Updated on 2025/12/26

写真a

 
YOSHIDA KENICHI
 
Organization
Undergraduate School School of Agriculture Professor
Title
Professor
External link

Research Interests

  • Biological sciences in general

Research Areas

  • Life sciences / Molecular biology

  • Life sciences / Developmental biology

  • Life sciences / Cell biology

Education

Books

  • Expression of green fluorescent protein in transgenic mice

    Methods in Enzymology  1999 

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MISC

  • Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation

    Ryuji Ikeda, Kenichi Yoshida, Ituro Inoue

    JOURNAL OF CELLULAR BIOCHEMISTRY   101 ( 1 )   147 - 154   2007.5

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  • Acute loss of transcription factor E2F1 induces mitochondrial biogenesis in HeLa cells

    Yuya Goto, Reiko Hayashi, Dongchon Kang, Kenichi Yoshida

    JOURNAL OF CELLULAR PHYSIOLOGY   209 ( 3 )   923 - 934   2006.12

  • CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation

    Reiko Hayashi, Yuya Goto, Ryuji Ikeda, Kazunari K. Yokoyama, Kenichi Yoshida

    JOURNAL OF BIOLOGICAL CHEMISTRY   281 ( 47 )   35633 - 35648   2006.11

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  • The small heat shock protein alpha B-crystallin inhibits differentiation-induced caspase 3 activation and myogenic differentiation

    Ryuji Ikeda, Kenichi Yoshida, Mina Ushiyama, Tatsuya Yamaguchi, Ken-ichi Iwashita, Toshitaka Futagawa, Yoshihiko Shibayama, Shigeru Oiso, Yasuo Takeda, Hiroko Kariyazono, Tatsuhiko Furukawa, Kazuo Nakamura, Shin-ichi Akiyama, Ituro Inoue, Katsushi Yamada

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   29 ( 9 )   1815 - 1819   2006.9

  • Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2

    So Tsukahara, Ryuji Ikeda, Shin Goto, Kenichi Yoshida, Rie Mitsumori, Yoshiko Sakamoto, Atsushi Tajima, Toru Yokoyama, Satoshi Toh, Ken-Ichi Furukawa, Ituro Inoue

    BIOCHEMICAL JOURNAL   398 ( 3 )   595 - 603   2006.9

  • A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS

    Reiko Hayashi, Takako Arauchi, Moe Tategu, Yuya Goto, Kenichi Yoshida

    Genomics, Proteomics and Bioinformatics   4 ( 3 )   156 - 164   2006.8

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  • Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F

    R Hayashi, Y Goto, A Haga, D Kobayashi, R Ikeda, K Yoshida

    GENE   367   126 - 134   2006.2

  • JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity

    Y Goto, R Hayashi, T MuramatSU, H Ogawa, Eguchi, I, Y Oshida, K Ohtani, K Yoshida

    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION   1759 ( 1-2 )   60 - 68   2006.1

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  • Geminin as a molecular target for the development of new anticancer drugs (Corresponding author)

    Mini-Reviews in Medicinal Chemistry   6 ( 4 )   461 - 462   2006

  • Identification of a novel cell-cycle-induced MCM family protein MCM9

    K Yoshida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   331 ( 2 )   669 - 674   2005.6

  • The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1

    R Ikeda, K Yoshida, S Tsukahara, Y Sakamoto, H Tanaka, K Furukawa, Inoue, I

    JOURNAL OF BIOLOGICAL CHEMISTRY   280 ( 9 )   8523 - 8530   2005.3

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  • Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters

    K Yoshida

    FEBS LETTERS   579 ( 6 )   1488 - 1492   2005.2

  • Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico (Corresponding author)

    International Journal of Molecular Medicine   16 ( 2 )   343 - 347   2005

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  • Identification and characterization of human ZNF18 gene in silico (Corresponding author)

    International Journal of Molecular Medicine   15 ( 3 )   545 - 548   2005

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  • Characterization of estrogen-induced F-box protein FBXO45 (Corresponding author)

    Oncology Reports   14 ( 2 )   531 - 535   2005

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  • Identification and characterization of a novel kelch-like gene KLHL15 in silico (Corresponding author)

    Oncology Reports   13 ( 6 )   1133 - 1137   2005

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  • Murine Mll2 gene and its expression

    43 ( 8 )   97 - 101   2005

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  • Polymorphisms in the prostaglandin E-2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach

    N Jinnai, T Sakagami, T Sekigawa, M Kakihara, T Nakajima, K Yoshida, S Goto, T Hasegawa, T Koshino, Y Hasegawa, H Inoue, N Suzuki, Y Sano, Inoue, I

    HUMAN MOLECULAR GENETICS   13 ( 24 )   3203 - 3217   2004.12

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  • Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor

    K Yoshida, Inoue, I

    ONCOGENE   23 ( 37 )   6250 - 6260   2004.8

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  • Regulation of Geminin and Cdt1 expression by E2F transcription factors

    K Yoshida, Inoue, I

    ONCOGENE   23 ( 21 )   3802 - 3812   2004.5

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  • Peptide binding to Geminin and inhibitory for DNA replication

    K Yoshida, Inoue, I

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   317 ( 1 )   218 - 222   2004.4

  • The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells

    K Yoshida, N Oyaizu, A Dutta, Inoue, I

    ONCOGENE   23 ( 1 )   58 - 70   2004.1

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  • Characterization of the 5'regulatory region of the mouse angiopoietin-like protein 4 (Corresponding author)

    Veterinary Research Communications   28 ( 4 )   299 - 305   2004

  • Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. International journal

    Mitsuru Ono, Tetsuya Shimizugawa, Mitsuru Shimamura, Kenichi Yoshida, Chisa Noji-Sakikawa, Yosuke Ando, Ryuta Koishi, Hidehiko Furukawa

    The Journal of biological chemistry   278 ( 43 )   41804 - 9   2003.10

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    Language:English  

    Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil domain-containing fragment-(17-207) and not the C-terminal fibrinogen-like domain-containing fragment-(207-460) increased the plasma triglyceride levels in mice. We also found that the N-terminal region 17-165 was required to increase plasma triglyceride levels in mice and that a substitution of basic amino acid residues in the region 61-66 of the fragment showed no increase in the plasma triglyceride levels and no inhibition of lipolysis by lipoprotein lipase. In addition, when we analyzed ANGPTL3 in human plasma, we detected cleaved fragments of ANGPTL3. By analyzing recombinant ANGPTL3 in mouse plasma, we found that it was cleaved at two sites, Arg221 downward arrow Ala222 and Arg224 downward arrow Thr225, which are located in the linker region between the coiled-coil domain and the fibrinogen-like domain. Furthermore, a cleavage-resistant mutant of ANGPTL3 was determined to be less active than wild-type ANGPTL3 in increasing mouse plasma triglyceride levels but not in inhibiting lipoprotein lipase activity. These findings suggest that the cleavage of ANGPTL3 is important for the activation of ANGPTL3 in vivo.

    DOI: 10.1074/jbc.M302861200

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  • Conditional expression of MCM7 increases tumor growth without altering DNA replication activity

    K Yoshida, Inoue, I

    FEBS LETTERS   553 ( 1-2 )   213 - 217   2003.10

  • Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7a and 7b isoforms of protocadherin 7, but not the 7c isoform

    K Yoshida

    CELLULAR & MOLECULAR BIOLOGY LETTERS   8 ( 3 )   735 - 741   2003

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    Language:English  

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  • Genomewide linkage and linkage disequilibrium analyses pinpoint the ossification of the posterior longitudinal ligament of the spine to COL6Al locus on chromosome 21

    American Journal of Human Genetics   73 ( 4 )   812 - 822   2003

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  • The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level

    Gene   311   135 - 143   2003

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  • Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

    K Yoshida, T Shimizugawa, M Ono, H Furukawa

    JOURNAL OF LIPID RESEARCH   43 ( 11 )   1770 - 1772   2002.11

  • ANGPTL3 decreases VLDL triglyceride clearance by inhibition of lipoprotein lipase

    Journal of Biological Chemistry   277 ( 37 )   33742 - 33748   2002

  • Targeting replication initiators for suppressing Epstein-Barr virus

    International Journal of Cancer   13   131   2002

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  • Suppression of tumourigenicity, and induction of differentiation of the canine mammary tumour cell line MCM-B2 by sodium phenylacetate

    M Watanabe, S Sugano, J Imai, K Yoshida, R Onodera, MR Amin, K Uchida, R Yamaguchi, S Tateyama

    RESEARCH IN VETERINARY SCIENCE   70 ( 1 )   27 - 32   2001.2

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  • Requirement of CDC45 for postimplantation mouse development (First Author)

    Molecular and Cellular Biology   21 ( 14 )   4598 - 4603   2001

  • Proteins involved in replication initiation and its regulation: ORC, Cdt1 and geminin

    Molecular Biology of the Cell   12   280   2001

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  • Replication from oriP of Epstein-Barr Virus requires human ORC and is inhibited by geminin (Co-first Author)

    Cell   106 ( 3 )   287 - 296   2001

  • Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family

    M Watanabe, K Yoshida, M Hida, H Kato, K Uchida, R Yamaguchi, S Tateyama, S Sugano

    GENE   256 ( 1-2 )   51 - 58   2000.10

  • Identification of a novel protocadherin gene (PCDH11) on human XY homology region in Xq21.3 (First Author)

    Genomics   62 ( 3 )   540 - 543   1999

  • cDNA cloning and chromosomal mapping of mouse BH-protocadherin (First Author)

    DNA Sequence   10 ( 1 )   43 - 47   1999

  • Interaction of protein phosphatase 1 with BH-protocadherin-c, a member of the cadherin superfamily (First Author)

    Nucleic Acids Symposium Series   10   56   1999

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  • BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase lalpha through its intracellular domain (First Author)

    FEBS Letters   460 ( 1 )   93 - 98   1999

  • Cloning, expression analysis,and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily (First Author)

    Genomics   49 ( 3 )   458 - 461   1998

  • Transmembrane-domain trapping: A novel method for isolation of cDNAs encoding putative membrane proteins

    Sumio Sugano, Kiyomi Yoshitomo-Nakagawa, Yong-Shen Yu, Junko Mizushlma-Sugano, Kenichi Yoshida

    DNA Research   5 ( 3 )   187 - 193   1998

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    Language:English   Publisher:Universal Academy Press Inc.  

    DOI: 10.1093/dnares/5.3.187

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  • Selective production of transgenic mice using green fluorescent protein as a marker

    T Takada, K Iida, T Awaji, K Itoh, R Takahashi, A Shibui, K Yoshida, S Sugano, G Tsujimoto

    NATURE BIOTECHNOLOGY   15 ( 5 )   458 - 461   1997.5

  • Liquid chromatographic determination of furazolidone in swine serum and avian egg (First Author)

    Journal of AOAC International   78 ( 4 )   1126 - 1129   1995

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  • SIMPLIFIED CLASSIFICATION METHOD FOR RESIDUAL ANTIBIOTICS BY MICROBIOLOGICAL ASSAY USING DRUG-RESISTANT BACTERIA

    K YOSHIDA, F KONDO

    JOURNAL OF THE FOOD HYGIENIC SOCIETY OF JAPAN   35 ( 5 )   543 - 547   1994.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3358/shokueishi.35.543

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  • Procedure for liquid chromatographic determination of thiamphenicol in bovine serum and milk (First Author)

    Journal of Liquid Chromatography   17 ( 12 )   2625 - 2632   1994

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  • A simple method for classification of antibiotics using ion exchange resins added to agar plates (First Author)

    Microbios   77 ( 311 )   111 - 119   1994

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  • New high-voltage electrophoretic procedure using a thin-layer plates for determination of residual aminoglycoside antibiotics in food (First Author)

    Proceedings of the 11th International Symposium of World Association of Veterinary Food Hygienists   451 - 456   1993

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Research Projects

  • Studies on the cell cycle regulation of animal cells, and its application to dissect the molecular mechanism of cell fate

    1995

    Grant-in-Aid for Scientific Research 

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    Grant type:Competitive

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