Language：English   Publishing type：Research paper (scientific journal)  

The autonomic nervous system regulates blood flow during postural changes to maintain homeostasis and cerebral perfusion, preventing symptoms such as dizziness and syncope. Previous orthostatic studies have primarily focused on a single region, such as the brain or peripheral blood vessels, limiting insight into systemic regulatory control. This study investigated blood flow regulation during an active orthostatic test by simultaneously measuring blood flow in the brain, left forearm, and right lower extremity using diffuse correlation spectroscopy. Results showed that lower limb blood flow decreased significantly while vascular resistance increased during upright posture, whereas cerebral blood flow remained relatively stable. These findings suggest that increased lower limb resistance compensates for the maintenance of cerebral perfusion, providing information on orthostatic blood flow regulation and its implications for autonomic dysfunction.Clinical Relevance- Understanding the differences in deep blood flow and vascular resistance responses at different sites during the orthostatic test may provide a detailed understanding of the pathogenesis of orthostatic hemodynamic disorders.

DOI： 10.1109/EMBC58623.2025.11252859

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Language：English   Publishing type：Research paper (scientific journal)  

The quantification of muscle blood flow is crucial in fields such as exercise physiology and rehabilitation medicine. While diffuse correlation spectroscopy (DCS) is a well-established, noninvasive method for measuring tissue blood flow, its widespread use is hindered by the need for expensive photon counters and its relatively low signal-to-noise ratio (SNR). Speckle contrast optical spectroscopy (SCOS), a novel technique utilizing a megapixel camera (e.g., a complementary metal- oxide-semiconductor camera), has emerged as a promising alternative. This method utilizes spatial speckle contrast to measure blood flow, offering a higher SNR at a reduced cost. This study evaluates the feasibility of SCOS in quantifying muscle blood flow under active conditions and compares its performance directly with that of DCS. The results indicate that SCOS is consistent with DCS in terms of relative blood flow index measurements, and its SNR surpasses that of DCS, particularly in detecting pulsatile blood flow. These findings position SCOS as a cost-effective, high-precision tool for monitoring skeletal muscle microcirculation during physical activities, potentially enhancing clinical and research applications in vascular function assessment.Clinical Relevance- SCOS presents a cost-effective alternative to DCS for the assessment of blood flow in active muscles, offering a superior SNR and enhanced detection of pulsatile flow. This advantage makes it valuable for evaluating vascular function in exercise physiology and rehabilitation contexts.

DOI： 10.1109/EMBC58623.2025.11254183

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Background

Microcirculatory dysfunction is a poor prognostic indicator for the management of critically ill patients, highlighting the need for the development of appropriate assessment methods. Current microcirculatory parameters are often indirect, invasive, or lack immediacy and continuity, with no standardised markers for critical care. Diffuse correlation spectroscopy (DCS), a near-infrared optical technique, facilitates the non-invasive real-time monitoring of microvascular dynamics via the blood flow index (BFI). However, the relationship between BFI and conventional microcirculatory parameters in hypovolemic shock remains unclear. This study examined the utility of DCS in assessing the microcirculation during hypovolemic shock in a canine model.

Methods

Six male beagle dogs underwent controlled blood withdrawal to induce hypovolemic shock, defined as a ≥ 30% decrease in cardiac output (CO) and mean arterial pressure (MAP) < 60 mmHg or systolic arterial pressure (SAP) < 90 mmHg. BFI was measured using a DCS device attached to the skin of the forelimb. From baseline to blood withdrawals followed by transfusions, changes in BFI were compared with microcirculatory parameters, mixed venous oxygen saturation (S_vO₂), core-to-skin temperature gradient (ΔT), veno-arterial difference in partial pressure of carbon dioxide (PCO₂ gap), and serum lactate. Correlation and receiver operating characteristic (ROC) analyses were performed to determine the cut-off value of relative BFI for predicting whether lactate levels exceeded 22.5 mg/dL.

Results

Blood withdrawal resulted in significant reductions in BFI, CO, and radial artery blood flow, with the corresponding deteriorations in the ΔT, S_vO₂, and PCO₂ gap and lactate levels. BFI showed significant correlations with ΔT (correlation coefficient [CC] = − 0.48, 95% confidence interval [CI] − 0.69 to − 0.18, p < 0.01), SvO₂ (CC = 0.67, 95% CI 0.43 to 0.81, p < 0.01), and PCO2 gap (CC = − 0.63, 95% CI − 0.79 to − 0.39, p < 0.01). ROC analysis identified a relative BFI threshold of 35.5% of the baseline for predicting elevated lactate levels, with 62% sensitivity and 100% specificity (AUC = 0.75).

Conclusions

Blood flow index measured by DCS reflects peripheral perfusion changes and is significantly correlated with clinical parameters during blood withdrawal and transfusion, highlighting its potential for non-invasive, continuous microcirculation monitoring in hypovolemic shock.

DOI： 10.1186/s40635-025-00761-9

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Other Link： https://link.springer.com/article/10.1186/s40635-025-00761-9/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)  

Objectives The aims of this study were to examine whether a portable wireless functional near-infrared spectroscopy device ([fNIRS] Hb-13-2, Astem Co., Ltd., Kanagawa, Japan) could potentially be used as a simple and minimally burdensome tool for screening cognitive function in older adults, particularly for identifying dementia-related changes, and to explore the feasibility of establishing a methodological framework for such assessment. Methods Subjects with dementia (n=10) and cognitively intact subjects (n=10) over 60 years of age were asked to perform a simple arithmetic task (Uchida-Kraepelin psychodiagnostic [UKP] test: 30 s × 5 trials) while undergoing frontal polar hemodynamic monitoring. Results Significantly increased changes in oxygenated hemoglobin (oxyHb) in Fp1 and Fp2 on the frontal polar cortex (FPC) during the task were more pronounced in the dementia subjects than in the cognitively intact subjects. In addition, the peak increase in oxyHb in cognitively intact subjects occurred in the first half of the task period, whereas it occurred in the second half of the task period in subjects with dementia. In all subjects, the relationship between increase/decrease of oxyHb in Fp1 and Fp2 and the UKP test results showed a positive correlation (R=0.307 and R=0.386, respectively). Conclusion The pattern and timing of hemodynamic responses in the FPC measured by portable fNIRS during the UKP test may have potential as a non-invasive screening indicator for cognitive decline.

DOI： 10.7759/cureus.85902

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Language：Japanese   Publisher：The Japanese Society for Artificial Intelligence  

DOI： 10.11517/pjsai.jsai2025.0_1o5os18b04

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DOI： 10.1007/978-3-031-78198-8_16

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.neuroimage.2024.120714

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.13.335

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DOI： 10.1364/BOE.522385

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DOI： 10.1152/japplphysiol.00863.2023

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DOI： 10.14326/abe.13.116

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OBJECTIVE: The neural correlates of creativity are not well understood. Using an improvised guitar task, we investigated the role of Broca's area during spontaneous creativity, regardless of individual skills, experience, or subjective feelings. RESULTS: Twenty guitarists performed improvised and formulaic blues rock sequences while hemodynamic responses were recorded using functional near-infrared spectroscopy. We identified a new significant response in Broca's area (Brodmann area [BA] 45L) and its right hemisphere homologue during improvised playing but not during formulaic playing. Our results indicate that bilateral BA45 activity is common during creative processes that involve improvisation across all participants, regardless of subjective feelings, skill, age, difficulty, history, or amount of practice. While our previous results demonstrated that the modulation of the neural network according to the subjectively experienced level of creativity relied on the degree of deactivation in BA46L, our current results independently show a common concurrent activity in BA45 in all participants. We suggest that this is related to the sustained execution of improvisation in "motor control," analogous to motor planning in speech control.

DOI： 10.1186/s13104-024-06727-6

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.14326/abe.13.100

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Publishing type：Research paper (international conference proceedings)  

DOI： 10.1364/translational.2024.js4a.17

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DOI： 10.1364/translational.2024.jm4a.14

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DOI： 10.14326/abe.13.66

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Publishing type：Research paper (international conference proceedings)  

DOI： 10.1364/translational.2024.js4a.18

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DOI： 10.1364/translational.2024.js4a.19

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<jats:sec><jats:title>Objective</jats:title><jats:p>Gait disturbance lowers activities of daily living in patients with Parkinson’s disease (PD) and related disorders. However, the effectiveness of pharmacological, surgical and rehabilitative treatments is limited. We recently developed a novel neuromodulation approach using gait-combined closed-loop transcranial electrical stimulation (tES) for healthy volunteers and patients who are post-stroke, and achieved significant entrainment of gait rhythm and an increase in gait speed. Here, we tested the efficacy of this intervention in patients with Parkinsonian gait disturbances.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Twenty-three patients were randomly assigned to a real intervention group using gait-combined closed-loop oscillatory tES over the cerebellum at the frequency of individualised comfortable gait rhythm, and to a sham control group.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Ten intervention sessions were completed for all patients and showed that the gait speed (<jats:italic>F</jats:italic><jats:sub>(1, 21)</jats:sub>=13.0, p=0.002) and stride length (<jats:italic>F</jats:italic><jats:sub>(1, 21)</jats:sub>=8.9, p=0.007) were significantly increased after tES, but not after sham stimulation. Moreover, gait symmetry measured by swing phase time (<jats:italic>F</jats:italic><jats:sub>(1, 21)</jats:sub>=11.9, p=0.002) and subjective feelings about freezing (<jats:italic>F</jats:italic><jats:sub>(1, 21)</jats:sub>=14.9, p=0.001) were significantly improved during gait.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These findings showed that gait-combined closed-loop tES over the cerebellum improved Parkinsonian gait disturbances, possibly through the modulation of brain networks generating gait rhythms. This new non-pharmacological and non-invasive intervention could be a breakthrough in restoring gait function in patients with PD and related disorders.</jats:p></jats:sec>

DOI： 10.1136/jnnp-2022-329966

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Publishing type：Research paper (scientific journal)  

DOI： 10.1364/BOE.498693

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neuroimage.2023.120354

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<jats:p>Progressive supranuclear palsy (PSP) is characterized by recurrent falls caused by postural instability, and a backward gait is considered beneficial for postural instability. Furthermore, a recent approach for rehabilitation combined with gait-oriented synchronized stimulation using non-invasive transcranial patterned stimulation could be promising for balance function. Here, we present a case of PSP with backward gait training combined with gait-synchronized transcranial alternating current stimulation (tACS). A 70-year-old woman with PSP-Richardson’s syndrome underwent backward gait training combined with synchronized cerebellar tACS. Initially, she underwent short-term intervention with combined training of backward gait with synchronized cerebellar tACS, asynchronized, or sham stimulation according to the N-of-1 study design. Synchronized tACS training demonstrated a decrease in postural instability, whereas asynchronized or sham stimulation did not. The additional long-term interventions of combined backward gait training with synchronized cerebellar tACS demonstrated further decrease in postural instability with improvements in gait speed, balance function, and fall-related self-efficacy in daily life. The present case describes a novel approach for motor symptoms in a patient with PSP. Backward gait training with synchronized cerebellar tACS may be a promising therapeutic approach.</jats:p>

DOI： 10.3389/fnhum.2023.1082555

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<jats:p>Most post-stroke patients have long-lasting gait disturbances that reduce their daily activities. They often show impaired hip and knee joint flexion and ankle dorsiflexion of the lower limbs during the swing phase of gait, which is controlled by the corticospinal tract from the primary motor cortex (M1). Recently, we reported that gait-synchronized closed-loop brain stimulation targeting swing phase-related activity in the affected M1 can improve gait function in post-stroke patients. Subsequently, a gait-training robot (Orthobot<jats:sup>®</jats:sup>) was developed that could assist lower-limb joint movements during the swing phase of gait. Therefore, we investigated whether gait-synchronized closed-loop brain stimulation combined with robot-assisted training targeting the swing phase could enhance the recovery of post-stroke gait disturbance. A 57-year-old female patient with chronic post-stroke hemiparesis underwent closed-loop brain stimulation combined with robot-assisted training for 10 min 2 years after left pons infarction. For closed-loop brain stimulation, we used transcranial oscillatory electrical current stimulation over the lesioned M1 foot area with 1.5 mA of DC offset and 0–3 mA of sine-wave formed currents triggered by the paretic heel contact to set the maximum current just before the swing phase (intervention A; two times repeated, A1 and A2). According to the N-of-1 study design, we also performed sham stimulation (intervention B) and control stimulation not targeting the swing phase (intervention C) combined with robot-assisted training in the order of A1-B-A2-C interventions. As a result, we found larger improvements in gait speed, the Timed Up and Go test result, and muscle strength after the A1 and A2 interventions than after the B and C interventions. After confirming the short-term effects, we performed an additional long-term intervention twice a week for 5 weeks, for a total of 10 sessions. Gait parameters also largely improved after long-term intervention. Gait-synchronized closed-loop brain stimulation combined with robot-assisted training targeting the swing phase of gait may promote the recovery of gait function in post-stroke patients. Further studies with a larger number of patients are necessary.</jats:p>

DOI： 10.3389/fnhum.2023.1082556

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neures.2022.09.004

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DOI： 10.3389/fnins.2022.964351

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<jats:title>Abstract</jats:title><jats:p>We investigated the neural correlates for chronic cancer pain conditions by retrospectively analyzing whole brain regions on 18F-fluoro-2-deoxyglucose-positron emission tomography images acquired from 80 patients with head and neck squamous cell carcinoma and esophageal cancer. The patients were divided into three groups according to perceived pain severity and type of analgesic treatment, namely patients not under analgesic treatment because of no or minor pain, patients with good pain control under analgesic treatment, and patients with poor pain control despite analgesic treatment. Uncontrollable cancer pain enhanced the activity of the hippocampus, amygdala, inferior temporal gyrus, and temporal pole. Metabolic connectivity analysis further showed that amygdala co-activation with the hippocampus was reduced in the group with poor pain control and preserved in the groups with no or minor pain and good pain control. The increased although imbalanced activity of the medial temporal regions may represent poor pain control in patients with cancer. The number of patients who used anxiolytics was higher in the group with poor pain control, whereas the usage rates were comparable between the other two groups. Therefore, further studies should investigate the relationship between psychological conditions and pain in patients with cancer and analyze the resultant brain activity.</jats:p><jats:p><jats:italic>Trial registration</jats:italic>: This study was registered at clinicaltrials.gov on 9/3/20 (NCT04537845).</jats:p>

DOI： 10.1038/s41598-022-18430-2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.11.1

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Language：English   Publishing type：Research paper (scientific journal)  

Aim: This investigation aims to advance the understanding of neural dynamics that underlies live and natural interactions during spoken dialogue between two individuals. Introduction: The underlying hypothesis is that functional connectivity between canonical speech areas in the human brain will be modulated by social interaction. Methods: Granger causality was applied to compare directional connectivity across Broca's and Wernicke's areas during verbal conditions consisting of interactive and noninteractive communication. Thirty-three pairs of healthy adult participants alternately talked and listened to each other while performing an object naming and description task that was either interactive or not during hyperscanning with functional near-infrared spectroscopy (fNIRS). In the noninteractive condition, the speaker named and described a picture-object without reference to the partner's description. In the interactive condition, the speaker performed the same task but included an interactive response about the preceding comments of the partner. Causality measures of hemodynamic responses from Broca's and Wernicke's areas were compared between real, surrogate, and shuffled trials within dyads. Results: The interactive communication was characterized by bidirectional connectivity between Wernicke's and Broca's areas of the listener's brain. Whereas this connectivity was unidirectional in the speaker's brain. In the case of the noninteractive condition, both speaker's and listener's brains showed unidirectional top-down (Broca's area to Wernicke's area) connectivity. Conclusion: Together, directional connectivity as determined by Granger analysis reveals bidirectional flow of neuronal information during dynamic two-person verbal interaction for processes that are active during listening (reception) and not during talking (production). Findings are consistent with prior contrast findings (general linear model) showing neural modulation of the receptive language system associated with Wernicke's area during a two-person live interaction. Impact statement The neural dynamics that underlies real-life social interactions is an emergent topic of interest. Dynamically coupled cross-brain neural mechanisms between interacting partners during verbal dialogue have been shown within Wernicke's area. However, it is not known how within-brain long-range neural mechanisms operate during these live social functions. Using Granger causality analysis, we show bidirectional neural activity between Broca's and Wernicke's areas during interactive dialogue compared with a noninteractive control task showing only unidirectional activity. Findings are consistent with an Interactive Brain Model where long-range neural mechanisms process interactive processes associated with rapid and spontaneous spoken social cues.

DOI： 10.1089/brain.2020.0790

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.14326/abe.11.179

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Language：English   Publisher：Japan Society of Neurovegetative Research  

Measuring discomfort during a virtual reality (VR) experience (VR sickness) is important to prevent health hazards and to encourage people to utilize VR technology safely. Using simultaneous measurements of subjective discomfort intensity and electrocardiogram (ECG), we investigated changes in the autonomic nervous activity related to the discomfort caused during a VR experience. In this study, the ECGs of sixteen healthy adults were monitored while they watched a 5-minute VR roller coaster video, which included various rotational and reciprocating motions, using a head-mounted display. The participants were instructed to continuously report their momentary intensity of discomfort using a slider device. Their heart rate variability was analyzed using the R-R interval data of ECGs to calculate the heart rate, the sympathetic nervous activity, and the parasympathetic nervous activity. The values obtained during the time periods of moderate to severe discomfort were compared with those during control periods, in which the roller coaster was at the station and motionless. The results indicate that participants' perceived discomfort was associated with increases in heart rate and sympathetic nervous activity, and a decrease in parasympathetic nervous activity. These results suggest that there is a significant association between autonomic activity and subjective discomfort during VR experiences. This kind of cardiac autonomic nervous activity could be used as a useful biological index for the objective evaluation of VR sickness.

DOI： 10.32272/ans.59.2_246

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Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

DOI： 10.1109/SII52469.2022.9708744

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Other Link： https://dblp.uni-trier.de/db/conf/sii/sii2022.html#YangHYOI22

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.10.158

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.10.150

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Language：Japanese   Publisher：日本バイオフィードバック学会  

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DOI： 10.14326/abe.10.70

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Physiological Society  

Previous studies showed that conduit artery blood flow rapidly increases after even a brief contraction of muscles within the dependent limb. Whether this rapid hyperemia occurs within contracted skeletal muscle in humans has yet to be confirmed, however. We therefore used diffuse correlation spectroscopy (DCS) to characterize the rapid hyperemia and vasodilatory responses within the muscle microvasculature induced by single muscle contractions in humans. Twenty-five healthy male volunteers performed single 1-s isometric handgrips at 20%, 40%, 60%, and 80% of maximum voluntary contraction. DCS probes were placed on the flexor digitorum superficialis muscle, and a skeletal muscle blood flow index (SMBFI) was derived continuously. At the same time, brachial artery blood flow (BABF) responses were measured using Doppler ultrasound. Single muscle contractions evoked rapid, monophasic increases in both SMBFI and BABF that occurred within 3 s after release of contraction. The initial and peak responses increased with increases in contraction intensity and were greater for BABF than for SMBFI at all intensities. BABF reached its peak within 5 to 8 s after the end of contraction. The SMBFI continued to increase after the BABF passed its peak and was decreasing toward the resting level and peaked about 10 to 15 s after completion of the contraction. We conclude that single muscle contractions induce rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature. Moreover, the characteristics of the rapid hyperemia and vasodilatory responses of skeletal muscle microvessels differ from those simultaneously evaluated in the upstream conduit artery.NEW & NOTEWORTHY Through the concurrent use of diffuse correlation spectroscopy and Doppler ultrasound, we provide the first evidence in humans that a single brief muscle contraction evokes rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature and the upstream conduit artery. We also show that the magnitude and time course of the contraction-induced rapid hyperemia and vasodilatory responses within skeletal muscle microvessels significantly differ from those in the conduit artery.

DOI： 10.1152/ajpheart.00761.2020

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Language：Japanese   Publisher：日本生体磁気学会  

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Manipulative therapy (MT) is applied to motor organs through a therapist's hands. Although MT has been utilized in various medical treatments based on its potential role for increasing the blood flow to the local muscle, a quantitative validation of local muscle blood flow in MT remains challenging due to the lack of appropriate bedside evaluation techniques. Therefore, we investigated changes in the local blood flow to the muscle undergoing MT by employing diffuse correlation spectroscopy, a portable and emerging optical measurement technology that non-invasively measures blood flow in deep tissues. This study investigated the changes in blood flow, heart rate, blood pressure, and autonomic nervous activity in the trapezius muscle through MT application in 30 volunteers without neck and shoulder injury. Five minutes of MT significantly increased the median local blood flow relative to that of the pre-MT period (p < 0.05). The post-MT local blood flow increase was significantly higher in the MT condition than in the control condition, where participants remained still without receiving MT for the same time (p < 0.05). However, MT did not affect the heart rate, blood pressure, or cardiac autonomic nervous activity. The post-MT increase in muscle blood flow was significantly higher in the participants with muscle stiffness in the neck and shoulder regions than in those without (p < 0.05). These results suggest that MT could increase the local blood flow to the target skeletal muscle, with minimal effects on systemic circulatory function.

DOI： 10.3389/fbioe.2021.800051

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

We developed a virtual reality (VR)-based gait training system, which could be used by inpatients to train their gait function in a simulated home environment, to reduce the risk of falling after discharge. The proposed system simulates the home environment on a head-mounted display, in which a user can walk around freely. The system provides visual feedback in the event of a collision with an indoor object such as a wall or furniture, prompting the user to modify his or her gait pattern. We first applied the system to healthy young adults and confirmed the usefulness of visual feedback in reducing the walking time and the number of collisions in the simulated room environment. Further, we applied the system to an inpatient with stroke and lower limb paralysis. The patient performed gait training based on a scenario of daily activity using the VR environment that mimicked his house. Five days of training significantly improved the gait and balance functions of the patient. These results suggest that the proposed system foster attention to the surrounding environment and improve gait function in both healthy participants and patients with stroke.Clinical Relevances-This study establishes the importance of visual feedback for VR-based gait training. Additionally, it provides a novel application of VR for gait and balance training in patients with stroke and lower limb paralysis.

DOI： 10.1109/EMBC46164.2021.9631077

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Other Link： https://dblp.uni-trier.de/db/conf/embc/embc2021.html#NagashimaIOTO21

Publishing type：Research paper (international conference proceedings)  

DOI： 10.1109/IPC48725.2021.9592861

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Language：Japanese   Publisher：国際医療福祉大学学会  

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Language：Japanese   Publisher：(一社)日本腎臓学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1111/psyg.12493

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/psyg.12493

Publisher：SPIE  

DOI： 10.1117/12.2542876

DOI： 10.1109/ipc48725.2021.9592861_references_DOI_RtEHdCfn1uEGzC802OFfSNE0sud

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Other Link： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19932/

Language：English   Publishing type：Research paper (scientific journal)  

A novel photonic method for remote monitoring of task-related hemodynamic changes in human brain activation is presented. Physiological processes associated with neural activity, such as nano-vibrations due to blood flow and tissue oxygenation in the brain, are detected by remote sensing of nano-acoustic vibrations using temporal spatial analysis of defocused self-interference random patterns. Temporal nanometric changes of the speckle pattern due to visual task-induced hemodynamic responses were tracked by this method. Reversing visual checkerboard stimulation alternated with rest epochs, and responsive signals were identified in occipital lobe using near-infrared spectroscopy. Temporal vibrations associated with these hemodynamic response functions were observed using three different approaches: (a) single spot illumination at active and control areas simultaneously, (b) subspots cross-correlation-based analysis, and (c) multiwavelength measurement using a magnitude-squared wavelet coherence function. Findings show remote sensing of task-specific neural activity in the human brain.

DOI： 10.1002/jbio.201900201

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Language：Japanese   Publisher：眼科臨床紀要会  

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DOI： 10.1117/12.2545267

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science ({PLoS})  

Gaming disorder, which is characterized by multiple cognitive and behavioral symptoms, often has comorbid psychiatric conditions such as depression and attention-deficit hyperactivity disorder. Neurobiological effects of the comorbid disorders so far reported are not converging, exhibiting positive and negative alterations of the connectivity in brain networks. In this study, we conducted resting-state functional magnetic-resonance imaging and whole brain functional connectivity analyses for young participants consisting of 40 patients diagnosed with the gaming disorder, with and without comorbid conditions, and 29 healthy controls. Compared to healthy controls, the gaming disorder-alone patients had partially diminished connectivities in the reward system and executive control network, within which there existed central nodes that served as a hub of diminished connections. In the gaming disorder patients who had comorbidity of autism spectrum disorder, the diminished connections were enlarged, with alteration of the hub nodes, to the entire brain areas involved in the reward system including cortical, subcortical and limbic areas that are crucial for reward processing, and to the whole cortical areas composing the executive control network. These observations suggest that the neurodevelopmental condition coexisting with the gaming disorder induced substantial impairment of the neural organizations associated with executive/cognitive and emotional functions, which are plausibly causal to the behavioral addiction, by rearranging and diminishing functional connectivities in the network.

DOI： 10.1371/journal.pone.0233780

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Language：English   Publishing type：Research paper (scientific journal)  

Direct eye contact between two individuals is a salient social behavior known to initiate and promote interpersonal interaction. However, the neural processes that underlie these live interactive behaviors and eye-to-eye contact are not well understood. The Dynamic Neural Coupling Hypothesis presents a general theoretical framework proposing that shared interactive behaviors are represented by cross-brain signal coherence. Using functional near-infrared spectroscopy (fNIRS) adapted for hyper scanning, we tested this hypothesis specifically for neural mechanisms associated with eye-to-eye gaze between human participants compared to similar direct eye-gaze at a dynamic video of a face and predicted that the coherence of neural signals between the two participants during reciprocal eye-to-eye contact would be greater than coherence observed during direct eye-gaze at a dynamic video for those signals originating in social and face processing systems. Consistent with this prediction cross-brain coherence was increased for signals within the angular gyrus (AG) during eye-to-eye contact relative to direct eye-gaze at a dynamic face video (p < 0.01). Further, activity in the right temporal-parietal junction (TPJ) was increased in the real eye-to-eye condition (p < 0.05, FDR corrected). Together, these findings advance a functional and mechanistic understanding of the AG and cross-brain neural coupling associated with real-time eye-to-eye contact.

DOI： 10.3389/fnhum.2020.00019

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

We investigated changes in cortical and autonomic nervous activity associated with discomfort feeling during experience in the virtual reality environment (VR sickness). Five young adults watched 3D-CG movies using a head-mounted display while their EEG and ECG responses were measured. Participants continuously reported their discomfort level by pinching a pressure sensor during their VR experience. The subjective discomfort level was negatively correlated with the delta wave activity of the parietal area and the beta wave activity of the central, parietal and occipital areas. No significant correlation was found with indices of cardiac autonomic nervous activity. Results suggest that the parietal cortical activity, which plays a crucial role in integrating the spatial and motor perception of the self, could be a potential biomarker for detecting VR sickness.

DOI： 10.11239/jsmbe.annual58.131

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Understanding how the brain modulates improvisation has been the focus of numerous studies in recent years. Models have suggested regulation of activity between default mode and executive control networks play a role in improvisational execution. Several studies comparing formulaic to improvised sequences support this framework and document increases in activity in medial frontal lobe with decreased activity in the dorsolateral prefrontal cortex (DLPFC). These patterns can be influenced through training and neural responses may differ between in beginner and expert musicians. Our goal was to test the generalizability of this framework and determine similarity in neural activity in the prefrontal cortex during improvisation. Twenty guitarists performed improvised and formulaic sequences in a blues rock format while brain activity was recorded using functional near-infrared spectroscopy. Results indicate similar modulation in DLPFC as seen previously. Specific decreases of activity from left DLPFC in the end compared to beginning or middle of improvised sequences were also found. Despite the range of skills of participants, we also found significant correlation between subjective feelings of improvisational performance and modulation in left DLPFC. Processing of subjective feelings regardless of skill may contribute to neural modulation and may be a factor in understanding neural activity during improvisation.

DOI： 10.1038/s41598-019-52348-6

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Language：English   Publishing type：Research paper (scientific journal)  

Face-specific neural processes in the human brain have been localized to multiple anatomical structures and associated with diverse and dynamic social functions. The question of how various face-related systems and functions may be bound together remains an active area of investigation. We hypothesize that face processing may be associated with specific frequency band oscillations that serve to integrate distributed face processing systems. Using a multimodal imaging approach, including electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), simultaneous signals were acquired during face and object picture viewing. As expected for face processing, hemodynamic activity in the right occipital face area (OFA) increased during face viewing compared to object viewing, and in a subset of participants, the expected N170 EEG response was observed for faces. Based on recently reported associations between the theta band and visual processing, we hypothesized that increased hemodynamic activity in a face processing area would also be associated with greater theta-band activity originating in the same area. Consistent with our hypothesis, theta-band oscillations were also localized to the right OFA for faces, whereas alpha- and beta-band oscillations were not. Together, these findings suggest that theta-band oscillations originating in the OFA may be part of the distributed face-specific processing mechanism.

DOI： 10.1117/1.NPh.6.4.045002

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Language：Japanese   Publisher：国際医療福祉大学学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：眼科臨床紀要会  

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Language：English   Publishing type：Research paper (scientific journal)  

We investigated the integration of sympathetic vasoconstriction and local vasodilation in the skeletal muscle and skin microvasculature of humans. In 39 healthy volunteers, we simultaneously measured the blood flow index in the flexor carpi radialis muscle using diffuse correlation spectroscopy and the skin using laser-Doppler flowmetry. We examined the effects of acute sympathoexcitation induced by forehead cooling on relatively weak and robust vasodilatory responses during postocclusive reactive hyperemia (PORH) induced by 70-sec and 10-min arterial occlusion in the upper arm. To increase sympathetic tone during PORH, forehead cooling was begun 60 sec before the occlusion release and ended 60 sec after the release. In the 70-sec occlusion trials, acute sympathoexcitation reduced the peak and duration of vasodilation in both skeletal muscle and skin. The inhibition of vasodilation by sympathoexcitation was blunted in both tissues by the robust vasodilatory stimulation produced by the 10-min occlusion, and the degree of blunting was greater in skeletal muscle than in skin, especially the initial and peak responses. Sympathoexcitation reduced the peak vasodilation only in skin, while it accelerated the initial vasodilation only in skeletal muscle. However, the decline in vasodilation after the peak was significantly hastened in skeletal muscle, shortening the duration of the vasodilation. We conclude that, in humans, the integration of sympathetic vasoconstriction and local vasodilation has different effects in skeletal muscle and skin and is likely an important contributor to the selective control of perfusion in the microcirculations of different tissues.

DOI： 10.14814/phy2.14070

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)  

Manipulative therapy (MT) is a typical treatment applied to the motor organ with a therapeutic objective in various medical fields. In a current clinical practice, however, the effectiveness of MT is subjectively evaluated by a therapist and/or a patient. MT has been expected to increase local blood flow and decrease edema and pain. However, these physiological changes have not been fully clarified due to the lack of non-invasive and cost-effective methodology to evaluate muscle blood flow. We here used diffuse correlation spectroscopy (DCS), a novel technique to non-invasively measure blood flow velocity, to quantitatively evaluate the effect of MT on the blood flow of the target muscle. Healthy participants (3 men/3 women, age: 22.5±0.7) took part in the study. Participants took a supine position on the treatment table to have a hip joint flexion test. The right leg was elevated to the maximum hip joint flection, and the hip flexion angle and the subjective pain intensity (evaluated by visual analog scale: VAS) were measured. Subsequently, the blood flow of the posterior surface of the femoral region was measured for 5 minutes at rest as a baseline. The blood flow of the same site was measured again after 5 minutes of MT. Finally, we measured a post-MT VAS under the hip joint flexion to the same angle as in the first flexion. Participant received two sessions of MT and control conditions, in which they received MT and no treatment (quiet rest for 5 minutes) between the two hip joint flexion measurements, respectively, in a random and counterbalanced order. Subjective pain intensity with hip joint flexion tended to decrease after MT (p=0.08) while no change was observed in case of control condition (p=0.41). The blood flow velocity of the treated muscle was significantly increased after MT relative to that of the pre-treatment state (p<0.05). There was no change in the blood flow velocity throughout the measurement in case of control condition. These results suggest that MT-induced mechanical pressure to the skin and muscle tissues promote venous return and increase local blood flow.

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Other Link： http://id.ndl.go.jp/bib/029769472

Language：Japanese   Publisher：日本体育大学  

拡散相関分光法(DCS)を用いて、手技療法前後の局所筋血流の変化を非侵襲的かつ定量的に評価した。腰部から下肢に怪我などの既往歴がない健康な被験者6名(男性3名、女性3名、平均22.5±0.7歳)を対象とした。手技療法は柔道整復師国家資格を有する者1名が行い、被験者は手技療法を行った場合(実験群)と行わない場合(対照群)の両方を計測し実験を遂行した。実験群では手技療法前後で大腿部後面の血流速度が増加の推移を呈していた。一方、手技療法をしない対照群では大腿部後面の血流速度の増加は認められなかった。実験群と対照群のPost安静時の有意な差は認められなかったが、実験群の手技療法前後の大腿部後面の血流計測ではPre安静時に比べPost安静時で有意な増加が認められた。一方、手技療法を行っていない対照群には有意差はみられなかった。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J02162&link_issn=&doc_id=20190611560001&doc_link_id=http%3A%2F%2Fid.nii.ac.jp%2F1444%2F00001284%2F&url=http%3A%2F%2Fid.nii.ac.jp%2F1444%2F00001284%2F&type=%E6%97%A5%E6%9C%AC%E4%BD%93%E8%82%B2%E5%A4%A7%E5%AD%A6%EF%BC%9A%E6%97%A5%E4%BD%93%E5%A4%A7%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80195_3.gif

Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

Music has been used for entertainment as well as for medical treatments that remedies physical conditions or psychiatric disorders. It is reported that better outcome can be expected when the music was selected along with personal preferences for these therapies. However it is difficult to find out personalized favorite music if the patient has difficulty in verbal communication due to ageing or developmental disorders. Therefore, this study aimed to develop an objective classification method of music preference based on cortical hemodynamic activities upon listening to the music clips. Fifteen healthy young adults listened their favorite and non-favorite music with their cortical activity measured with 38-channel functional near infrared spectroscopy (fNIRS). Eleven features were extracted from the time-courses of fNIRS signals from the left primary auditory area, the superior temporal gyrus, and the subcentral area. One- to four- dimensional features were individually selected using a leave-one-out cross-validation with two classification algorithms of Fisher linear discriminant analysis (LDA) and support vector machine. The best mean accuracy rate of 92.2 ± 1.7% was obtained when an LDA classifier with four features derived from oxy-hemoglobin signals were adopted showing that our proposed method is valid to classify individual music preference.

DOI： 10.1109/EMBC.2019.8856351

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Other Link： https://dblp.uni-trier.de/rec/conf/embc/2019

Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.8.23

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Renal hypoxia is an aggravating factor for tubulointerstitial damage, which is strongly associated with renal prognosis in diabetic kidney disease (DKD). Therefore, urinary markers that can detect renal hypoxia are useful for monitoring DKD. OBJECTIVE: To determine the correlation between urinary liver-type fatty acid-binding protein (L-FABP) and renal hypoxia using a novel animal model of type 2 diabetes. METHODS: Male spontaneously diabetic Torii (SDT) fatty rats (n = 6) were used as an animal model of type 2 diabetes. Age- and sex-matched Sprague-Dawley (SD) rats (n = 8) were used as controls. Body weight, systolic blood pressure, and blood glucose levels were measured at 8, 12, 16, and 24 weeks of age. Urine samples and serum and kidney tissues were collected at 24 weeks of age. Microvascular blood flow index (BFI) was measured using diffuse correlation spectroscopy before sampling both the serum and kidneys for the evaluation of renal microcirculation at the corticomedullary junction. RESULTS: Obesity, hyperglycemia, and hypertension were observed in the SDT fatty rats. Focal glomerular sclerosis, moderate interstitial inflammation, and fibrosis were significantly more frequent in SDT fatty rats than in SD rats. While the frequency of peritubular endothelial cells and phosphoendothelial nitric oxide synthase levels were similar in both types of rats, the degree of renal hypoxia-inducible factor-1α (HIF-1α) expression was significantly higher (and with no change in renal vascular endothelial growth factor expression levels) in the SDT fatty rats. Urinary L-FABP levels were significantly higher and renal microvascular BFI was significantly lower in the SDT fatty rats than in the SD rats. Urinary L-FABP levels exhibited a significant positive correlation with renal HIF-1α expression and a significant negative correlation with renal microvascular BFI. CONCLUSIONS: Urinary L-FABP levels reflect the degree of renal hypoxia in DKD in a type 2 diabetic animal model. Urinary L-FABP may thus prove useful as a renal hypoxia marker for monitoring DKD in patients with type 2 diabetes in clinical practice.

DOI： 10.1159/000503926

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

Individual capacity of recall memory varies greatly, even in healthy young adults. Nevertheless, the difference in brain circuitry underlying varied memory capacity has yet to be fully investigated. We acquired electroencephalographic meas-urements of 43 healthy young adults who performed a demanding working memory task and studied the changes in re-gional cortical activity in relation to different memory performances. The memory task involved the sequential presenta-tion of seven arrow pictures to encode and the participants were required to report the direction of one of the arrows in the sequence within the retrieval period. We divided the participants into three groups of high-, intermediate-, and low-performance based on the weighted hierarchical grouping method. Regional brain activities were source-localized using the multiple sparse priors method in the high- and low-performance groups and group differences were determined by non-parametric permutation tests. Our findings showed that participants with higher memory performance exhibited wider distribution of cortical activity including the prefrontal and parieto-posterior cortices whereas lower performance participants only

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：ISCIE  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：OSA Publishing  

We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia waths highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.

DOI： 10.1364/BOE.9.004539

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：The American Physiological Society  

DOI： 10.1152/ajpheart.00010.2018

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER  

DOI： 10.1016/j.neures.2017.10.002

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Oxford Academic  

Neural mechanisms that mediate dynamic social interactions remain understudied despite their evolutionary significance. The interactive brain hypothesis proposes that interactive social cues are processed by dedicated brain substrates and provides a general theoretical framework for investigating the underlying neural mechanisms of social interaction. We test the specific case of this hypothesis proposing that canonical language areas are upregulated and dynamically coupled across brains during social interactions based on talking and listening. Functional near-infrared spectroscopy (fNIRS) was employed to acquire simultaneous deoxyhemoglobin (deOxyHb) signals of the brain on partners who alternated between speaking and listening while doing an Object Naming & Description task with and without interaction in a natural setting. Comparison of interactive and non-interactive conditions confirmed an increase in neural activity associated with Wernicke's area including the superior temporal gyrus (STG) during interaction (P = 0.04). However, the hypothesis was not supported for Broca's area. Cross-brain coherence determined by wavelet analyses of signals originating from the STG and the subcentral area was greater during interaction than non-interaction (P < 0.01). In support of the interactive brain hypothesis these findings suggest a dynamically coupled cross-brain neural mechanism dedicated to pathways that share interpersonal information.

DOI： 10.1093/scan/nsy070

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：ISCIE  

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Language：Japanese   Publisher：国際医療福祉大学学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Ltd  

DOI： 10.1016/j.neuropsychologia.2018.04.016

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：ISCIE  

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Language：Japanese   Publisher：国際医療福祉大学学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Ireland Ltd  

DOI： 10.1016/j.neulet.2017.07.051

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：SPIE  

DOI： 10.1117/12.2287609

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：SPIE  

DOI： 10.1117/12.2288044

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Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

DOI： 10.1109/SMC.2018.00016

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Other Link： https://dblp.uni-trier.de/db/conf/smc/smc2018.html#OnoWSIMKT18

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.Annual56.66

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：SPIE  

DOI： 10.1117/12.2287610

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DOI： 10.1016/j.neuroimage.2017.06.018

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

Diffuse correlation spectroscopy (DCS) is an emerging optical technique for noninvasive measurement of hemodynamics of living tissues. Using emitter and detector optical probes attached to the body surface, DCS estimates the mean speed of blood flow in the tissue, through which the emitted near-infrared light propagates (blood flow index: BFI). The advantage of DCS is that the mean blood flow in deeper tissues such as muscle layers can be measured noninvasively. To investigate the sensitivity of DCS in detecting the physiological changes of blood flow in deep and shallow tissues, we measured the blood flow speed in 14 healthy participants during a reactive hyperemia test and skin temperature changes. In the reactive hyperemia test, blood flow returned to the steady state faster in deep tissues than in shallow tissues, and temperature-dependent reallocation of local blood flow in shallow and deep tissues was clearly observed. These results demonstrate that DCS can measure the differences in physiological blood flow dynamics in deep and shallow tissues, suggesting the potential use of DCS to noninvasively quantify changes at microcirculation level in both shallow and deep tissue laye

DOI： 10.14326/abe.6.53

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.55.1

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：SPIE  

DOI： 10.1117/12.2250718

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1117/12.2250718

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.55.9

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.55.39

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.55Annual.503

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Language：Japanese   Publisher：国際医療福祉大学学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Kanagawa Odontological Society  

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Other Link： http://search.jamas.or.jp/link/ui/2017171969

Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：RISP  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Kokubyo Gakkai  

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DOI： 10.1371/journal.pone.0150636

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-Blackwell  

DOI： 10.1002/cre2.32

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Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

DOI： 10.1109/APSIPA.2016.7820761

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Other Link： https://dblp.uni-trier.de/db/conf/apsipa/apsipa2016.html#OnoTM16

Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1109/EMBC.2016.7591984

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DOI： 10.1088/1741-2560/12/6/066004

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：北隆館，ニュー・サイエンス社  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society for Disability and Oral Health  

It is well known in many nursing homes that swallowing exercises promote the maintenance of swallowing function. Using swallowing exercises, we evaluated the antioxidant activity of saliva against reactive oxygen species such as HO and O2•−, in individuals from different generations.Subjects：Individuals who provided informed consent, had normal levels of repetitive saliva swallowing, and did not perform swallowing exercises every day were eligible for this study. The following groups were investigated separately：group A：subjects aged 20-49 years；group B：subjects aged 50-70 years；group C：subjects aged 80 years and over.Method：After collecting general information such as any possible complicating factors, resting saliva was collected before and after the swallowing exercises. The ability of the saliva to scavenge HO• and O2•− was measured using the X-band electron spin resonance spin trap method.Result：There was no significant inter-group difference between antioxidant values for resting saliva before and after the swallowing exercises, although there were large individual differences. It was further observed that group C had an increased O2•− antioxidant capacity, and an increased HO• antioxidant capacity, generated from the Fe2＋/H2O2 system. This was considered to be owing to the effects of aging or of general disease. In the comparison between saliva before and after swallowing exercises, the HO• scavenging ability of the saliva was significantly elevated after swallowing exercises compared with before swallowing exercises in group A, but not in groups B or C.The above results suggest that swallowing exercises can be used in group A for the activation of muscle function related to swallowing, and also to activate the defense mechanisms of the oral antioxidant system. However, there were no significant effects of swallowing exercises in groups B and C in this study. Thus, we would like to assess the antioxidant effects of adequate exercise, which is involved in the maintenance and improvement of swallowing/oral muscular functions, and the continuous effects of swallowing exercises in these groups.

DOI： 10.14958/jjsdh.36.616

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Other Link： http://search.jamas.or.jp/link/ui/2016083219

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Institute of Electrical Engineers of Japan  

DOI： 10.1541/ieejeiss.135.954

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：IEEE  

Using video clips of hand movement to facilitate motor imagery and evoke strong ERD, we investigated the appropriate imagery task to discriminate ERD of "Pinch" and "Hold" movements in healthy controls and stroke patients. Participants watched 4 types of video clips that were a combination of 2 hand actions (pinch a small metal ball ("Pinch") or hold a tennis ball ("Hold")) and 2 object properties (ball rolls into the hand ("Move" condition) or stay still close to the hand ("Stop" condition)). The mean decrease in the mu band power from the baseline was 47.0±8.8% and 45.9±5.5% in healthy controls and patients, respectively, showing that all video clips evoked stable ERD. However, the relationship in ERD power between these hand actions varied across participants and object properties. We therefore calculated the absolute value of difference in ERD power between two hand actions (adERD) to further investigate the appropriate object property of the video clip stimuli. The mean adERD across participants and object properties was 22.3±6.0% in healthy controls and 33.9±6.6% in patients, showing a good contrast between the ERD powers between 2 hand actions. The adERD was significantly larger in Move condition than Stop condition at electrode C6 in healthy participants for left hand imagery. Similar tendency was also found at electrode C3 in right paralyzed patients. The post-experiment questionnaire demonstrated that the ease in hand motor imagery was greater in Move condition compared to Stop condition in all participant groups. These results suggest that the video clip stimuli with Move object properties are appropriate to induce stable ERD for classification of Pinch and Hold movements.

DOI： 10.1109/EMBC.2015.7319418

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Other Link： https://dblp.uni-trier.de/rec/conf/embc/2015

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neulet.2015.05.023

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DOI： 10.3791/52116

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Neurovegetative Research  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Hindawi Publishing Corporation  

DOI： 10.1155/2015/294068

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DOI： 10.1155/2015/395705

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DOI： 10.1109/EMBC.2015.7319388

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Other Link： https://dblp.uni-trier.de/rec/conf/embc/2015

Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1109/EMBC.2015.7318730

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Other Link： https://dblp.uni-trier.de/rec/conf/embc/2015

Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

We have developed an unsupervised multi-class classification algorithm of Steady-State Visual Evoked Potential (SSVEP)-based-BCI. Our previously proposed algorithm detects the frequency that gives maximum peak-to-baseline amplitude of the spectrum power among the frequency bands corresponding to the flicker light stimuli at the three electrodes arranged in occipital area, and majority voting among these electrodes determines the final output. To further increase the accuracy, we examined whether (1) a feature that incorporates the peak-to-baseline amplitude of the spectrum power at the harmonic frequencies of the flicker frequency in addition to those at the fundamental frequency, and/or (2) a winner-take-all fashion of classification algorithm (classification based on the feature at a single electrode showing the maximum peak-to-baseline amplitude among three electrodes), could improve the accuracy. Mean accuracy (N=32) obtained from the classification algorithm using spectrum features at first and second harmonics in a winner-take-all selection strategy was 79.2%, which is significantly better than the accuracy from our previous classification algorithm (68.8%, p<0.001)

DOI： 10.11239/jsmbe.53.S252_01

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2224/sbp.2015.43.7.1123

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DOI： 10.1155/2015/294068

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本アンチエイジング歯科学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：St. Marianna University  

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Other Link： http://search.jamas.or.jp/link/ui/2015382585

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Soc. of Med. Electronics and Biol. Engineering  

DOI： 10.11239/jsmbe.52.SY-22

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DOI： 10.1016/j.neuroimage.2013.05.071

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Other Link： https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage85.html#OnoNTSSTBN14

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/1471-2202-15-4

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DOI： 10.11239/jsmbe.52.O-176

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DOI： 10.11239/jsmbe.52.O-452

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DOI： 10.1620/tjem.230.49

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DOI： 10.1109/EMBC.2013.6611269

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Other Link： https://dblp.uni-trier.de/rec/conf/embc/2013

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This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

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DOI： 10.1016/j.neulet.2012.05.035

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DOI： 10.1186/1744-9081-8-26

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DOI： 10.3109/10253890.2011.614296

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DOI： 10.1016/j.neulet.2011.12.015

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.neulet.2012.01.045

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1109/ICCME.2012.6275737

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1109/ICCME.2012.6275735

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1152/ajpheart.01224.2010

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PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neulet.2011.08.023

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PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s12548-011-0012-9

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：神奈川歯科大学学会  

21〜54歳の男性14名、女性4名(平均年齢35.7±6.1歳)を対象に、磁気共鳴機能画像法(fMRI)を用い、チューイングが与えるストレス負荷による扁桃体と前頭前野の応答への影響をについて検討した。ストレス課題は非常ベル音と爆発音の合成音とし、チューイングは無味無臭のブロック状ガムを用いた。32秒間の課題表示の後に32秒間のコントロール(課題表示無しのリラックス)状態を4回繰り返し、同様にストレス刺激下でガムチューイングの後にコントロール状態を4回繰り返した。また、ストレス課題表示の前後5分間に採血して血中のACTH、アドレナリン、ノルアドレナリンの濃度を測定した。その結果、ガムチューイングにより、ストレスによって増加した前頭前野と扁桃体の賦活化は減衰し、上昇した血中ストレスマーカーの濃度は低下した。また、VASによるストレス度評価ではストレス度はチューイング後に約44%軽減した。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2011&ichushi_jid=J00226&link_issn=&doc_id=20110819240001&doc_link_id=%2Fcn0kanas%2F2011%2F004601%2F002%2F0007-0017%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcn0kanas%2F2011%2F004601%2F002%2F0007-0017%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jpor.2010.09.006

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PubMed

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Language：English  

DOI： 10.1016/j.neures.2011.07.748

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Language：English  

DOI： 10.1016/j.neures.2011.07.1216

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：神奈川歯科大学学会  

食前にガムチューイングを実施し、体重および栄養摂取量の変化を検索した。食前ガムチューイング実施前と食前ガムチューイング実施後の腹部の脂肪量を定量的に計測した。さらに、脳で食欲の調節に関わる食中枢にチューイングが及ぼす影響を調べた。また、9週間の食前ガムチューイング終了後、ガムチューイングなしの状態でリバウンドの状態を検討した。女子大学生53例を対象とした。39例に体重減少を認めた。食前ガムチューイングの期間に相応して体重が減少し、肥満の程度が高いほど体重減少量が大きかった。体重のリバウンドは緩やかで、5週間経過してもガムチューイング実施前の値まで戻らなかった。内臓脂肪と皮下脂肪はともにガムチューイング実施前より有意に減少した。摂取エネルギー量は食前ガムチューイングの実施により経時的に低下した。ガムチューイングで視床下部腹内側部にBOLDシグナルの増強がみられ、外側部では逆に減衰した。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J00226&link_issn=&doc_id=20110222290003&doc_link_id=%2Fcn0kanas%2F2010%2F004502%2F003%2F0090-0099%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcn0kanas%2F2010%2F004502%2F003%2F0090-0099%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.1111/j.1365-2842.2010.02079.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s12548-010-0047-3

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Publisher：Elsevier BV  

DOI： 10.1016/j.neures.2010.07.2416

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Language：Japanese   Publishing type：Research paper (scientific journal)  

Scopus

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Language：English  

DOI： 10.1016/j.neures.2010.07.1448

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neulet.2009.08.030

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neures.2009.04.011

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neuroscience.2008.04.057

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Language：English   Publishing type：Part of collection (book)   Publisher：Springer Japan  

DOI： 10.1007/978-4-431-73242-6_5

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Language：English   Publishing type：Part of collection (book)   Publisher：Springer Japan  

DOI： 10.1007/978-4-431-73242-6_7

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1088/1742-6596/97/1/012239

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Language：English   Publishing type：Part of collection (book)   Publisher：Springer Japan  

DOI： 10.1007/978-4-431-73242-6_6

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Other Link： http://orcid.org/0000-0003-3844-3061

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.ics.2007.02.027

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1088/1742-6596/43/1/297

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1109/TASC.2005.849980

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.2221/jcsj.40.44

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Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：The Institute of Electronics, Information and Communication Engineers  

A biomagnetic measurement system on mice using a dc superconducting quantum interference device magnetometer has been developed. We are going to use it for comparative magnetocardiogram (MCG) studies of disease-model mice, which are generated by gene modification or drug inducement, to clarify the mechanism of disease development in a living body. We measured MCG on wild-type and aconitine-induced arrhythmia model mice. The difference in the spatial distribution and the time course of MCG signals between regular sinus rhythm and arrhythmia was clearly evaluated. The result suggested that the presented system would be capable for the screening of cardiac excitation on mice in good spatial and time resolution.

CiNii Research

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1063/1.1772517

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Academy of Clinical Neurophysiology  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/S0921-4534(01)01138-8

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CiNii Research

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J-GLOBAL

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J-GLOBAL

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Publisher：IEEE  

DOI： 10.1109/VR.2019.8798136

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Other Link： https://dblp.uni-trier.de/db/conf/vr/vr2019.html#ZhangKO19

J-GLOBAL

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：Japanese   Publisher：眼科臨床紀要会  

CiNii Research

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Language：Japanese   Publisher：眼科臨床紀要会  

CiNii Research

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.11239/jsmbe.55Annual.565

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CiNii Research

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.11239/jsmbe.55Annual.562

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CiNii Research

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.11239/jsmbe.55Annual.556

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CiNii Research

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

DOI： 10.11239/jsmbe.55Annual.526

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CiNii Research

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Language：Japanese   Publisher：(一社)日本老年歯科医学会  

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Language：Japanese   Publisher：日本生体磁気学会  

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Language：Japanese   Publisher：(一社)日本抗加齢医学会  

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Language：Japanese   Publisher：(一社)日本老年歯科医学会  

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Publisher：IEEE  

DOI： 10.1109/IWW-BCI.2015.7073053

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Other Link： https://dblp.uni-trier.de/db/conf/bci3/bci2015.html#ShiratoriTIO15

Publisher：IEEE  

DOI： 10.1109/IWW-BCI.2015.7073021

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Other Link： https://dblp.uni-trier.de/db/conf/bci3/bci2015.html#TsubakidaSIO15

Language：Japanese   Publisher：(一社)日本障害者歯科学会  

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Language：Japanese   Publisher：(一社)日本抗加齢医学会  

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Language：Japanese   Publisher：日本生体磁気学会  

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：Japanese   Publisher：日本自律神経学会  

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：Japanese   Publisher：日本自律神経学会  

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Language：Japanese   Publisher：日本生体磁気学会  

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Language：English  

DOI： 10.1016/j.neulet.2012.01.045

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Language：Japanese   Publisher：神奈川歯科大学学会  

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2011.07.1671

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2011.07.1616

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2011.07.1174

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2011.07.1255

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Language：English   Publishing type：Book review, literature introduction, etc.  

DOI： 10.1111/j.1365-2842.2010.02079.x

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2010.07.2417

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Language：English   Publishing type：Research paper, summary (international conference)  

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2010.07.1754

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2010.07.1747

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DOI： 10.1016/j.neures.2010.07.1449

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Language：Japanese  

CiNii Research

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2009.09.991

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2009.09.989

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2009.09.915

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CiNii Research

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Language：Japanese   Publisher：The Institute of Electronics, Information and Communication Engineers  

CiNii Research

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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CiNii Research

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CiNii Research

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J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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DOI： 10.1016/j.neures.2007.06.1322

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Language：English   Publishing type：Research paper, summary (international conference)  

DOI： 10.1016/j.neures.2007.06.687

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CiNii Research

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Language：Japanese   Publisher：The Institute of Electronics, Information and Communication Engineers  

Disease-model mice generated by gene modification or administered of drug are provided to investigate the mechanism of heart disease development or treatment. We have developed a biomagnetic measurement system for mice with a high spatial resolution and enough magnetic sensitivity using a dc SQUID magnetometer, and we measured MCG on a normal mouse and a cardiac infarct model mouse more than once, and focused on the temporal change of heart activities. We found that the heart activity is weakening with time.

CiNii Research

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CiNii Research

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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CiNii Research

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J-GLOBAL

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J-GLOBAL

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Understanding the dynamics of cortical communication within a single brain and/or between multiple brains is one of the most challenging topics in the field of systems neuroscience. Previous studies of brain electrical activity have shown region- and frequency band- specific changes in oscillatory activity, suggesting the existence of multiple cortical networks governed by the oscillatory activities of different frequency bands. Here we demonstrate an application of multivariate Granger causality (MVGC) analysis to electroencephalography (EEG) data during a two-person, eye-contact experiment to explore the directional dynamics of the EEG frequency components which are involved in real human face-to-face communication as compared to gaze at a face picture.

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Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Jeju, Korea  

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Venue：熊本  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Saitama  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Yokohama  

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Language：English   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Award type：Award from Japanese society, conference, symposium, etc. 

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Award type：Award from publisher, newspaper, foundation, etc. 

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