Updated on 2026/03/07

写真a

 
MUKAI HIDEO
 
Organization
Undergraduate School School of Science and Technology Senior Assistant Professor
Title
Senior Assistant Professor
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Degree

  • Ph.D. ( The University of Tokyo )

Research Interests

  • 量子情報

  • 量子誤り訂正

  • 量子計算

  • neural circuits

  • ブレインマシンインターフェース

  • 神経科学

  • Machine learning

Research Areas

  • Informatics / Intelligent informatics

  • Life sciences / Neuroscience - general

  • Informatics / Perceptual information processing

  • Life sciences / Biophysics

Research History

  • Department of Computer Science, School of Science and Technology, Meiji University   Lecturer

    2013.4

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  • Department of Biochemistry, Faculty of Medicine, Saitama Medical University   Assistant Professor

    2011.8 - 2013.3

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  • Nihon University   College of Humanities and Sciences   Assistant Professor (non-tenured)

    2010.4 - 2011.7

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  • The University of Tokyo

    2006.4 - 2010.3

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Professional Memberships

Committee Memberships

  •   日本生物物理学会 分野別専門委員  

    2015   

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    Committee type:Academic society

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  • 日本生物物理学会   分野別専門委員  

    2013   

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Papers

  • Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music Reviewed

    Yuuki Ooishi, Hideo Mukai, Ken Watanabe, Suguru Kawato, Makio Kashino

    PLOS ONE   12 ( 12 )   e0189075   2017.12

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    DOI: 10.1371/journal.pone.0189075

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  • KAINATE-INDUCED NETWORK ACTIVITY IN THE ANTERIOR CINGULATE CORTEX Reviewed

    R. Shinozaki, Y. Hojo, H. Mukai, M. Hashizume, T. Murakoshi

    NEUROSCIENCE   325   20 - 29   2016.6

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    DOI: 10.1016/j.neuroscience.2016.03.025

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  • Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus Reviewed

    Gen Murakami, Yasushi Hojo, Mari Ogiue-Ikeda, Hideo Mukai, Pierre Chambon, Kohei Nakajima, Yuuki Ooishi, Tetsuya Kimoto, Suguru Kawato

    BRAIN RESEARCH   1621   133 - 146   2015.9

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    DOI: 10.1016/j.brainres.2014.12.002

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  • Estradiol rapidly modulates spinogenesis in hippocampal dentate gyrus: Involvement of kinase networks Reviewed

    Yasushi Hojo, Arisa Munetomo, Hideo Mukai, Muneki Ikeda, Rei Sato, Yusuke Hatanaka, Gen Murakami, Yoshimasa Komatsuzaki, Tetsuya Kimoto, Suguru Kawato

    HORMONES AND BEHAVIOR   74   149 - 156   2015.8

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    DOI: 10.1016/j.yhbeh.2015.06.008

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  • Acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus Reviewed

    Yoshitaka Hasegawa, Hideo Mukai, Makoto Asashima, Yasushi Hojo, Muneki Ikeda, Yoshimasa Komatsuzaki, Yuuki Ooishi, Suguru Kawato

    FRONTIERS IN NEURAL CIRCUITS   8   56   2014.6

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    DOI: 10.3389/fncir.2014.00056

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  • Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus Reviewed

    Miyuki Yoshiya, Yoshimasa Komatsuzaki, Yasushi Hojo, Muneki Ikeda, Hideo Mukai, Yusuke Hatanaka, Gen Murakami, Mitsuhiro Kawata, Tetsuya Kimoto, Suguru Kawato

    Frontiers in Neural Circuits   7 ( 191 )   191   2013.11

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    DOI: 10.3389/fncir.2013.00191

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  • Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen Reviewed

    Yuuki Ooishi, Suguru Kawato, Yasushi Hojo, Yusuke Hatanaka, Shimpei Higo, Gen Murakami, Yoshimasa Komatsuzaki, Mari Ogiue-Ikeda, Tetsuya Kimoto, Hideo Mukai

    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY   131 ( 1-2 )   37 - 51   2012.8

  • Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear Steroid Receptors in the Hippocampus Reviewed

    Yuuki Ooishi, Hideo Mukai, Yasushi Hojo, Gen Murakami, Yoshitaka Hasegawa, Tomu Shindo, John H. Morrison, Tetsuya Kimoto, Suguru Kawato

    CEREBRAL CORTEX   22 ( 4 )   926 - 936   2012.4

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    DOI: 10.1093/cercor/bhr164

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  • Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus Reviewed

    Yoshimasa Komatsuzaki, Yusuke Hatanaka, Gen Murakami, Hideo Mukai, Yasushi Hojo, Minoru Saito, Tetsuya Kimoto, Suguru Kawato

    PLOS ONE   7 ( 4 )   e34124   2012.4

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    DOI: 10.1371/journal.pone.0034124

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  • Automated Analysis of Spines from Confocal Laser Microscopy Images: Application to the Discrimination of Androgen and Estrogen Effects on Spinogenesis Reviewed

    Hideo Mukai, Yusuke Hatanaka, Kenji Mitsuhashi, Yasushi Hojo, Yoshimasa Komatsuzaki, Rei Sato, Gen Murakami, Tetsuya Kimoto, Suguru Kawato

    CEREBRAL CORTEX   21 ( 12 )   2704 - 2711   2011.12

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    DOI: 10.1093/cercor/bhr059

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  • The binding site for acute corticosterone effects on N-methyl-D-aspartate receptor-mediated Ca2+ signals in mouse hippocampal slices Reviewed

    Osanai H, Suzuki A, Komatsuzaki Y, Mukai H, Kawato S, Saito M

    Journal of Biophysical Chemistry   2 ( 4 )   430 - 433   2011.11

  • Endogenous Synthesis of Corticosteroids in the Hippocampus Reviewed

    Shimpei Higo, Yasushi Hojo, Hirotaka Ishii, Yoshimasa Komatsuzaki, Yuuki Ooishi, Gen Murakami, Hideo Mukai, Takeshi Yamazaki, Daiichiro Nakahara, Anna Barron, Tetsuya Kimoto, Suguru Kawato

    PLOS ONE   6 ( 7 )   e21631   2011.7

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    DOI: 10.1371/journal.pone.0021631

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  • Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity. Reviewed International journal

    Yasushi Hojo, Shimpei Higo, Suguru Kawato, Yusuke Hatanaka, Yuuki Ooishi, Gen Murakami, Hirotaka Ishii, Yoshimasa Komatsuzaki, Mari Ogiue-Ikeda, Hideo Mukai, Tetsuya Kimoto

    Frontiers in endocrinology   2 ( Article 43 )   43 - 43   2011

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    Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen. Recently, we also revealed the hippocampal synthesis of corticosteroids. The accurate concentrations of these hippocampus-synthesized steroids are determined by liquid chromatography-tandem mass-spectrometry in combination with novel derivatization. The hippocampal levels of 17β-estradiol (E2), testosterone (T), dihydrotestosterone (DHT), and corticosterone (CORT), are 5-15 nM, and these levels are sufficient to modulate synaptic plasticity. Hippocampal E2 modulates memory-related synaptic plasticity not only slowly/genomically but also rapidly/non-genomically. Slow actions of E2 occur via classical nuclear receptors (ERα or ERβ), while rapid E2 actions occur via synapse-localized or extranuclear ERα or ERβ. Nanomolar concentrations of E2 change rapidly the density and morphology of spines in hippocampal neurons. ERα, but not ERβ, drives this enhancement/suppression of spinogenesis in adult animals. Nanomolar concentrations of androgens (T and DHT) and CORT also increase the spine density. Kinase networks are involved downstream of ERα and androgen receptor. Newly developed Spiso-3D mathematical analysis is useful to distinguish these complex effects by sex steroids and kinases. Significant advance has been achieved in investigations of rapid modulation by E2 of the long-term depression or the long-term potentiation.

    DOI: 10.3389/fendo.2011.00043

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  • Regulation of synaptic plasticity by hippocampus synthesized estradiol Reviewed

    Anna M. Barron, Yasushi Hojo, Hideo Mukai, Shimpei Higo, Yuuki Ooishi, Yusuke Hatanaka, Mari Ogiue-Ikeda, Gen Murakami, Tetsuya Kimoto, Suguru Kawato, Yasushi Hojo, Hideo Mukai, Tetsuya Kimoto, Suguru Kawato, Yasushi Hojo, Hideo Mukai, Gen Murakami, Tetsuya Kimoto, Suguru Kawato, Mari Ogiue-Ikeda, Suguru Kawato, Suguru Kawato

    Hormone Molecular Biology and Clinical Investigation   7 ( 2 )   361 - 375   2011

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    DOI: 10.1515/HMBCI.2011.118

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  • Modulation of synaptic plasticity by brain estrogen in the hippocampus. Reviewed

    Mukai H, Kimoto T, Hojo Y, Kawato S, Murakami G, Higo S, Hatanaka Y, Ogiue-Ikeda M

    Biochimica et biophysica acta   1800   1030 - 1044   2010.10

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  • Modulation of synaptic plasticity by brain estrogen in the hippocampus Reviewed

    Hideo Mukai, Tetsuya Kimoto, Yasushi Hojo, Suguru Kawato, Gen Murakami, Shimpei Higo, Yusuke Hatanaka, Mari Ogiue-Ikeda

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   1800 ( 10 )   1030 - 1044   2010.10

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    DOI: 10.1016/j.bbagen.2009.11.002

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  • Comparison between Hippocampus-Synthesized and Circulation-Derived Sex Steroids in the Hippocampus Reviewed

    Yasushi Hojo, Shimpei Higo, Hirotaka Ishii, Yuuki Ooishi, Hideo Mukai, Gen Murakami, Toshihiro Kominami, Tetsuya Kimoto, Seijiro Honma, Donald Poirier, Suguru Kawato

    ENDOCRINOLOGY   150 ( 11 )   5106 - 5112   2009.11

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    DOI: 10.1210/en.2009-0305

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  • Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus Reviewed

    Yusuke Hatanaka, Hideo Mukai, Kenji Mitsuhashi, Yasushi Hojo, Gen Murakami, Yoshimasa Komatsuzaki, Rei Sato, Suguru Kawato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   381 ( 4 )   728 - 732   2009.4

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    DOI: 10.1016/j.bbrc.2009.02.130

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  • Estrogen synthesis in the brain - Role in synaptic plasticity and memory Reviewed

    Yasushi Hojo, Gen Murakami, Hideo Mukai, Shimpei Higo, Yusuke Hatanaka, Mari Ogiue-Ikeda, Hirotaka Ishii, Tetsuya Kimoto, Suguru Kawato

    MOLECULAR AND CELLULAR ENDOCRINOLOGY   290 ( 1-2 )   31 - 43   2008.8

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    DOI: 10.1016/j.mce.2008.04.017

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  • Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons Reviewed

    Mari Ogiue-Ikeda, Nobuaki Tanabe, Hideo Mukai, Yasushi Hojo, Gen Murakami, Tomokazu Tsurugizawa, Norio Takata, Tetsuya Kimoto, Suguru Kawato

    BRAIN RESEARCH REVIEWS   57 ( 2 )   363 - 375   2008.3

  • Local production of estrogen and its rapid modulatory action on synaptic plasticity Reviewed

    Kawato S, Hojo Y, Mukai H, Murakami G, Ogiue-Ikeda M, Ishii H, Kimoto T

    Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment   143 - 169   2008

  • 3P-228 Activin increases dendritic spines in the adult hippocampal neurons(The 46th Annual Meeting of the Biophysical Society of Japan)

    Mukai Hideo, Hatanaka Yuusuke, Tsurugizawa Tomokazu, Nakanishi Hironori, Asashima Makoto, Kawato Suguru

    Seibutsu Butsuri   48   S162   2008

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    DOI: 10.2142/biophys.48.S162_6

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  • Local production of sex hormones and their modulation of hippocampal synaptic plasticity Reviewed

    Hirotaka Ishii, Tomokazu Tsurugizawa, Mari Ogiue-Ikeda, Makoto Asashima, Hideo Mukai, Gen Murakami, Yasushi Hojo, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENTIST   13 ( 4 )   323 - 334   2007.8

  • Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons Reviewed

    Hideo Mukai, Tomokazu Tsurugizawa, Gen Murakami, Shiro Kominami, Hirotaka Ishii, Mari Ogiue-Ikeda, Norio Takata, Nobuaki Tanabe, Aizo Furukawa, Yasushi Hojo, Yuuki Ooishi, John H. Morrison, William G. M. Janssen, John A. Rose, Pierre Chambon, Shigeaki Kato, Shunsuke Izumi, Takeshi Yamazaki, Tetsuya Kimoto, Suguru Kawato

    JOURNAL OF NEUROCHEMISTRY   100 ( 4 )   950 - 967   2007.2

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    DOI: 10.1111/j.1471-4159.2006.04264.x

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  • 1P190 The differnces in physiological significance for androgen and estrogen in the rat hippocampus(Neurons and sensory system,Poster Presentations)

    Hojo Yasushi, Higo Shimpei, Mukai Hideo, Kominami Shiro, Harada Nobuhiro, Honma Seijiro, Kimoto Tetsuya, Kawato Suguru

    Seibutsu Butsuri   47   S71   2007

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    DOI: 10.2142/biophys.47.S71_1

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  • Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus Reviewed

    Gen Murakami, Tomokazu Tsurugizawa, Yusuke Hatanaka, Yoshimasa Komatsuzaki, Nobuaki Tanabe, Hideo Mukai, Yasushi Hojo, Shiro Kominami, Takeshi Yamazaki, Tetsuya Kimoto, Suguru Kawato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   351 ( 2 )   553 - 558   2006.12

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    DOI: 10.1016/j.bbrc.2006.10.066

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  • 海馬シナプスにおける脳ステロイドの合成とP450の局在(Synthesis of brain steroids and localization of P450s in the hippocampal synapses)

    Hojo Yasushi, Nakajima Kouhei, Nakanishi Hironori, Higo Shimpei, Ishii Hirotaka, Mukai Hideo, Morrison John H., Janssen William G.M., Kominami Shiro, Harada Nobuhiro, Kimoto Tetsuya, Kawato Suguru

    生物物理   46 ( Suppl.2 )   S392 - S392   2006.10

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  • Enhancement of nitric oxide production by association of nitric oxide synthase with N-methyl-D-aspartate receptors via postsynaptic density 95 in genetically engineered Chinese hamster ovary cells: real-time fluorescence imaging using nitric oxide sensitive dye Reviewed

    H Ishii, K Shibuya, Y Ohta, H Mukai, S Uchino, N Takata, JA Rose, S Kawato

    JOURNAL OF NEUROCHEMISTRY   96 ( 6 )   1531 - 1539   2006.3

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    DOI: 10.1111/j.1471-4159.2006.03656.x

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  • Local neurosteroid production in the hippocampus: Influence on synaptic plasticity of memory Reviewed

    Hideo Mukai, Tomokazu Tsurugizawa, Mari Ogiue-Ikeda, Gen Murakami, Yasushi Hojo, Hirotaka Ishii, Tetsuya Kimoto, Suguru Kawato

    NEUROENDOCRINOLOGY   84 ( 4 )   255 - 263   2006

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    DOI: 10.1159/000097747

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  • Role of cytochrome P450 in synaptocrinology: Endogenous estrogen synthesis in the brain hippocampus Reviewed

    Gen Murakami, Nobuaki Tanabe, Hiro-taka Ishii, Mari Ogiue-Ikeda, Tomokazu Tsurugizawa, Hideo Mukai, Yasushi Hojo, Norio Takata, Aizo Furukawa, Tetsuya Kimoto, Suguru Kawato

    DRUG METABOLISM REVIEWS   38 ( 3 )   353 - 369   2006

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    DOI: 10.1080/03602530600724068

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  • Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology Reviewed

    H Mukai, N Takata, HT Ishii, N Tanabe, Y Hojo, A Furukawa, T Kimoto, S Kawato

    NEUROSCIENCE   138 ( 3 )   757 - 764   2006

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    DOI: 10.1016/j.neuroscience.2005.09.010

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  • Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus Reviewed

    T Tsurugizawa, H Mukai, N Tanabe, G Murakami, Y Hojo, S Kominami, K Mitsuhashi, Y Komatsuzaki, JH Morrison, WGM Janssen, T Kimoto, S Kawato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   337 ( 4 )   1345 - 1352   2005.12

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    DOI: 10.1016/j.bbrc.2005.09.188

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  • Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus Reviewed

    Y Komatsuzaki, G Murakami, T Tsurugizawa, H Mukai, N Tanabe, K Mitsuhashi, M Kawata, T Kimoto, Y Ooishi, S Kawato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   335 ( 4 )   1002 - 1007   2005.10

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    DOI: 10.1016/j.bbrc.2005.07.173

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  • Acute repetitive transcranial magnetic stimulation reactivates dopaminergic system in lesion rats Reviewed

    H Funamizu, M Ogiue-Ikeda, H Mukai, S Kawato, S Ueno

    NEUROSCIENCE LETTERS   383 ( 1-2 )   77 - 81   2005.7

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    DOI: 10.1016/j.neulet.2005.04.018

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  • 3P268 Activin A modulates dendritic spines in rat hippocampus

    Mitsuhashi K., Mukai H., Hojo Y., Asashima M., Fukui A., Kawato S.

    Seibutsu Butsuri   45   S270   2005

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    DOI: 10.2142/biophys.45.S270_4

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  • ラット脳海馬におけるストレスステロイド合成機構の解析(Analysis of neurosteroidgenic enzymes in stress steroid synthesis in adult rat hippocampus)

    Sonoki Yasuhiro, Ishii Hirotaka, Mukai Hideo, Hojo Yasushi, Furukawa Aizo, Yamada Makoto, Kawato Suguru

    生化学   76 ( 8 )   867 - 867   2004.8

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  • Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017 alpha and P450 aromatase localized in neurons Reviewed

    Y Hojo, T Hattori, T Enami, A Furukawa, K Suzuki, HT Ishii, H Mukai, JH Morrison, WGM Janssen, S Kominami, N Harada, T Kimoto, S Kawato

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   101 ( 3 )   865 - 870   2004.1

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    DOI: 10.1073/pnas.2630225100

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  • 3P220 Activin A acutely increases dendritic spine density in rat hippocampus

    Mitsuhashi K., Mukai H., Hojo Y., Asashima M., Fukui A., Kawato S.

    Seibutsu Butsuri   44   S244   2004

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    DOI: 10.2142/biophys.44.S244_4

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  • 3P234 Intracellular distribution analysis of estrogen receptor alpha in the hippocampus

    Murakami G., Kominami S., Mukai H., Hojo Y., Kimoto T., Kawato S.

    Seibutsu Butsuri   44   S248   2004

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    DOI: 10.2142/biophys.44.S248_2

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  • Modulation of synaptic plasticity of hippocampal neurons by estrogen and endocrine disrupters

    Kawato S, Takata N, Hojo Y, Kimoto T

    Biophysics   43 ( 1 )   S22   2003.8

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    DOI: 10.2142/biophys.43.S22_3

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  • Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction. Reviewed International journal

    Keisuke Shibuya, Norio Takata, Yasushi Hojo, Aizo Furukawa, Nobuaki Yasumatsu, Tetsuya Kimoto, Taihei Enami, Kumiko Suzuki, Nobuaki Tanabe, Hirotaka Ishii, Hideo Mukai, Taiki Takahashi, Taka-aki Hattori, Suguru Kawato

    Biochimica et biophysica acta   1619 ( 3 )   301 - 16   2003.2

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    Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, 17beta-estradiol and testosterone as well as their sulfate esters. These brain neurosteroids are synthesized by cytochrome P450s (P450scc, P45017alpha and P450arom) from endogenous cholesterol. Synthesis is acutely dependent on the Ca(2+) influx attendant upon neuron-neuron communication via N-methyl-D-aspartate (NMDA) receptors. Pregnenolone sulfate, estradiol and corticosterone rapidly modulate neuronal signal transduction and the induction of long-term potentiation via NMDA receptors and putative membrane steroid receptors. Brain neurosteroids are therefore promising neuromodulators that may either activate or inactivate neuron-neuron communication, thereby mediating learning and memory in the hippocampus.

    DOI: 10.1016/S0304-4165(02)00489-0

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  • Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction Reviewed

    K Shibuya, N Takata, Y Hojo, A Furukawa, N Yasumatsu, T Kimoto, T Enami, K Suzuki, N Tanabe, H Ishii, H Mukai, T Takahashi, T Hattoria, S Kawato

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   1619 ( 3 )   301 - 316   2003.2

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  • Analysis of localization of estrogen receptor alpha in the rat hippocampus

    Murakami G., Mukai H., Hojo Y., Kominami S., Janssen William, Morrison John, Kawato S.

    Seibutsu Butsuri   43   S235   2003

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    DOI: 10.2142/biophys.43.S235_1

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  • ニューロステロイドによる海馬神経伝達のモジュレーション (神経伝達機構の分子的記述)

    川戸 佳, 向井 秀夫

    医学のあゆみ   202 ( 13 )   1049 - 1052   2002.9

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  • Mechanism of acute action of estrogen on the rat brain

    Yamanaka M, Mukai H, Furukawa A, Ishii H, Kawato S

    Seibutsu Butsuri   41   S142   2001

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    DOI: 10.2142/biophys.41.S142_1

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  • Acute effect of progesterone on intracellular calcium concentration changes in GT1-7 neurons.

    Chiyo T, Mukai H, Ishii H, Kawato S, Ohta Y

    Seibutsu Butsuri   41   S148   2001

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    DOI: 10.2142/biophys.41.S148_3

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  • Effect of neurosteroids on nitric oxide signaling and calcium signaling in CHO cells co-expressing NMDA receptors and nNOS

    Shibuya K, Mukai H, Uchino S, Kominami S, Nagano T, Kawato S

    Seibutsu Butsuri   41   S142   2001

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    DOI: 10.2142/biophys.41.S142_2

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  • Effects of neurosteroids on Ca2+ signaling mediated by recombinant N-methyl-D-aspartate receptor expressed in Chinese hamster ovary cells Reviewed

    H Mukai, S Uchino, S Kawato

    NEUROSCIENCE LETTERS   282 ( 1-2 )   93 - 96   2000.3

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    DOI: 10.1016/S0304-3940(00)00868-5

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  • Analysis of the regulation of NMDA-induced Nitric oxide production by PREGS in CHO cells expressing NMDA receptors and nNOS

    Shibuya K., Mukai H., Uchino S., Kominami S., Nagano T., Kawato S.

    Seibutsu Butsuri   40   S214   2000

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    DOI: 10.2142/biophys.40.S214_4

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  • Imaging analysis of NO signals in reconstructed system of NO producing process

    Shibuya k., Mukai H., Uchino S., Kominami S., Nagano T., Kawato S.

    Seibutsu Butsuri   39   S209   1999

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    DOI: 10.2142/biophys.39.S209_2

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  • Imaging of calcium oscillations and activity of cytochrome P-450 in adrenocortical cells Reviewed

    T Kimoto, H Mukai, R Homma, T Bettou, D Nishimura, Y Ohta, S Kawato

    OXYGEN HOMEOSTASIS AND ITS DYNAMICS   1   252 - 259   1998

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  • Digital fluorescence imaging of elementary steps of neurosteroid synthesis in rat brain glial cells Reviewed

    T Kimoto, H Asou, Y Ohta, H Mukai, AA Chernogolov, S Kawato

    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS   15 ( 9-10 )   1231 - 1240   1997.6

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    DOI: 10.1016/S0731-7085(96)01987-5

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Books

  • “Local Production of Estrogen and its Rapid Modulatory Action on Synaptic Plasticity" in Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment, Ed.. Ritsner, M.S. and Weizman, A.

    Kawato, S, Hojo, Y, Mukai, H, Murakami, G, Ogiue-Ikeda, M, Ishii, H, Kimoto, T

    Springer  2008 

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  • Rapid increase of spines by dihydrotestosterone and testosterone in hippocampal neurons: Dependence on synaptic androgen receptor and kinase networks Reviewed

    Hatanaka Y, Hojo Y, Mukai H, Murakami G, Komatsuzaki Y, Kim J, Ikeda M, Hiragushi A, Kimoto T, Kawato S

    Brain Research   2015

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  • NMDA刺激によるマウス脳海馬のカルシウム信号に対するコルチコステロンの急性作用 : レーザー共焦点イメージングによる解析

    金 セワ, 島崎 亮, 鈴木 章義, 小山内 裕美, 小松崎 良将, 向井 秀夫, 斎藤 稔

    バイオイメージング   20 ( 2 )   167 - 168   2011.8

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  • Sex hormone synthesis and synaptocrinology in rat hippocampal synapses

    Yasushi Hojo, Shimpei Higo, Hideo Mukai, Nobuhiro Harada, Takeshi Yamazaki, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   71   E264 - E264   2011

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    DOI: 10.1016/j.neures.2011.07.1152

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  • Corticosterone induced rapid spinogenesis via synaptic glucocorticoid receptor and kinases in rat hippocampus

    Yoshimasa Komatsuzaki, Yasushi Hojo, Yusuke Hatanaka, Gen Murakami, Hideo Mukai, Suguru Kawato

    NEUROSCIENCE RESEARCH   71   E218 - E218   2011

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    DOI: 10.1016/j.neures.2011.07.949

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  • Automated analysis of spines from confocal laser microscopy images: Application to the discrimination of androgen and estrogen effects on hippocampal neurons

    Hideo Mukai, Yusuke Hatanaka, Kenji Mitsuhashi, Yasushi Hojo, Suguru Kawato

    NEUROSCIENCE RESEARCH   71   E216 - E216   2011

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    DOI: 10.1016/j.neures.2011.07.939

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  • Novel methods and its applications for analysis of spines in neurons

    Hideo Mukai, Yasushi Hojo, Yuusuke Hatanaka, Kenji Mitsuhashi, Makoto Asashima, Suguru Kawato

    NEUROSCIENCE RESEARCH   68   E231 - E231   2010

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    DOI: 10.1016/j.neures.2010.07.1022

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  • Corticosterone rapidly modulates AMPA receptor-driven Ca2+ signals in mouse hippocampal CA1 region

    Minoru Saito, Masaki Tsutsumi, Wakako Sawada, Hiromi Osanai, Akiyoshi Suzuki, Yoshimasa Komatsuzaki, Hideo Mukai, Suguru Kawato

    NEUROSCIENCE RESEARCH   68   E122 - E122   2010

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    DOI: 10.1016/j.neures.2010.07.2111

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  • Modulation of synaptic plasticity by estrogen and androgen in the hippocampus

    Hideo Mukai, Suguru Kawato

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S49 - S49   2010

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  • Sex hormone synthesis and synaptocrinology in the hippocampal synapses of adult male rats

    Yasushi Hojo, Shimpei Higo, Hideo Mukai, Nobuhiro Harada, Seijiro Honma, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   68   E281 - E281   2010

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    DOI: 10.1016/j.neures.2010.07.1249

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  • Activin increases dendritic spines in the adult hippocampal neurons

    Hideo Mukai, Yusuke Hatanaka, Tomokazu Tsurugizawa, Makoto Asashima, Suguru Kawato

    NEUROSCIENCE RESEARCH   65   S221 - S221   2009

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    DOI: 10.1016/j.neures.2009.09.1232

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  • RAPID MODULATION OF SYNAPTIC PLASTICITY BY HIPPOCAMPAL-DERIVED SEX-STEROIDS

    Hideo Mukai, Yuusuke Hatanaka, Rei Sato, Yuuki Ooishi, Mari Ogiue-Ikeda, Yasushi Hojo, Suguru Kawato

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   280 - 280   2009

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  • NEUROSTEROID SYNTHESIS AND SYNAPTOCRINOLOGY IN THE HIPPOCAMPAL SYNAPSES

    Yasushi Hojo, Shimpei Higo, Hideo Mukai, Gen Murakami, Takeshi Yamazaki, Nobuhiro Harada, Seijiro Honma, Tetsuya Kimoto, Suguru Kawato

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   293 - 293   2009

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  • Neurosteroid synthesis and synaptocrinology in the hippocampal synapses

    Yasushi Hojo, Shimpei Higo, Toshihiro Kominami, Hideo Mukai, Takeshi Yamazaki, Nobuhiro Harada, Seijiro Honma, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   65   S222 - S222   2009

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    DOI: 10.1016/j.neures.2009.09.1238

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  • 海馬シナプスにおけるニューロステロイドの合成と局所分泌

    HOJO YASUSHI, HIGO SHIMPEI, MUKAI HIDEO, MURAKAMI GEN, KOMINAMI SHIRO, HARADA NOBUHIRO, HONMA SEIJIRO, KIMOTO TETSUYA, KAWATO SUGURU

    生化学   3T16-3   2008

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  • Neurosteroid synthesis and synaptocrinology in the hippocampal synapses

    Yasushi Hojo, Shimpei Higo, Hideo Mukai, Gen Murakami, Shiro Kominami, Nobuhiro Harada, Honma Seijiro, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   61   S108 - S108   2008

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  • Effect of estrogen on spine regulation in hippocampus

    Gen Murakami, Rei Sato, Tomokazu Tsurugizawa, Yusuke Hatanaka, Yoshimasa Komatsuzaki, Yasushi Hojo, Hideo Mukai, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   61   S108 - S108   2008

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  • Activin increases dendritic spines in the adult hippocampal neurons

    Hideo Mukai, Yuusuke Hatanaka, Tomokazu Tsurugizawa, Hironori Nakanishi, Suguru Kawato

    NEUROSCIENCE RESEARCH   61   S108 - S108   2008

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  • 1P209 Synaptic Localization of Estrogen Receptor alpha in the Rat Hippocampus(Neural network and brain computing,Poster Presentations)

    Mukai Hideo, Kominami Shiro, Murakami Gen, Hojo Yasushi, Kawato Suguru

    Seibutsu Butsuri   47 ( 1 )   S75   2007.11

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    DOI: 10.2142/biophys.47.S75_4

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  • 海馬神経細胞樹状突起スパインのアクチビンによる増加効果の解析

    向井 秀夫, 畑中 悠佑, 釣木澤 朋和, 中西 広典, 川戸 佳

    バイオイメージング   16 ( 2 )   91 - 92   2007.10

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  • Synaptic estrogen receptors in principal neurons of hippocampus

    Hideo Mukai, Gen Murakami, Shiro Kominami, Shimpei Higo, Yasushi Hojo, John H. Morrison, Suguru Kawato

    NEUROSCIENCE RESEARCH   58   S222 - S222   2007

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  • Steroid synthesis and synaptocrinology in the hippocampal synapses

    Yasushi Hojo, Shimpei Higo, Hideo Mukai, John H. Morrison, William G. M. Janssen, Shiro Kominami, Nobuhiro Harada, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   58   S76 - S76   2007

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  • 海馬神経細胞スパインに及ぼす環境ホルモン及び性ステロイドの効果

    畑中 悠佑, 田辺 信聡, 釣木沢 朋和, 向井 秀夫, 北條 泰嗣, 木本 哲也, 川戸 佳

    環境ホルモン学会研究発表会要旨集   9回   170 - 170   2006.11

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  • Synthesis of brain steroids and localization of P450s in the hippocampal neurons

    HOJO Yasushi, HOJO Yasushi, HOJO Yasushi, NAKAJIMA Kouhei, NAKAJIMA Kouhei, NAKANISHI Hironori, NAKANISHI Hironori, HIGO Shimpei, HIGO Shimpei, ISHII Hirotaka, ISHII Hirotaka, MUKAI Hideo, MUKAI Hideo, MORRIOSON John H., JANSSEN William G.M., KOMINAMI Shiro, HARADA Nobuhiro, KIMOTO Tetsuya, KIMOTO Tetsuya, KIMOTO Tetsuya, KAWATO Suguru, KAWATO Suguru, KAWATO Suguru

    生化学   2006

  • Synaptic localization of estrogen receptor alpha in the hippocampal pyramidal and granule neurons of adult male rat

    Hideo Mukai, Gen Murakami, Shirou Kominami, John H. Morrison, William G. M. Janssen, Tetsuya Kimoto, Suguru Kawato

    NEUROSCIENCE RESEARCH   55   S160 - S160   2006

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  • 3P269 Analysis of Estrogen Receptor alpha localization in rat hippocampus by centrifugal preparation and immunological approach

    Murakami G., Kominami S., Mukai H., Kimoto T., Kawato S.

    Seibutsu Butsuri   45 ( 1 )   S271   2005.10

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    DOI: 10.2142/biophys.45.S271_1

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  • 3P266 ラット海馬シナプスにおけるエストロゲン受容体の局在解析(神経回路・脳の情報処理))

    向井 秀夫, 村上 元, 小南 思郎, Janssen William, Morrison John, 川戸 佳

    生物物理   45 ( 1 )   2005.10

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  • 単一神経細胞の可視化による、海馬CA1錐体神経細胞の形態に対する環境ホルモンの急性効果の解析

    田辺 伸聡, 釣木澤 朋和, 三橋 賢司, 荻上 池田 真理, 小松崎 良将, 向井 秀夫, 木本 哲也, 川戸 佳

    バイオイメージング   14 ( 3 )   107 - 108   2005.9

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  • 環境ホルモンBishpenol‐Aはラット海馬神経細胞のスパイン形態を急性的に変化させる

    田辺伸聡, 小松崎良将, 釣木沢朋和, 三橋賢司, 大石悠貴, 村上元, 石井寛高, 木本哲也, 向井秀夫, 川戸佳

    日本内分泌かく乱化学物質学会研究発表会要旨集   7th   257 - 257   2004.12

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  • 3P235 Synaptic localization of estrogen receptor alpha and neurosteroidogenic enzymes in the hippocampus

    Mukai H., Kominami S., Murakami G., Hojo Y., Janssen William, Morrison John, Kawato S.

    Seibutsu Butsuri   44 ( 1 )   S248   2004.11

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    DOI: 10.2142/biophys.44.S248_3

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  • 環境ホルモンBisphenol-Aはラット海馬神経細胞のスパイン形態を急性的に変化させる

    田辺 伸聡, 小松崎 良将, 釣木澤 朋和, 三橋 賢司, 大石 悠貴, 村上 元, 石井 寛高, 木本 哲也, 向井 秀夫, 川戸 佳

    生物物理   44 ( Suppl.1 )   S245 - S245   2004.11

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  • シンポジウム「脳内ステロイドリセプターの今」参加記

    向井 秀夫

    日本比較内分泌学会ニュース = Newsletter of Japan Society for Comparative Endocrinology   107   37 - 38   2002.12

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  • NO合成酵素の細胞膜への局在化は脳の記憶・学習に関与するNOを効果的に産生させる

    渋谷啓介, 石井寛高, 向井秀夫, 内野茂夫, 長野哲雄, 川戸佳

    日本生物物理学会年会講演予稿集   40th   S74   2002.11

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  • 遺伝子発現人工細胞を用いたニューロステロイド作用機構の可視化

    渋谷 啓介, 向井 秀夫, 山中 麻里, 石井 寛高, 田辺 伸聡, 川戸 佳

    バイオイメージング   10 ( 3 )   152 - 153   2001.10

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  • ラット脳におけるエストロゲンの急性作用機構

    山中麻里, 向井秀夫, 古川愛造, 石井寛高, 川戸佳

    日本生物物理学会年会講演予稿集   39th   S142   2001.10

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  • GT1‐7細胞のカルシウムイオン濃度は,progesteroneの添加により急速に上昇する

    千代智子, 向井秀夫, 石井寛高, 川戸佳, 太田善浩

    日本生物物理学会年会講演予稿集   39th   S148   2001.10

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  • 脳内でのニューロステロイドの急性的な合成とnon‐genomic作用

    川戸佳, 木本哲也, 北条康嗣, 服部高明, 榎並太平, 安松信明, 田辺伸聡, 石井寛高, 向井秀夫

    日本内分泌学会雑誌   77 ( 2 )   304 - 304   2001.9

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  • Estrogen receptor in the rat brain

    Mukai H, Yamanaka M, Furukawa A, Kawato S

    Seibutsu Butsuri   41 ( 1 )   S141   2001.9

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    DOI: 10.2142/biophys.41.S141_4

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  • 人工NO産生細胞における神経ステロイドによるNO産生増強の可視化解析

    渋谷啓介, 向井秀夫, 内野茂夫, 小南思郎, 長野哲雄, 川戸佳

    日本生物物理学会年会講演予稿集   39th   2001

  • 遺伝子発現人工細胞を用いたニューロステロイド作用機構の可視化

    渋谷啓介, 向井秀夫, 山中麻里, 石井寛高, 田辺伸聡, 川戸佳

    バイオイメージング   10 ( 3 )   2001

  • 神経ステロイドによるNMDA受容体を介する細胞内情報伝達過程制御の可視化解析

    向井 秀夫, 渋谷 啓介, 内野 茂夫, 小南 思郎, 川戸 佳

    バイオイメージング   9 ( 3 )   126 - 127   2000.11

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  • Effect of neurosteroids on calcium signaling mediated by NMDA receptors

    Mukai H., Uchino S., Shibuya K., Kawato S.

    Seibutsu Butsuri   40 ( 1 )   S214   2000.8

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    DOI: 10.2142/biophys.40.S214_3

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  • ニューロステロイドによるGluRε2/ζ1型NMDA受容体を介するCa2+信号の増強

    向井秀夫, 内野茂夫, 渋谷啓介, 川戸佳

    日本神経科学大会プログラム・抄録集   23rd   2000

  • 神経ステロイドによるNMDA受容体を介する細胞内情報伝達過程制御の可視化解析

    向井秀夫, 渋谷啓介, 内野茂夫, 小南思郎, 川戸佳

    バイオイメージング   9 ( 3 )   2000

  • 神経ステロイドによるNMDA受容体を介する細胞機能修飾の可視化解析

    向井 秀夫, 渋谷 啓介, 内野 茂夫, 小南 思郎, 長野 哲雄, 川戸 佳

    バイオイメージング   8 ( 2 )   127 - 128   1999.9

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  • Ca感受性GFP融合蛋白質Cameleonの発現によるグリア細胞のCa応答の可視化

    北條 泰嗣, 向井 秀夫, 細谷 俊彦, 木本 哲也, 川戸 佳

    バイオイメージング   7 ( 3 )   143 - 143   1998.10

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  • Visualization of calcium response in rat glial cslls with expression of Ca sensitive GFP fusion protein Cameleon.

    Mukai H., Hojo Y., Hosoya T., Kimoto T., Kawato S.

    Biophysics   38 ( 2 )   S135   1998.9

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  • 脳グリア細胞におけるカルシウム信号とコレステロール取り込みのイメージング

    太田 善浩, 木本 哲也, 別筒 正, 向井 秀夫, 川戸 佳, 阿相 皓晃

    バイオイメージング   5 ( 3 )   118 - 119   1996.10

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  • 低密度リポ蛋白質の副腎皮質細胞内イメージングと蛋白運動解析

    別筒 正, 太田 善浩, 山田 真, 向井 秀夫, 木本 哲也, 川戸 佳

    バイオイメージング   5 ( 3 )   102 - 103   1996.10

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  • P450sccの活性の蛍光によるリアルタイム観察

    新村 芳人, 向井 秀夫, 太田 善浩, 川戸 佳

    日本分子生物学会年会プログラム・講演要旨集   19   144 - 144   1996.8

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  • 副腎皮質細胞による低密度リポ蛋白質(LDL)取り込みのイメージングと細胞内におけるLDL会合状態の測定

    向井 秀夫, 山田 慎, 木本 哲也, 太田 善浩, 川戸 佳

    日本バイオイメージング学会学術集会講演要旨集   4   53 - 54   1995.10

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