Ichinose, Mikie Nakabayashi, Yumie Ono

    Journal of applied physiology (Bethesda, Md. : 1985)   139 ( 4 )   988 - 999   2025.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Muscle metaboreflex is activated in limb skeletal muscles during high-intensity exercise that increases respiratory demand, but its effects on respiratory muscle blood flow remain unknown. Therefore, we investigated whether metaboreflex activation in the forearm alters blood flow in the intercostal muscles. Sixteen healthy young male subjects performed isometric handgrip at 30% of maximal voluntary contraction for 2 min, followed by either postexercise muscle ischemia (PEMI; metaboreflex activation condition) or a control recovery. Respiratory variables were controlled postexercise to match baseline levels. Microvascular blood flow index (BFI) in the left intercostal muscles was monitored using diffuse correlation spectroscopy, and cardiovascular variables were recorded. To reduce respiratory motion artifacts, BFI and vascular resistance index (VRI) were analyzed during breath-holding periods. During PEMI, both mean arterial pressure (MAP) and BFI were significantly elevated compared with rest [medians (IQRs), MAP: 92.1 (84.4-94.4) vs. 110.2 (102.4-116.4) mmHg, P < 0.001; BFI: 3.5 (2.8-4.9) vs. 4.2 (3.8-6.4) ×10-9 cm2·s-1, P = 0.002] and higher than that in the control condition [MAP: 91.0 (89.4-101.7) vs. 110.2 (102.4-116.4) mmHg, P < 0.001; BFI: 3.3 (2.5-4.5) vs. 4.2 (3.8-6.4) ×10-9 cm2·s-1, P < 0.001], whereas VRI remained unchanged [23.4 (19.0-29.9) vs. 23.2 (17.4-30.4) mmHg·(×10-9 cm2·s-1)-1, P = 0.375]. These findings suggest that muscle metaboreflex activation enhances intercostal muscle BFI via a pressor response without evidence of significant local vasoconstriction. This study demonstrates reflex-mediated increases in intercostal muscle BFI and highlights the role of the metaboreflex in supporting ventilation.NEW & NOTEWORTHY We show for the first time that activation of the muscle metaboreflex in limb skeletal muscle increases intercostal muscle blood flow index via a pressor response without evidence of significant local vasoconstriction. This reflex-driven enhancement of respiratory muscle perfusion may serve to support ventilation during high-intensity exercise, revealing a novel integrative mechanism by which the cardiovascular system prioritizes oxygen delivery to respiratory muscles under metabolic stress.

    DOI： 10.1152/japplphysiol.00577.2025

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  • Analysis of Time-Series Changes in Blood Flow and Vascular Resistance across Multiple Sites during Active Orthostatic Test. Reviewed International journal

    Tohko Tabuchi, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference   2025   1 - 4   2025.7

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    The autonomic nervous system regulates blood flow during postural changes to maintain homeostasis and cerebral perfusion, preventing symptoms such as dizziness and syncope. Previous orthostatic studies have primarily focused on a single region, such as the brain or peripheral blood vessels, limiting insight into systemic regulatory control. This study investigated blood flow regulation during an active orthostatic test by simultaneously measuring blood flow in the brain, left forearm, and right lower extremity using diffuse correlation spectroscopy. Results showed that lower limb blood flow decreased significantly while vascular resistance increased during upright posture, whereas cerebral blood flow remained relatively stable. These findings suggest that increased lower limb resistance compensates for the maintenance of cerebral perfusion, providing information on orthostatic blood flow regulation and its implications for autonomic dysfunction.Clinical Relevance- Understanding the differences in deep blood flow and vascular resistance responses at different sites during the orthostatic test may provide a detailed understanding of the pathogenesis of orthostatic hemodynamic disorders.

    DOI： 10.1109/EMBC58623.2025.11252859

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  • Effects of warm-up on muscle hemodynamics: a focus on muscle strength and exercise intensity in women. Reviewed International journal

    Haruka Mizuno, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference   2025   1 - 4   2025.7

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    Language：English   Publishing type：Research paper (international conference proceedings)  

    In sports, warm-up is important to prevent injuries and improve performance. Previous studies have reported that warm-up increases blood flow in the conduit arteries of active limbs. However, its effects on downstream active muscles remain unclear, particularly in women. This study aimed to investigate the effect of warm-up on blood flow dynamics in active muscles of female participants using diffuse correlation spectroscopy, a noninvasive optical technique that measures blood flow velocity in peripheral tissues. Thirteen female participants performed two consecutive bouts of rhythmic handgrip exercises at 10, 30, and 50% of their maximum voluntary contraction strength. The increase in muscle blood flow that was observed during the second bout relative to the first was considered as an effect of warm-up. The results showed that warm-up significantly enhanced muscle blood flow during subsequent exercise. Subgroup analysis indicated that participants with higher grip strength may require more intense exercises to achieve the full benefits of a warm-up.Clinical Relevance- Diffuse correlation spectroscopy enables measurement of muscle blood flow, thereby revealing the optimum exercise intensity to achieve warm-up for different individuals. This can contribute to the development of individualized programs in sports and medical settings.

    DOI： 10.1109/EMBC58623.2025.11253342

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  • Feasibility of Speckle Contrast Optical Spectroscopy for Quantifying Active Muscle Blood Flow. Reviewed International coauthorship International journal

    Tomoya Yamamoto, Vika Tarle, Masashi Ichinose, Nisan Ozana, Yumie Ono

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference   2025   1 - 5   2025.7

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    Language：English   Publishing type：Research paper (international conference proceedings)  

    The quantification of muscle blood flow is crucial in fields such as exercise physiology and rehabilitation medicine. While diffuse correlation spectroscopy (DCS) is a well-established, noninvasive method for measuring tissue blood flow, its widespread use is hindered by the need for expensive photon counters and its relatively low signal-to-noise ratio (SNR). Speckle contrast optical spectroscopy (SCOS), a novel technique utilizing a megapixel camera (e.g., a complementary metal- oxide-semiconductor camera), has emerged as a promising alternative. This method utilizes spatial speckle contrast to measure blood flow, offering a higher SNR at a reduced cost. This study evaluates the feasibility of SCOS in quantifying muscle blood flow under active conditions and compares its performance directly with that of DCS. The results indicate that SCOS is consistent with DCS in terms of relative blood flow index measurements, and its SNR surpasses that of DCS, particularly in detecting pulsatile blood flow. These findings position SCOS as a cost-effective, high-precision tool for monitoring skeletal muscle microcirculation during physical activities, potentially enhancing clinical and research applications in vascular function assessment.Clinical Relevance- SCOS presents a cost-effective alternative to DCS for the assessment of blood flow in active muscles, offering a superior SNR and enhanced detection of pulsatile flow. This advantage makes it valuable for evaluating vascular function in exercise physiology and rehabilitation contexts.

    DOI： 10.1109/EMBC58623.2025.11254183

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  • Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy. Reviewed International journal

    Hiroki Matsushita, Koki Kurono, Mikie Nakabayashi, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada, Masashi Ichinose, Yumie Ono, Keita Saku

    Intensive care medicine experimental   13 ( 1 )   53   2025.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40635-025-00761-9

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  • The blood flow and vascular responses in dynamically exercising skeletal muscles evoked by combination of cold stimulation and voluntary apnea in humans Reviewed

    Ryoko Matsutake, Tomomi Fujimoto, Masashi Ichinose, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu

    European Journal of Applied Physiology   2024.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00421-024-05643-8

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    Other Link： https://link.springer.com/article/10.1007/s00421-024-05643-8/fulltext.html

  • Correlation of diabetic renal hypoperfusion with microvascular responses of the skeletal muscle: a rat model study using diffuse correlation spectroscopy. Reviewed International journal

    Mikie Nakabayashi, Jun Tanabe, Yuji Ogura, Masashi Ichinose, Yugo Shibagaki, Atsuko Kamijo-Ikemori, Yumie Ono

    Biomedical optics express   15 ( 6 )   3900-3913   2024.6

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    Using diffuse correlation spectroscopy, we assessed the renal blood flow and thigh muscle microvascular responses in a rat model of type 2 diabetes. The blood flow index at the renal surface decreased significantly with arterial clamping, cardiac extirpation, and the progression of diabetic endothelial dysfunction. Renal blood flow measured in diabetic and nondiabetic rats also showed a significant correlation with the reactive hyperemic response of the thigh muscle. These results suggest shared microcirculatory dysfunction in the kidney and skeletal muscle and support endothelial responses in the skeletal muscle as a potential noninvasive biomarker of renal hypoperfusion.

    DOI： 10.1364/BOE.522385

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  • Differential changes in blood flow and oxygen utilization in active muscles between voluntary exercise and electrical muscle stimulation in young adults. Reviewed International journal

    Makoto Katagiri, Mikie Nakabayashi, Yasuhiro Matsuda, Yumie Ono, Masashi Ichinose

    Journal of applied physiology (Bethesda, Md. : 1985)   136 ( 5 )   1053 - 1064   2024.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/japplphysiol.00863.2023

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  • Computational Model for Blood Pressure Estimation Using Pulse Wave Transit Time Reviewed

    Haruka Mizuno, Tohko Tabuchi, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics   2024

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    Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1364/translational.2024.jm4a.14

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  • Verification of Fiber-less Diffuse Correlation Spectroscopy using Reactive Hyperemia Test Reviewed

    Tomoya Yamamoto, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics   2024

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    Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1364/translational.2024.js4a.17

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  • Blood pressure estimation using pulse transit time between two peripheral points Reviewed

    Tohko Tabuchi, Haruka Mizuno, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    Optical Tomography and Spectroscopy, OT and S 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics   2024

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    Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1364/translational.2024.js4a.19

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  • Deep-learning-based separation of shallow and deep layer blood flow rates in diffuse correlation spectroscopy. Reviewed International coauthorship International journal

    Mikie Nakabayashi, Siwei Liu, Nawara Mahmood Broti, Masashi Ichinose, Yumie Ono

    Biomedical optics express   14 ( 10 )   5358 - 5375   2023.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Diffuse correlation spectroscopy faces challenges concerning the contamination of cutaneous and deep tissue blood flow. We propose a long short-term memory network to directly quantify the flow rates of shallow and deep-layer tissues. By exploiting the different contributions of shallow and deep-layer flow rates to auto-correlation functions, we accurately predict the shallow and deep-layer flow rates (RMSE = 0.047 and 0.034 ml/min/100 g of simulated tissue, R2 = 0.99 and 0.99, respectively) in a two-layer flow phantom experiment. This approach is useful in evaluating the blood flow responses of active muscles, where both cutaneous and deep-muscle blood flow increase with exercise.

    DOI： 10.1364/BOE.498693

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  • Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans Reviewed International coauthorship International journal

    Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T.

    Pflügers Archiv - European Journal of Physiology   475   527 - 539   2023.1

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    DOI： 10.1007/s00424-022-02780-x

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  • Effects of Pre-Exercise Voluntary Hyperventilation on Metabolic and Cardiovascular Responses During and After Intense Exercise. Reviewed International journal

    Kohei Dobashi, Masashi Ichinose, Naoto Fujii, Tomomi Fujimoto, Takeshi Nishiyasu

    Research quarterly for exercise and sport   1 - 12   2022.9

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    Purpose: We investigated the effects of pre-exercise voluntary hyperventilation and the resultant hypocapnia on metabolic and cardiovascular responses during and after high-intensity exercise. Methods: Ten healthy participants performed a 60-s cycling exercise at a workload of 120% peak oxygen uptake in control (spontaneous breathing), hypocapnia and normocapnia trials. Hypocapnia was induced through 20-min pre-exercise voluntary hyperventilation. In the normocapnia trial, voluntary hyperpnea was performed with CO2 inhalation to prevent hypocapnia. Results: Pre-exercise end-tidal CO2 partial pressure was lower in the hypocapnia trial than the control or normocapnia trial, with similar levels in the control and normocapnia trials. Average V˙O2 during the entire exercise was lower in both the hypocapnia and normocapnia trials than in the control trial (1491 ± 252vs.1662 ± 169vs.1806 ± 149 mL min-1), with the hypocapnia trial exhibiting a greater reduction than the normocapnia trial. Minute ventilation during exercise was lower in the hypocapnia trial than the normocapnia trial. In addition, minute ventilation during the first 10s of the exercise was lower in the normocapnia than the control trial. Pre-exercise hypocapnia also reduced heart rates and arterial blood pressures during the exercise relative to the normocapnia trial, a response that lasted through the subsequent early recovery periods, though end-tidal CO2 partial pressure was similar in the two trials. Conclusions: Our results suggest that pre-exercise hyperpnea and the resultant hypocapnia reduce V˙O2 during high-intensity exercise. Moreover, hypocapnia may contribute to voluntary hyperventilation-mediated cardiovascular responses during the exercise, and this response can persist into the subsequent recovery period, despite the return of arterial CO2 pressure to the normocapnic level.

    DOI： 10.1080/02701367.2022.2121371

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  • Hypertension depresses arterial baroreflex control of both heart rate and cardiac output during rest, exercise, and metaboreflex activation. Reviewed International coauthorship International journal

    O'Leary Donal S, Mannozzi Joseph, Augustyniak Robert A, Ichinose Masashi, Spranger Marty D

    American journal of physiology. Regulatory, integrative and comparative physiology   2022.9

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    DOI： 10.1152/ajpregu.00093.2022

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  • Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans Reviewed

    Shodai Moriyama, Masashi Ichinose, Kohei Dobashi, Ryoko Matsutake, Mizuki Sakamoto, Naoto Fujii, Takeshi Nishiyasu

    Physiological Reports   10 ( 8 )   2022.4

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.14814/phy2.15274

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.14814/phy2.15274

  • Cardiovascular regulations during exercise: Competition between Regulations of Active Skeletal Muscle Blood Flow and Arterial Blood Pressure

    一之瀬真志

    明治大学経営学部人文科学論集   68   39 - 53   2022.3

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    Authorship：Lead author,　Corresponding author   Language：Japanese  

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  • 運動時循環調節反応の個人差 Invited

    渡邊和仁,一之瀬真志,藤井直人,西保 岳

    体育の科学   72 ( 3 )   176 - 182   2022.3

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    Language：Japanese   Publisher：杏林書院  

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  • Evaluation of Local Skeletal Muscle Blood Flow in Manipulative Therapy by Diffuse Correlation Spectroscopy. Reviewed International coauthorship International journal

    Matsuda Yasuhiro, Nakabayashi Mikie, Suzuki Tatsuya, Zhang Sinan, Ichinose Masashi, Ono Yumie

    Frontiers in bioengineering and biotechnology   9   800051 - 800051   2022.1

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    Manipulative therapy (MT) is applied to motor organs through a therapist's hands. Although MT has been utilized in various medical treatments based on its potential role for increasing the blood flow to the local muscle, a quantitative validation of local muscle blood flow in MT remains challenging due to the lack of appropriate bedside evaluation techniques. Therefore, we investigated changes in the local blood flow to the muscle undergoing MT by employing diffuse correlation spectroscopy, a portable and emerging optical measurement technology that non-invasively measures blood flow in deep tissues. This study investigated the changes in blood flow, heart rate, blood pressure, and autonomic nervous activity in the trapezius muscle through MT application in 30 volunteers without neck and shoulder injury. Five minutes of MT significantly increased the median local blood flow relative to that of the pre-MT period (p < 0.05). The post-MT local blood flow increase was significantly higher in the MT condition than in the control condition, where participants remained still without receiving MT for the same time (p < 0.05). However, MT did not affect the heart rate, blood pressure, or cardiac autonomic nervous activity. The post-MT increase in muscle blood flow was significantly higher in the participants with muscle stiffness in the neck and shoulder regions than in those without (p < 0.05). These results suggest that MT could increase the local blood flow to the target skeletal muscle, with minimal effects on systemic circulatory function.

    DOI： 10.3389/fbioe.2021.800051

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  • Diffuse Optics for Probing Oxygen Metabolism of Active Muscles Invited Reviewed International journal

    Ono Yumie, Nakabayashi Mikie, Ichinose Masashi

    2021 IEEE Photonics Conference (IPC)   1 - 2   2021.10

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    Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

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  • Dual-channel Diffuse Correlation Spectroscopy for Simultaneous Blood Flow Measurement of Multiple Muscles Reviewed International journal

    Tsuchiya Tomohiro, Yamamoto Yukihiko, Nakabayashi Mikie, Ichinose Masashi, Ono Yumie

    Biophotonics Congress 2021 OSA Technical Digest   JTu4A.7   2021.4

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  • Rapid vasodilation within contracted skeletal muscle in humans: new insight from concurrent use of diffuse correlation spectroscopy and Doppler ultrasound. Reviewed International journal

    Ichinose Masashi, Nakabayashi Mikie, Ono Yumie

    American journal of physiology. Heart and circulatory physiology   320 ( 2 )   H654 - H667   2021.2

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Previous studies showed that conduit artery blood flow rapidly increases after even a brief contraction of muscles within the dependent limb. Whether this rapid hyperemia occurs within contracted skeletal muscle in humans has yet to be confirmed, however. We therefore used diffuse correlation spectroscopy (DCS) to characterize the rapid hyperemia and vasodilatory responses within the muscle microvasculature induced by single muscle contractions in humans. Twenty-five healthy male volunteers performed single 1-s isometric handgrips at 20%, 40%, 60%, and 80% of maximum voluntary contraction. DCS probes were placed on the flexor digitorum superficialis muscle, and a skeletal muscle blood flow index (SMBFI) was derived continuously. At the same time, brachial artery blood flow (BABF) responses were measured using Doppler ultrasound. Single muscle contractions evoked rapid, monophasic increases in both SMBFI and BABF that occurred within 3 s after release of contraction. The initial and peak responses increased with increases in contraction intensity and were greater for BABF than for SMBFI at all intensities. BABF reached its peak within 5 to 8 s after the end of contraction. The SMBFI continued to increase after the BABF passed its peak and was decreasing toward the resting level and peaked about 10 to 15 s after completion of the contraction. We conclude that single muscle contractions induce rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature. Moreover, the characteristics of the rapid hyperemia and vasodilatory responses of skeletal muscle microvessels differ from those simultaneously evaluated in the upstream conduit artery.NEW & NOTEWORTHY Through the concurrent use of diffuse correlation spectroscopy and Doppler ultrasound, we provide the first evidence in humans that a single brief muscle contraction evokes rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature and the upstream conduit artery. We also show that the magnitude and time course of the contraction-induced rapid hyperemia and vasodilatory responses within skeletal muscle microvessels significantly differ from those in the conduit artery.

    DOI： 10.1152/ajpheart.00761.2020

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  • Voluntary hypocapnic hyperventilation lasting 5 min and 20 min similarly reduce aerobic metabolism without affecting power outputs during Wingate anaerobic test. Reviewed International journal

    Dobashi Kohei, Fujii Naoto, Ichinose Masashi, Fujimoto Tomomi, Nishiyasu Takeshi

    European journal of sport science   17 ( 8 )   1 - 8   2020.9

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    AbstractTwenty minutes of voluntary hypocapnic hyperventilation prior to exercise reduces the aerobic metabolic rate with a compensatory increase in the anaerobic metabolic rate without affecting exercise performance during the Wingate anaerobic test (WAnT). Thus, pre-exercise hypocapnic hyperventilation may be a useful means of stressing the anaerobic energy system during training, ultimately improving anaerobic exercise performance. However, it remains unclear whether a shorter (e.g., 5 min) pre-exercise hypocapnic hyperventilation is sufficient to reduce the aerobic metabolic rate during high-intensity exercise. We therefore compared the effects of 5-min and 20-min pre-exercise hypocapnic hyperventilation on aerobic metabolism during the 30-s WAnT. Ten healthy young males and one female performed the WAnT following 20 min of spontaneous breathing (control trial) or 5 or 20 min of voluntary hypocapnic hyperventilation. Both the 5-min and 20-min hyperventilation reduced end-tidal CO2 partial pressure (an index of arterial CO2 partial pressure) to ∼23 mmHg, whereas it remained unchanged during the spontaneous breathing. The peak, mean and minimum power outputs during the WAnT did not differ among the three trials. Oxygen uptake during the WAnT was lower in both the 5-min (1493 ± 257 mL min-1) and 20-min (1397 ± 447 mL min-1) hyperventilation trials than during the control trial (1847 ± 286 mL min-1), and was similar in the two hyperventilation trials. These results suggest that 5 min of pre-exercise hypocapnic hyperventilation reduces aerobic metabolism during the 30-s WAnT to a level similar to that seen with the 20-min hyperventilation. Moreover, exercise performance was unaffected, which implies anaerobic metabolism was enhanced.

    DOI： 10.1080/17461391.2020.1812728

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  • Optical evaluation of microvascular function at early and chronic stages of diabetes Reviewed International journal

    Sasaki S, Nakabayashi M, Ono Y, Ichinose M.

    Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies,   112370R   2020.2

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  • Real-time detection of fatigue effect on active muscle hemodynamics using diffuse correlation spectroscopy Reviewed International journal

    Nozaki K, Nakabayashi M, Ichinose M, Ono Y.

    Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies,   112370N   2020.2

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  • KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX. Reviewed International coauthorship International journal

    Fujii N, McGarr GW, McNeely BD, Ichinose M, Nishiyasu T, Kenny GP.

    Eur J Pharmacol   866:172828   2020.1

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  • Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX. Reviewed International coauthorship International journal

    Fujii N, McGarr GW, Ichinose M, Nishiyasu T, Kenny GP.

    Microcirculation   e12586   2019.8

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  • Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature. Reviewed International journal

    Ichinose M, Nakabayashi M, Ono Y.

    Physiol Rep.   7 ( 7:e14070 )   1 - 16   2019.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We investigated the integration of sympathetic vasoconstriction and local vasodilation in the skeletal muscle and skin microvasculature of humans. In 39 healthy volunteers, we simultaneously measured the blood flow index in the flexor carpi radialis muscle using diffuse correlation spectroscopy and the skin using laser-Doppler flowmetry. We examined the effects of acute sympathoexcitation induced by forehead cooling on relatively weak and robust vasodilatory responses during postocclusive reactive hyperemia (PORH) induced by 70-sec and 10-min arterial occlusion in the upper arm. To increase sympathetic tone during PORH, forehead cooling was begun 60 sec before the occlusion release and ended 60 sec after the release. In the 70-sec occlusion trials, acute sympathoexcitation reduced the peak and duration of vasodilation in both skeletal muscle and skin. The inhibition of vasodilation by sympathoexcitation was blunted in both tissues by the robust vasodilatory stimulation produced by the 10-min occlusion, and the degree of blunting was greater in skeletal muscle than in skin, especially the initial and peak responses. Sympathoexcitation reduced the peak vasodilation only in skin, while it accelerated the initial vasodilation only in skeletal muscle. However, the decline in vasodilation after the peak was significantly hastened in skeletal muscle, shortening the duration of the vasodilation. We conclude that, in humans, the integration of sympathetic vasoconstriction and local vasodilation has different effects in skeletal muscle and skin and is likely an important contributor to the selective control of perfusion in the microcirculations of different tissues.

    DOI： 10.14814/phy2.14070

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  • Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study. Reviewed International coauthorship International journal

    Ono Y, Esaki K, Takahashi Y, Nakabayashi M, Ichinose M, Lee K.

    Biomed Opt Express   9 ( 9 )   4539 - 4551   2018.9

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    We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.

    DOI： 10.1364/BOE.9.004539

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  • Sympathoexcitation constrains vasodilation in the human skeletal muscle microvasculature during post-occlusive reactive hyperemia. Reviewed International journal

    Ichinose M, Nakabayashi M, Ono Y.

    Am J Physiol Heart Circ Physiol.   315 ( 2 )   H242 - H253   2018.8

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    We used diffuse correlation spectroscopy to investigate sympathetic vasoconstriction, local vasodilation, and integration of these two responses in the skeletal muscle microvasculature of 20 healthy volunteers. Diffuse correlation spectroscopy probes were placed on the flexor carpi radialis muscle or vastus lateralis muscle, and a blood flow index was derived continuously. We measured hemodynamic responses during sympathoexcitation induced by forehead cooling, after which the effects of the increased sympathetic tone on vasodilatory responses during postocclusive reactive hyperemia (PORH) were examined. PORH was induced by releasing arterial occlusion (3 min) in an arm or leg. To increase sympathetic tone during PORH, forehead cooling was begun 60 s before the occlusion release and ended 60 s after the release. During forehead cooling, mean arterial pressure rose significantly and was sustained at an elevated level. Significant vasoconstriction and decreases in blood flow index followed by gradual blunting of the vasoconstriction also occurred. The time course of these responses is in good agreement with previous observations in animals. The acute sympathoexcitation diminished the peak vasodilation during PORH only in the vastus lateralis muscle, but it hastened the decline in vasodilation after the peak in both the flexor carpi radialis muscle and vastus lateralis muscle. Consequently, the total vasodilatory response assessed as the area of the vascular conductance during the first minute of PORH was significantly diminished in both regions. We conclude that, in humans, the integrated effects of sympathetic vasoconstriction and local vasodilation have an important role in vascular regulation and control of perfusion in the skeletal muscle microcirculation. NEW & NOTEWORTHY We used diffuse correlation spectroscopy to demonstrate that acute sympathoexcitation constrains local vasodilation in the human skeletal muscle microvasculature during postocclusive reactive hyperemia. This finding indicates that integration of sympathetic vasoconstriction and local vasodilation is importantly involved in vascular regulation and the control of perfusion of the skeletal muscle microcirculation in humans.

    DOI： 10.1152/ajpheart.00010.2018

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  • トレーニング適応と血圧調節－圧受容器反射と筋代謝受容器反射－ Invited

    一之瀬真志

    体育の科学   68 ( 4 )   279 - 285   2018.4

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  • Voluntary apnea during dynamic exercise activates the muscle metaboreflex in humans Reviewed

    Masashi Ichinose, Mayumi Matsumoto, Naoto Fujii, Narumi Yoshitake, Takeshi Nishiyasu

    American Journal of Physiology - Heart and Circulatory Physiology   314 ( 3 )   H434 - H442   2018.3

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    DOI： 10.1152/ajpheart.00367.2017

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  • Evaluation of blood flow in human exercising muscle by diffuse correlation spectroscopy: A phantom model study Reviewed

    Mikie Nakabayashi, Yumie Ono, Masashi Ichinose

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE   10486   2018

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    DOI： 10.1117/12.2288044

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  • The carotid baroreflex modifies the pressor threshold of the muscle metaboreflex in humans Reviewed

    Masashi Ichinose, Tomoko Ichinose-Kuwahara, Kazuhito Watanabe, Narihiko Kondo, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   313 ( 3 )   H650 - H657   2017.9

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    DOI： 10.1152/ajpheart.00816.2016

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  • Blood flow measurement of human skeletal muscle during various exercise intensity using diffuse correlation spectroscopy (DCS) Reviewed

    Yuya Murakami, Yumie Ono, Masashi Ichinose

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE   10059   2017

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    DOI： 10.1117/12.2250718

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  • Blood flow measurement of human skeletal muscle during various exercise intensities using diffuse correlation spectroscopy (DCS) Reviewed

    Yuya Murakami, Yumie Ono, Masashi Ichinose

    OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE XII   10059   1 - 10   2017

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    DOI： 10.1117/12.2250718

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  • Influence of forearm muscle metaboreceptor activation on sweating and cutaneous vascular responses during dynamic exercise Reviewed

    Tatsuro Amano, Masashi Ichinose, Yoshimitsu Inoue, Takeshi Nishiyasu, Shunsaku Koga, Glen P. Kenny, Narihiko Kondo

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   310 ( 11 )   R1332 - R1339   2016.6

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    DOI： 10.1152/ajpregu.00545.2015

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  • Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans Reviewed

    Masashi Ichinose, Tomoko Ichinose-Kuwahara, Narihiko Kondo, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   309 ( 10 )   R1234 - R1242   2015.11

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    DOI： 10.1152/ajpregu.00063.2015

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  • Cardiovascular responses to forearm muscle metaboreflex activation during hypercapnia in humans Reviewed

    Stephane Delliaux, Masashi Ichinose, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   309 ( 1 )   R43 - R50   2015.7

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    DOI： 10.1152/ajpregu.00402.2014

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  • Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans Reviewed

    Tatsuro Amano, Masashi Ichinose, Yoshimitsu Inoue, Takeshi Nishiyasu, Shunsaku Koga, Narihiko Kondo

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   308 ( 12 )   R990 - R997   2015.6

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    DOI： 10.1152/ajpregu.00005.2015

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  • Stimulation of the cardiopulmonary baroreflex enhances ventricular contractility in awake dogs: a mathematical analysis study Reviewed

    Javier A. Sala-Mercado, Mohsen Moslehpour, Robert L. Hammond, Masashi Ichinose, Xiaoxiao Chen, Sell Evan, Donal S. O'Leary, Ramakrishna Mukkamala

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   307 ( 4 )   R455 - R464   2014.8

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    DOI： 10.1152/ajpregu.00510.2013

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  • Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans Reviewed

    Tatsuro Amano, Masashi Ichinose, Takeshi Nishiyasu, Yoshimitsu Inoue, Shunsaku Koga, Mikio Miwa, Narihiko Kondo

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   306 ( 10 )   R728 - R734   2014.5

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    DOI： 10.1152/ajpregu.00515.2013

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  • Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation? Invited Reviewed

    Masashi Ichinose, Seiji Maeda, Narihiko Kondo, Takeshi Nishiyasu

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   114 ( 3 )   451 - 465   2014.3

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    DOI： 10.1007/s00421-013-2691-y

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  • Oxygen Delivery and Blood Pressure Regulation during Exercise

    Masashi Ichinose

    人文科学論集   60 ( 60 )   33-52 - 52   2014.3

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  • Individual differences in cardiac and vascular components of the pressor response to isometric handgrip exercise in humans Reviewed

    Kazuhito Watanabe, Masashi Ichinose, Rei Tahara, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   306 ( 2 )   H251 - H260   2014.1

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    DOI： 10.1152/ajpheart.00699.2013

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  • Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans Reviewed

    Naoto Fujii, Masashi Ichinose, Yasushi Honda, Bun Tsuji, Kazuhito Watanabe, Narihiko Kondo, Takeshi Nishiyasu

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   113 ( 1 )   51 - 62   2013.1

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    DOI： 10.1007/s00421-012-2413-x

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  • Muscle metaboreflex-induced coronary vasoconstriction limits ventricular contractility during dynamic exercise in heart failure Reviewed

    Matthew Coutsos, Javier A. Sala-Mercado, Masashi Ichinose, ZhenHua Li, Elizabeth J. Dawe, Donal S. O'Leary

    American Journal of Physiology - Heart and Circulatory Physiology   304 ( 7 )   H1029 - H1037   2013

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    DOI： 10.1152/ajpheart.00879.2012

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  • Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans Reviewed

    Masashi Ichinose, Kazuhito Watanabe, Naoto Fujii, Narihiko Kondo, Takeshi Nishiyasu

    American Journal of Physiology - Heart and Circulatory Physiology   304 ( 11 )   H1568 - H1575   2013

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    DOI： 10.1152/ajpheart.00833.2012

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  • Dynamic cardiac output regulation at rest, during exercise, and muscle metaboreflex activation: impact of congestive heart failure Reviewed

    Masashi Ichinose, Javier A. Sala-Mercado, Matthew Coutsos, ZhenHua Li, Tomoko K. Ichinose, Elizabeth Dawe, Dominic Fano, Donal S. O'Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   303 ( 7 )   R757 - R768   2012.10

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    DOI： 10.1152/ajpregu.00119.2012

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  • Cardiovascular regulation during exercise - Contribution of peripheral reflexes. Invited International journal

    Ichinose M, Watanabe K, Fujii N, Nishiyasu T.

    Journal of Physical Fitness and Sports Medicine   1 ( 3 )   437-445   2012.9

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  • 800-m and 1500-m run times relate to anaerobic performance in competitive runners Reviewed

    N. Fujii, T. Ogawa, M. Ichinose, K. Hayashi, T. Nishiyasu

    Gazzetta Medica Italiana Archivio per le Scienze Mediche   171 ( 4 )   491 - 501   2012.8

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  • Relationships between the extent of apnea-induced bradycardia and the vascular response in the arm and leg during dynamic two-legged knee extension exercise Reviewed

    Takeshi Nishiyasu, Rina Tsukamoto, Katsuhito Kawai, Keiji Hayashi, Shunsaku Koga, Masashi Ichinose

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   302 ( 3 )   H864 - H871   2012.2

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    DOI： 10.1152/ajpheart.00413.2011

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  • Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans Invited Reviewed

    Masashi Ichinose, Takeshi Nishiyasu

    FRONTIERS IN PHYSIOLOGY   3 ( 314 )   1-10   2012

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    DOI： 10.3389/fphys.2012.00314

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  • Evaluation of muscle metaboreflex function through graded reduction in forearm blood flow during rhythmic handgrip exercise in humans Reviewed

    Masashi Ichinose, Stephane Delliaux, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   301 ( 2 )   H609 - H616   2011.8

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    DOI： 10.1152/ajpheart.00076.2011

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  • Sweating responses and the muscle metaboreflex under mildly hyperthermic conditions in sprinters and distance runners Reviewed

    Tatsuro Amano, Masashi Ichinose, Shunsaku Koga, Yoshimitsu Inoue, Takeshi Nishiyasu, Narihiko Kondo

    JOURNAL OF APPLIED PHYSIOLOGY   111 ( 2 )   524 - 529   2011.8

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    DOI： 10.1152/japplphysiol.00212.2011

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  • Effect of CO2 on the ventilatory sensitivity to rising body temperature during exercise Reviewed

    Keiji Hayashi, Yasushi Honda, Natsuki Miyakawa, Naoto Fujii, Masashi Ichinose, Shunsaku Koga, Narihiko Kondo, Takeshi Nishiyasu

    JOURNAL OF APPLIED PHYSIOLOGY   110 ( 5 )   1334 - 1341   2011.5

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    DOI： 10.1152/japplphysiol.00010.2010

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  • Arterial blood pressure regulation during orthostatic stress in humans: Baroreflex control of muscle sympathetic nerve activity

    Masashi Ichinose

    人文科学論集   57 ( 57 )   115-131 - 131   2011.3

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  • Individual differences in the heart rate response to activation of the muscle metaboreflex in humans Reviewed International journal

    Watanabe K, Ichinose M, Fujii N, Matsumoto M, and Nishiyasu T

    American Journal of Physiology Heart and Circulatory Physiology   299 ( 5 )   H1708-H1714   2010.9

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  • Muscle metaboreflex-induced coronary vasoconstriction functionally limits increases in ventricular contractility Reviewed

    Matthew Coutsos, Javier A. Sala-Mercado, Masashi Ichinose, ZhenHua Li, Elizabeth J. Dawe, Donal S. O&apos, Leary

    JOURNAL OF APPLIED PHYSIOLOGY   109 ( 2 )   271 - 278   2010.8

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    DOI： 10.1152/japplphysiol.01243.2009

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  • Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure Reviewed

    Xiaoxiao Chen, Javier A. Sala-Mercado, Robert L. Hammond, Masashi Ichinose, Soroor Soltani, Ramakrishna Mukkamala, Donal S. O'Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   299 ( 1 )   H62 - H69   2010.7

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    DOI： 10.1152/ajpheart.00922.2009

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  • Regulation of blood pressure during exercise: Interactions between arterial barorefelx and muscle metaborefelx

    Masashi Ichinose

    人文科学論集   56 ( 56 )   75-85 - 85   2010.3

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  • Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise Reviewed

    Javier A. Sala-Mercado, Masashi Ichinose, Matthew Coutsos, Zhenhua Li, Dominic Fano, Tomoko Ichinose, Elizabeth J. Dawe, Donal S. O&apos, Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   298 ( 2 )   H594 - H600   2010.2

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    DOI： 10.1152/ajpheart.00908.2009

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  • Modulation of cardiac output alters the mechanisms of the muscle metaboreflex pressor response Reviewed

    Masashi J. Ichinose, Javier A. Sala-Mercado, Matthew Coutsos, ZhenHua Li, Tomoko K. Ichinose, Elizabeth Dawe, Donal S. O&apos, Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   298 ( 1 )   H245 - H250   2010.1

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    DOI： 10.1152/ajpheart.00909.2009

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  • Baroreflex and Muscle Metaboreflex: Control of Muscle Sympathetic Nerve Activity Invited Reviewed

    Masashi Ichinose, Mitsuru Saito, Narihiko Kondo, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 12 )   2037 - 2045   2008.12

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    DOI： 10.1249/MSS.0b013e318180bc59

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  • Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling Reviewed

    Masashi Ichinose, Mitsuru Saito, Naoto Fujii, Takeshi Ogawa, Keiji Hayashi, Narihiko Kondo, Takeshi Nishiyasu

    JOURNAL OF PHYSIOLOGY-LONDON   586 ( 11 )   2753 - 2766   2008.6

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    DOI： 10.1113/jphysiol.2007.150060

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  • Spontaneous baroreflex control of heart rate versus cardiac output: altered coupling in heart failure Reviewed

    Javier A. Sala-Mercado, Masashi Ichinose, Robert L. Hammond, Matthew Coutsos, Tomoko Ichinose, Marco Pallante, Ferdinando Iellamo, Donal S. O'Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   294 ( 3 )   H1304 - H1309   2008.3

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    DOI： 10.1152/ajpheart.01186.2007

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  • Spontaneous baroreflex control of cardiac output during dynamic exercise, muscle metaboreflex activation, and heart failure Reviewed

    Masashi Ichinose, Javier A. Sala-Mercado, Donal S. O'Leary, Robert L. Hammond, Matthew Coutsos, Tomoko Ichinose, Marco Pallante, Ferdinando Iellamo

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   294 ( 3 )   H1310 - H1316   2008.3

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    DOI： 10.1152/ajpheart.01187.2007

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  • Regulation of blood pressure and sympathetic nerve activity during exercise in humans -muscle metaboreflex and arterial baroreflex function- Reviewed

    Takeshi, Nishiyasu, Mitsuru, Saito, Narihiko, Kondo, Masashi, Ichinose

    Proceeding of 2008 Korean Society of Exercise Physiology Summer Conference,   1-6   2008.1

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  • Spontaneous baroreflex control of heart rate during exercise and muscle metaboreflex activation in heart failure Reviewed

    Ferdinando Iellamo, Javier A. Sala-Mercado, Masashi Ichinose, Robert L. Hammond, Marco Pallante, Tomoko Ichinose, Larry W. Stephenson, Donal S. O'Leary

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   293 ( 3 )   H1929 - H1936   2007.9

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    DOI： 10.1152/ajpheart.00564.2007

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  • Effects of posture on peripheral vascular responses to lower body positive pressure Reviewed

    Takeshi Nishiyasu, Shigeko Hayashida, Asami Kitano, Kei Nagashima, Masashi Ichinose

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   293 ( 1 )   H670 - H676   2007.7

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    DOI： 10.1152/ajpheart.00462.2006

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  • Relationship between resting ventilatory chemosensitivity and maximal oxygen uptake in moderate hypobaric hypoxia Reviewed International journal

    Ogawa T, Hayashi K, Ichinose M, Nishiyasu T.

    Journal of Applied Physiology   103 ( 4 )   1221-1226   2007.7

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  • Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature Reviewed

    Donal S. O'Leary, Javier A. Sala-Mercado, Robert L. Hammond, Eric J. Ansorge, Jong-Kyung Kim, Jaime Rodriguez, Dominic Fano, Masashi Ichinose

    JOURNAL OF APPLIED PHYSIOLOGY   103 ( 1 )   190 - 194   2007.7

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    DOI： 10.1152/japplphysiol.00139.2007

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  • Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex Reviewed

    Masashi Ichinose, Shunsaku Koga, Naoto Fujii, Narihiko Kondo, Takeshi Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   293 ( 1 )   H416 - H424   2007.7

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    DOI： 10.1152/ajpheart.01196.2006

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  • Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise Reviewed

    Javier A. Sala-Mercado, Masashi Ichinose, Robert L. Hammond, Tomoko Ichinose, Marco Pallante, Larry W. Stephenson, Donal S. O'Leary, Ferdinando Iellamo

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   292 ( 6 )   H2867 - H2873   2007.6

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    DOI： 10.1152/ajpheart.00043.2006

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  • Metabolic response during intermittent graded sprint running in moderate hypobaric hypoxia in competitive middle-distance runners Reviewed

    Takeshi Ogawa, Keiji Hayashi, Masashi Ichinose, Hiroyuki Wada, Takeshi Nishiyasu

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   99 ( 1 )   39 - 46   2007.1

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    DOI： 10.1007/s00421-006-0315-5

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  • Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress Reviewed

    Masashi Ichinose, Mitsuru Saito, Naoto Fujii, Narihiko Kondo, Takeshi Nishiyasu

    JOURNAL OF PHYSIOLOGY-LONDON   576 ( 3 )   947 - 958   2006.11

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    DOI： 10.1113/jphysiol.2006.117507

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  • Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans Reviewed

    M Ichinose, M Saito, N Kondo, T Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   290 ( 4 )   H1419 - H1426   2006.4

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    DOI： 10.1152/ajpheart.00847.2005

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  • The muscle metaboreflex does/does not restore blood flow to contracting muscles

    T Nishiyasu, M Ichinose

    JOURNAL OF APPLIED PHYSIOLOGY   100 ( 2 )   750 - 750   2006.2

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  • 運動時の血流制御 Invited

    西保 岳,一之瀬 真志,近藤 徳彦,斉藤 満.

    体育の科学   55 ( 12 )   901-906   2005.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans Reviewed

    M Ichinose, T Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   288 ( 4 )   H1532 - H1538   2005.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpheart.00673.2004

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  • Comparison of cardiovascular responses between lower body negative pressure and head-up tilt Reviewed International journal

    Kitano A, Shoemaker JK, Ichinose M, Wada H, and Nishiyasu T.

    Journal of Applied Physiology   98 ( 6 )   2081-2086   2005.4

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  • Modulation of the control of muscle sympathetic nerve activity during orthostatic stress in humans Reviewed

    Ichinose M, Saito M, Ogawa T, Hayashi K, Kondo N, and Nishiyasu T.

    American Journal of Physiology-Heart and Circulatory Physiology   287 ( 5 )   H2147-H2153 - H2153   2004.11

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  • Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans Reviewed

    M Ichinose, M Saito, A Kitano, K Hayashi, N Kondo, T Nishiyasu

    JOURNAL OF PHYSIOLOGY-LONDON   557 ( 1 )   321 - 330   2004.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2003.057133

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  • Muscle metaboreflex modulates the arterial baroreflex dynamic effect on peripheral vascular conductance in humans Reviewed

    T Nishiyasu, M Ichinose

    FASEB JOURNAL   18 ( 4 )   A650 - A650   2004.3

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  • Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans Reviewed

    M Ichinose, M Saito, H Wada, A Kitano, N Kondo, T Nishiyasu

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   286 ( 2 )   H701 - H707   2004.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpheart.00618.2003

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  • Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans Reviewed

    M Ichinose, M Saito, H Wada, A Kitano, N Kondo, T Nishiyasu

    JOURNAL OF PHYSIOLOGY-LONDON   544 ( 3 )   939 - 948   2002.11

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    DOI： 10.1113/physiol.2002.024794

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▼display all

Books

  • 身体運動と呼吸・循環機能

    編集 宮村実晴（ Role： Joint author）

    真興交易（株）医書出版部  2012.8 

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    Responsible for pages：Ⅱ部 循環機能 14.代謝および圧受容器反射の相互作用,301-309.   Language：Japanese   Book type：Scholarly book

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  • 運動生理学のニューエビデンス

    （ Role： Joint author）

    真興交易（株）医書出版部  2010.11 

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    Responsible for pages：「末梢反射と循環調節」292-297   Language：Japanese   Book type：Scholarly book

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MISC

  • 筋代謝受容器反射が呼吸筋血流量に及ぼす影響-拡散相関分光法を用いて-

    一之瀬真志, 中林実輝絵, 小野弓絵

    日本運動生理学会大会プログラム・抄録集   31st   2023

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  • 拡散相関分光法による深部組織血流計測能の検証:生体模擬ファントムによる検証

    中林実輝絵, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   62nd   2023

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  • 筋電気刺激が局所的な血流および酸素代謝に与える影響

    片桐誠, 中林実輝絵, 松田康宏, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   62nd   2023

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  • 拡散相関分光法を用いた血液透析中の下肢筋血流動態の計測

    土屋智裕, 中林実輝絵, 中林実輝絵, 高山卓, 藤島理恵, 小島茂樹, 櫻田勉, 柴垣有吾, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   61st   2022

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  • 拡散相関分光法と近赤外分光法の同時計測による局所筋の血流動態と酸素動態の評価

    中林実輝絵, 中林実輝絵, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   61st   2022

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  • 筋電気刺激による筋運動と随意筋運動における骨格筋血流動態の比較

    片桐誠, 中林実輝絵, 中林実輝絵, 松田康宏, 松田康宏, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   61st   2022

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  • Noninvasive evaluation of tissue circulatory and metabolic activity by combined diffuse correlation and near-infrared spectroscopy

    小野弓絵, 中林実輝絵, 中林実輝絵, 一之瀬真志

    Optics & Photonics Japan講演予稿集(CD-ROM)   2020   2020

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  • Measurement of muscle hemodynamics during bicycle exercise using diffusion correlation spectroscopy

    野崎寛一郎, 中林実輝絵, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   59th   2020

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  • 拡散相関分光法を用いた筋疲労時の活動筋血流動態の計測

    野崎寛一郎, 中林実輝絵, 佐々木翔太郎, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   58th   2019

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  • 運動中の任意の筋動態における血流速度評価法の開発

    佐々木翔太郎, 中林実輝絵, 野崎寛一郎, 一之瀬真志, 小野弓絵

    日本生体医工学会大会プログラム・抄録集(Web)   58th   2019

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  • Importance of Venous Return for Muscle Metaboreflex-mediated Stroke Volume and Cardiac Output Responses

    Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   49 ( 5 )   255 - 255   2017.5

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    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1249/01.mss.0000517551.96853.05

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  • Dynamic Modulation of Spontaneous Cardiac Baroreflex Sensitivity to Changes in Workloads in Humans

    Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   48 ( 5 )   367 - 367   2016.5

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    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1249/01.mss.0000486113.26728.aa

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  • Individual Differences in Components of the Pressor Responses to Isometric and Dynamic Handgrip Exercise in Humans

    Kazuhito Watanabe, Masashi Ichinose, Bun Tsuji, Seiji Maeda, Takeshi Nishiyasu

    FASEB JOURNAL   30   2016.4

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  • Importance of Venous Return for Muscle Metaboreflex-mediated Stroke Volume and Cardiac Output Responses

    Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   47 ( 5 )   255 - 255   2015.5

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  • Carotid Baroreflex Modifies Pressor Threshold of Muscle Metaboreflex in Humans

    Masashi Ichinose, Tomoko Ichinose, Kazuhito Watanabe, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   47 ( 5 )   418 - 418   2015.5

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    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1249/01.mss.0000477569.94733.32

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  • Time-Dependent Changes in Individual Differences in Components of the Pressor Responses to Isometric Handgrip Exercise

    Kazuhito Watanabe, Masashi Ichinose, Bun Tsuji, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   47 ( 5 )   739 - 739   2015.5

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    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1249/01.mss.0000478747.60358.c7

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  • 前腕部における筋代謝受容器活動が自転車運動時の熱放散反応に及ぼす影響

    天野達郎, 一之瀬真志, 井上芳光, 西保岳, 近藤徳彦

    体力科学   64 ( 6 )   2015

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  • ハンドグリップ運動時における血圧上昇要因の個人差:運動様式の違いに着目して

    渡邊和仁, 一之瀬真志, 辻文, 前田清司, 西保岳

    体力科学   64 ( 6 )   2015

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  • 頸動脈洞圧受容器反射が筋代謝受容器反射の昇圧閾値に及ぼす影響

    一之瀬真志, 一之瀬智子, 渡邊和仁, 西保岳

    体力科学   64 ( 6 )   2015

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  • Increase in Exercising Leg Blood Flow Improves Endurance Performance during Dynamic Planter Flexion Exercise

    Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   46 ( 5 )   343 - 343   2014.5

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  • 動的運動時における活動肢血流量の増加が持久性運動能力と循環および呼吸反応に及ぼす影響

    一之瀬真志, 一之瀬智子, 西保岳

    体力科学   63 ( 6 )   2014

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  • 活動筋血流量と血圧調節の関係性-神経性循環調節の役割-

    一之瀬真志

    日本運動生理学会大会プログラム・抄録集   22nd   2014

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  • 静的ハンドグリップ運動時における血圧上昇要因の個人差:運動中の経時的変化に着目して

    渡邊和仁, 一之瀬真志, 西保岳

    日本運動生理学会大会プログラム・抄録集   22nd   2014

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  • 2C14-1 Time-dependent changes in individual differences in components of the pressor responses to isometric handgrip exercise in humans(The Proceedings of the 22nd Annual Meetings of Japan Society of Exercise and Sports Physiology July 19・20, (Okayama)) :

    Watanabe Kazuhito, Ichinose Masashi, Nishiyasu Takeshi

    Advances in exercise and sports physiology   20 ( 4 )   117 - 117   2014

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    Language：English   Publisher：Japan Society of Exercise and Sports Physiology  

    CiNii Research

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=194676

  • 筋代謝受容器活動が安静温熱負荷時の熱放散反応に及ぼす影響

    天野達郎, 一之瀬真志, 井上芳光, 西保岳, 古賀俊策, 近藤徳彦

    日本生理人類学会誌   19   2014

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  • Increase in Exercising Leg Blood Flow Attenuates Systemic Cardiovascular Responses During Dynamic Planter Flexion Exercise

    Masashi Ichinose, Tomoko Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   45 ( 5 )   515 - 515   2013.5

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  • Individual Differences in Cardiac and Vascular Components of the Pressor Responses to Isometric Handgrip Exercise in Humans

    Kazuhito Watanabe, Masashi Ichinose, Rei Tahara, Takeshi Nishiyasu

    FASEB JOURNAL   27   2013.4

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  • 静的ハンドグリップ運動時における心拍出量および末梢血管抵抗の反応の個人差

    渡邊和仁, 一之瀬真志, 田原麗衣, 西保岳

    体力科学   62 ( 6 )   2013

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  • 筋代謝受容器反射が血中免疫細胞動態に及ぼす影響

    一之瀬真志, 鈴井正敏, 竹田和由

    体力科学   62 ( 6 )   2013

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  • Muscle Metaboreflex Modulates Dynamic Cardiovascular and Cerebrovascular Responses to Acute Hypotension in Humans

    Masashi Ichinose, Kazuhito Watanabe, Bun Tsuji, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   44   877 - 877   2012.5

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  • バドミントン競技選手における血管内皮機能および反射性循環調節に関する研究-利き腕と非利き腕に着目して-

    田原麗衣, 渡邊和仁, 一之瀬真志, 吹田真士, 前田清司, 西保岳

    体力科学   61 ( 6 )   2012

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  • 筋からの複合的な求心性入力が発汗反応に及ぼす影響

    天野達郎, 一之瀬真志, 三輪樹生, 井上芳光, 西保岳, 近藤徳彦

    体力科学   61 ( 6 )   2012

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  • 動的足底屈運動時における下腿陰圧負荷が活動肢血流量および中心循環反応に及ぼす影響

    一之瀬真志, 一之瀬智子, 西保岳

    体力科学   61 ( 6 )   2012

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  • Muscle Metaboreflex Modulates Dynamic Cardiovascular Responses to Acute Hypotension in Humans

    Masashi Ichinose, Kazuhito Watanabe, Naoto Fujii, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   43 ( 5 )   749 - 749   2011.5

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  • 1-A-08 Spontaneous baroreflex control of heart rate during activation of the muscle metaboreflex in the forearm and calf in humans(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) :

    WATANABE Kazuhito, ICHINOSE Masashi, FUJII Naoto, NISHIYASU Takeshi

    Advances in exercise and sports physiology   17 ( 2 )   45 - 45   2011

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=194242

  • S-II-2 Cardiovascular controls during exercise in humans : Interactions between peripheral reflexes(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) :

    Nishiyasu Takeshi, Saito Mitsuru, Kondo Narihiko, Ichinose Masashi

    Advances in exercise and sports physiology   17 ( 2 )   35 - 35   2011

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=194222

  • 1-B-02 Arterial blood pressure response to severe passive heating at rest relates to hyperthermia-induced hyperventilation(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) :

    FUJII Naoto, ICHINOSE Masashi, TSUJI Bun, WATANABE Kazuhito, KONDO Narihiko, NISHIYASU Takeshi

    Advances in exercise and sports physiology   17 ( 2 )   56 - 56   2011

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=194263

  • 筋代謝受容器反射活性時における動脈圧受容器反射による心拍調節機能:活動部位の違いに着目して

    渡邊和仁, 一之瀬真志, 藤井直人, 西保岳

    日本運動生理学会大会プログラム・抄録集   19th   2011

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  • 安静加温時における動脈血圧反応と換気亢進反応との関係

    藤井直人, 一之瀬真志, 辻文, 渡邉和仁, 近藤徳彦, 西保岳

    日本運動生理学会大会プログラム・抄録集   19th   2011

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  • 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環反応

    一之瀬真志, 渡邊和仁, 藤井直人, 西保岳

    日本運動生理学会大会プログラム・抄録集   19th   2011

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  • 2-C-02 Muscle metaboreflex modulates dynamic cardiovascular responses to acute hypotension in humans(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) :

    ICHINOSE Masashi, WATANABE Kazuhito, FUJII Naoto, NISHIYASU Takeshi

    Advances in exercise and sports physiology   17 ( 2 )   76 - 76   2011

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=194303

  • Muscle Metaboreflex Functions During Dynamic Exercise in Humans

    Masashi Ichinose, Kazuhito Watanabe, Stephane Delliaux, Naoto Fujii, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   42 ( 5 )   244 - 245   2010.5

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  • 筋代謝受容器反射の活性レベルの差異が循環調節に及ぼす影響

    渡邊和仁, 一之瀬真志, 藤井直人, 西保岳

    体力科学   59 ( 6 )   2010

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  • 運動時におけるヒトの循環調節特性-ヒトとイヌの筋代謝受容器反射の機能の比較-

    一之瀬真志

    日本生理人類学会誌   15   2010

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  • ヒトの動的運動時における筋代謝受容器反射の特性

    一之瀬真志, 渡邊和仁, 藤井直人, 西保岳

    体力科学   59 ( 6 )   2010

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  • 運動強度の違いが息止め時の活動筋の酸素動態に及ぼす影響

    松本真由美, 藤井直人, 一之瀬真志, 西保岳

    体力科学   58 ( 6 )   2009

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  • 筋代謝受容器反射活性時における心拍応答と心臓自律神経および動脈圧受容器反射の関係

    渡邊和仁, 一之瀬真志, 藤井直人, 松本真由美, 西保岳

    体力科学   58 ( 6 )   2009

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  • 心拍出量の変化が動的運動時における筋代謝受容器反射の昇圧メカニズムに及ぼす影響

    一之瀬真志

    体力科学   58 ( 6 )   2009

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  • 160. 運動中の息止め時における血圧上昇のメカニズムに関する研究 : 筋代謝受容器反射に着目して(呼吸・循環,一般口演,第63回日本体力医学会大会)

    松本 真由美, 藤井 直人, 一之瀬 真志, 吉武 成美, 西保 岳

    体力科學   57 ( 6 )   712 - 712   2008.12

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  • Effects Of Compression Timing On Femoral Blood Flow During Rhythmical Calf Compression Synchronized To HR

    Takeshi Nishiyasu, Yoshiro Nakayama, Masashi Ichinose

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 5 )   S267 - S267   2008.5

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  • Role Of The Muscle Metaboreflex In Cardiovascular Responses To Apnea During Exercise In Humans

    Mayumi Matsumoto, Naoto Fujii, Masashi Ichinose, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 5 )   S268 - S268   2008.5

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  • 運動中の息止め時における血圧上昇のメカニズムに関する研究-筋代謝受容器反射に着目して-

    松本真由美, 藤井直人, 一之瀬真志, 吉武成美, 西保岳

    体力科学   57 ( 6 )   2008

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  • 運動時の反射性循環調節

    西保岳, 一之瀬真志, 近藤徳彦, 斉藤満

    体力科学   56 ( 1 )   2007

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  • Effects of body heating on the cardiovascular responses during handgrip exercise and post-exercise ischemia

    西保岳, 丹信介, 曽根涼子, 林恵嗣, 一之瀬真志

    筑波大学体育科学系紀要   30   2007

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  • 体温上昇に伴う換気量亢進反応に対するトレーニング効果に関する研究

    西保岳, 本田靖, 藤井直人, 小川剛司, 一之瀬真志, 林恵嗣

    筑波大学体育科学系紀要   30   2007

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  • ヘッドアップチルト時における心拍および血流の調節-自発性変動に注目して-

    前田良孝, 一之瀬真志, 西保岳

    体力科学   56 ( 6 )   2007

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  • リズミカルな下腿圧迫が下肢血流量に及ぼす影響-心周期同期に注目して-

    中山芳郎, 一之瀬真志, 西保岳

    体力科学   55 ( 6 )   2006

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  • The Changes In Vascular Conductance In Exercising Limb During Apnea In Humans

    Takeshi Nishiyasu, Rina Tsukamoto, Keiji Hayashi, Masashi Ichinose, Shunsaku Koga

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S224 - S224   2005.5

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  • Effects Of Posture On Central And Peripheral Vascular Responses To Lower Body Positive Pressure

    Masashi Ichinose, Shigeko Hayashida, Asami Kitano, Takeshi Nishiyasu

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S221 - S221   2005.5

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  • 筋代謝受容器刺激時における末梢血管調節に関する研究-末梢血管抵抗の自発性変動に注目して-

    一之瀬真志, 古賀俊策, 近藤徳彦, 西保岳

    体力科学   54 ( 6 )   2005

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  • 異なる2種類の陽圧呼吸法が末梢循環動態に及ぼす影響(呼吸・循環, 第59回日本体力医学会大会)

    和田 浩幸, 一之瀬 真志, 西保 岳

    体力科學   53 ( 6 )   693 - 693   2004.12

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    CiNii Research

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  • ハンドグリップ運動時における動脈圧受容器反射調節の経時的変化-筋交感神経活動からみて-

    一之瀬真志, 斉藤満, 近藤徳彦, 西保岳

    体力科学   53 ( 6 )   2004

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  • 運動中の止息による活動筋血流動態の変化

    塚本理奈, 一之瀬真志, 林恵嗣, 西保岳

    体力科学   53 ( 6 )   2004

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  • 異なる2種類の陽圧呼吸法が末梢循環動態に及ぼす影響

    和田浩幸, 一之瀬真志, 西保岳

    体力科学   53 ( 6 )   2004

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  • 346. 異なる2種類の陽圧呼吸法が循環系に及ぼす影響(呼吸・循環)

    和田 浩幸, 斉藤 満, 一之瀬 真志, 近藤 徳彦, 西保 西保

    体力科學   52 ( 6 )   887 - 887   2003.12

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  • 異なる2種類の陽圧呼吸法が循環系に及ぼす影響

    和田浩幸, 斉藤満, 一之瀬真志, 近藤徳彦, 西保岳

    体力科学   52 ( 6 )   2003

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  • 2P16 Modulation of arterial baroreflex dynamic response during orthostatic stress in humans :

    Ichinose Masashi, Saito Mitsuru, Kondo Narihiko, Nishiyasu Takeshi

    Advances in exercise and sports physiology   9 ( 4 )   187 - 187   2003

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=193246

  • 起立性ストレス下での筋交感神経活動と心拍調節の関係

    一之瀬真志, 斉藤満, 林恵嗣, 和田浩幸, 近藤徳彦, 西保岳

    体力科学   52 ( 6 )   2003

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  • 深部体温と皮膚温が筋交感神経活動へ及ぼす影響

    林恵嗣, 斎藤満, 小川剛司, 一之瀬真志, 近藤徳彦, 西保岳

    体力科学   52 ( 6 )   2003

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  • 心肺圧受容器減負荷時における頚動脈圧受容器反射の動的特性に関する研究

    一之瀬真志, 斉藤満, 近藤徳彦, 西保岳

    日本運動生理学会大会プログラム・抄録集   11th   2003

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  • 1P9 The effect of muscle metaboreflex on arterial baroreflex control of muscle sympathetic nerve activity :

    Ichinose Masashi, Saito Mitsuru, Wada Hiroyuki, Kitano Asami, Kondo Narihiko, Nishiyasu Takeshi

    Advances in exercise and sports physiology   8 ( 4 )   168 - 168   2002

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    Other Link： http://hdl.handle.net/2241/7756

  • 1P14 Comparison of cardiovascular responses between LBPP and head-down tilt :

    KITANO Asami, WADA Hiroyuki, ICHINOSE Masashi, NISHIYASU Takeshi

    Advances in exercise and sports physiology   8 ( 4 )   171 - 171   2002

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    Other Link： http://hdl.handle.net/2241/7752

  • 1P12 The effect of increasing work load and pedaling frequency on mechanical efficiency during moderate intensity cycling exercise :

    WADA Hiroyuki, KITANO Asami, ICHINOSE Masashi, NISHIYASU Takeshi

    Advances in exercise and sports physiology   8 ( 4 )   170 - 170   2002

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    Other Link： http://hdl.handle.net/2241/7753

  • Validity of triaxial accelerometer for assessment of physical activity in adults and children.

    松坂晃, 稲葉勉, 竹田優子, 一之瀬真志, 山添正行, 塚越晶子, 野村知弘, 松坂佳子, 富樫泰一

    茨城大学教育学部紀要 自然科学   ( 50 )   2001

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  • 2種類の起立性ストレスに対する末梢循環動態

    北野旭美, 和田浩幸, 一之瀬真志, 西保岳

    体力科学   50 ( 6 )   2001

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  • 無酸素性機械効率と有酸素性機械効率の比較

    和田浩幸, 北野旭美, 一之瀬真志, 西保岳

    体力科学   50 ( 6 )   2001

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  • 筋代謝受容器反射活性時における頚動脈圧受容器反射を介した筋交換神経活動の調節

    一之瀬真志, 斉藤満, 北野旭美, 和田浩幸, 近藤徳彦, 西保岳

    体力科学   50 ( 6 )   2001

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Presentations

  • 活動筋微小循環の適応：利き腕と非利き腕の血流反応の比較

    一之瀬 真志, 中林 実輝絵, 小野 弓絵

    第79回日本体力医学会大会  2025.9 

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    Event date： 2025.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Feasibility of Speckle Contrast Optical Spectroscopy for Quantifying Active Muscle Blood Flow

    Tomoya Yamamoto, Vika Tarle, Masashi Ichinose, Nisan Ozana, Yumie Ono

    47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2025.7 

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    Event date： 2025.7

    Language：English   Presentation type：Oral presentation (general)  

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  • Analysis of Time-Series Changes in Blood Flow and Vascular Resistance across Multiple Sites during Active Orthostatic Test

    Tohko Tabuchi, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2025.7 

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    Event date： 2025.7

    Language：English   Presentation type：Oral presentation (general)  

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  • Effects of warm-up on muscle hemodynamics: a focus on muscle strength and exercise intensity in women

    Haruka Mizuno, Mikie Nakabayashi, Masashi Ichinose, Yumie Ono

    47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2025.7 

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    Event date： 2025.7

    Language：English   Presentation type：Poster presentation  

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  • 運動強度に注目したウォーミングアップによる活動筋血流促進効果の検討

    水野 晴香, 中林 実輝絵, 一之瀬 真志, 小野 弓絵

    第64回日本生体医工学会大会  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

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  • スペックルコントラスト光学分光法を用いた活動筋における脈動性血流の評価

    山本 智也, 一之瀬 真志, Vika Tarle, Nisan Ozana, 小野 弓絵

    第64回日本生体医工学会大会  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

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  • 能動起立試験における複数部位での血流応答の同時計測

    田渕 瞳子, 中林 実輝絵, 一之瀬 真志, 小野 弓絵

    第64回日本生体医工学会大会  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

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  • The Accuracy of Continuous and Non-invasive Peripheral Blood Flow Monitoring Using Diffuse Correlation Spectroscopy in Hypovolemic Shock: An Animal Study International conference

    H Matsushita, K Kurono, M Nakabayashi, S Yokota, H Morita, K Sato, Y Yoshida, M Ichinose, Y Ono, K Saku.

    The 24th KSCCM-JSICM Joint Congress, The 3rd Joint Scientific Congress of TSCCM, TSECCM and JSICM  2024.3 

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    Event date： 2024.3

    Language：English   Presentation type：Oral presentation (general)  

    Venue：北海道札幌市   Country/Region：Japan  

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  • 拡散相関分光法による経皮的血流モニタリングは出血性ショックにおける末梢血流量を連続的に可視化する

    松下裕貴,黒野晃暉,中林実輝絵,横田翔平,森田英剛,佐藤 啓,吉田祐希,一之瀬真志,小野弓絵,朔 啓太

    第51回日本集中治療医学会学術集会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道札幌市   Country/Region：Japan  

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  • 活動筋の皮膚・筋血流を分離する拡散相関分光法の深層学習アプローチ Invited

    小野弓絵,中林実輝絵,Nawara Mahmood Broti,劉司威,一之瀬真志

    第29回医用近赤外線分光法研究会  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：静岡県浜松市   Country/Region：Japan  

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  • 筋電気刺激の刺激周波数および皮脂の厚さが局所筋血流・酸素代謝率に与える影響

    片桐誠, 中林実輝絵, 松田康宏, 一之瀬真志, 小野弓絵

    生体医工学シンポジウム2023  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：熊本県熊本市   Country/Region：Japan  

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  • 運動への意識が活動筋酸素代謝率に与える効果の検討

    宇賀田麗衣, 中林実輝絵, 一之瀬真志, 小野弓絵

    生体医工学シンポジウム2023  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：熊本県熊本市   Country/Region：Japan  

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  • 筋温度が活動筋の酸素消費速度に及ぼす影響

    廣田俊作, 中林実輝絵, 古賀俊策, 一之瀬真志, 小野弓絵

    生体医工学シンポジウム2023  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：熊本県熊本市   Country/Region：Japan  

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  • 筋代謝受容器反射が呼吸筋血流量に及ぼす影響‐拡散相関分光法を用いて‐

    一之瀬 真志,中林 実輝絵,小野 弓絵

    第３１回日本運動生理学会大会  2023.8 

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    Event date： 2023.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：茨城県つくば市   Country/Region：Japan  

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  • Effects of Motor Imagery on Peripheral Muscle Blood Flow International conference

    R Ugata, M Nakabayashi, Y Ono, M Ichinose

    EMBC2023  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Poster presentation  

    Venue：Sydney   Country/Region：Australia  

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  • 筋電気刺激が局所的な血流および酸素代謝に与える影響

    片桐 誠, 中林実輝絵, 松田康宏, 一之瀬真志, 小野弓絵

    第62回日本生体医工学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：愛知県名古屋市   Country/Region：Japan  

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  • 筋温度が局所の骨格筋循環動態に及ぼす影響

    廣田俊作, 中林実輝絵, 古賀俊策, 一之瀬真志, 小野弓絵

    第62回日本生体医工学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：愛知県名古屋市   Country/Region：Japan  

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  • 拡散相関分光法による深部組織血流計測能の検証：生体模擬ファントムによる検証

    中林実輝絵,一之瀬真志,小野弓絵

    第62回日本生体医工学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Poster presentation  

    Venue：愛知県名古屋市   Country/Region：Japan  

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  • 筋を意識した運動が脳活動と筋活動に与える影響の検討

    宇賀田麗衣, 中林美輝絵, 一之瀬真志, 小野弓絵

    第62回日本生体医工学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Poster presentation  

    Venue：愛知県名古屋市   Country/Region：Japan  

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  • 運動開始時の微小循環レベル酸素消費量～拡散相関分光法とNIRS法の併用～

    古賀俊策, 中林実輝絵, 廣田俊作, 一之瀬真志, 奥島 大, 小野弓絵

    呼吸研究会  2022.12 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country/Region：Japan  

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  • 骨格筋における代謝性血管拡張‐導管動脈と微小循環での血流反応の違い‐

    一之瀬 真志,中林 実輝絵,小野 弓絵

    第７７回日本体力医学会大会  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：栃木県（オンライン開催）   Country/Region：Japan  

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  • 筋電気刺激は同等の強度の随意運動と比較して局所的な酸素代謝および血流を促進する

    片桐誠, 中林美輝絵, 松田康宏, 一之瀬真志, 小野弓絵

    生体医工学シンポジウム2022  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country/Region：Japan  

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  • 筋電気刺激による筋運動と随意筋運動における骨格筋血流動態の比較

    片桐誠, 中林美輝絵, 松田康宏, 一之瀬真志, 小野弓絵

    第61回日本生体医工学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Poster presentation  

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  • 拡散相関分光法を用いた血液透析中の下肢筋血流動態の計測

    土屋智裕, 中林実輝絵, 髙山卓, 藤島理恵, 小島茂樹, 櫻田勉, 柴垣有吾, 一之瀬真志, 小野弓絵

    第61回日本生体医工学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 拡散相関分光法と近赤外分光法の同時計測による局所筋の血流動態と酸素動態の評価

    中林実輝絵,一之瀬真志,小野弓絵

    第61回日本生体医工学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：新潟県新潟市  

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  • Diffuse Optics for Probing Oxygen Metabolism of Active Muscles Invited International conference

    Ono Y, Nakabayashi M, Ichinose M

    IEEE Photonics Conference  2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Online   Country/Region：Canada  

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  • 拡散相関分光法と近赤外分光法を組み合わせた局所筋の酸素代謝率検出に関する検討

    第27回医用近赤外線分光法研究会, 第25回酸素ダイナミクス研究会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Online  

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  • 拡散相関分光法を用いた局所筋血流計測による手技療法の評価

    第27回医用近赤外線分光法研究会, 第25回酸素ダイナミクス研究会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Dual-channel Diffuse Correlation Spectroscopy for Simultaneous Blood Flow Measurement of Multiple Muscles International conference

    Tsuchiya T, Yamamoto Y, Nakabayashi M, Ichinose M, Ono Y.

    OSA Biophotonics Congress: Optics in the Life Sciences  2021.4 

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    Event date： 2021.4

    Language：English   Presentation type：Poster presentation  

    Venue：Online  

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  • 拡散相関分光法とNIRSによる組織循環・代謝機能の評価 Invited

    小野 弓絵,中林 実輝絵,一之瀬 真志

    日本光学会年次学術講演会(OPJ2020)  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：Online   Country/Region：Japan  

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  • Detection of tissue metabolic rate of oxygen: a combined near-infrared spectroscopy and diffuse correlation spectroscopy study Invited International conference

    Ono Y, Nakabayashi M, Kono M, Ichinose M.

    International Conference on Complex Medical and Engineering 2020  2020.8 

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    Event date： 2020.8

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Online   Country/Region：Japan  

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  • 拡散相関分光法を用いた自転車運動中筋血流動態の計測

    野崎 寛一郎, 中林 実輝絵, 一之瀬 真志, 小野 弓絵

    第59回 日本生体医工学会大会  2020.5 

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    Event date： 2020.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Online   Country/Region：Japan  

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  • Beat-by-beat blood flow change during handgrip exercise using diffuse correlation spectroscopy

    M Nakabayashi, M Ichinose, Y Ono

    第59回 日本生体医工学会大会  2020.5 

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    Event date： 2020.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Online   Country/Region：Japan  

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  • Optical evaluation of microvascular function at early and chronic stages of diabetes International conference

    Sasaki S, Nakabayashi M, Ono Y, Ichinose M.

    SPIE Photonics West  2020.2 

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    Event date： 2020.2

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Francisco, CA   Country/Region：United States  

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  • Real-time detection of fatigue effect on active muscle hemodynamics using diffuse correlation spectroscopy International conference

    Nozaki K, Nakabayashi M, Ichinose M, Ono Y.

    SPIE Photonics West  2020.2 

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    Event date： 2020.2

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Francisco, CA   Country/Region：United States  

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  • Spontaneous baroreflex control of heart rate during activation of the muscle metaboreflex in the forearm and calf in humans International conference

    Watanabe K, Ichinose M, Fujii N, Tsuji B, Sugihara A, Niwa T, Nishiyasu T.

    16th Annual Congress of the European College of Sport Science  2011.7 

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    Event date： 2011.7

    Language：English   Presentation type：Poster presentation  

    Venue：Liverpool, UK.   Country/Region：United Kingdom  

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  • Muscle metaborefelx modulates dynamic cardiovascular responses to acute hypotension in humans International conference

    Ichinose M, Watanabe K, Fujii N, Nishiyasu T.

    American College of Sports Medicine 58th annual meeting  2011.6  American College of Sports Medicine

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    Event date： 2011.5 - 2011.6

    Language：English   Presentation type：Poster presentation  

    Venue：Denver, CO   Country/Region：United States  

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  • Muscle Metaboreflex Functions During Dynamic Exercise in Humans International conference

    Ichinose M, Watanabe K, Delliaux S, Fuiji N, Nishiyasu T.

    American College of Sports Medicine 57th annual meeting  2010.6  American College of Sports Medicine

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    Event date： 2010.5

    Language：English   Presentation type：Poster presentation  

    Venue：Baltimore, MD   Country/Region：United States  

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  • Pilot canine investigation of the cardiopulmonary baroreflex control of ventricular contractility. International conference

    Sala-Mercado JA, Chen X, Hammond RL, Ichinose M, O'Leary DS, Mukkamala R.

    31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2009.9 

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    Event date： 2009.9

    Language：English   Presentation type：Poster presentation  

    Venue：Minneapolis, MN   Country/Region：United States  

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  • Dynamic control of maximal ventricular elastance in conscious dogs before and after pacing-induced heart failure. International conference

    Chen X, Mukkamala R, Sala-Mercado JA, Hammond RL, Ichinose M, Soltani S, O'Leary DS.

    31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society  2009.9 

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    Event date： 2009.9

    Language：English   Presentation type：Poster presentation  

    Venue：Minneapolis, MN   Country/Region：United States  

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  • Modulation of cardiac output alters the mechanisms of the muscle metaboreflex during dynamic exercise. International conference

    1. Ichinose M, Sala-Mercado JA, Coutsos M, Li Z, Ichinose T, O’Leary DS.

    Experimental Biology 2009  2009.4 

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    Event date： 2009.4

    Language：English   Presentation type：Poster presentation  

    Venue：New Orleans, LA   Country/Region：United States  

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  • Preferential baroreflex control of left ventricular diastolic function at rest and during mild dynamic exercise. International conference

    2. Sala-Mercado JA, Ichinose M, Coutsos M, Li Z, Ichinose T, O’Leary DS.

    Experimetal Biology 2009  2009.4 

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    Event date： 2009.4

    Language：English   Presentation type：Poster presentation  

    Venue：New Orleans, LA   Country/Region：United States  

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  • Effects of compression timing on femoral blood flow during rhythmical calf compression synchronized to the cardiac cycle International conference

    Nishiyasu T Nakayama Y, Ichinose M.

    American College of Sports Medicine 55th annual meeting  2008.5 

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    Event date： 2008.5

    Language：English   Presentation type：Poster presentation  

    Venue：Indianapolis, IN   Country/Region：United States  

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  • Role of the muscle metaboreflex in cardiovascular responses to apnea during exercise in humans International conference

    Matsumoto M, Fujii N, Ichinose M, Nishiyasu T.

    American College of Sports Medicine 55th annual meeting  2008.5 

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    Event date： 2008.5

    Language：English   Presentation type：Poster presentation  

    Venue：Indianapolis, IN   Country/Region：United States  

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  • Muscle metaboreflex control of coronary blood flow and ventricular contractility during dynamic exercise International conference

    Coutsos M, Sala-Mercado JA, Ichinose M, Li ZH, O'Leary DS.

    Experimental Biology 2008  2008.4 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

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  • Dynamic cardiac output regulation during exercise, muscle metaboreflex activation and heart failure International conference

    Ichinose M, Sala-Mercado JA, Coutsos M, Ichinose T, O'Leary DS.

    Experimental Biology 2008  2008.4 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

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  • Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise International conference

    Sala-Mercado JA, Ichinose M, Coutsos M, Ichinose T, O'Leary DS.

    Experimental Biology 2008  2008.4 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

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  • 筋収縮が誘起する迅速な骨格筋血流増加反応‐導管動脈と骨格筋微小循環での血流反応の違い‐

    一之瀬 真志,中林 実輝絵,小野 弓絵

    第75回日本体力医学会大会  2020.9 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Evaluation of Functional Sympatholysis Occurring Within Contracting Skeletal Muscle Microvasculature in Humans International conference

    Ichinose M, Nakabayashi M, Nozaki K, Sasaki S, Ono Y.

    American College of Sports Medicine 67th Annual Meeting  2020.5 

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  • 筋収縮が誘起する迅速な活動筋血管拡張反応‐拡散相関分光法を用いた検討‐

    一之瀬真志,中林実輝絵,小野弓絵

    第74回日本体力医学会大会  2019.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：茨城県つくば市  

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  • 運動時及び回復時の呼吸循環応答に及ぼす運動前自発的過換気の影響‐運動強度に着目‐

    土橋康平,一之瀬真志,松竹涼子,坂本みずき,藤井直人,西保 岳

    第74回日本体力医学会大会  2019.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：茨城県つくば市  

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  • 動脈血二酸化炭素分圧低下を伴う運動前自発的過換気が運動と息止めを同時に開始した時の循環応答に及ぼす影響

    坂本みずき,一之瀬真志,土橋康平,松竹涼子,藤井直人,西保 岳

    第74回日本体力医学会大会  2019.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：茨城県つくば市  

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  • 動脈血酸素分圧および二酸化炭素分圧が運動中息止め時の循環応答に及ぼす影響

    松竹涼子,一之瀬真志,藤本友臣,土橋康平,藤井直人,西保 岳

    第74回日本体力医学会大会  2019.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：茨城県つくば市  

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  • 骨格筋活動を考慮した組織血流速度評価法の開発

    佐々木 翔太朗,中林 実輝絵,野崎 寛一郎,一之瀬 真志,小野 弓絵

    第58回 日本生体医工学会  2019.6 

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  • 拡散相関分光法を用いた筋疲労時の活動筋血流動態の計測

    野崎 寛一郎, 中林 実輝絵, 佐々木 翔太郎, 一之瀬 真志, 小野 弓絵

    第58回 日本生体医工学会  2019.6 

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  • Integrated Effects of Sympathetic Vasoconstriction and Local Vasodilation in Human Skeletal Muscle and Skin Microvasculature International conference

    Ichinose M, Nakabayashi M, Ono Y.

    American College of Sports Medicine 66th Annual Meeting  2019.5 

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    Language：English   Presentation type：Poster presentation  

    Venue：Orland, Florida, USA.  

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  • 運動前自発的過換気時間の違い（5分および20分）が高強度運動及び回復時の生理応答に及ぼす影響

    土橋康平,藤井直人,一之瀬真志,藤本知臣,西保 岳

    第73回日本体力医学会大会  2018.9  日本体力医学会

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：福井県福井市  

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  • 動脈血CO2分圧が運動中の息止時における循環応答に及ぼす影響

    松竹涼子,藤本知臣,土橋康平,一之瀬真志,藤井直人,西保 岳

    第73回日本体力医学会大会  2018.9  日本体力医学会

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：福井県福井市  

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  • 骨格筋微小循環における局所性血管拡張と交感神経性血管収縮の複合作用ー拡散相関分光法を用いてー

    一之瀬真志,中林実輝絵,小野弓絵

    第73回日本体力医学会大会  2018.9  日本体力医学科

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福井県福井市  

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  • Evaluation of blood flow in human exercising muscle by diffuse correlation spectroscopy: a phantom model study International conference

    Nakabayashi M, Ono Y, Ichinose M.

    SPIE PHOTONICS WEST BIOS 2018  2018.2 

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    Language：English   Presentation type：Oral presentation (general)  

    Venue：San Francisco, California, USA.  

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  • KV, KATP, and KCa channels are involved in cutaneous reactive hyperemia but not venous occlusion induced cutaneous vasoconstriction in young adults International conference

    Fujii N, Ichinose M, Nishiyasu T, McNeely B, Kenny G.

    The 17th International Conference on Environmental Ergonomics  2017.11 

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    Language：English   Presentation type：Oral presentation (general)  

    Venue：Kobe, Hyogo, Japan  

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  • Reduction of venous return abolishes muscle metaboreflex-mediated rise in cardiac output in exercising humans International conference

    Ichinose M, Ichinose T, Nishiyasu T.

    The 17th International Conference on Environmental Ergonomics  2017.11 

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    Language：English   Presentation type：Poster presentation  

    Venue：Kobe, Hyogo, Japan.  

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  • Combined effects of cold pressor test and apnea on cardiovascular responses during dynamic two-legged knee extension exercise International conference

    Matsutake R, Fujimoto T, Watanabe K, Ichinose M, Fujii N, Nishiyasu T.

    The 17th International Conference on Environmental Ergonomics  2017.11 

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    Language：English   Presentation type：Oral presentation (general)  

    Venue：Kobe, Hyogo, Japan  

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  • Separate effects of voluntary hyperventilation and resultant hypocapnia on metabolic and cardiovascular responses during and following supramaximal exercise International conference

    Dobashi K, Fujii N, Fujimoto T, Tanigawa S, Ichinose M, Nishiyasu T.

    The 17th International Conference on Environmental Ergonomics  2017.11 

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    Language：English   Presentation type：Oral presentation (general)  

    Venue：Kobe, Hyogo, Japan.  

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  • 筋代謝受容器反射による心拍出量増加反応における静脈還流量の重要性

    一之瀬真志,一之瀬智子,西保 岳

    第72回日本体力医学会大会  2017.9 

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    Venue：愛媛県松山市  

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  • 運動時における手掌冷却と息止めが循環応答に及ぼす影響

    松竹涼子,藤本知臣,渡邊和仁,一之瀬真志,藤井直人,西保 岳

    第72回日本体力医学会大会  2017.9 

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  • 運動前自発的過換気が高強度運動時およびその後の休息時の生理応答に及ぼす影響

    土橋康平,藤井直人,藤本知臣,谷川 聡,一之瀬真志,西保 岳

    第72回日本体力医学会大会  2017.9 

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    Venue：愛媛県松山市  

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  • Importance of Venous Return for Muscle Metaboreflex-mediated Stroke Volume and Cardiac Output Responses International conference

    Ichinose M, Ichinose T, Nishiyasu T.

    American College of Sports Medicine 64th Annual Meeting  2017.5 

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    Venue：Denver, Colorado, USA  

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  • Blood flow measurement of human skeletal muscle during various exercise intensities using diffuse correlation spectroscopy (DCS) International conference

    Murakami Y, Ono Y, Ichinose M.

    SPIE PHOTONICS WEST BIOS 2017  2017.2 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：San Francisco, California, USA.  

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  • 非定常負荷運動に対する動脈圧受容器反射感受性の応答

    一之瀬 真志,一之瀬 智子,西保 岳

    第71回日本体力医学会大会  2016.9 

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    Venue：岩手県盛岡市  

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  • 運動時の反射性循環調節‐圧受容器反射を中心に‐

    第24回日本運動生理学会大会  2016.7 

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：熊本県熊本市  

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  • Dynamic Modulation of Spontaneous Cardiac Baroreflex Sensitivity to Changes in Workloads in Humans International conference

    Ichinose M, Ichinose T, Nishiyasu T.

    American College of Sports Medicine 63rd Annual Meeting  2016.6 

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    Language：English   Presentation type：Poster presentation  

    Venue：Boston, Massachusetts USA.  

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  • 頸動脈圧受容器反射が筋代謝受容器反射の昇圧閾値に及ぼす影響

    一之瀬真志,一之瀬智子,渡邊和仁,西保 岳

    第７０回日本体力医学会大会  2015.9 

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    Venue：和歌山県和歌山市  

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  • ハンドグリップ運動時における血圧上昇要因の個人差：運動様式の違いに着目して

    渡邊和仁,一之瀬真志,辻 文,前田清司,西保 岳

    第７０回日本体力医学会大会  2015.9 

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    Venue：和歌山県和歌山市  

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  • 前腕部における筋代謝受容器活動が自転車運動時の熱放散反応に及ぼす影響

    天野達郎,一之瀬真志,井上芳光,西保 岳,近藤徳彦

    第７０回日本体力医学会大会  2015.9 

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    Venue：和歌山県和歌山市  

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  • 運動時の循環・代謝調節 筋代謝受容器反射 Invited

    呼吸研究会（第２９回）運動と循環 合同研究会  2015.9 

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    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：和歌山県和歌山市  

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  • Pressor threshold of muscle metaboreflex is modulated during unloading of carotid baroreceptors in humans. International conference

    Ichinose M, Ichinose T, Watanabe K, Nishiyasu T.

    16th International Conference on Environmental Ergonomics  2015.6 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：Portsmouth, UK.  

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  • Time-Dependent Changes in Individual Differences in Components of the Pressor Responses to Isometric Handgrip Exercise. International conference

    Watanabe K, Ichinose M, Tsuji B, Nishiyasu T.

    American College of Sports Medicine 62nd annual meeting  2015.5 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：San Diego, California, USA.  

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  • Carotid Baroreflex Modifies Pressor Threshold of Muscle Metaboreflex in Humans International conference

    Ichinose M, Ichinose T, Watanabe K, Nishiyasu T.

    American College of Sports Medicine 62nd annual meeting  2015.5 

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    Language：English   Presentation type：Poster presentation  

    Venue：San Diego, California, USA.  

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  • Neural Cardiovascular Control during Exercise: Contribution of Exercising Muscle Blood Flow to Systemic Blood Pressure Regulations Invited

    International Symposium on Human Adaptation to Environment and Whole-body Coordination  2015.3  Japan Society of Physiological Anthropology

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    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Kobe, Hyougo, Japan  

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  • 動的運動時における活動肢血流量の増加が持久性運動能力と循環および呼吸反応に及ぼす影響

    一之瀬真志,一之瀬智子,西保 岳

    第69回日本体力医学会大会  2014.9  日本体力医学会大会

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：長崎県長崎市  

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  • 静的ハンドグリップ運動時における血圧上昇要因の個人差：運動中の経時的変化に着目して

    渡辺和仁,一之瀬真志,西保 岳

    第22回日本運動生理学会大会  2014.7  日本運動生理学会大会

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    Venue：岡山県倉敷市  

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  • 活動筋血流量と血圧調節の関係性‐神経性循環調節の役割‐ Invited

    第22回日本運動生理学会大会  2014.7  日本運動生理学会

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    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：岡山県倉敷市  

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  • Natural Killer Cells Response To The Muscular Metaboreflex International conference

    Suzui M, Ichinose M, Takeda K, Yagita H, Shek PN, Shephard RJ.

    American College of Sports Medicine 61st annual Meeting  2014.5 

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  • Increase in Exercising Leg Blood Flow Improves Endurance Performance during Dynamic Planter Flexion Exercise International conference

    Ichinose M, Ichinose T, Nishiyasu T.

    American College of Sports Medicine 61st annual Meeting  2014.5 

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    Venue：Orlando, Florida USA.  

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  • 筋代謝受容器反射が血中免疫細胞動態に及ぼす影響

    一之瀬真志,鈴井正敏,竹田和由

    第68回日本体力医学会  2013.9 

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    Venue：東京都  

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  • 静的ハンドグリップ運動時における心拍出量および末梢血管抵抗の反応の個人差

    渡邊和仁,一之瀬真志,田原麗衣,西保 岳

    第68回日本体力医学会  2013.9 

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  • Increase in Exercising Leg Blood Flow Attenuates Systemic Cardiovascular Responses During Dynamic Planter Flexion Exercise. International conference

    Ichinose M, Ichinose T, Nishiyasu T.

    American College of Sports Medicine 60th annual Meeting  2013.5 

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    Venue：Indianapolis, Indiana, USA.  

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  • Reflex cardiovascular control during exercise: contribution of muscle metaboreflex in humans

    Integrated physiology to exercise, exercise training, environment and health  2012.12  Kobe University

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    Venue：Hyougo  

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  • バトミントン競技選手における血管内皮機能および反射性循環調節に関する研究‐利き腕と非利き腕に着目して‐

    田原麗衣,渡邊和仁,一之瀬真志,吹田真士,前田清司,西保 岳

    第67回日本体力医学会大会  2012.9 

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  • 筋からの複合的な求心性入力が発汗反応に及ぼす影響

    天野達郎,一之瀬真志,三輪樹生,井上芳光,西保 岳,近藤徳彦

    第67回日本体力医学会大会  2012.9 

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  • 動的足底屈運動時における下腿陰圧負荷が活動肢血流量および中心循環反応に及ぼす影響

    一之瀬真志,一之瀬智子,西保 岳

    第67回日本体力医学会大会  2012.9 

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    Venue：岐阜県  

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  • Muscle metaboreflex modulates dynamic cardiovascular and cerebrovascular responses to acute hypotension in humans

    Ichinose M, Watanabe K, Tsuji B and Nishiyasu T

    The Systems Biology of Exercise: Cardio-Respiratory and Metabolic Integration  2012.8 

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    Language：English   Presentation type：Poster presentation  

    Venue：Leeds, GBR  

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  • Muscle metaboreflex Modulates Dynamic Cardiovascular and Cerebrovascular Responses to Acute Hypotension in Humans International conference

    Ichinose M, Watanabe K, Tsuji B, Nishiyasu T.

    American College of Sports Medicine 59th annual Meeting  2012.6 

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    Venue：San Francisco, California  

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  • 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環応答

    一之瀬真志,渡邊和仁,藤井直人,西保岳

    第19回日本運動生理学会大会  2011.8 

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  • 筋代謝受容器反射活性時における動脈圧受容器反射による心拍調節機能：活動部位の違いに着目して

    渡邊 和仁,一之瀬 真志,藤井 直人,西保 岳.

    第19回日本運動生理学会大会  2011.8 

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  • Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans

    Kazuhito Watanabe, Masashi Ichinose, Stephane Delliaux, Naoto Fujii and Takeshi Nishiyasu

    Biotechnology and Biological Sciences Research Council-Japanese Partnership Symposium  2011.7 

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  • Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans International conference

    Watanabe K, Ichinose M, Delliaux S, Fujii N, Nishiyasu T.

    14th International Conference on Environmental Ergonomics  2011.7 

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  • Muscle Metaboreflex Functions during Dynamic Exercise in Humans

    "University of Tsukuba, Body and Mind Integrative Sciences (BAMIS) project 6th Seminar"  2010.9  University of Tsukuba

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  • 筋代謝受容器反射の活性レベルの差異が循環調節に及ぼす影響

    渡邊和仁,藤井直人,西保岳

    第65回日本体力医学会大会  2010.9  日本体力医学会

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  • ヒトの動的運動時における筋代謝受容器反射の特性

    渡邊和仁,藤井直人,西保岳

    第65回日本体力医学会大会  2010.9  日本体力医学会

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  • 運動時における反射性循環調節の相互作用

    2010年 運動と循環研究会  2010.9  運動と循環研究会

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  • Integrative cardiovascular regulation during exercise: interactions between arterial baroreflex and muscle metaboreflex

    The 87th Annual Meeting of the Physiological Society of Japan  2010.5  Physiological Society of Japan

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  • Characteristics of cardiovascular regulation during exercise in humans - Comparisons of the muscle metaboreflex function in humans and dogs -

    62nd Conference of Japan Society of Physiological Anthropology  2010.5 

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  • 筋代謝受容器反射活性時の心拍応答と心臓自律神経および動脈圧受容器反射の関係

    渡邊 和仁,一之瀬 真志,藤井 直人,松本 真由美,西保 岳.

    第64回日本体力医学会  2009.9 

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  • 運動強度の違いが息止め時の活動筋の酸素動態に及ぼす影響

    松本 真由美,藤井 直人,一之瀬 真志,西保 岳.

    第64回日本体力医学会  2009.9 

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  • 心拍出量の変化が動的運動時における筋代謝受容器反射の昇圧メカニズムに及ぼす影響

    "一之瀬 真志,Sala-Mercado JA, Coutsos M, LiZ, 一之瀬(桑原)智子, O’Leary DS."

    第64回日本体力医学会  2009.9 

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  • Characteristics of heart rate response to activation of muscle metaboreflex in humans.

    "Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T."

    International Sprots Science Network Forum in Nagano 2009  2009.8 

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  • Regulation of blood pressure during exercise: Interactions between arterial baroreflex and muscle metaboreflex. Invited

    International Sprots Science Network Forum in Nagano 2009  2009.8 

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  • "Dynamic cardiac output regulation during exercise, muscle metaboreflex activation and heart failure"

    "Ichinose M, Sala-Mercado JA, Coutsos M, Ichinose T, O'Leary DS."

    Experimental Biology 2008  2008.4 

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  • 運動時における反射性循環調節 －動脈圧受容器反射と筋代謝受容器反射の相互作用－

    筑波大学人間総合科学研究科，特別セミナー 招待講演  2008.3  筑波大学人間総合科学研究科

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  • Regulation of blood pressure and sympathetic nerve activity during exercise: stress and modulation of arterial baroreflex function

    Invited talk in University of Western Ontario  2007.10  "University of Western Ontario, London, Ontario, Canada"

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  • Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise.

    "Sala-Mercado JA, Ichinose M, Coutsos M, Ichinose T, O’Leary DS."

    Regional Hypertension Workshop  2007.9 

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  • Spontaneous baroreflex control of cardiac output during dynamic exercise and muscle metaboreflex activation in normal and heart failure conditions

    1st Tsukuba-Detroit Scientific Symposium  2007.6 

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  • Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex.

    "Ichinose M, Koga S, Kondo N, Nishiyasu T."

    American College of Sports Medicine 54th annual meeting  2007.6 

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  • Baroreflex control of muscle sympathetic nerve activity: activated muscle metaboreflex in humans Invited International conference

    Ichinose M

    American College of Sports Medicine 54th annual meeting  2007.5 

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  • Muscle metaboreflex activation attenuates spontaneous baroreflex control of heart rate during dynamic exercise.

    "Ichinose M, Sala-Mercado JA, Ichinose T, Pallante M, Iellamo F, O'Leary DS."

    Experimental Biology 2007  2007.4 

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  • リズミカルな下腿圧迫が下肢血流量におよぼす影響 －心周期同期に注目して－

    中山 芳郎,一之瀬 真志,西保 岳.

    第6１回日本体力医学会  2006.9 

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  • Sequential modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans.

    "一之瀬 真志, 斉藤 満, 近藤 徳彦, 西保 岳."

    第19回ニューログラム研究会  2006.6 

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  • Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress in humans.

    "Ichinose M, Saito M, Kondo N, Nishiyasu T."

    Experimental Biology 2006  2006.4 

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  • Changes in left ventricular function and cerebral blood flow during apnea in exercising humans.

    "Nishiyasu T, Tsukamoto R, Fujii N, Ichinose M."

    Experimental Biology 2006  2006.4 

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  • 運動時における反射性循環調節 －動脈圧受容器反射を中心に－．

    日本大学医学部社会医学講座 招待講演  2005.12  日本大学医学部社会医学講座

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  • 筋代謝受容器刺激時における末梢血管調節に関する研究 －末梢血管抵抗の自発性変動に注目して－

    一之瀬 真志,古賀 俊策,近藤 徳彦,西保 岳.

    第60回日本体力医学会  2005.9 

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  • 運動時の反射性循環調節－動脈圧受容器反射を中心に－

    運動と循環研究会，若手シンポジウム  2005.7 

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  • 運動時における反射性循環調節 －動脈圧受容器反射を中心に－

    神戸大学発達科学部 招待講演  2005.7  神戸大学発達科学部

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  • Regulation of blood pressure and sympathetic nerve activity during exercise: stress and modulation of arterial baroreflex function

    第18回ニューログラム研究会，国際シンポジウム  2005.6 

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  • The changes in vascular conductance in exercising limb during apnea in humans.

    "Nishiyasu T, Tsukamoto R, Hayashi K, Ichinose M."

    American College of Sports Medicine 52nd annual meeting  2005.6 

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  • Effects of posture on central and peripheral vascular responses to lower body positive pressure.

    "Ichinose M, Hayashida S, Kitano A, Nishiyasu T."

    American College of Sports Medicine 52nd annual meeting  2005.6 

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  • 2種類の陽圧呼吸法が末梢循環動態に及ぼす影響．

    "和田 浩幸, 一之瀬 真志, 西保 岳."

    第59回日本体力医学会  2004.9 

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  • 運動中の止息による活動筋血流動態の変化．

    "塚本 里奈,一之瀬 真志, 林 恵嗣, 西保 岳."

    第59回日本体力医学会  2004.9 

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  • ハンドグリップ運動時における動脈圧受容器反射調節の経時的変化－筋交感神経活動からみて－

    "一之瀬 真志, 斉藤 満, 近藤 徳彦, 西保 岳."

    第59回日本体力医学会  2004.9 

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  • Muscle metaboreflex modulates the arterial baroreflex dynamic effect on peripheral vascular conductance in humans

    "Nishiyasu T, Ichinose M."

    Experimental Biology 2004  2004.4 

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  • Sequential modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans

    "Ichinose M, Saito M, Kondo N, Nishiyasu T."

    Experimental Biology 2004  2004.4 

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  • 深部体温と皮膚温が筋交感神経活動へ及ぼす影響

    "林 恵嗣, 斉藤 満, 小川 剛司, 一之瀬 真志, 近藤 徳彦, 西保 岳."

    第58回日本体力医学会  2003.9 

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  • 起立性ストレス下での筋交感神経活動と心拍調節の関係.

    "一之瀬 真志, 斉藤 満, 林 恵嗣, 和田 浩幸, 近藤 徳彦, 西保 岳"

    第58回日本体力医学会  2003.9 

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  • 異なる2種類の陽圧呼吸法が循環系に及ぼす影響

    "和田 浩幸, 斉藤 満, 一之瀬 真志, 近藤 徳彦, 西保 岳."

    第58回日本体力医学会  2003.9 

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  • ペダル回転数及び負荷の増加が低強度自転車運動時の機械効率に与える影響.

    "和田 浩幸, 北野 旭美, 一之瀬 真志, 西保 岳."

    第10回日本運動生理学会  2003.8 

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  • 心肺圧受容器減負荷時における頚動脈圧受容器反射の動的特性に関する研究.

    "一之瀬 真志, 斉藤 満, 近藤 徳彦, 西保 岳."

    第11回日本運動生理学会  2003.8 

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  • Modulation of arterial baroreflex control of muscle sympathetic nervous activity by muscle metaboreflex in humans.

    "Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T."

    Experimental Biology 2003  2003.4 

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  • Control of muscle sympathetic nerve activity during orthostatic stress in humans.

    "Nishiyasu T, Ichinose M, Wada H, Hayashi K, Kondo N, Saito, M."

    Experimental Biology 2003  2003.4 

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  • LBNP及びHead Down Tilt時における循環動態

    "北野 旭美, 和田 浩幸, 一之瀬 真志, 西保 岳."

    第10回日本運動生理学会  2002.7 

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  • 筋代謝受容器反射が動脈圧受容器反射による筋交感神経活動調節に及ぼす影響.

    "一之瀬 真志, 斉藤 満, 北野 旭美, 和田 浩幸, 近藤 徳彦, 西保 岳."

    第10回日本運動生理学会  2002.7 

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  • Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans

    "Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T."

    Experimental Biology 2002  2002.4 

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  • Comparison of cardiovascular responses between LBNP and head-up tilt. Experimental biology.

    "Nishiyasu T, Ichinose M, Wada H, Kitano A."

    Experimental Biology 2002  2002.4 

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  • 2種類の起立性ストレスに対する末梢循環動態

    "北野 旭美, 和田 浩幸, 一之瀬 真志, 西保 岳."

    第56回日本体力医学会  2001.9 

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  • 筋代謝受容器反射活性時における頚動脈圧受容器反射を介した筋交感神経活動の調節.

    "一之瀬 真志, 斉藤 満, 北野 旭美, 和田 浩幸, 近藤 徳彦, 西保 岳."

    第56回日本体力医学会  2001.9 

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  • 無酸素性機械効率と有酸素性機械効率の比較

    "和田 浩幸, 北野 旭美, 一之瀬 真志, 西保 岳."

    第56回日本体力医学会  2001.9 

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Awards

  • 2025年度全国大会優秀賞

    2025.5   一般社団法人 人工知能学会   深層学習を用いた末梢血流脈波による心拍出量の推定

    黒野 晃暉, 松下 裕貴, 中林 実輝絵, Nawara Mahmood Broti, 一之瀬 真志, 朔 啓太, 小野 弓絵

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  • 日本生体医工学会 研究奨励賞・阿部賞

    2023.5   日本生体医工学会大会   拡散相関分光法と近赤外分光法の同時計測による局所筋の血流動態と酸素動態の評価

    中林実輝絵, 一之瀬真志, 小野弓絵

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    Award type：Award from Japanese society, conference, symposium, etc.  Country/Region：Japan

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  • 日本生体医工学学会 研究奨励賞・阿部賞

    2023.5   日本生体医工学会大会   拡散相関分光法と近赤外分光法の同時計測による局所筋の血流動態と酸素動態の評価

    中林実輝絵, 一之瀬真志, 小野弓絵

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  • コニカミノルタ科学技術振興財団・日本生体医工学会大会奨励賞／学生賞

    2023.5   日本生体医工学会大会   拡散相関分光法による深部組織血流計測能の検証：生体模擬ファントムによる検証

    中林実輝絵, 一之瀬真志, 小野弓絵

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  • Young Investigator's Award 最優秀賞

    2022.6   日本生体医工学会大会   拡散相関分光法を用いた血液透析中の下肢筋血流動態の計測

    土屋智裕, 中林実輝絵, 髙山卓, 藤島理恵, 小島茂樹, 櫻田勉, 柴垣有吾, 一之瀬真志, 小野弓絵

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    Award type：Award from Japanese society, conference, symposium, etc.  Country/Region：Japan

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  • 大塚スポーツ医科学賞 奨励賞

    2014.9   日本体力医学会   動的運動時における活動肢血流量の増加が持久性運動能力と循環および呼吸反応に及ぼす影響

    一之瀬真志,一之瀬智子,西保 岳

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Research Projects

  • Heterogeneity of local muscle oxygen consumption kinetics during exercise

    Grant number：25K14604  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 低酸素下運動時の呼吸筋活動が循環調節機構に及ぼす影響-呼吸筋トレーニングの提言-

    Grant number：24K14452  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    小川 剛司, 一之瀬 真志

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    Authorship：Coinvestigator(s) 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • 運動時の呼吸筋血流量反応とトレーニング効果の解明：光学的非侵襲測定法を用いて

    Grant number：23K27978  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    一之瀬 真志, 小野 弓絵

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    Grant amount：\18980000 （ Direct Cost: \14600000 、 Indirect Cost：\4380000 ）

    本研究では，拡散相関分光法(DCS)を用いた呼吸筋血流量の非侵襲測定法を開発・確立し，運動時の呼吸筋血流量反応とその調節メカニズムおよびトレーニング効果を明らかにすることを目指す。2023年度においては，呼吸筋血流量の測定に対応したDCS血流計測システムの開発と呼吸筋血流量の定量評価法を検討した。
    呼吸筋活動の変化と血流量反応の関係を調べるため，安静時の随意過換気により呼吸筋の活動を定量的に変化させた際の呼吸筋血流量反応を測定した。随意過換気の方法は，呼吸回数を15回毎分とし，１回換気量を1000, 1500, 2000, 2500 mlに増加させ，各水準で90秒間維持することとした。測定対象とする呼吸筋は肋間筋とし，第７肋間中腋窩線上にDCS血流計のプローブを装着した。プローブ装着位置において，超音波診断装置を用いてDCS血流計の測定可能深度（皮下約1.5cm）に肋間筋が含まれることを確認した。呼気ガス分析装置を用いて，呼吸・呼気ガスパラメーターをブレス・バイ・ブレス法で測定した。換気量の増加にともない肋間筋血流量は漸増し，両者には強い正の相関関係が認められた。また，換気量の変化に対応して肋間筋血流量が変化する様子を連続的に捉えることに成功した。
    呼吸筋血流量測定に対応したDCS血流計測システムの開発として，計測プログラムの改良によるサンプリング周波数の向上と呼吸流量シグナルをトリガとし呼吸位相に対応する血流分析法を検討した。また，複数の呼吸筋および四肢骨格筋での同時計測を行うための装置の多チャンネル化にも取り組んだ。ただし，世界的な半導体需要の高まりにともない，多チャンネル化に不可欠な多チャンネルフォトンカウンタの納入時期が当初の想定よりも大きく遅れたため，多チャンネル化した装置による測定は予備的実験に留め，次年度以降において本格的な導入を予定している。

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  • Search for biomarkers of active muscle function to predict sarcopenia

    Grant number：21K19738  2021.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship：Coinvestigator(s) 

    Grant amount：\6370000 （ Direct Cost: \4900000 、 Indirect Cost：\1470000 ）

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  • Development of a non-invasive method for measuring oxygen uptake of active muscle using optical technology and elucidation of training effects

    2020.4 - 2023.3

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    Authorship：Principal investigator 

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  • Rapid active muscle hyperemia at the onset of exercise and elucidation of training effects: using diffuse correlation spectroscopy

    2019.4 - 2023.3

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    Authorship：Principal investigator 

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  • Evaluation of active muscle blood flow response and training effects - using a new measurement method by diffuse correlation spectroscopy

    2016.4 - 2019.3

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    Authorship：Principal investigator 

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  • Regulation of arterial blood pressure during exercise: function of the aortic arch baroreflex

    2015.4 - 2018.3

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    Authorship：Principal investigator 

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  • Effects of reflex cardiovascular regulation on active muscle blood flow and exercise performance

    2013.4 - 2016.3

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    Authorship：Principal investigator 

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  • Relationship between blood immune cell dynamics and regulation of circulation, autonomic nervous system, and hormone secretion during exercise

    2012.4 - 2014.3

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    Authorship：Principal investigator 

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  • Interaction of cardiovascular reflexes during exercise

    Grant number：22680049  2010.4 - 2013.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (A)

    ICHINOSE Masashi

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    Authorship：Principal investigator 

    In this study, 1) we established experimental technique to quantify the characteristics of the muscle metaboreflex during dynamic exercise in humans. In addition, 2) we found that during activation of the muscle metaboreflex, the arterial baroreflex-mediated peripheral vasoconstriction is enhanced. Such interaction of the peripheral reflexes could contribute to the cardiovascular regulation during exercise. These findings advance elucidation of mechanisms of cardiovascular regulation during exercise, and will be a significant academic base in considering the safety of exerciseand the efficacy of the exercise training in promotion of health.

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  • Effects of exercise training on autonomic nervous activity and blood pressure regulation during exercise

    Grant number：21800059  2009.4 - 2010.3

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    Authorship：Principal investigator 

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  • Neural cardiovascular regulation during exercise

    2005.4 - 2008.3

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    Authorship：Principal investigator 

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  • 運動と暑熱トレーニングが反射性循環調節に及ぼす影響

    Grant number：05J03884  2005 - 2007

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

    一之瀬 真志

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    Grant amount：\3400000 （ Direct Cost: \3400000 ）

    末梢血管抵抗の調節は,運動時や暑熱環境などの様々なストレス下における血圧や末梢血流量の調節に極めて重要である.本研究は,末梢血管抵抗が自発性に変動するという特性に着目し,末梢血管抵抗の変動が交感神経活動の増加や局所性調節によってどのように影響されるかを調べ,さらにこれらが,運動や暑熱トレーニングによってどのように変化するかを検討する。本年度では,以下の課題1,2について検討した.
    課題1,暑熱下運動トレーニングが末梢血管抵抗の自発性変動に及ぼす影響
    暑熱下運動トレーニングは末梢血管調節や自律神経活動に影響することが知られている.そこで,短期間(6日間)の暑熱下(気温37℃,湿度50%)での運動トレーニング(20分間の最大酸素摂取量の50%での自転車運動を10分間の休憩を挟んで4回繰り返す)が常温下安静時における上肢の末梢血管抵抗変動に及ぼす影響を検討した.暑熱下運動トレーニングによって,1)安静時心拍数の低下,体温上昇に対する皮膚の血管拡張反応の向上,および最大酸素摂取量の増加がみられたが,2)末梢血管変動には有意な変化はみられなかった.このことから,短期間の暑熱下運動トレーニングは末梢血管抵抗変動には影響しないことが示唆された.
    課題2.筋代謝受容器反射刺激時における動脈圧受容器反射機能変化が循環調節に及ぼす影響.
    心拍出量を連続的に測定可能な動物モデル(イヌ)を用いてbeat-to-beatの心拍出量調節を定量化する手法を開発し,これが,動的運動時および筋代謝受容器反射刺激時にどのように変化するかを検討した.その結果,1)運動強度の増加にともなって心拍数調節と心拍出量調節の反応性が低下すること,また2)筋代謝受容器刺激は心拍数調節の反応性を低下するが,心拍出量調節の反応性には影響しないことが明らかになった.このような変化は運動時の血圧調節メカニズムの一つであると考えられる.

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Social Activities

  • Editorial Board member of the American Journal of Physiology – Heart and Circulatory Physiology

    Role(s)： Organizing member

    American Physiological Society  American Journal of Physiology – Heart and Circulatory Physiology  2020.1 - 2024.12

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    Type：Newspaper, magazine

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  • 茨城県立日立第一高等学校健康教育講座講師

    Role(s)： Lecturer

    2011.11

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