Organization
Undergraduate School School of Science and Technology Associate Professor
Title
Associate Professor
External link
Research Areas
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Life sciences / Neuroscience - general
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Life sciences / Basic brain sciences
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Manufacturing technology (mechanical,electrical/electronic, chemical engineering) / Measurement engineering
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Life sciences / Neuroanatomy and physiology
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Informatics / Sensitivity (kansei) informatics
Research History
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Associate Professor
2014.4
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National Institute of Advanced Industrial Science and Technology
2011.4 - 2012.3
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Chief Researcher
2010.4 - 2013.3
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Chief Researcher
2009.10 - 2010.3
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Researcher
2003.4 - 2009.9
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Researcher
2001.4 - 2003
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Researcher
1998.4 - 2001.3
Papers
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Stable wide-field voltage imaging for observing neuronal plasticity at the neuronal network level Reviewed
Tominaga T, Kajiwara R, Tominaga Y
Biophysics and Physicobiology 2023
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A novel pneumatic skin sensory stimulator and its application to a two‐point discrimination test Reviewed
Hashikawa F, Mizunuma S, Ofuchi S, Kajiwara R
Electronics and Communications in Japan 105 ( 3 ) e12362 - e12362 2022.8
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膜電位イメージングで見えるようになったもの Reviewed
冨永 貴志, 梶原 利一, 冨永 洋子
生物物理 61 ( 6 ) 404 - 408 2021.11
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Takashima I, Kajiwara R
Brain Sciences 11 ( 10 ) 1294 - 1294 2021.9
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Kajiwara R, Tominaga T
BioEssays 43 ( 3 ) 2000084 - 2000084 2020.11
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Network plasticity involved in the spread of neural activity within the rhinal cortices as revealed by voltage-sensitive dye imaging in mouse brain slices Reviewed
Kajiwara R, Tominaga Y, Tominaga T
Front. Cell. Neurosci. doi: 10.3389/fncel.2019.00020 2019.1
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Wavelet correlation analysis for quantifying similarities and real-time estimates of information encoded or decoded in single-trial oscillatory brain waves Reviewed
Sato T, Kajiwara R, Takashima I, Iijima T
Wavelet theory and its applications 15 - 42 2018.10
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Development of an ex vivo brain lactic acid monitoring system Reviewed
Negishi S, Kamada S, Kajiwara R, Kaneko Y, Yoon DH, Sekiguchi T, Shoji S, Kudo H
IEEJ Transactions on Sensors and Micromachines 137 ( 1 ) 38 - 43 2017
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A novel method for quantifying similarities between oscillatory neural responses in wavelet time-frequency power profiles Reviewed
Sato T, Kajiwara R, Takashima I, Iijima T
BRAIN RESEARCH 1636 107 - 117 2016.4
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The ventral tegmental area modulates intracortical microstimulation (ICMS)-evoked M1 activity in a time-dependent manner Reviewed
Kunori N, Kajiwara R, Takashima I
NEUROSCIENCE LETTERS 616 38 - 42 2016.3
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Early exposure to urethane anesthesia: Effects on neuronal activity in the piriform cortex of the developing brain Reviewed
Kajiwara R, Takashima I
NEUROSCIENCE LETTERS 600 121 - 126 2015.7
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Voltage-Sensitive Dye Imaging of Primary Motor Cortex Activity Produced by Ventral Tegmental Area Stimulation Reviewed
Kunori N, Kajiwara R, Takashima I
JOURNAL OF NEUROSCIENCE 34 ( 26 ) 8894 - 8903 2014.6
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Algorithm of olfactory information processing for discrimination of similar odors. Reviewed
Sato T, Hirino J, Matsukawa M, Furudono Y, Kajiwara R, Takashima I, Iijima T
Aroma Research 15 ( 1 ) 3 - 9 2014.2
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【匂い情報処理メカニズムの解明に向けて】類似したニオイを識別するための嗅覚の仕組み
佐藤 孝明, 廣野 順三, 松川 睦, 古殿 雄一, 梶原 利一, 高島 一郎, 川崎 隆史, 飯島 敏夫
Aroma Research 15 ( 1 ) 3 - 9 2014.2
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VSD imaging method of <I>ex vivo</I> brain preparation. Reviewed
Tominaga T, Kajiwara, R, Tominaga Y
J Neurosci Neuroeng 2 211 - 219 2013
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Neural circuit analysis using isolated whole brain preparation Reviewed
Kajiwara R, Takashima I
Brain and Nerve 62 ( 3 ) 243 - 254 2010.3
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Optical imaging of rat prefrontal neuronal activity evoked by stimulation of the ventral tegmental area Reviewed
Watanabe Y, Kajiwara R, Takashima I
NEUROREPORT 20 ( 9 ) 875 - 880 2009.6
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Architecture of odor information processing in the olfactory system Reviewed
Sato T, Hirono J, Hamana H, Ishikawa T, Shimizu A, Takashima I, Kajiwara R, Iijima T
ANATOMICAL SCIENCE INTERNATIONAL 83 ( 4 ) 195 - 206 2008.12
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Counting contacts between neurons in 3D in confocal laser scanning images Reviewed
Wouterlood FG, Boekel AJ, Kajiwara R, Belien JAM
JOURNAL OF NEUROSCIENCE METHODS 171 ( 2 ) 296 - 308 2008.6
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Convergence of entorhinal and CA3 inputs onto pyramidal neurons and interneurons in hippocampal area CA1 - An anatomical study in the rat Reviewed
Kajiwara R, Wouterlood FG, Sah A, Boekel AJ, Baks-te Bulte LTG, Witter MP
HIPPOCAMPUS 18 ( 3 ) 266 - 280 2008
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Olfactory information converges in the amygdaloid cortex via the piriform and entorhinal cortices: observations in the guinea pig isolated whole-brain preparation Reviewed
Kajiwara R, Tominaga T, Takashima I
EUROPEAN JOURNAL OF NEUROSCIENCE 25 ( 12 ) 3648 - 3658 2007.6
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Voltage-sensitive dye imaging of intervibrissal fur-evoked activity in the rat somatosensory cortex Reviewed
Takashima, I, R Kajiwara, T Iijima
NEUROSCIENCE LETTERS 381 ( 3 ) 258 - 263 2005.6
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Olfactory input to the parahippocampal region of the isolated guinea pig brain reveals weak entorhinal-to-perirhinal interactions Reviewed
Biella GR, Gnatkovsky V, Takashima I, Kajiwara R, Iijima T, de Curtis M
EUROPEAN JOURNAL OF NEUROSCIENCE 18 ( 1 ) 95 - 101 2003.7
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Amygdala input promotes spread of excitatory neural activity from perirhinal cortex to the entorhinal-hippocampal circuit Reviewed
Kajiwara R, Takashima I, Mimura Y, Witter MP, Iijima T
JOURNAL OF NEUROPHYSIOLOGY 89 ( 4 ) 2176 - 2184 2003.4
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Functional mapping of optically detected neural activity onto a standardized cortical structure of rodent barrels Reviewed
Takashima, I, R Kajiwara, T Iijima
IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS E85D ( 1 ) 143 - 151 2002.1
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Membrane potential microscope for functional brain imaging Reviewed
Takashima I, Kajiwara R, Iijima T
Kyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers 56 ( 3 ) 476 - 481 2002
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Voltage-sensitive dye versus intrinsic signal optical imaging: comparison of optically determined functional maps from rat barrel cortex Reviewed
Takashima I, Kajiwara R, Iijima T
NEUROREPORT 12 ( 13 ) 2889 - 2894 2001.9
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High-speed videography system using a pair of imagers for biological applications Reviewed
Kajiwara R, Takashima I, Murano K, Mimura Y, Iijima T
24TH INTERNATIONAL CONGRESS ON HIGH-SPEED PHOTOGRAPHY AND PHOTONICS 4183 969 - 977 2001
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High-speed, high-resolution epifluorescence imaging system using CCD sensor and digital storage for neurobiological research Reviewed
Takashima I, Kajiwara R, Murano K, Iijima T, Morinaka Y, Komobuchi H
24TH INTERNATIONAL CONGRESS ON HIGH-SPEED PHOTOGRAPHY AND PHOTONICS 4183 978 - 989 2001
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Optical recording study of granule cell activities in the hippocampal dentate gyrus of kainate-treated rats Reviewed
Otsu Y, Maru E, Ohata H, Takashima I, Kajiwara R, Iijima T
JOURNAL OF NEUROPHYSIOLOGY 83 ( 4 ) 2421 - 2430 2000.4
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CCDを用いたリアルタイム神経活動イメージングシステム
高島一郎, 梶原利一, 飯島 敏夫
電子技術総合研究所彙報 63 11 - 25 1999
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高島一郎, 佐藤孝明, 梶原利一, 飯島敏夫
電子技術総合研究所彙報 63 ( 8 ) 27 - 36 1999
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Real-time optical imaging provides "dynamic map of brain activity" Reviewed
Iijima T, Takashima I, Inase M, Kajiwara R, Shinoda M, Takahashi T, Tsukada K, Hirose H, Niisato K
ICONIP'98: THE FIFTH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING JOINTLY WITH JNNS'98: THE 1998 ANNUAL CONFERENCE OF THE JAPANESE NEURAL NETWORK SOCIETY - PROCEEDINGS, VOLS 1-3 329 - 332 1998
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Functional organization of chromaffin cells and cholinergic synaptic transmissiom in rat adrenal medulla Reviewed
Kajiwara R, Sand O, Kidokoro Y, Barish ME, Iijima T
Japanese Journal of Physiology 47 ( 5 ) 449 - 464 1997.10
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Entorhinal-hippocampal interactions revealed by real-time imaging Reviewed
Iijima T, Witter MP, Ichikawa M, Tominaga T, Kajiwara R, Matsumoto G
SCIENCE 272 ( 5265 ) 1176 - 1179 1996.5
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Reverberating Circuit in the Entorhinal-Hippocampal System Revealed by Real-Time Imaging. Invited Reviewed
Iijima T, Witter MP, Ichikawa M, Tominaga T, Kajiwara R, Matsumoto G
International Conference on Molecular Electronics and Biocomputing 50 - 57 1995.9
Books
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Wavelet correlation analysis for quantifying similarities and real-time estimates of information encoded or decoded in single-trial oscillatory brain wave
Sato T, Kajiwara R, Takashima I, Iijima T（ Role： Joint authorChapter 2）
InTechOpen 2018.10
MISC
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Membrane Potential Imaging with Voltage-sensitive Dye (VSD) for Long-term Recording Reviewed
冨永貴志, 冨永貴志, 梶原利一, 冨永洋子
生物物理(Web) 61 ( 6 ) 404 - 408 2021
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Multi-analyte monitoring system for organ-level biomonitoring using Os-HRP redox reaction
32 1 - 4 2015.10
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Stable recording of stimulus-evoked field potentials in the anesthetized rat
WATANABE Yumiko, KAJIWARA Riichi, SAKAI Hideto, TAKASHIMA Ichiro
Neuroscience Research 65 ( Supplement 1 ) 2009
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Heartbeat Noise Compensation for in vivo Optical Recording of Neural Activity
Takashima Ichiro, Kajiwara Riichi, Ishikawa Takahiro, Iijima Toshio
Proceedings of the IEICE General Conference 2001 ( 1 ) 82 - 82 2001.3
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Video Microscopy System for Neurovascular Research
Kajiwara Riichi, Takashima Ichiro, Mimura Yuka, Iijima Toshio
Proceedings of the IEICE General Conference 2001 ( 1 ) 81 - 81 2001.3
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高島 一郎, 梶原 利一, 飯島 敏夫
研究会講演予稿 183 13 - 18 2001.1
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Membrane Potential Microscope. High-Speed Imaging of Neural Activity.
高島一郎, 梶原利一, 飯島敏夫, 森中康弘, 菰淵寛仁
映像情報メディア学会技術報告 25 ( 3(IPU2001 1-6) ) 2001
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高島 一郎, 梶原 利一, 飯島 俊夫
電子技術総合研究所彙報 63 ( 8 ) 279 - 293 1999.9
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Real-time imaging of neuronal activity using voltage-sensitive dye.
飯島敏夫, 稲瀬正彦, 高島一郎, 梶原利一, 秋山修二, 高橋俊光, 塚田薫, 広瀬秀顕, 新里和恵
脳の科学 20 1998
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神経興奮を見る
飯島敏夫, 市川道教, 高島一郎, 梶原利一
蛋白質・核酸・酵素「見る技術」（共立出版） 1100 - 1105 1997
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Imaging technology. Bio imaging of molecules and cells. Part II. Technology observing biofunctions. 3. Observing intraorganism.3-2 . Observation at cellular and organism level.Neuronal excitement is observed.
飯島敏夫, 市川道教, 高島一郎, 梶原利一
蛋白質 核酸 酵素 42 ( 7 ) 1997
Presentations
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Design and Assessment of a Pneumatic Skin Stimulator for the Evaluation of Cognitive Bias Effects on Tactile Thresholds
Motoyoshi T., Kajiwara R.
2024.9
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Measuring the level of activity and dopamine release in mice during a novel object exploration task
Muroya K., Iguchi T., Sakurai J., Miyazaki K., Kajiwara R.
2024.9
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Insights into the functional organization of rhinal cortices from analysis of oscillatory propagation of membrane potential optical signals
Masunaga S., Ogihara K., Tominaga Y., Tominaga T., Kajiwara R.
2024.9
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Influence of Success Experience on Rat Reward Waiting Behavior
Okano K., Muroya K., Ishida R., Saito R., Katayama N., Komura Y., Kajiwara R.
2024.9
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In-vivo and ex-vivo optical imaging of somatosensory cortical activity in rat model of central pain following thalamus lesion
Nagasaka K., Hyodo M., Bando D., Suzuki T., Onishi H., Higo N., Kajiwara R., Takashima I.
JNS Meeting Planner Fukuoka: Japan Neuroscience Society, 2024 Online., Program No. 3P-105 第47回日本神経科学大会 2024.7
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Effect of reward acquisition experience during waiting behavior on subsequent waiting time: Insights from a reinforcement learning model based on behavioral data in rats
Ishida R., Okano K., Muroya K., Saito R., Katayama N., Komura Y., Kajiwara R.
JNS Meeting Planner Fukuoka: Japan Neuroscience Society, 2024 Online., Program No. 1P-459 第47回日本神経科学大会 2024.7
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Sensing dopamine release in the brain of rodents using fibre photometry.
2024.7
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Development of an Air-Puff Skin Stimulation System for Cross-Modal Perception Research
2024.7
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Development of an experimental system for analyzing auditory preference behavior in rats
2024.7
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膜電位光シグナルの振動伝播現象解析から探る嗅皮質神経回路の機能構造解析
斎藤雄輝, 増永心, 岡野晃大, 冨永洋子, 冨永貴志, 梶原 利一
第129回日本解剖学会総会・全国学術集会 2024.3
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Social Novelty Seeking Behavior Analysis in C57BL/6 Mice at Different Developmental Stages
Iwaoka M., Saito Y., Ide Y., Tominaga T., Kajiwara R.
JNS Meeting Planner Sendai: Japan Neuroscience Society, 2023. Online., Program No. 3Pa-090 2023.8
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Effects of the experience for different reward waiting times on subjective sense of time: a rat behavioral analysis
Okano K., Saito Y., Inoue T., Masunaga S., Komura Y., Kajiwara R.
JNS Meeting Planner Sendai: Japan Neuroscience Society, 2023. Online., Program No. 1Pm-076 2023.8
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マウススライス標本で電位感受性色素を用いてイメージングされた嗅周囲皮質(PC)と嗅内野(EC)との皮質神経振動
Tominaga T, Tominaga Y, Kajiwara R
生物物理(Web) 2021.11
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ラットのトーン識別と音色選好を分析するための行動アッセイ系
Matsuzaki K, Okubo M, Komura Y, Kajiwara R
Journal of Physiological Sciences (Web) 2021.3
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Two-point discriminability and skin-rabbit illusion induced by the air pressure stimulation on a human forearm
水沼将太, 大淵さつき, 梶原利一
日本感性工学会春季大会(Web) 2021.3
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待機行動に対する側坐核へのムチモール注入の効果及びネットワーク活動の脳切片解析
Okada N, Okubo M, Machida Y, Komura Y, Tominaga T, Kajiwara R
Journal of Physiological Sciences (Web) 2020.3
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Involvement of GABAergic transmission in the nucleus accumbens related to cue-selection behavior with a waiting period
Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R
Proc of Life Eng Symp 2019 2019.8
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嗅周囲皮質/嗅内皮質ネットワーク可塑性への遅延性不活性化カリウム電流の関与:マウス脳スライスの膜電位イメージング
Kajiwara R, Tomminaga Y, Tominaga T
2019.7
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慢性疼痛を生み出す大脳皮質神経回路の膜電位イメージング解析
兵藤道大, 長坂和明, 山田悠太, 岩崎智洋, 高島一郎, 梶原利一
第14回日本感性工学会春季大会予稿集2p20 2019.3
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In vivo evaluation of apatite-fiber scaffolds with enhanced mechanical property using a rat calvarial defect model
大野李瑛, 永田幸平, 横田倫啓, 湯座丞太郎, 諸富公昭, 磯貝典孝, 梶原利一, 相澤守
日本バイオマテリアル学会大会予稿集(Web) 2019
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ラット頭蓋冠欠損モデルを用いたリン酸三カルシウムファイバースキャフォルドの骨形成能の評価
大野李瑛, 永田幸平, 横田倫啓, 湯座丞太郎, 諸富公昭, 磯貝典孝, 梶原利一, 相澤守
日本セラミックス協会年会講演予稿集(CD-ROM) 2019
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ラット頭蓋冠欠損モデルを用いたアパタイトファイバースキャフォルドのin vivo評価
大野李瑛, 永田幸平, 横田倫啓, 湯座丞太郎, 諸富公昭, 磯貝典孝, 梶原利一, 相澤守
日本セラミックス協会年会講演予稿集(CD-ROM) 2018
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Supersensitive odor discrimination is controlled in part by initial interactions of receptor-G-protein and cortical oscillatory responses
SATO Takaaki, KOBAYAKAWA Reiko, KOBAYAKAWA Ko, EMURA Makoto, ITOHARA Shigeyoshi, KAWASAKI Takashi, KAJIWARA Riichi, TAKASHIMA Ichiro, IIJIMA Toshio, TSUBOI Akio, MATSUMURA Hiroyoshi
生物物理(Web) 2016
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Os-HRP酸化還元反応を用いた多成分モニタリング用マイクロフロー計測システム
根岸周也, 河合望, 梶原利一, 工藤寛之, 高島一郎
センサ・マイクロマシンと応用システムシンポジウム(CD-ROM) 2015
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Tominaga Takashi, Tominaga Yoko, Kajiwara Riichi
Seibutsu Butsuri 2013 The Biophysical Society of Japan General Incorporated Association
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Whole-scale voltage imaging of limbic network using isolated brain preparation
Kajiwara R, Takashima I, Tominaga T
日本神経科学会大会抄録集(Web) 2013
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Nagasaka Kazuaki, Watanabe Yumiko, Kunori Nobuo, Kajiwara Riichi, Takashima Ichiro
Seibutsu Butsuri 2013 The Biophysical Society of Japan General Incorporated Association
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Optical imaging of neuronal activity in rat primary motor cortex evoked by stimulation of the ventral tegmental area
Nobuo Kunori, Riichi Kajiwara, Fumihiro Shuto, Setsuji Hisano, Ichiro Takashima
NEUROSCIENCE RESEARCH 2011 ELSEVIER IRELAND LTD
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Repetitive olfactory nerve stimulation induced enhancement of neural activities in the amygdaloid cortex of guinea pig isolated whole brain
Riichi Kajiwara, Takashi Tominaga, Ichiro Takashima
NEUROSCIENCE RESEARCH 2011 ELSEVIER IRELAND LTD
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Stable recording of stimulus-evoked field potentials in the anesthetized rat
Yumiko Watanabe, Riichi Kajiwara, Hideto Sakai, Ichiro Takashima
NEUROSCIENCE RESEARCH 2009 ELSEVIER IRELAND LTD
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Optical imaging of the rat prefrontal neuronal activity evoked by the Stimulation of the ventral tegmental area
Yumiko Watanabe, Riichi Kajiwara, Ichiro Takashima
Neuroscience Res 2008 ELSEVIER IRELAND LTD
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Visualization of the convergence of entorhinal and hippocampal CA3 input onto CA1 neurons
Riichi Kajiwara, Floris G. Wouterlood, Anupam Sah, Amber J. Boekel, Lucienne T. G. Baks-te Bulte, Menno P. Witter
Neuroscience Res 2007 ELSEVIER IRELAND LTD
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光計測法によるサル運動前野・一次運動野の機能的連関の解析
広瀬秀顕, 高島一郎, 梶原利一, 村松朱愛, かけい慎治, 稲瀬正彦, 飯島敏夫
日本神経科学大会プログラム・抄録集 2002
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Isolated whole brain with the nose revealed the basic property of odor-induced oscillatory local field potentials in anterior piriform cortex.
Sato T, Takashima I, Kajiwara R, Iijima T
International Symposium on Life Science and Human Technology:Stress,Signaling,Sensing, and Imaging 2001.11
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High-speed, High-resolution epifluoresence CCD imaging system for monitoring neural activity
Kajiwara R, Takashima I, Murano K, Iijima T
Society for Neuroscience 31st Annual Meeting, Abstract 2001.11
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In Vitro Preparation of Isolated Whole Brain with Nose for Study of Information Processing in Olfactory CNS.
Sato T, Takashima I, Kajiwara R, Murano K, Mimura Y, Tsukada K, Iijima T
4th International Conference on Biological Physics 2001.7
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脳神経活動in vivo光計測における心拍由来アーティファクトの除去
高島一郎, 梶原利一, 石川享宏, 飯島敏夫
電子情報通信学会大会講演論文集 2001
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ビデオ顕微鏡を用いた脳血管イメージングと神経活動の同時記録システム
梶原利一, 高島一郎, 見村夕香, 飯島敏夫
電子情報通信学会大会講演論文集 2001
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Amygdala inputs promote propagation of neural activity in the perirhinal cortex to the entorhinal/hippocampal neurocircuit: An optical imaging study.
R.Kajiwara, I.Takashima, Y.Mimura, T.Iijima
Society for Neuroscience, Abstract 2000.11
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ニオイ刺激の違いにより生じるきゅう上皮付き単離全脳試料における梨状様皮質活動の相違
佐藤孝明, 高島一郎, 梶原り一, 塚田薫, 見村夕香, 飯島敏夫
日本神経科学大会プログラム・抄録集 2000
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Electrical properties and synaptic currents of rat chromaffin cells in situ.
R.Kajiwara, O.Sand, Y.Kidokoro, M.Barish, T.Iijima
Society for Neuroscience, Abstract 1996.11
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Air Pressure Control Device for Two-point Discrimination Test.
2021.9
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Behavioral analysis of tone discrimination and auditory preference in rats.
Inoue T, Matsuzaki K, Kanemaki G, Komura Y, Kajiwara R
Program No. 1P-069 JNS Meeting Planner 2021: Japan Neuroscience Society, 2021 Online. 2021.7
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Optical membrane potential recordings with voltage-sensitive dye (VSD) enabling recordings of rare and unique neuronal activity patterns.
Tominaga Y, Kajiwara R, Tominaga T
2021 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2021. Online. Program No. P377.02. 2021
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A voltage-sensitive dye imaging of neural propagation in rhinal cortices of immature and mature mouse
MachidaY, Yamada Y, Tominaga T, KajiwaraR
JNS Meeting Planner 2020: Japan Neuroscience Society, 2020 Online. Program No. 3P-057. 2020.7
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Contribution of the GABAergic and dopaminergic systems in the nucleus accumbens to patience for a future reward in rats.
Okubo M, Matsuzaki K, Okada N, Komura Y, Kajiwara R
JNS Meeting Planner 2020: Japan Neuroscience Society, 2020 Online., Program No. 2P-129 2020.7
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Time-lapse optical imaging system for monitoring the resting membrane potential change of neurons in a mouse brain slice.
Machida Y, Yamada Y, Mizunuma S, Tominaga T, Kajiwara R
Proc of Life Eng Symp 2019, 139-142 / ISSN: 2187-9605 2019.8
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Contribution of nucleus accumbens to impulsive choice behavior based on the last reward experience International conference
Yuza J, Okubo M, Komura Y, Kajiwara R
Neuroscience 2018 2018.11 Society for Neuroscience
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Real-time electrochemical monitoring of lactic-acid released from an <I>in vitro</I> mouse brain slice preparation International conference
Firdaus bin Zailuddin MI, Kamada S, Tojyo Y, Takashima I, Kudo H, Kajiwara R
Neuroscience 2018 2018.11 Society for Neuroscience
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Limbic network dynamics analyzed by wide-field <I>ex vivo</I> VSD imaging Invited
Kajiwara R
Life Engineering Symposium (LE2018) 2018.9 計測自動制御学会
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Sound discrimination analysis in rats using an alternative maze task
Seki A, Yuza J, Iwasaki T, Kajiwara R
Life Engineering Symposium (LE2018) 2018.9 計測自動制御学会
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Development of Voltage-sensitive dye imaging system using an industrial grade CMOS camera
Yamada Y, Hyodo M, Izzat M, TominagaT, Kajiwara R
Life Engineering Symposium (LE2018) 2018.9 計測自動制御学会
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The role of nucleus accumbens for tolerance to delayed reward using two-choice maze in rats International conference
Yuza J, Okubo M, Komura Y, Kajiwara R
FENS forum 2018 2018.7 Federation of European Neuroscience Societies (FENS)
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Continuous quantitative measurement of lactic-acid released from an <I>in vitro</I> mouse brain slice using electrochemical biosensor International conference
Firdaus bin Zailuddin MI, Kamada S, Tojyo Y, Takashima I, Kudo H, Kajiwara R
The 8th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2018) 2018.1
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Network properties of limbic neurons revealed by voltage-sensitive dye imaging. Invited International conference
Kajiwara R
The 8th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2018) 2018.1
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Generation of a red-wavelength shifted voltage-sensitive fluorescence protein for dynamics analysis International conference
Sato I, Kiyosue K, Kajiwara R, Doi M
Neuroscience 2017 2017.11 Society for Neuroscience
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Experimental Design for Investigating the Acoustic Preference in Rats International conference
Okamoto K, Fujimoto K, Komura Y, Kajiwara, R
Neuroscience 2017 2017.11 Society for Neuroscience
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Real time monitoring system for lactic acid released from <I>ex vivo</I> preparations International conference
Kamada S, Negishi S, Takashima I, Kudo H, Kajiwara R
Neuroscience 2017 2017.11 Society for Neuroscience
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Voltage-sesitive dye signal analysis of inhibitory components in mouse perirhinal-entorrhinal cortical slices International conference
Wakayama Y, Kamada S, Yamada Y, Tominaga T, Kajiwara R
Neuroscience 2017 2017.11 Society for Neuroscience
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Experimental system for investigating the impulsive-control behavior in delayed reward task of rats.
Yuza J, Seki A, Okamoto K, Komura Y, Kajiwara R
Life Engineering Symposium (LE2017) 2017.9 計測自動制御学会
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Network plasticity facilitating the neural excitation propagation between the perirhinal and entorhinal cortices as revealed by voltage-sensitive dye imaging International conference
Kajiwara R, Wakayama Y, Tominaga Y, Tominaga T
Neuroscience 2016 2016.11 Society for Neuroscience
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Continuous lactic acid monitoring system for various <I>ex vivo</I> block preparations
Kamada S, Negishi S, Kudo H, Takashima I, Kajiwara R
Life Engineering Symposium (LE2016) 2016.11 計測自動制御学会
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Voltage-sensitive dye imaging of the neuronal propagation between the perirhinal and entorhinal cortices in mice brain slices
Wakayama Y, Kamada S, Hyodo M, Tominaga T, Kajiwara R
Life Engineering Symposium (LE2016) 2016.11 計測自動制御学会
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Experimental design for investigating the music preference in rats
Okamoto K, Komura Y, Kajiwara R
Life Engineering Symposium (LE2016) 2016.11 計測自動制御学会
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Whole-scale voltage imaging of limbic network using <I>ex vivo</I> brain preparations Invited International conference
Kajiwara R
Int Symp on Trans Neurosci & XXXII Ann Conf of the Indian Acad Neurosci 2014.11 Indian Academy of Neuroscience
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Whole-scale voltage imaging of limbic network using isolated brain preparation.
Kajiwara R
Neuro2013 2013.6 The Japan Neuroscience Society
Industrial property rights
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再現性のある現象の画像撮像方法及び装置
梶原利一, 高島一郎
Awards
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入澤記念JJP優秀論文賞
1998.3 日本生理学会 Functional Organization of Chromaffin Cells and Cholinergic Synaptic Transmission in Rat Adrenal Medulla
Kajiwara R, Sand O, Kidokoro Y, Barish ME, Iijima T
Research Projects
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Toward Dissecting Salience Network Dynamics through Whole-Brain Optical Imaging and E/I-Imbalanced Animal Models
Grant number：25H01156 2025.4 - 2030.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Grant amount：\45760000 （ Direct Cost: \35200000 、 Indirect Cost：\10560000 ）
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好奇心と記憶が織りなす新奇性追求行動の神経基盤とその可変性
Grant number：23K28178 2023.4 - 2028.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
梶原 利一, 宮崎 勝彦, 冨永 貴志
Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）
新奇な物事に惹きつけられる度合いは，人によって，あるいは，年齢によっても異なるように見える．本研究では，こうした差異の基になる脳情報処理機構を調査するにあたり，動物（マウス）が新奇物体を好んで接近する行動に要する処理を，①新奇性への接近行動を開始させる処理，②新奇性の「評価と記憶」の処理，③好奇心のような感性が惹起する「報酬期待」の処理，の三種に分類する．その上で，各々のプロセスを担う神経基盤を調査する計画とした．
(1)新奇性探索行動解析では，実験箱への順化の過程を，マウスの行動量により可視化し，環境順化に要する時間が，想定していた3日（10min/day）よりも長く必要である可能性が示唆された．また，DeepLabCutを活用してマウス(C57BL/6J)の鼻先が物体へ向いている状態を正確にトラックするツールを開発した．これを用いて，正方形 (40×40×40 cm)の実験箱で，10分間の二物体探索行動を解析した所，新奇物体へ積極的に接近する行動が，試験開始から約2分後に急激に消失する事が判明した．
(2)探索行動中の脳活動計測のための，ファイバーフォトメトリー計測実験系を新たに構築し，ドーパミン（GRAB_DA）およびカルシウム（GCaMP）のシグナル計測に着手した．自由行動化のマウスで実際に計測したところ，ドーパミンやカルシウムの応答と思われるシグナルが検出できたものの，期待していた程の強さではなかった．組織学的な検証の結果，目的の部位にタンパク質が発現していたため，光ファイバーの埋込み位置に改善の余地があると結論した．
(3)嗅周囲野・嗅内野における膜電位イメージング解析では，4-AP及びGanbazine 灌流下における刺激誘導性オシレーションのウェーブレット解析を行い，35野の特性が嗅内野の特性に近いことを明らかにした． -
好奇心と記憶が織りなす新奇性追求行動の神経基盤とその可変性
Grant number：23H03488 2023.4 - 2028.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
梶原 利一, 宮崎 勝彦, 冨永 貴志
Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）
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心拍が刻む感受性の窓：感性情報処理の神経基盤
Grant number：21H03532 2021.4 - 2026.3
日本学術振興会 科学研究費助成事業 基盤研究(B) 基盤研究(B)
高島 一郎, 冨永 貴志, 梶原 利一
Grant amount：\16250000 （ Direct Cost: \12500000 、 Indirect Cost：\3750000 ）
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心拍が刻む感受性の窓：感性情報処理の神経基盤
Grant number：23K21713 2021.4 - 2026.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
高島 一郎, 冨永 貴志, 渡辺 由美子, 梶原 利一
Grant amount：\16250000 （ Direct Cost: \12500000 、 Indirect Cost：\3750000 ）
脳波計測では、被験者心拍の収縮期と拡張期により、体性感覚誘発電位が変化することが知られているものの、心拍周期と外部刺激のタイミングによって生じる感覚野応答変化の詳細は未だよく分かっていない。そこで本研究は動物モデルを用いて脳神経活動を記録し、心拍動が神経活動を調節するメカニズムの解明を試みる。昨年度に引き続き、麻酔下ラットの心拍収縮期および拡張期に感覚刺激を与え、体性感覚野皮質に誘発される応答を局所フィールド電位計測法により解析する実験を行った。刺激トライアル毎の感覚応答のバラツキを解析した結果、収縮期における感覚応答のバラツキが収縮期のそれより大きいという現象が、実験個体数を増やしても再現されることが示された。一方で、膜電位イメージングを用いた感覚応答評価では、光応答振幅／空間的広がりの何れにおいても、心拍周期に依存する応答変化は検出できなかった。膜電位イメージング法は、心拍動に起因するアーティファクトを最小限に除去するようにプログラミングした信号処理を行うことから、本研究が対象とする心拍由来の応答変化検出には不向きである可能性が考えられた。また、本年度は、脳血管系への作用も指摘されている経頭蓋電気刺激（直流電気刺激）の組み合わせ効果についての実験も開始した。直流電気刺激が脳血管系制御を介して、心拍周期依存の感覚応答変化を調節することを検証する実験までは進めなかったものの、予備実験の段階で新しいタイプの神経可塑性現象を発見し論文発表を行った。
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Developement of detection and analysis of brain circuit E/I imbalance induced by chemical exposure using membrane potential imaging
Grant number：21H03606 2021.4 - 2025.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
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Optical Detection and Analysis of E/I Imbalance in Brain Circuits Induced by Chemical Exposure through Membrane Potential Imaging
Grant number：23K21755 2021.4 - 2025.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
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Association of pulsatile circulation with brain function and brain disease: an approach using ex vivo whole brain preparations
Grant number：19K22990 2019.6 - 2022.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
Takashima Ichiro
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
The effects of pulsatile flow on brain parenchyma have not been well understood. Therefore, we examined the effect of pulsatile circulation on the brain using ex vivo whole brain preparations and an artificial blood circulation system. First, an experimental system was developed in which whole brain preparations could maintain physiological activity for 5 hours by pulsatile circulation of artificial blood. Next, electrical stimulation was given to the lateral olfactory tracts at different phases of the pulsatile flow to elicit neural activity, and the neural responses in the piriform cortex were analyzed. The results revealed a phenomenon in which local field potential activity changes relative to the phase of the pulsatile flow, suggesting that pulsatile circulation may modulate brain function.
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経験依存的な聴覚嗜好性行動を司る神経回路の同定と動態解析
Grant number：19K12190 2019.4 - 2023.3
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
梶原 利一, 冨永 貴志, 高島 一郎
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
本研究では，嗜好性表出の脳内神経機構を，齧歯類の聴覚系に着目して明らかにすることを目指した．特に，聴覚入力に対して生じる「嗜好」が，知覚・記憶のプロセスを経て形成される「親密度」と結びつく可能性(後天的に獲得される嗜好)に着目し，神経行動・生理・解剖・薬理学的な手法を駆使して研究を進める計画とした．その第一歩として，ある種の音の「好み」が，生得的な要因により生じるものなのか，あるいは，後天的な要因によるものなのかという問題に取り組んだ．その際，動物の行動評価の際に用いる飲水報酬が，その後の選好行動に後天的な影響を与える可能性に着目して，行動実験パラダイムを構築した．ラットが，U字型ならびにM字型迷路下において，両端に提示される異なる音源を自発的に選択した行動を調査した結果，白色ノイズ音源とViolin音源には，ラットが生得的に好まない成分が含まれていることが示唆された．また，薬理学的解析，電気生理学的解析を行うための専用の行動実験系の構築に臨んだ．構築した実験系の評価を行うため，報酬待機行動課題を用いて，側坐核へのムシモルおよびドーパミン拮抗薬の注入実験を行い，それぞれの薬液が，ラットの待機行動に影響を及ぼすことが確認できた．また，「親密度」に関わる処理を担う可能性が示唆されている嗅周囲皮質について，聴覚野や前頭皮質と海馬との間に位置して，どのような役割を担っているのか？を脳スライスの膜電位イメージングにより解析し，in vivo行動下での神経活動の薬理阻害実験に活用するための知見を得た．
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Kansei, motivation and emotion-related neural networks underlying motor priming
Grant number：17H01810 2017.4 - 2020.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
Takashima Ichiro
Grant type：Competitive
To elucidate effects of dopaminergic and cholinergic activation on motor learning, we analyzed motor performance and cortical activity during electrical stimulation to the ventral tegmental area (VTA) or to the nucleus basalis of Meynert (NBM). Using the horizontal ladder task, it was found that VTA activation improved stepping performance (foot fault score) of rats. Transcranial direct current stimulation (tDCS) over the motor cortex restored the left-right motor imbalance in rat model of Parkinson’s disease. Furthermore, topographical mapping between the NBM and frontal cortex was determined, and electrical stimulation to the posterior part of the NBM was found to suppress excessive sensorimotor activity in the damaged brain. These findings may provide insight for future development of neurorehabilitation.
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Grant number：16K04923 2016.10 - 2019.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
KUDO HIROYUKI
Grant type：Competitive
A biomonitoring system aimed at assessment of lactic acid secretion from living organ sample was developed and utilized in brain lactic acid monitoring. Also, the biomonitoring system was tested in other applications. Using the biomonitoring system, (1) lactic acid produced in metabolic activity in block brain samples, (2) dependence of lactic acid secretion on the biochemical stimulation. (3) Also, our system was confirmed to be useful not only in the monitoring of organ level phenomenon, but also useful in monitoring of body fluids within individual-levels.
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Development of comprehensive membrane voltage imaging techniques to elucidate the neuronal basis for the emergence of " individuality"
Grant number：16H06532 2016.6 - 2021.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Tominaga Takashi
Grant amount：\107640000 （ Direct Cost: \82800000 、 Indirect Cost：\24840000 ）
The purpose of this study is to understand the emergent mechanism of "individuality" that guarantees the diversity of human behavior. In this project, we aim to develop measurement and evaluation techniques for brain circuit functions using experimental animals (mice and rats). The emergence of "individuality" depends on the function of large-scale, complex neural circuits consisting of many neurons and glial cells. To date, measurement methods of such neural circuit function is limited. In addition, the differences in the neural circuit functions responsible for the "individuality" are too small to detect and are easily hidden in the variability. Here, we have created a measurement technique using membrane voltage measurement with voltage-sensitive dyes to precisely capture the dynamics of large-scale neural circuit function.
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The neural network and its dynamics concerning with preference behavior
Grant number：16K00380 2016.4 - 2019.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Kajiwara Riichi, Komura Yutaka
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
We aimed to identify the neural circuit, which elicited the preference behavior in rodents and to obtain findings which contribute to the understanding of its dynamics. Therefore, we designed the alternative selection task by using modified M-shaped-maze (70cm x 40cm x 45cm) to test the discrimination ability and the preference for different sound stimuli in rats and mice. Notably, we analyzed the behavior by focusing on the difference of acoustic stimulus in melody, tone, and tempo. As a result, 1) the rats could discriminate the type (timbre) of sound stimuli such as the difference among piano, violin, and bell, 2) specific animals exhibit preference behavior in which they chose the sound played by piano or violin more than the bell. Microinjection of muscimol (an agonist of GABAA receptor) during the behavioral experiment performed in the maze suggested that the orbitofrontal cortex and nucleus accumbens might contribute to the alternative selection behavior.
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Grant number：15K00413 2015.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Tominaga Takashi, TANEMURA Kentaro, YOSHIMURA Hiroshi, MUTOH Hiroki
Grant type：Competitive
This study aims to clarify how abnormality of E / I balance causes neuronal circuit information processing abnormality with voltage-sensitive dye (VSD) imaging. The precise activation control of E / I was involved in the short-term plasticity caused by the θ - γ cycle in the hippocampal CA 1 field. The observation was published as a paper in the first year. We have been proceeding with further verification in valproic acid administration model but no significant difference could be found with regard to this short term plasticity phenomenon with respect to this θ - γ cycle. Therefore, we focused on extraction of plastic change caused by this phenomenon and carried out research. I believe that basic data on the relationship of E / I balance disorder have been accumulated.
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Grant number：24500269 2012.4 - 2016.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Kajiwara Riichi, TOMINAGA TAKASHI, TAKASHIMA ICHIRO, SATO TAKAAKI
Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）
How do the learning tasks inducing emotional responses cause the change of the brain function? For solving this problem, we focused on the fusional approach of animal behavioral analysis and ex vivo physiological analysis. We created model animals using a conditioned odor aversion (COA) learning paradigm. Additionally, exploratory surveys using voltage-sensitive dye (VSD) imaging of ex vivo brain preparations were performed. The visualization of the critical brain region for the learning behavior by applying the VSD imaging to brain preparations of COA model was unsuccessful. However, by applying VSD imaging to the olfactory cortices harvested from urethane-experienced animals, abnormal neural activity in response to electrical stimulation to the lateral olfactory tract was observed. This observation suggests that improvements in learning paradigm and recording procedures may enable us to measure the change of brain activities caused by behavioral changes controlled by the emotion.
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Biomonitoring device based on soft-materials and microelectromechanical systems
Grant number：24310099 2012.4 - 2015.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
KUDO Hiroyuki, MITSUBAYASHI Kohji, ARAKAWA Takahiro, KAJIWARA Riichi
Grant amount：\20540000 （ Direct Cost: \15800000 、 Indirect Cost：\4740000 ）
In this research, a high sensitive biosensing system suitable for multi-scale and multi-analyte biomonitoring. On the basis of biosensensors formed on the soft polymers, we utilized an Os-HRP modified carbon electrode, on which lactate oxidase was immobilized, formed on the PET sheet for biomonitoring purpose. The sensing system was utilized in the monitoring of lactic acid contained in the sweat and CSF, respectively. As a result, both lactic acid was successfully monitored using our system. The level of lactic acid in the sweat after anaerobic exercise increased by 7.2 folds in comparison with that of normal situation. This indicates that the biosensor reflects the physiological situation of the human subject.
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快・不快情動が操る嗅覚表象の単離脳イメージング:行動解析との融合的アプローチ
2012.4 - 2015.3
基盤研究(C)
梶原利一
Authorship：Principal investigator Grant type：Competitive
Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）
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扁桃体ネットワークの動作機構と投射様式の同時可視化解析～嗅覚系を中心として～
2009.4 - 2011.3
若手研究(B)
梶原利一
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
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Visualization analysis of network physiology and anatomy of the amygdala-focusing on olfaction-
Grant number：21700389 2009 - 2010
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
KAJIWARA Riichi
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
In order to reveal the functional organization of the amygdaloid network, we developed the optical recording system using a guinea pig isolated whole brain. By using this experimental setup, we analyzed the dependency of stimulus intensity and frequency on the spatiotemporal patterns of the neural activity evoked by the electrical shock to olfactory nerve. In addition to the imaging study, laminar profiles of evoked field potentials were recorded in the amygdala using a multichannel silicon probe. Current source density analysis performed on the field responses revealed the propagation pattern of the neural activity in the deep structure of the amygdaloid cortex.
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香りが記憶や情動と結びつく際の脳内神経機構に関する研究
2007.10 - 2009.3
財団法人コスメトロジー研究振興財団
梶原利一
Authorship：Principal investigator Grant type：Competitive
Grant amount：\1000000 （ Direct Cost: \1000000 ）
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単離脳標本を用いた扁桃体－海馬システム間の相互作用に関する生理学及び解剖学的研究
2004.4 - 2006.3
若手研究(B)
梶原利一
Authorship：Principal investigator Grant type：Competitive
Grant amount：\3100000 （ Direct Cost: \3100000 ）
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単離脳標本を用いた扁桃体-海馬システム間の相互作用に関する生理学及び解剖学的研究
Grant number：16700315 2004 - 2005
日本学術振興会 科学研究費助成事業 若手研究(B) 若手研究(B)
梶原 利一
Grant amount：\3100000 （ Direct Cost: \3100000 ）
嗅覚情報伝達経路に関する知見を総合すると、嗅球-梨状皮質から、嗅内皮質を介して海馬へ入力する経路では「認識」に関する情報が、扁桃体周囲皮質を介して扁桃核に入力する経路では「情動」に関する情報が、それぞれ並列に処理されると考えられている。一方、これら二経路を結びつける回路については不明な点が多い。
平成16年度の研究では、辺縁系神経回路の構造を保持したin vitro単離脳標本に膜電位イメージング手法を適用する事で、前述の二つの経路が外側嗅索の電気刺激により実際に活性化される事を確認した。又、実験の過程で、嗅内皮質で惹起された神経活動が海馬のみならず扁桃体周囲皮質へも伝達している可能性が示唆された。平成17年度は以下の実験により、扁桃体周囲皮質が嗅内皮質と機能的にリンクしている可能性を検証し、成果の一部を北米神経科学学会にて発表した。(1)局所的破壊が神経活動伝播パターンに及ぼす影響:梨状皮質外側部を破壊した場合、嗅内皮質への神経活動伝播が阻害されると共に、嗅内皮質から扁桃体周囲皮質への神経活動伝播も消失した。この時、梨状皮質-扁桃体周囲皮質間の神経活動伝播パターンに影響は無かった。又、梨状皮質内側部の破壊は、これと相反する結果を示した。(2)単一細胞記録解析:扁桃体周囲皮質の単一細胞内記録を行い、外側嗅索の電気刺激により惹起されるシナプス電位を解析した結果、多くの細胞のシナプス後電位は二峰性を示し、ピーク間隔は刺激強度に依存して変化する事が判った。細胞外記録電位及びイメージングの結果とも良く対応する事から、潜時の早いピークは嗅内皮質から、後発のピークは扁桃体周囲皮質からの神経支配に起因するものである事が推測された。
これらの結果は、扁桃体周囲皮質が、梨状皮質からの嗅覚情報入力を受けると共に、嗅内皮質を介した高次の嗅覚情報も受け取り、統合している可能性を示唆している。
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