Updated on 2026/04/03

写真a

 
ISHIHARA YASUTOSHI
 
Organization
Undergraduate School School of Science and Technology Professor
Title
Professor
External link

Degree

  • 博士(工学) ( 2002.3   長岡技術科学大学 )

  • 修士(工学) ( 1989.3   長岡技術科学大学 )

  • 学士(工学) ( 1987.3   長岡技術科学大学 )

Research Interests

  • 画像診断システム

  • 計測システム

  • 低侵襲治療システム

Research Areas

  • Manufacturing technology (mechanical,electrical/electronic, chemical engineering) / Measurement engineering

  • Life sciences / Medical systems  / 医用システム(Medical Systems)

Education

  • Nagaoka University of Technology

    1987.4 - 1989.3

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Research History

  • Meiji University   Professor

    2012.4

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  • Meiji University   Associate Professor

    2010.4 - 2012.3

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  • Meiji University

    2010.4 - 2012.3

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  • Nagaoka University of Technology

    2007.4 - 2010.3

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  • Nagaoka University of Technology   Associate Professor

    2007.4 - 2010.3

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  • Nagaoka University of Technology   Associate Professor (as old post name)

    2004.4 - 2007.3

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  • Nagaoka University of Technology

    2004.4 - 2007.3

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Professional Memberships

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Papers

  • Feasibility Study of Vibrating Magnetic Nanoparticle Imaging Using Focused Ultrasound Reviewed

    Shoki Kaiho, Yasutoshi Ishihara

    63 ( 4-5 )   125 - 132   2025.11

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11239/jsmbe.63.125

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  • Displacement measurement of magnetic particles by ultrasonic vibration Reviewed

    K. Yaginuma, Y. Ishihara

    International Workshop on Magnetic Particle Imaging 2022   8 ( 1 )   2022.3

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  • Magnetic particle imaging using discrete sampling and image reconstruction with few orthogonal bases obtained by singular value decomposition of selected delta responses Reviewed International journal

    Y. Ono, Y. Ishihara

    International Journal on Magnetic Particle Imaging   6 ( 2 )   2003003.1 - 2003003.8   2020.4

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  • Preliminary experiments for detection of reflected signals from magnetic nanoparticles by ultrasound Reviewed International journal

    H. Huang, Y. Ishihara

    International Workshop on Magnetic Particle Imaging 2022   2020.3

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  • Displacement measurement for new MPI system based on vibrating magnetic nano particles Reviewed International journal

    K. Moriwaki, Y. Ishihara

    International Workshop on Magnetic Particle Imaging   2019.3

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  • Image reconstruction method of magnetic particle imaging using orthogonality of singular value decomposition Reviewed International journal

    Y. Ono, Y. Ishihara

    International Workshop on Magnetic Particle Imaging   2019.3

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  • Development of a simulation model for magnetic nanoparticle imaging using ultrasonic vibration Reviewed International journal

    M. Watanabe, S. Urushibata, Y. Ishihara

    International Workshop on Magnetic Particle Imaging   2019.3

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  • 外部加振による磁化信号を利用した磁性ナノ粒子イメージングの信号対雑音比の改善 Reviewed

    漆畑智士, 石原康利

    57 ( 1 )   8 - 14   2019.1

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  • Improvement of detection sensitivity for MPI system based on vibrating particles Reviewed International journal

    S. Urushibata, T. Takagi, T. Hatsuda, A. Matsuhisa, M. Arayama, Y. Ishihara

    International Workshop on Magnetic Particle Imaging   2017.3

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  • Evaluation of magnetic field strength for FFP line scanning driven by low electric currents Reviewed International journal

    A. Kuzuhara, T. Hatsuda, T. Takagi, S. Takahashi, M. Arayama, Y. Ishihara

    International Workshop on Magnetic Particle Imaging   2017.3

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  • Optimization of I-shaped Cell for Noninvasive Blood Glucose Measurement based on Photoacoustic Spectroscopy International journal

    K. Okada, K. Tachibana, R. Kobayashi, Y. Ishihara

    38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society   2016.8

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  • Magnetic signal detection method based on active vibration of magnetic nanoparticles Reviewed International journal

    A. Matsuhisa, T. Hatsuda, T. Takagi, M. Arayama, Y. Ishihara

    International Workshop on Magnetic Particle Imaging 2016   2016.3

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  • Magnetic signal separation using independent component analysis Reviewed International journal

    M. Arayama, T. Takagi, T. Hatsuda, A. Matsuhisa, Y. Ishihara

    International Workshop on Magnetic Particle Imaging 2016   2016.3

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  • PSF Estimation for Restoration of Zoom-Blurred Endoscope Images International journal

    K. Otsuzumi, Y. Ishihara

    The 2016 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing   20 ( 4 )   213 - 216   2016.3

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:Research Institute of Signal Processing, Japan  

    In order to remove zoom blurring caused due to the movement of the endoscope in the depth direction, it is necessary to obtain the point spread function (PSF) from the degraded image. However, the PSF of a zoom-blurred image has not been clearly modeled because zoom blurring depends on the position of the image. In this study, we propose a method to estimate the PSF of a zoom-blurred image and conduct a fundamental experiment to confirm its validity.

    DOI: 10.2299/jsp.20.213

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  • Development of a High-Sensitivity and Portable Cell Using Helmholtz Resonance for Noninvasive Blood Glucose-Level Measurement Based on Photoacoustic Spectroscopy Reviewed

    K. Tachibana, K. Okada, R. Kobayashi, Y. Ishihara

    2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)   6477 - 6480   2016

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  • Image Reconstruction Method Using Orthonormal Basis by Singular Value Decomposition for Magnetic Particle Imaging Reviewed

    TAKAGI Tomoyuki, TSUCHIYA Hiroki, HATSUDA Tomoki, ISHIHARA Yasutoshi

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 5 )   276 - 282   2015.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Medical and Biological Engineering  

    Recently, magnetic particle imaging (MPI) has gained attention as a new medical imaging diagnosis technology. In MPI, an image is reconstructed by detecting the signals from magnetic nanoparticles (MNPs) injected into the body. Since MNPs have the property of accumulating in cancer cells, MPI is expected to be applicable to early diagnosis of cancer. The fundamental method of MPI involves reconstructing the MNP distribution by detecting the odd harmonics generated from MNPs. However, this method has a problem in that image blurring and artifacts occur due to signals from MNPs outside the signal detection region. In order to resolve this problem, a reconstruction method based on solution of the inverse problem has been proposed. This method suppresses image blurring and artifacts by considering the signals from MNPs outside the target measurement region. However, this method requires huge matrix operation and thereby increasing reconstruction time. In this paper, we propose a new image reconstruction method with orthonormal basis calculated using singular value decomposition. The system function and the observed signals from the distribution of unknown MNPs, which are used for image reconstruction, are expanded using the orthonormal basis. Since the proposed method has a reduced matrix size compared with the conventional solution of the inverse problem, image reconstruction time can be reduced. By numerical simulation, we confirmed that image reconstruction with an image quality equivalent to that of the conventional solution of the inverse problem was obtained in 1/39 calculation time for a 11×11 matrix size image.

    DOI: 10.11239/jsmbe.53.276

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    Other Link: https://jlc.jst.go.jp/DN/JLC/20021015227?from=CiNii

  • Simulation Study on Iterative Reconstruction Method for Time-Correlation Magnetic Particle Imaging With Continuous Trajectory Scan Reviewed

    Shota Shimizu, Takumi Homma, Hiroki Tsuchiya, Yasutoshi Ishihara

    IEEE TRANSACTIONS ON MAGNETICS   51 ( 2 )   6501004.1 - 6501004.4   2015.2

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    DOI: 10.1109/TMAG.2014.2332096

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  • Experimental Evaluation of an Iterative Reconstruction Method for Time-Correlation Magnetic Particle Imaging Reviewed

    Hiroki Tsuchiya, Takumi Homma, Shota Shimizu, Yasutoshi Ishihara

    IEEE TRANSACTIONS ON MAGNETICS   51 ( 2 )   6502204.1 - 6502204.4   2015.2

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    DOI: 10.1109/TMAG.2014.2330874

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  • TWO-DIMENSIONAL MAGNETIC IMAGING SYSTEM FOR EVALUATING ITERATIVE RECONSTRUCTION METHOD BASED ON TIME-CORRELATION INFORMATION Reviewed

    Hiroki Tsuchiya, Shota Shimizu, Tomoki Hatsuda, Tomoyuki Takagi, Tomoaki Noguchi, Yasutoshi Ishihara

    2015 5TH INTERNATIONAL WORKSHOP ON MAGNETIC PARTICLE IMAGING (IWMPI)   P26 - P26   2015

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  • A BASIC STUDY OF AN IMAGE RECONSTRUCTION METHOD USING NEURAL NETWORKS FOR MAGNETIC PARTICLE IMAGING Reviewed

    Tomoki Hatsuda, Shota Shimizu, Hiroki Tsuchiya, Tomoyuki Takagi, Tomoaki Noguchi, Yasutoshi Ishihara

    2015 5TH INTERNATIONAL WORKSHOP ON MAGNETIC PARTICLE IMAGING (IWMPI)   P19 - P19   2015

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  • A BASIC STUDY OF AN IMAGE RECONSTRUCTION METHOD USING NEURAL NETWORKS FOR MAGNETIC PARTICLE IMAGING Reviewed

    Tomoki Hatsuda, Shota Shimizu, Hiroki Tsuchiya, Tomoyuki Takagi, Tomoaki Noguchi, Yasutoshi Ishihara

    2015 5TH INTERNATIONAL WORKSHOP ON MAGNETIC PARTICLE IMAGING (IWMPI)   P19 - P19   2015

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  • IMAGE RECONSTRUCTION METHOD BASED ON ORTHONORMAL BASIS OF OBSERVATION SIGNAL BY SINGULAR VALUE DECOMPOSITION FOR MAGNETIC PARTICLE IMAGING Reviewed

    Tomoyuki Takagi, Shota Shimizu, Hiroki Tsuchiya, Tomoki Hatsuda, Tomoaki Noguchi, Yasutoshi Ishihara

    2015 5TH INTERNATIONAL WORKSHOP ON MAGNETIC PARTICLE IMAGING (IWMPI)   P25 - P25   2015

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  • An image reconstruction method using singular value decomposition for magnetic particle imaging Reviewed International journal

    S. Shimizu, H. Tsuchiya, T. Takagi, T. Hatsuda, T. Noguchi, Y. Ishihara

    EMBS Micro and Nanotechnology in Medicine Conference   53 ( 5 )   276 - 282   2014.12

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:Japanese Society for Medical and Biological Engineering  

    Recently, magnetic particle imaging (MPI) has gained attention as a new medical imaging diagnosis technology. In MPI, an image is reconstructed by detecting the signals from magnetic nanoparticles (MNPs) injected into the body. Since MNPs have the property of accumulating in cancer cells, MPI is expected to be applicable to early diagnosis of cancer. The fundamental method of MPI involves reconstructing the MNP distribution by detecting the odd harmonics generated from MNPs. However, this method has a problem in that image blurring and artifacts occur due to signals from MNPs outside the signal detection region. In order to resolve this problem, a reconstruction method based on solution of the inverse problem has been proposed. This method suppresses image blurring and artifacts by considering the signals from MNPs outside the target measurement region. However, this method requires huge matrix operation and thereby increasing reconstruction time. In this paper, we propose a new image reconstruction method with orthonormal basis calculated using singular value decomposition. The system function and the observed signals from the distribution of unknown MNPs, which are used for image reconstruction, are expanded using the orthonormal basis. Since the proposed method has a reduced matrix size compared with the conventional solution of the inverse problem, image reconstruction time can be reduced. By numerical simulation, we confirmed that image reconstruction with an image quality equivalent to that of the conventional solution of the inverse problem was obtained in 1/39 calculation time for a 11×11 matrix size image.

    DOI: 10.11239/jsmbe.53.276

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    Other Link: https://jlc.jst.go.jp/DN/JLC/20021015227?from=CiNii

  • Construction of 2D Imaging System for Magnetic Particle Imaging

    49 ( 8 )   426 - 429   2014.8

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  • Simulation study on iterative reconstruction method for time-correlation magnetic particle imaging with continuous trajectory scan Reviewed International journal

    S. Shimizu, T. Honma, H. Tsuchiya, Y. Ishihara

    International Workshop on Magnetic Particle Imaging 2014   106 - 106   2014.3

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  • Evaluation of magnetic nanoparticle samples made from biocompatible ferucarbotran by time-correlation magnetic particle imaging reconstruction method Reviewed

    Yasutoshi Ishihara, Takumi Honma, Satoshi Nohara, Yoshio Ito

    BMC MEDICAL IMAGING   13 ( 15 )   1 - 10   2013.6

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    DOI: 10.1186/1471-2342-13-15

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  • Reduction of image blurring for time-correlation magnetic particle imaging Reviewed

    Takumi Homma, Shota Shimizu, Yasutoshi Ishihara

    2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013   25 - 25   2013

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    DOI: 10.1109/IWMPI.2013.6528342

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  • Separation of Ferucarbotran: A leading candidate of MPI tracer for practical use Reviewed

    Satoshi Nohara, Ichiro Kato, Yoshio Ito, Takumi Honma, Yasutoshi Ishihara

    2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013   22 - 22   2013

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    DOI: 10.1109/IWMPI.2013.6528339

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  • Experimental Study on a Reconstruction Method to Suppress Image Artifacts for Magnetic Nanoparticle Imaging Reviewed

    HONMA Takumi, NAKAGAWA Yohei, ISHIHARA Yasutoshi

    BME   50 ( 6 )   543 - 551   2012.12

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    Current imaging technologies such as magnetic resonance imaging (MRI). X-ray computed tomography (X-ray CT), and positron emission tomography (PET) are utilized in the medical field. Moreover, a new imaging technology called magnetic particle imaging (MPI) has been proposed, and has attracted attention. This technology can image a distribution of internally administered magnetic nanoparticles (MNPs). In MPI, since a signal generated from MNPs is detected directly, high sensitivity and high spatial resolution are expected compared to MRI that uses the same MNPs as a medical contract media. In this method, a magnetization response from MNPs from a target region is detected by scanning a local distribution of magnetic field. However, the image blurring and artifacts appear due to the interference of magnetization response generated from the MNPs outside target region, so that image resolution is degraded. We have already proposed a new image reconstruction method that focused on the difference between the waveform of electromotive force generated from a target region and outside region. In this paper, we verified the validity of this proposed method by using the prototype system and numerical experiment considering the prototype system's specifications. As a result, the image artifacts were suppressed, and the image resolution was about 10.3 mm in numerical experiment. We also indicated that the image artifacts were decreased by 32% compared with conventional method in the experiment with the prototype system. However, since the image resolution was about 12 mm in this experiment, it needed to be more improved.

    DOI: 10.11239/jsmbe.50.543

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  • Correlation-Based Image Reconstruction Methods for Magnetic Particle Imaging Reviewed

    Yasutoshi Ishihara, Tsuyoshi Kuwabara, Takumi Honma, Yohei Nakagawa

    IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS   E95D ( 3 )   872 - 879   2012.3

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    DOI: 10.1587/transinf.E95.D.872

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  • Correlation-based image reconstruction methods for magnetic particle imaging

    Yasutoshi Ishihara, Tsuyoshi Kuwabara, Takumi Honma, Yohei Nakagawa

    IEICE Transactions on Information and Systems   E95-D ( 3 )   872 - 879   2012

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    DOI: 10.1587/transinf.E95.D.872

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  • Heating characteristics with a re-entrant type applicator in consideration of tissue blood flow rate Reviewed

    T. Ishimori, Y. Ishihara

    2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)   5695 - 5698   2012

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  • Experimental evaluation of correlation-based image reconstruction method for magnetic particle imaging Reviewed

    Takumi Honma, Yasutoshi Ishihara

    Springer Proceedings in Physics   140   143 - 148   2012

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    DOI: 10.1007/978-3-642-24133-8_23

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  • Determination of Measurable Depth Based on Optical Modulation Frequency by Photoacoustic Spectroscopy

    WADAMORI Naoki, ISHIHARA Yasutoshi

    Transactions of Japanese Society for Medical and Biological Engineering   49 ( 1 )   220-225 - 225   2011.2

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    A measurable depth of the blood glucose level by using photoacoustic spectroscopy (PAS) was discussed experimentally in order to improve detection sensitivity. Since a measurable depth of the PAS based on a modulation frequency of the chopped light irradiated to a sample, the relationship between modulation frequency and the thickness of a sample was evaluated. In our experiments, the photoacoustic detector consisted of an acoustic resonant pipe and an optical microphone, and a two-layer model composed of silicone sheets with the different optical absorption were used. We varied the thickness of the upper-layer for the two-layer model from 0.50 to 5.00 mm at each modulation frequencies to investigate the relationship between the measurable depth and the modulation frequency. As results, it is shown that the measurable depth was 2-3 mm with modulation frequency of 1.6-1.9 kHz. Furthermore, the reason for the measurable depth to be deeper than the thermal diffusion length of a sample was discussed. From these analyses of thermoelastic wave, the relation between the photoacoustic signal propagation and the measurable depth in a tissue was clarified.

    DOI: 10.11239/jsmbe.49.220

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    Other Link: http://search.jamas.or.jp/link/ui/2011272780

  • Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles

    Yasutoshi Ishihara, Tsuyoshi Kuwabara, Naoki Wadamori

    MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING   7965   79652J.1-79652J.8   2011

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    DOI: 10.1117/12.878127

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  • Non-invasive temperature measurement by using phase changes in electromagnetic waves in a cavity resonator Reviewed

    Yasutoshi Ishihara, Hiroshi Ohwada

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   27 ( 7 )   726 - 736   2011

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    DOI: 10.3109/02656736.2011.602038

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  • A fundamental numerical analysis for noninvasive thermometry integrated in a heating applicator based on the reentrant cavity

    H. Ohwada, Y. Ishihara

    Thermal Med.   26 ( 2 )   51-62,   2010.7

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  • Small Gradient Coil Design Method with Target Field Apploximation

    HIRASAWA Takeshi, ISHIHARA Yasutoshi

    The IEICE transactions on information and systems   J93-D ( 6 )   1048-1055 - 1055   2010.6

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    Other Link: http://search.jamas.or.jp/link/ui/2010281819

  • High-Resolution Image Reconstruction Method on the Molecular Imaging Using Magnetic Nanoparticles

    KUSAYAMA Yusuke, ISHIHARA Yasutoshi

    The IEICE transactions on information and systems   J92-D ( 9 )   1653-1662 - 1662   2009.9

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    Other Link: http://search.jamas.or.jp/link/ui/2009321750

  • Noninvasive Thermometry on the Heating Applicator Based on the Reentrant Cavity

    OHWADA Hiroshi, ISHIHARA Yasutoshi

    The IEICE transactions on information and systems   J92-D ( 4 )   562-570 - 570   2009.4

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    Other Link: http://search.jamas.or.jp/link/ui/2009181068

  • FEM連成解析に基づく生体用光音響セルの設計手法

    和田森 直, 石原康利

    Biomedical Themology   28 ( 2 )   39-47   2009.1

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  • Resolution improvement of the molecular imaging technique based on magnetic nanoparticles

    Yasutoshi Ishihara, Yusuke Kusayama

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE   7258   725841.1–725841.8   2009

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    DOI: 10.1117/12.807335

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  • Gradient Coil Design Method for Handy MRI

    T. Hirasawa, Y. Ishihara

    WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, VOL 25, PT 2 - DIAGNOSTIC IMAGING   25   837 - 840   2009

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  • Localized heating characteristics of hyperthermia using a reentrant cavity

    Y. Ishihara, N. Wadamori

    Journal of Medical Engineering and Technology   32 ( 5 )   348 - 357   2008.9

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    DOI: 10.1080/03091900802058953

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  • 完全非侵襲がん治療を目的とした温度測定法に関する研究

    中谷電子計測技術振興財団年報   22   12-18   2008.8

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  • Improvement in localized heating characteristics by loading dielectrics in a heating applicator based on a cylindrical reentrant cavity

    Y. Ishihara, ほか3名

    Thermal medicine   24 ( 2 )   61-72   2008.8

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  • 有限要素解析に基づく経皮的PA信号検出器の高感度化に関する検討

    和田森 直, 石原康利

    生体医工学   46 ( 2 )   238-245   2008.4

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  • An improvement of the localized heating characteristics by the rotation of a heating applicator based on a reentrant cavity

    N. Wadamori

    10th International Congress on Hyperthermic Oncology Munich   116   2008.4

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  • パターン投影3次元計測による管腔臓器内壁病変の高精度診断法の研究

    内視鏡医学研究振興財団25周年記念業績集   116   2008.3

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  • がん温熱療法における非侵襲温度計測法に関する研究

    大和田 寛, 石原康利

    Biomedical Themology   27 ( 2 )   56-63   2008.3

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  • Regional Heating by Insertion of Dielectrics and Rotation of the Focused Electric Field in the Hyperthermia

    Yasuyuki Kameyama, Yasutoshi Ishihara

    2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8   4380 - +   2008

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  • Heating applicator based on reentrant cavity with optimized local heating characteristics

    Y. Ishihara, Y. Kameyama, Y. Minegishi, N. Wadamori

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   24 ( 8 )   694 - 704   2008

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    DOI: 10.1080/02656730802117064

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  • Photoacoustic depth profiling of a skin model for non-invasive glucose measurement

    Naoki Wadamori, Ryou Shinohara, Yasutoshi Ishihara

    2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8   5644 - 5647   2008

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  • 集束電界を利用した非侵襲がん治療装置の開発

    立石科学技術振興財団助成研究成果集   16   49-53   2007.9

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  • 数値解析モデルにおける光熱変換信号の発生・伝搬機序の基礎検討

    和田森 直

    Biomedical Thermology   27 ( 1 )   34 - 34   2007.8

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  • がん温熱療法における非侵襲温度計測法に関する研究

    大和田 寛

    Biomedical Thermology   27 ( 2 )   33   2007.8

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  • A noninvasive temperature measurement regarding the heating applicator based on a reentrant cavity

    3名

    STM/WCIO Joint Annual Meeting   230-231   2007.5

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  • Hyperthermia applicator based on a reentrant cavity for localized head and neck tumors

    Yasutoshi Ishihara, Yuya Gotanda, Naoki Wadamori, Jin-ichi Matsuda

    REVIEW OF SCIENTIFIC INSTRUMENTS   78 ( 2 )   Web版   2007.2

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    DOI: 10.1063/1.2437203

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  • Hyperthermia applicator based on a reentrant cavity for localized head and neck tumors

    Yasutoshi Ishihara, Yuya Gotanda, Naoki Wadamori, Jin-ichi Matsuda

    REVIEW OF SCIENTIFIC INSTRUMENTS   78 ( 2 )   024301.1–024301.8   2007.2

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    DOI: 10.1063/1.2437203

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  • Noninvasive thermometry in a reentrant resonant cavity applicator

    Yasutoshi Ishihara, Yuichiro Endo, Hiroshi Ohwada, Naoki Wadamori

    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16   1487 - +   2007

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  • Applying to an Adaptive Filter for Measurements of Physiological Information on the Human Body by a Photoacoustic Spectroscopy

    WADAMORI Naoki, MATSUDA Jin-ichi, ISHIHARA Yasutoshi

    Journal of Japan Society for Design Engineering   41 ( 12 )   644-651 - 651   2006.12

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  • An optimized small heating applicator based on reentrant cavity for localized neck and head tumors

    2名

    J. J. Hyperthermic Oncology   152   2006.10

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  • Non-invasive temperature mapping using NMR

    Physiological Function and Information Processing Systems   61-68   2005.1

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  • Monitoring Internal Body Heat Using Water Proton Chemical Shift During a Fast Spin Echo Pulse Sequence

    Yasutoshi Ishihara, Kazuya Okamoto, Tomoyuki Kanamatsu, Yasuzo Tsukada

    Systems and Computers in Japan   35 ( 2 )   49 - 58   2004.2

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    DOI: 10.1002/scj.10376

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  • Monitoring Internal Body Heating Using Water Proton Chemical Shift during a Fast Spin Echo Pulse Sequence

    ISHIHARA Yasutoshi, OKAMOTO Kazuya, KANAMATSU Tomoyuki, TSUKADA Yasuzo

    The transactions of the Institute of Electronics, Information and Communication Engineers. D-II   J85-D-Ⅱ ( 5 )   931-939 - 939   2002.5

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    Other Link: http://search.jamas.or.jp/link/ui/2002203604

  • Temperature monitoring of internal body heating induced by decoupling pulses in animal C-13-MRS experiments

    Y Ishihara, H Watanabe, K Okamoto, T Kanamatsu, Y Tsukada

    MAGNETIC RESONANCE IN MEDICINE   43 ( 6 )   796 - 803   2000.6

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  • High-resolution human brain 13C-MRS and MRSI

    K. Okamoto, M. Umeda, ほか4名

    SMR, 8th Annual Meeting Denver   1850   2000.4

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  • A novel EPI reconstruction technique using multiple RF coil sensitivity maps

    S. Kuhara, Y. Kassai, ほか3名

    SMR, 8th Annual Meeting Denver   154   2000.4

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  • Quantitative analysis of in vivo 2D ^1^H-^13^C HSQC spectra using complex nonlinear least-squares curve-fitting

    H. Watanabe, M. Umeda, ほか4名

    SMR, 8th Annual Meeting Denver   1949   2000.4

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  • Human brain glucose metabolism mapping using multislice 2D H-1-C-13 correlation HSQC spectroscopy

    H Watanabe, M Umeda, Y Ishihara, K Okamoto, K Oshio, T Kanamatsu, Y Tsukada

    MAGNETIC RESONANCE IN MEDICINE   43 ( 4 )   525 - 533   2000.4

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  • 3D localized H-1-C-13 heteronuclear single-quantum coherence correlation spectroscopy in vivo

    H Watanabe, Y Ishihara, K Okamoto, K Oshio, T Kanamatsu, Y Tsukada

    MAGNETIC RESONANCE IN MEDICINE   43 ( 2 )   200 - 210   2000.2

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  • High-resolution human brain ^13^C-MRS and MRSI

    K. Okamoto, M. Umeda, Y. Ishihara, ほか4名

    Medical Review   68   44-49   1999.5

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  • High-performance coil system for ^1^H-observed ^13^C-MRS

    K. Okamoto, M. Umeda, ほか4名

    SMR, 7th Annual Meeting Philadelphia   737   1999.5

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  • High sensitivity ^1^H-^13^C HSQC spectroscopy using a high strength gradient system

    H. Watanabe, M. Umeda, ほか4名

    SMR, 7th Annual Meeting Philadelphia   1611   1999.5

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  • ^13^C-MRSによる非侵襲的代謝計測

    岡本和也, 渡邉英宏, 石原康利, ほか4名

    メディカルレビュー   71   37-43   1998.11

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  • In vivo 3D localized C-13 spectroscopy using modified INEPT and DEPT

    H Watanabe, Y Ishihara, K Okamoto, K Oshio, T Kanamatsu, Y Tsukada

    JOURNAL OF MAGNETIC RESONANCE   134 ( 2 )   214 - 222   1998.10

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  • Feasibility studies of temperature monitoring during clinical applications

    6名

    SMR, 6th Annual Meeting Sydney   751   1998.4

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  • Human brain ^13^C-MRS & I with high SNR & 3D localized pulse sequences and specially developed probe system

    K. Okamoto, M. Umeda, ほか4名

    SMR, 6th Annual Meeting Sydney   1870   1998.4

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  • Human brain glucose metabolism mapping using multislice ^1^H-^13^C HSQC spectroscopy

    H. Watanabe, M. Umeda, ほか4名

    SMR, 6th Annual Meeting Sydney   360   1998.4

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  • Safe coil configurations for ^1^H-decoupled ^13^C-MRS in vivo

    6名

    SMR, 6th Annual Meeting Sydney   745   1998.4

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  • Multivoxel ^1^H-^13^C HSQC spectroscopy using multislice techniques with a 2IzSz state

    H. Watanabe, M. Umeda, ほか5名

    SMR, 5th Annual Meeting Vancouver   1436   1997.4

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  • Monitoring internal body heating during a fast spin echo pulse sequence

    7名

    SMR, 5th Annual Meeting Vancouver   262   1997.4

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  • Monitoring internal body heating induced by radio-frequency irradiation -Comparison of measured temperature changes and SAR distribution computed numerically-

    7名

    SMR, 5th Annual Meeting Vancouver   1953   1997.4

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  • Transmitting/receiving coil system developed for in vivo ^13^C-MRS

    M. Yoshikawa, ほか6名

    SMR, 4th Annual Meeting New York   1422   1996.4

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  • A two-dimensional real-time temperature mapping for evaluating inner body heating induced by decoupling pulses

    7名

    SMR, 4th Annual Meeting New York   1755   1996.4

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  • Practical design rule development of dual-tuned birdcage coil

    M. Yoshikawa, ほか6名

    SMR, 4th Annual Meeting New York   1421   1996.4

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  • Spatially 3D-localized HSQC by using modified INEPT

    H. Watanabe, M. Yoshikawa, ほか5名

    SMR, 4th Annual Meeting New York   1220   1220   1996.4

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  • Temperature mapping using water proton chemical shift obtained with 3D-MRSI: Feasibility in vivo

    K Kuroda, Y Suzuki, Y Ishihara, K Okamoto, Y Suzuki

    MAGNETIC RESONANCE IN MEDICINE   35 ( 1 )   20 - 29   1996.1

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  • PRECISE AND FAST TEMPERATURE MAPPING USING WATER PROTON CHEMICAL-SHIFT

    Y ISHIHARA, A CALDERON, H WATANABE, K OKAMOTO, Y SUZUKI, K KURODA, Y SUZUKI

    MAGNETIC RESONANCE IN MEDICINE   34 ( 6 )   814 - 823   1995.12

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  • Novel Imaging Methods for Temparature Distribution in the Human Body. Non-Invasive Imaging of Internal Body Temperature Using Proton Chemical Shift.

    黒田輝, 玉井伸男, 鈴木裕, 石原康利, 岡本和也, 鈴木義規

    Medical Imaging Technology   13 ( 5 )   703-709   1995.9

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  • Temperature mapping using water proton chemical shift: Comparison between phase mapping and MRSI methods

    K. Kuroda, N. Tamai, Y. Suzuki, ほか2名

    SMR, 3rd Annual Meeting Nice   1171   1995.8

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  • 3-D localized ^13^C spectroscopy by modified INEPT and DEPT

    H. Watanabe, M. Yoshikawa, ほか6名

    SMR, 3rd Annual Meeting Nice   1935   1995.8

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  • Distribution of intracellular and extracellular water molecules in developing rat’s midbrain

    M. Matsumae, H. Atsumi, R. Tsugane, O. Sato, H. Watanabe, M. Yoshikawa, ほか3名

    SMR, 3rd Annual Meeting Nice   1792   1995.8

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  • Evaluation of internal body heating induced by ^1^H decoupling pulses -Real-time temperature mapping using the water proton chemical shift-

    8名

    SMR, 3rd Annual Meeting Nice   1225   1995.8

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  • MRI monitoring during high-intensity focused ultrasound treatment

    T. Suzuki, K. Fujimoto, S. Aida, ほか5名

    SMR, 3rd Annual Meeting Nice   1177   1995.8

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  • A precise and fast temperature mapping using water proton chemical shift

    Yasutoshi Ishihara, Arturo Calderon, Hidehiro Watanabe, Kazuya Okamoto, Yoshinori Suzuki, Kagayaki Kuroda, Yutaka Suzuki

    Magnetic Resonance in Medicine   34 ( 6 )   814 - 823   1995

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    DOI: 10.1002/mrm.1910340606

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  • Water proton magnetic resonance spectroscopic imaging

    K. Kuroda, K. Abe, S. Tsutsumi, Y. Ishihara, ほか2名

    Advanced Techniques and Clinical Applications in Biomedical Thermology   13   43-62 - 62   1994.11

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  • Temperature mapping using water proton chemical shift

    K. Kuroda, N. Somatani, Y. Suzuki, ほか2名

    SMR, 2nd Annual Meeting San Francisco   1569   1569   1994.8

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  • Imaging of sub-ms T2 components in a rat’s brain

    H. Watanabe, ほか7名

    SMR, 2nd Annual Meeting San Francisco   772   1994.8

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  • Water proton magnetic resonance spectroscopic imaging

    K. Kuroda, K. Abe, S. Tsutsumi, Y. Ishihara, ほか2名

    Biomedical Thermology   13 ( 4 )   43-62 - 62   1994.4

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  • A Non-invasive Temperature Mapping Method by Water Proton MRSI.

    黒田輝, 中川敬由, 堤四郎, 石原康利, 鈴木義規, 佐藤幸三

    電子情報通信学会論文誌 D-2   J76-D-Ⅱ ( 3 )   765-775   1993.3

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  • Precise field adjustment for ^1^H-MRSI of cerebral metabolites

    6名

    SMRM, 10th Annual Meeting San Francisco   471   1991.8

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  • Proton magnetic resonance spectroscopic imaging of cerebral metabolites in cat’s brain

    10名

    Medical & Biomedical Engineering & Computing   779   1991.7

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  • 皮膚表面温度のダイナミックシミュレーション

    松田甚一, 城野典隆, 加藤和夫, 石原康利, 三宅 仁

    医学・生物学サーモロジー   vol.8 ( No.1 )   42-45   1988.6

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  • 医用サーモグラフィによる生体周期現象の画像解析 Reviewed

    松田甚一, 石原康利, ほか2名

    映像情報メディカル   19 ( 24 )   1275-1280 - 1280   1987.12

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▼display all

Books

  • Magnetic Particle Imaging: A Novel SPIO Nanoparticle Imaging Technique

    ( Role: Joint authorExperimental evaluation of correlation-based image reconstruction method for magnetic particle imaging, in Magnetic Particle Imaging)

    2012.3  ( ISBN:9783642241321

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    Responsible for pages:143-148   Language:Japanese  

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  • Electromagnetic wave

    ( Role: Joint author)

    Y. Ishihara, T. Kuwabara, N. Wadamori  2011.6  ( ISBN:9789533073040

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    Responsible for pages:493-510   Language:English   Book type:Scholarly book

    Image resolution and sensitivity improvements of a molecular imaging technique based on magnetic nanoparticles

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  • New Developments in Biomedical Engineering

    Y. Ishihara, N. Wadamori, H. Ohwada( Role: Joint authorNoninvasive localized heating and temperature monitoring based on a cavity applicator for hyperthermia)

    2010.1  ( ISBN:9789537619572

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    Responsible for pages:569-590   Language:English   Book type:Scholarly book

    Noninvasive localized heating and temperature monitoring based on a cavity applicator for hyperthermia

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MISC

  • 21015 Image reconstruction methods to improve image quality for magnetic particle imaging

    HOMMA Takumi, SHIMIZU Shota, Tsuchiya HIROKI, ISHIHARA Yasutoshi

    2014 ( 20 )   "21015 - 1"-"21015-2"   2014.3

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    Magnetic particle imaging (MPI) is one of the medical imaging technologies that are being used for early diagnosis of cancer and cardiovascular diseases. In MPI, the magnetic field gradient and alternative magnetic fields are applied from outside the body, and then the magnetization signal is generated from magnetic nanoparticles (MNPs). Furthermore, an image reconstruction is performed using this magnetization signal. However, the image quality is degraded by interference signals generated from outside of the objective region, when the magnetic field is insufficient to saturate the magnetization of MNPs. In this study, the particle distribution is estimated iteratively from the error between the detected magnetization signal and the calculated signal that estimated the previous reconstructed image. In order to confirm the validity of this proposed method, we performed numerical experiments on the condition that complex particle distribution. As results, image quality was upgraded and the image resolution was approximately 1.0 mm in numerical experiment.

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  • A Study of the Noninvasive Thermometry for the Hyperthermia Applicator Based on the Reentrant Cavity

    OHWADA Hiroshi, ISHIHARA Yasutoshi

    IEICE technical report   107 ( 218 )   11 - 14   2007.9

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    The hyperthermia, which heats cancer tissue around 43℃, is an effective therapeutic technique that is used with radiotherapy or with carcinostatic. However, it is necessary to use thermocouple or an optical fiber type thermometer to confirm a heating effect. In this report, we propose the noninvasive thermometry method paying attention to the characteristics of the electrical field of the TM mode formed between reentrant electrodes, and the temperature dependence of the dielectrics. In order to evaluate the possibility, numerical analysis using the FDTD method was carried out and basic examination of the thermometry which can be fused with a heating applicator was performed.

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    Other Link: http://search.jamas.or.jp/link/ui/2008098146

  • A Preliminary Study on the Molecular Imaging Device using Magnetic Nanoparticles

    KUSAYAMA Yusuke, ISHIHARA Yasutoshi

    IEICE technical report   107 ( 218 )   15 - 18   2007.9

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    Recently, Magnetic Particle Imaging (MPI) is expected as a early diagnosis technology for the disease such as cancers. MPI is the molecular imaging technology using the nonlinear magnetic characteristic of the magnetic nanoparticles, and a slight magnetic signal from the magnetic nanoparticles administered to the living body is detected based on the nonlinear response caused by electromagnetic irradiation from outside a living body. This time, we analyzed the numerical model to realize the MPI and the imaging technique to obtain the high-resolution using numerical mathematics as a basic study. As a result of the examination, it was confirmed to be able to well realize the MPI in the used numerical model. Moreover, the high-resolution image was obtained by appropriate use the odd and even harmonics, based on the nonlinear response caused from the magnetic nanoparticles.

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    Other Link: http://search.jamas.or.jp/link/ui/2008098147

  • PASによる非侵襲血糖値モニタリングの試み

    和田森 直, 石原 康利, 松田 甚一

    Biomedical thermology : the journal of the Japanese Society of Thermorogy = 医学・生物学サーモロジー   24 ( 1 )   15 - 15   2004.6

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Presentations

  • 加振型MPIに向けた集束超音波による生体模擬ゲルの振動変位計測

    加藤功基, 石原康利

    日本生体医工学会関東支部若手研究者発表会  2025.11 

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  • 磁気粒子イメージング(MPI)のポテンシャル ~画像化技術の現状と展望~ Invited

    石原康利

    第49回日本磁気学会学術講演会  2025.9 

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  • 水励起光音響分光法による時系列データに再帰型ニューラルネットワークを適用したグルコース濃度推定精度の向上

    鈴木太陽, 石原康利

    第64回日本生体医工学会大会  2025.6 

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  • 水励起近赤外分光法による時系列データに再帰型ニューラルネットワークを適用したグルコース濃度推定法の検討

    朝倉慎之佑, 石原康利

    第64回日本生体医工学会大会  2025.6 

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  • Model-agnostic meta-learning を用いた磁性ナノ粒子イメージングにおける画像再構成法の検討

    中川大瑚, 石原康利

    第64回日本生体医工学会大会  2025.6 

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  • 集束超音波を利用した加振型MPI の基礎検討

    金澤駿作, 石原康利

    第64回日本生体医工学会大会  2025.6 

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  • U-Net に基づく磁性ナノ粒子イメージングの画像再構成法

    水越優太, 石原康利

    日本生体医工学会関東支部若手研究者発表会2024  2024.11 

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  • 非侵襲血糖値計測システムにおける高感度小型化セルの有限要素法による解析

    山田陽大, 石原康利

    日本設計工学会 秋季大会研究発表講演会  2024.9 

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  • 超音波振動型磁性ナノ粒子イメージングの実現に向けた基礎検討

    海保翔希, 石原康利

    日本設計工学会 秋季大会研究発表講演会  2024.9 

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  • 集束超音波に基づく加振型磁性ナノ粒子イメージングの有限要素解析による変位評価

    金澤駿作, 石原康利

    生体医工学シンポジウム2024  2024.9 

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  • 集束超音波による加振変位に基づく磁性ナノ粒子イメージングの検討

    金澤駿作, 石原康利

    第63回日本生体医工学会大会  2024.5 

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  • 水励起近赤外分光強度分布にニューラルネットワークを適用したグルコース濃度推定法の精度評価

    朝倉慎之佑, 石原康利

    第63回日本生体医工学会大会  2024.5 

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  • 水励起近赤外分光法にニューラルネットワークを適用した新しいグルコース濃度推定法の検討

    朝倉慎之佑, 石原康利

    電子情報通信学会総合大会ISS特別企画  2024.3 

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  • 磁気ナノ粒子イメージング(MPI)の課題と展望

    石原康利

    電力・エネルギーフォーラム/低温工学・超電導学会 第3回超電導応用研究会シンポジウム  2022.12 

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  • 集束超音波による磁性ナノ粒子の周数シフトを利用した画像化法の検討

    森田幹也, 石原康利

    日本生体医工学会関東支部若手研究者発表会2021  2021.12 

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  • 光音響分法によるグルコース濃度推定精の改善を目的とした励起光照射の導入と検討

    (151) 山下英, 石原康利

    日本生体医工学会関東支部若手研究者発表会2021  2021.12 

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  • 励起光照射で得られる音響信号の変化にニューラルネットワークを適用したグルコース濃度推定

    石井洸多, 石原康利

    日本生体医工学会関東支部若手研究者発表会2021  2021.12 

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  • 集束超音波を用いた振動型磁性ナノ粒子イメージングにおける粒子の振動特性関す研究

    柳沼克也, 石原康利

    日本生体医工学会関東支部若手研究者発表会2021  2021.12 

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  • 非侵襲血糖値計測におけるニューラルネットワークを用いた濃度推定

    山本翔太, 石原康利

    日本生体医工学会関東支部若手研究者発表会2018  2018.12 

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  • 内視鏡の前後移動により劣化した画像の復元に関する研究

    桜井雅斗, 石原康利

    日本生体医工学会関東支部若手研究者発表会2018  2018.12 

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  • 超音波照射による振動を利用した磁性ナノ粒子イメージングの基礎検討

    漆畑智士, 石原康利

    生体医工学シンポジウム2018  2018.9 

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  • 磁性ナノ粒子イメージングにおける磁性ナノ粒子の能動振動を用いた SN 比の改善

    漆畑智士, 石原康利

    日本設計工学会 秋季研究発表講演会  2017.10 

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  • 光音響分光法に基づく非侵襲血糖値計測における独立成分分析を用いた雑音抑制に関する研究

    橘康平, 石原康利

    日本設計工学会 秋季研究発表講演会  2017.10 

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  • ニューラルネットワークを用いた磁性ナノ粒子イメージングの高分解能化

    藤田浩充, 石原康利

    生体医工学シンポジウム2017  2017.9 

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  • 特異値分解を用いた磁性ナノ粒子イメージングのノイズ耐性改善

    高木智幸, 土屋寛貴, 初田朋希, 石原康利

    生体医工学シンポジウム2016  2016.9 

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  • 光音響分光法に基づく非侵襲血糖値計測における音響セルの高感度化・小型化

    岡田康, 小林良平, 橘康平, 石原康利

    日本機械学会 第28回バイオエンジニアリング講演会  2016.1 

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  • 磁性ナノ粒⼦イメージングにおける特異値直交基底を⽤いた画像再構成法

    高木智幸, 土屋寛貴, 初田朋希, 石原康利

    日本生体医工学会関東支部若手研究者発表会2015  2015.11 

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  • 光⾳響分光法に基づく非侵襲血糖値計測におけるヘルムホルツ型共鳴セルの⾼感度化及び小型化の検討

    橘康平, 岡田康, 小林良平, 石原康利

    日本生体医工学会関東支部若手研究者発表会2015  2015.11 

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  • 特異値分解による直交基底を用いた磁性ナノ粒子イメージングにおける逆問題再構成手法の検討

    高木智幸, 土屋寛貴, 初田朋希, 石原康利

    生体医工学シンポジウム2015  2015.9 

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  • 磁性ナノ粒子イメージングにおけるニューラルネットワークを用いた画像再構成法に関する基礎検討

    初田朋希, 土屋寛貴, 高木智幸, 石原康利

    生体医工学シンポジウム2015  2015.9 

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  • 内視鏡におけるスーパーピクセルセグメンテーションを用いた空間依存ボケ画像の再構成

    小堤健士, 石原康利

    日本機械学会2015年度年次大会  2015.9 

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  • 磁性ナノ粒子イメージングにおける特異値分解を用いた画像再構成手法

    清水翔太, 土屋寛貴, 初田朋希, 高木智幸, 野口智暁, 石原康利

    日本生体医工学会関東支部若手研究者発表会2014  2014.11 

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  • 磁性ナノ粒子イメージングにおけるスキャン軌道と画像分解能に関する検討

    清水翔太, 土屋寛貴, 初田朋希, 高木智幸, 野口智暁, 石原康利

    生体医工学シンポジウム2014  2014.9 

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  • 磁性ナノ粒子イメージングにおける画質向上を目的とした画像再構成法

    本間拓実, 清水翔太, 土屋寛貴, 石原康利

    日本機械学会 関東支部第20期総会・講演会  2014.3 

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  • 磁性ナノ粒子イメージングにおける遺伝的アルゴリズムを用いた画像再構成法

    本間拓実, 清水翔太, 土屋寛貴, 石原康利

    日本機械学会 第26回バイオエンジニアリング講演会  2014.1 

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  • 磁性ナノ粒子イメージングにおける遺伝的アルゴリズムを用いた画像再構成手法

    本間拓実, 清水翔太, 土屋寛貴, 石原康利

    日本生体医工学会関東支部若手研究者発表会2013  2013.11 

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  • 磁性ナノ粒子イメージングにおける2次元画像化システムの構築について

    本間拓実, 清水翔太, 土屋寛貴, 石原康利

    日本設計工学会 秋季研究発表講演会  2013.10 

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  • オプティカルフローを用いた内視鏡の移動撮影により劣化し画像の復元に関する研究

    金道亮介, 石原康利

    生体医工学シンポジウム2013  2013.9 

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  • 物体の立形状を利用した内視鏡画像列重ね合わせ技法に関する基礎検討

    小沼昂弘, 石原康利

    生体医工学シンポジウム2013  2013.9 

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  • 磁性ナノ粒子イメージングにおける反復処理を用いた画像再構成法

    本間拓実, 清水翔太, 土屋寛貴, 石原康利

    生体医工学シンポジウム2013  2013.9 

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  • 磁性ナノ粒子イメージングにおける逐次近似を用いた画像再構成法の数値解析による検討

    清水翔太, 本間拓実, 土屋寛貴, 石原康利

    生体医工学シンポジウム2013  2013.9 

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  • 磁性ナノ粒子イメージングにおける画像分解能の改善に関する研究

    本間拓実, 石原 康利

    日本生体医工学会関東支部若手研究者発表会2012  2012.11 

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  • 非侵襲血糖値計測における背景雑音の抑制技術に関する研究

    楊振謖, 深澤 涼平, 石原康利

    生体医工学シンポジウム2012  2012.9 

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  • 幾何学パターン投影による三次元形状検出に関する研究

    宮瀬悟吏, 石原 康利

    生体医工学シンポジウム2012  2012.9 

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  • 磁性ナノ粒子イメージングにおける粒子径が再構成画像に与える影響について

    本間拓実, 石原 康利

    生体医工学シンポジウム2012  2012.9 

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  • 磁性ナノ粒子を用いた画像診断システムの黎明と展望

    第43回ナノバイオ磁気工学専門研究会  2012.6 

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  • 組織血流量を考慮したリエントラント型 アプリケータの局所加温特性に関する基礎検討

    石森貴大, 石原康利

    生体医工学シンポジウム2011  2011.9 

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  • 光音響分光法における生体情報計測用I字型セルの解析

    浅野達彦, 楊振謖, 石原康利, 和田森直

    生体医工学シンポジウム2011  2011.9 

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  • 光音響分光法を用いた生体情報計測プローブの小型化・高感度化に関する研究

    楊振謖, 浅野達彦, 石原康利, 和田森直

    生体医工学シンポジウム2011  2011.9 

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  • 磁性ナノ粒子を用いた分子イメージングにおける高分解能画像化手法について

    本間拓実, 仲川洋平, 石原康利

    生体医工学シンポジウム2011  2011.9 

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  • 磁性ナノ粒子を用いた画像診断装置の画像再構成法に関する研究

    仲川洋平, 本間拓実, 石原康利

    生体医工学シンポジウム2011  2011.9 

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  • MRIを利用した加温・測温技術の原理と展望

    第15回全身ハイパーサーミア学会・関東ハイパーサーミア学会合同学術研究会  2011.2 

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  • 組織血流量を考慮したリエントラント型アプリケータの局所加温特性に関する基礎検討

    酢谷拓也, 和田森 直, 坪根 正, 石原康利

    平成22年度電子情報通信学会信越支部大会  2010.10  電子情報通信学会信越支部

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  • 磁性ナノ粒子を用いた分子イメージングにおける高分解能画像化手法の検討

    桑原剛志, 和田森 直, 坪根 正, 石原康利

    平成22年度電子情報通信学会信越支部大会  2010.10  電子情報通信学会信越支部

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  • 光音響信号検出装置における生体用セルの小型化に関する検討

    立花 秀樹,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • 内視鏡画像の高精細化に適した超解像手法の検討

    小林 正典,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • 磁性ナノ粒子を用いた分子イメージング手法の検討

    桑原 剛志・和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • ハンディMRI構築に向けた高周波磁場コイルの設計及び数値解析

    平沢 壮,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • マルチプロセッサを用いた画像処理応用例

    望月 健一,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • リング・スポークパターン投影による三次元形状検出に関する研究

    土田 寛之,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • 事例ベース型超解像手法における解像度向上のための特徴量に関する検討

    坂牧 伸一,和田森 直

    平成21年度電子情報通信学会信越支部大会  2009.10 

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  • 生データが奏でる調べ~波から画像へ~

    第37回日本磁気共鳴医学会大会  2009.10 

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  • ハンディMRIにおける主磁場の最適化及びシミュレーション

    平沢壮, 和田森 直

    第29回生体医工学会甲信越支部大会  2009.9 

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  • リエントラント型アプリケータを用いた加温領域の集束化に関する研究

    酢谷拓也, 和田森 直

    日本ハイパーサーミア学会第26回大会  2009.9 

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  • 知覚学習に伴う自律神経反応の変化―瞳孔反応からメンタルエフォートを推定する―

    竹内龍人,酢谷拓也,テオドール パンテゥス,田中靖人

    信学技報  2009.6 

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  • ハンディMRIシステムにおける小型傾斜磁場コイルの最適化

    平沢壮, 和田森 直

    第48回生体医工学会大会  2009.4 

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  • デッドボリュームの削減による生体用光音響セルの高感度化

    和田森 直

    第48回生体医工学会大会  2009.4 

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  • 磁性ナノ粒子を利用した分子イメージングの高分解能化に関する検討

    草山裕助

    電子情報通信学会信越支部大会  2008.9 

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  • ハンディMRIにおける静磁場分布の最適化に関する検討

    岡部将志

    電子情報通信学会信越支部大会  2008.9 

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  • リエントラント型アプリケータを用いた加温領域の焦点化に関する研究

    亀山泰幸

    日本ハイパーサーミア学会第25回大会  2008.9 

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  • リング・スポークパターン投影による三次元形状計測の有用性についての検討

    土田寛之

    電子情報通信学会信越支部大会  2008.9 

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  • 傾斜磁場コイルの最適化によるハンディMRIの撮像領域拡大

    平沢壮

    電子情報通信学会信越支部大会  2008.9 

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  • ICHO2008から見た世界のハイパーサーミアの現状 –工学の立場から、新規加温装置を中心に–

    日本ハイパーサーミア学会第25回大会  2008.9 

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  • ハイパーサーミアにおける加温領域の焦点化に関する検討

    亀山泰幸, 林慧, 酢谷拓也

    電子情報通信学会信越支部大会  2008.9 

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  • ハイパーサーミアにおける集束電界回転による加温領域の焦点化

    亀山泰幸

    生体医工学シンポジウム  2008.9 

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  • 磁性ナノ粒子を利用した分子イメージングにおける高分解能画像再構成法

    草山裕介

    生体医工学シンポジウム  2008.9 

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  • 光マイクロホンを用いた光音響信号検出器に関する基礎検討

    和田森 直

    第47回日本生体医工学会大会  2008.5 

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  • 誘電体性状を利用したリエントラント型加温方式における局所加温の検討

    林 慧, 亀山泰幸

    電子情報通信学会信越支部大会  2007.9 

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  • ハイパーサーミアにおける集束電界回転による加温領域の焦点化

    亀山泰幸

    生体医工学シンポジウム  2007.9 

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  • がん温熱療法における非侵襲温度計測法に関する研究

    大和田 寛

    電子情報通信学会技術研究報告  2007.9 

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  • 光マイクを用いた光音響信号の高感度検出に関する検討

    篠原 亮, 東山仁人, 和田森 直

    電子情報通信学会信越支部大会  2007.9 

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  • 光音響分光法による生体計測装置の高感度化に向けた基礎検討

    東山仁人, 篠原 亮, 和田森 直

    電子情報通信学会信越支部大会  2007.9 

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  • 内視鏡画像を対象とした認識的超解像に関する研究

    石田英之

    電子情報通信学会信越支部大会  2007.9 

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  • 有限要素法解析に基づく経皮的PAS信号検出器の高感度化に関する検討

    和田森 直

    生体医工学シンポジウム  2007.9 

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  • ハンディMRIに関する基礎検討

    岡部将志

    電子情報通信学会信越支部大会  2007.9 

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  • リエントラント型加温アプリケータにおける非侵襲温度計測法の提案 –加温・測温融合システムへの挑戦–

    大和田 寛, 和田森 直

    日本ハイパーサーミア学会第24回大会  2007.9 

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  • 消化器官展開画像の再構成手法に関する研究

    高橋順平

    生体医工学シンポジウム  2007.9 

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  • 磁性ナノ粒子を利用した分子イメージング装置に関する基礎検討

    草山裕助

    電子情報通信学会技術研究報告  2007.9 

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  • 数値解析モデルにおける光熱変換信号の発生・伝搬機序の基礎検討

    和田森 直

    日本サーモロジー学会第24回大会  2007.8 

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  • がん温熱療法における非侵襲温度計測法に関する研究

    大和田 寛

    日本サーモロジー学会第24回大会  2007.8 

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  • 生体等価モデルにおける光音響信号特性の数値的検討

    和田森 直

    第46回日本生体医工学会大会  2007.4 

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  • 消化器官展開画像の再構成手法に関する検討

    高橋順平

    第46回日本生体医工学会大会  2007.4 

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  • RF CMOS-MEMSの検討(2):RF MEMSスイッチの低電圧化

    草山裕助, 桑原 啓, 佐藤昇男, 森村浩季, 阪田知巳, 工藤和久, 矢野正樹, 町田克之, 石井 仁

    第54回応用物理学関係連合講演会  2007.3 

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  • 光音響分光法による血中グルコース濃度検出装置の小型化に関する検討

    伊藤 純, 東山仁人, 和田森 直

    電子情報通信学会信越支部大会  2006.9 

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  • リエントラント型加温方式における局所加温の検討

    井野祐一郎

    電子情報通信学会信越支部大会  2006.9 

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  • 光音響分光法による生体計測装置の小型化に向けた検討

    伊藤 純, 東山仁人, 和田森 直

    電子情報通信学会信越支部大会  2006.9 

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  • トレーニング画像を用いる超解像手法について

    石田英之

    電子情報通信学会信越支部大会  2006.9 

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  • ハイパーサーミアにおける非侵襲温度計測法についての基礎検討

    遠藤雄一郎, 和田森 直

    電子情報通信学会信越支部大会  2006.9 

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  • 小型リエントラント型アプリケータの局所加温特性改善の検討

    峯岸康充, 和田森 直

    電子情報通信学会信越支部大会  2006.9 

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  • 消化器官展開画像の再構成手法の関する検討

    高橋順平

    電子情報通信学会信越支部大会  2006.9 

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  • リエントラント型アプリケータにおける集束加温の試み

    和田森 直

    第20回新潟ハイパーサーミア研究会  2006.5 

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  • 人体形状計測に適した投影パターンの検討

    小見山 勝, 峯岸康充, 和田森 直

    電子情報通信学会信越支部大会  2005.10 

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  • PASによる非侵襲生体情報計測の検討

    永井隆史, 伊藤 純, 和田森 直

    電子情報通信学会信越支部大会  2005.10 

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  • 局所加温用リエントラント型アプリケータの検討

    和田森 直

    日本ハイパーサーミア学会  2005.9 

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  • リエントラント型アプリケータの電界集束に関する基礎検討

    和田森 直

    日本ハイパーサーミア学会  2005.9 

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  • 頭部加温用リエントラント型アプリケータの開発

    五反田 裕也,和田森 直,松田甚一

    第19回新潟ハイパーサーミア研究会  2005.5 

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  • Non-invasive temperature mapping using NMR

    Physiological Function and Information Processing Systems  2005.1 

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  • 微小空間漏れ磁界分布の落斜型電子光源による三次元計測の基礎検討

    西尾 祐,和田森 直,松田甚一

    電子情報通信学会信越支部大会  2004.10 

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  • 擬似差動型高感度PAS信号検出用セルの基礎特性

    羽鳥貴則,和田森 直,松田甚一

    電子情報通信学会信越支部大会  2004.10 

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  • 非侵襲生体情報計測を目的としたPAS光源の検討

    米山達哉,和田森 直,松田甚一

    電子情報通信学会信越支部大会  2004.10 

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  • ガボール変換を用いた3次元多角形形状計測

    大友正人,和田森 直,松田甚一

    電子情報通信学会信越支部大会  2004.10 

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  • 局所加温用小型リエントラント型アプリケータの開発

    五反田裕也,和田森 直,松田甚一

    電子情報通信学会信越支部大会  2004.10 

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  • 頭部加温用リエントラント型アプリケータの基礎検討

    松田甚一,五反田裕也,和田森 直

    日本ハイパーサーミア学会  2004.9 

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  • リエントラント型アプリケータによるラット頭部加温実験

    和田森 直,松田甚一,高橋英明,宇塚岳夫,田中隆一

    日本ハイパーサーミア学会  2004.9 

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  • PASによる非侵襲血糖値モニタリングの試み

    和田森 直,松田甚一

    BIOMEDICAL THERMOLOGY  2004.6 

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  • リエントラント型アプリケータの深部加温特性の実験的検討

    和田森 直,松田甚一,高橋英明,宇塚岳夫,田中隆一

    第24回日本エム・イー学会甲信越支部大会  2004 

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  • 3Dインタラクティブロケータの開発

    "油井正生, 星野 勉, 葛西由守, 久原重英, 似鳥俊明, 高原太郎, 小林邦典, 蜂屋順一"

    第28回日本磁気共鳴医学会大会  2000.10 

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  • 高感度^13^C代謝物イメージング法 第三法

    渡邉英宏, 梅田匡朗, 岡本和也, 小田正記, 金松知幸, 塚田裕三

    第27回日本磁気共鳴医学会大会  1999.9 

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  • 送信用^1^H-^13^C 2重同調QDコイル-受信用6チャンネルフェーズドアレイコイルの開発

    梅田匡朗, 渡邉英宏, 岡本和也, 小田正記, 金松知幸, 塚田裕三

    第27回日本磁気共鳴医学会大会  1999.9 

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  • 高感度13C-MRSによる脳代謝の計測

    岡本和也, 梅田匡朗, 渡邉英宏, 小田正記, 金松知幸, 塚田裕三

    第12回臨床MR脳機能研究会  1999.8 

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  • 高感度^13^C代謝物イメージング法 第二法

    渡邉英宏, 梅田匡朗, 岡本和也, 小田正記, 金松知幸, 塚田裕三

    第26回日本磁気共鳴医学会大会  1998.9 

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  • 人頭部用^1^H-^13^C 2重同調QDコイルの開発

    梅田匡朗, 渡邉英宏, 岡本和也, 小田正記, 金松知幸, 塚田裕三

    第26回日本磁気共鳴医学会大会  1998.9 

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  • 高感度^13^C代謝物イメージング法

    "渡邉英宏, 梅田匡朗, 岡本和也, 小田正記, 金松知幸, 塚田裕三"

    第25回日本磁気共鳴医学会大会  1997.9 

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  • ^13^Cグルコースを用いた人頭部^13^C-MRS&I

    "岡本和也, 梅田匡朗,渡邉英宏, 小田正記, 金松知幸, 塚田裕三"

    第25回日本磁気共鳴医学会大会  1997.9 

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  • 高周波パルス印加に伴う生体内温度変化計測法

    "梅田匡朗,渡邉英宏, 岡本和也, 小田正記, 金松知幸, 塚田裕三"

    第25回日本磁気共鳴医学会大会  1997.9 

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  • 高アンモニア血症サルにおける脳内グルタミン代謝の変化-無侵襲的in vivo ^13^C-MRSによる研究-

    "小田正記, 金松知幸, 押尾晃一, 高原ひろみ, 塚田裕三, 渡邉英宏, 岡本和也"

    第12回13C医学応用研究会  1996.11 

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  • デカップリングパルス印加に伴う生体内温度変化の計測

    "渡邉英宏, 岡本和也, 小田正記, 押尾晃一, 金松知幸, 塚田裕三"

    NMR討論会  1996.11 

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  • 局所励起ge-HSQC法によるin vivo ^13^C-MRS

    "渡邉英宏, 岡本和也, 小田正記, 押尾晃一, 金松知幸, 塚田裕三"

    第12回13C医学応用研究会  1996.11 

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  • 局所励起HSQC法によるin vivo ^13^C-MRS

    "渡邉英宏, 吉川美弥, 岡本和也, 小田正記, 押尾晃一, 金松知幸, 塚田裕三"

    第24回日本磁気共鳴医学会大会  1996.9 

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  • デカップリングパルス印加に伴う生体内温度変化の計測

    "吉川美弥, 渡邉英宏, 岡本和也, 小田正記, 押尾晃一, 金松知幸, 塚田裕三"

    第24回日本磁気共鳴医学会大会  1996.9 

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  • 水プロトン磁気共鳴周波数による生体内の非侵襲温度分布画像化法の検討-3D-MRSI法とPM(Phase Map)法の比較-

    "玉井伸男, 黒田 輝, 鈴木 裕, 岡本和也, 鈴木義規"

    医用電子と生体工学  1995.10 

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  • 局所励起分極移動法の開発

    "渡邉英宏, 吉川美弥, 岡本和也, 鈴木義規, 小田正記, 金松知幸, 塚田裕三"

    第23回日本磁気共鳴医学会大会  1995.9 

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  • サルへの[1-^13^C]D-ブドウ糖経口投与で脳in vivo ^13^C-MRSによる^13^C-アミノ酸代謝の計測ができる

    "金松知幸, 押尾晃一, 小田正記, 塚田裕三, 吉川美弥, 渡辺英宏, 岡本和也"

    第23回日本磁気共鳴医学会大会  1995.9 

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  • プロトン磁気共鳴による生体内温度分布の非侵襲画像化

    "黒田 輝, 玉井伸男, 鈴木 裕, 岡本和也, 鈴木義規"

    日本ハイパーサーミア学会  1995.9 

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  • ラット中脳における細胞内外水分子プロトンの観察

    "松前光紀, 佐藤 修, 津金隆一, 渡邉英宏, 吉川美弥, 岡本和也"

    第23回日本磁気共鳴医学会大会  1995.9 

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  • 水プロトン磁気共鳴周波数による生体内温度分布画像化法の検討-生きた動物における有用性の検討-

    "黒田 輝, 杣谷直俊, 鈴木 裕, 岡本和也, 鈴木義規"

    第8回日本ME学会秋季大会・生体情報の可視化技術研究会  1994.10 

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  • 水プロトン磁気共鳴周波数による非侵襲温度分布画像化法の検討―動物体内の温度分布画像化実験―

    "杣谷直俊, 黒田 輝, 鈴木 裕, 岡本和也, 鈴木義規"

    日本ハイパーサーミア学会第11回大会  1994.9 

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  • [1-^13^C]D-ブドウ糖投与後のサル脳in vivo ^13^C-MRSによるアミノ酸代謝の研究

    "金松知幸, 小田正記, 塚田裕三, 渡辺英宏, 岡本和也, 鈴木義規"

    第22回日本磁気共鳴医学会大会  1994.9 

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  • ^1^Hデカップリングパルス印加に伴う生体内発熱分布の画像化

    "渡邉英宏, 岡本和也, 鈴木義規, 小田正記, 金松知幸, 塚田裕三"

    第22回日本磁気共鳴医学会大会  1994.9 

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  • ^1^H観測^13^Cスペクトロスコピー

    "渡邉英宏, 岡本和也, 鈴木義規, 小田正記, 金松知幸, 塚田裕三"

    第22回日本磁気共鳴医学会大会  1994.9 

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  • 水プロトン化学シフトによる生体内温度分布画像化法の検討

    "渡邊英宏, 守 清巳, 岡本和也, 鈴木義規, 黒田 輝, 鈴木 裕"

    日本医学物理学会  1994.9 

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  • 水プロトン化学シフトによる生体内温度分布画像化法の検討-温度分布の高速画像化法の検討-

    "渡邊英宏, 守 清巳, 岡本和也, 鈴木義規, 黒田 輝, 鈴木裕"

    第33回日本ME学会春季大会  1994.5 

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  • 水プロトン化学シフトによる生体内温度分布画像化法の検討-生体組織における温度依存性の支配要因の検討-

    "黒田 輝, 杣谷直俊, 鈴木裕, 岡本和也, 鈴木義規"

    第33回日本ME学会春季大会  1994.5 

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  • 化学シフトによる生体内温度分布計測法の検討

    "渡邊英宏, 守 清巳, 岡本和也, 鈴木義規, 佐藤幸三, 阿部公輔, 黒田 輝, 鈴木 裕"

    第21回日本磁気共鳴医学会大会  1993.9 

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  • NMRによる温度分布の無侵襲画像計測(Ⅲ)-水プロトンMRSIによる温度分布画像化法の検討-

    "黒田 輝, 阿部公輔, 堤 四郎, 鈴木義規, 佐藤幸三"

    第6回日本ME学会秋季大会・生体温度計測表示と臨床温度計測研究会  1992.10 

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  • 化学シフトによる非侵襲温度分布計測の検討

    "渡邊英宏, 守 清巳, 岡本和也, 鈴木義規, 佐藤幸三, 黒田 輝, 堤 四郎"

    第19回日本磁気共鳴医学会大会  1992.3 

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  • "定量的^31^P,^1^H代謝物画像化の検討"

    "渡邉英宏, 守 清巳, 岡本和也, 鈴木義規, 佐藤幸三, 伊藤 薫, 池田 公, 津金隆一, 佐藤 修"

    第19回日本磁気共鳴医学会大会  1992.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • "静脈洞灌流障害モデルにおける^1^H, ^31^P-MRSIおよび超高分解能MRIの検討"

    "伊藤 薫, 池田 公, 津金隆一, 佐藤 修, 渡邊英宏, 守 清巳, 岡本和也, 鈴木義規, 佐藤幸三"

    第19回日本磁気共鳴医学会大会  1992.3 

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  • 4.7T-MRIシステムによるin vivo高分解能MRI(Ⅱ)

    "鈴木義規, 渡邊英宏, 守 清巳, 岡本和也, 佐藤幸三, 伊藤 薫, 池田 公, 津金隆一, 佐藤 修"

    第19回日本磁気共鳴医学会大会  1992.3 

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  • プロトンケミカルシフトによる無侵襲温度分布画像化に関する基礎検討

    "黒田 輝, 中川敬由, 中田 聡, 阿部公輔, 堤 四郎, 鈴木義規, 佐藤幸三"

    日本ハイパーサーミア学会第8回大会  1991.10 

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  • 4.7T-MRIシステムによるin vivo高分解能MRI(Ⅰ)

    "守 清巳, 渡辺英宏, 岡本和也, 鈴木義規, 佐藤幸三, 伊藤 薫, 池田 公, 津金隆一, 佐藤 修"

    第18回日本磁気共鳴医学会大会  1991.9 

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  • MRSI-SR法によるT1計測

    "渡辺英宏, 守 清巳, 岡本和也, 鈴木義規, 佐藤幸三, 伊藤 薫, 池田 公, 津金隆一, 佐藤 修"

    第17回日本磁気共鳴医学会大会  1991.3 

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  • A new MRI reconstruction method

    "A. Calderon, Y. Suzuki, K. Okamoto, K. Mori, H. Watanabe, K. Satoh"

    第17回日本磁気共鳴医学会大会  1991.3 

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  • NMR温度計測における複素線形予測法による温度分解能の改善

    "三木陽一郎, 中川敬由, 黒田 輝, 堤 四郎, 鈴木義規, 佐藤幸三"

    平成2年電気関係学会関西支部連合大会  1990.11 

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  • NMRによる温度分布の無侵襲画像計測(Ⅱ)-線形予測法の適用による温度分解能の向上-

    "黒田 輝, 三木陽一郎, 中川敬由, 堤 四郎, 鈴木義規, 佐藤幸三"

    第5回日本ME学会秋季大会・生体温度計測表示と臨床温度計測研究会  1990.10 

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  • 複素線形予測法を適用したNMR無侵襲温度分布計測の検討

    "黒田 輝, 三木陽一郎, 中川敬由, 堤 四郎, 鈴木義規, 佐藤幸三"

    日本ハイパーサーミア学会第7回大会  1990.10 

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  • 脳静脈灌流障害モデルにおける31P-MRSIの検討

    "伊藤 薫, 池田 公, 津金隆一, 佐藤 修, 鈴木義規, 岡本和也, 守 清巳, 渡辺英宏, 佐藤幸三"

    第16回日本磁気共鳴医学会大会  1990.9 

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  • 4.7T小型MRI&Sによる^1^H-MRI及び^31^P-MRSI

    "鈴木義規, 岡本和也, 守 清巳, 渡辺英宏, 前田秀明, 浦田昌身, 矢沢 孝, 佐藤明男, 佐藤幸三"

    第16回日本磁気共鳴医学会大会  1990.9 

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  • Phase Mapping法を用いた磁場均一性調整法

    "岡本和也, 守 清巳, 渡邉英宏, 鈴木義規, 佐藤幸三, 伊藤 薫, 池田 公, 津金隆一, 佐藤 修"

    第16回日本磁気共鳴医学会大会  1990.9 

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  • 皮膚表面温度のダイナミックシミュレーション

    "松田甚一, 城野典隆, 加藤和夫, 三宅 仁"

    BIOMEDICAL THERMOLOGY  1988 

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  • ダイナミックシミュレーションによる皮膚表面の熱伝達特性

    大江康宏,松田甚一,三宅 仁

    第8回日本エム・イー学会甲信越支部大会  1988 

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  • 医用サーモグラフィーによる生体周期現象解析

    城野典隆,三宅 仁,松田甚一

    第7回日本エム・イー学会甲信越支部大会  1987 

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  • 医用サーモグラフィによる生体周期現象の画像解析

    "城野典隆, 三宅 仁, 松田甚一"

    BIOMEDICAL THERMOLOGY  1987 

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  • 同期トランジェントサーモグラフィーシステム

    池ノ辺正樹,森 義彦,城野典隆,青柳欽也,松田甚一,三宅 仁

    第6回日本エム・イー学会甲信越支部大会  1986 

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Industrial property rights

  • 濃度測定装置、濃度測定方法及び非一時的記録媒体

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    Application no:PCT/JP2018/043732  Date applied:2018.11

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  • パラメータ計測装置、パラメータ計測方法、およびプログラム

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    Application no:2013-45981  Date applied:2013.3

    Patent/Registration no:6080004  Date issued:2017.1

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  • 磁性ナノ粒子の磁化応答信号を利用した画像再構成装置及び画像再構成方法

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    Application no:2009-16562 

    Announcement no:2010-172410 

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Research Projects

  • 超音波音響放射圧による粒子振動を利用した磁性ナノ粒子イメージングシステムの開発

    2020.4 - 2025.3

    基盤研究 (A) 

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    Authorship:Principal investigator 

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  • Influence of the water signal on the excitation light in non-invasive blood glucose level measurement

    Grant number:16K12881  2016.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Ishihara Yasutoshi

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    Authorship:Principal investigator 

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    No prospect of actually using non-invasive blood glucose level measurement has yet emerged. Several main reasons are that the glucose concentration in blood is low, and that it cannot carry out the separation measurement of the glucose from water.
    We have proposed a method that the ratio of the water signal to an observation signal could be estimated by superimposing the excitation light corresponding to the absorption peak of water (1450 nm) on measurement light (1600 nm). It was shown clearly by the experiments in this study that measurement light intensity increases with excitation light intensity in glucose solution. It was also indicated quantitatively that this signal change is an effect according to heat in addition to the effect by light. A possibility that the separation measurement of the glucose signal could be exactly carried out from an observation signal was indicated by using these effects.

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  • Magnetic particle imaging system with fast data acquisition and high image resolution

    Grant number:15H03038  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Ishihara Yasutosh

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    Authorship:Principal investigator 

    Grant amount:\16640000 ( Direct Cost: \12800000 、 Indirect Cost:\3840000 )

    Diagnosing cancers and cardiovascular diseases at an early stage by magnetic particle imaging (MPI) has been expected. In MPI, however, strong gradient magnetic field strength is needed to obtain high image resolution. In this study, the new algorithm that can make image reconstruction of the image data acquired fast with high image resolution was proposed. The validity of the image reconstruction method was evaluated by numerical analysis, and satisfactory image quality was obtained compared with the conventional method. In addition, the two-dimensional MPI system was constructed and validity of the proposed image reconstruction method was clarified experimentally. Furthermore, the new signal acquisition method for detecting a magnetization signal by vibrating a magnetic nanoparticle without using an alternating current magnetic field was proposed, and the feasibility was shown.

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  • 非侵襲血糖値計測を具現化する検出目的信号の『空間的』・『成分的』分離識別法の研究

    2013.4 - 2015.3

    (独)日本学術振興会  挑戦的萌芽研究 

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  • Spatial and component separations of the photoacoustic signal for achieving noninvasive blood glucose measurement

    Grant number:25560242  2013.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    YASUTOSHI Ishihara

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    In order to measure the glucose concentration in a capillary bed based on photoacoustic spectroscopy, the techniques of separating unnecessary signal components generated from water and discriminating unnecessary signal components generated from the epidermis are required. The method of irradiating with the excitation light according to the absorption wavelength of water simultaneously with observation light was proposed to suppress the signal component originating in water. It was shown clearly that observation light intensity changes with irradiation of excitation light about 1% per 1% of glucose concentration. Therefore, a possibility that the water signal component in an observation signal could be estimated by irradiation of excitation light was indicated. In addition, it was confirmed that the glucose distribution of the depth about 5 mm from the surface could be identified by irradiating with the modulated observation light.

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  • Improvement of the MPI image resolution by using spatial property of magnetization

    Grant number:24300184  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    ISHIHARA Yasutoshi

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    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )

    Magnetic particle imaging (MPI) has attracted interest for the early diagnosis of cancer and cardiovascular disease. This procedure can be used for signal acquisition with high sensitivity and spatial resolution compared with magnetic resonance imaging. However, because an unnecessary magnetization response will be detected from the target region near the magnetic nanoparticle (MNP), the spatial resolution deteriorates and/or an artifact will appear in the region where an MNP originally does not exist.
    In this study, the image quality and spatial resolution of MPI are improved using an image reconstruction method based on the correlation information of an observed magnetization signal and system function. In particular, the particle distribution is estimated iteratively from the difference between a reference image reconstructed using correlation information and an image calculated theoretically by numerical analysis.

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  • 非侵襲血糖値計測における精度・安定性向上のための水溶媒信号の抑圧・分離法の研究

    2011.4 - 2013.3

    挑戦的萌芽研究 

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  • A suppression and separation method of the water solvent signal for the improvement of the accuracy and stability in noninvasive blood glucose measurement

    Grant number:23650311  2011 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    ISHIHARA Yasutoshi

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    In a noninvasive blood glucose measurement based on a near infrared light, it is necessary to suppress the signal of the water solvent, which is the main causes of background noise, to improve the accuracy and stability of measurement. In this research, we proposed the method of measuring a glucose signal, irradiating a sample with the excitation light that has a wavelength corresponding to the maximum absorption of the water molecule. It was shown that the signal originated from the water molecule could be separated effectively, as a result of the fundamental experiment. Furthermore, it was shown clearly that glucose concentration could be estimated by about 10% of precision for measurement based on this method.

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  • 磁性ナノ粒子を利用した超選択的がん治療法と非侵襲温度分布計測法との融合

    2008.4 - 2011.3

    基盤研究 (B) 

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  • A fusion of super-selective cancer therapy and noninvasive temperature measurement based on magnetic nanoparticles

    Grant number:20300155  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    ISHIHARA Yasutoshi

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    Grant amount:\18980000 ( Direct Cost: \14600000 、 Indirect Cost:\4380000 )

    Fundamental research which aimed at realization of the fused system of heating cancer treatment system and the diagnosis system based on a characteristics of magnetic nanoparticles was performed. As results, the following things were clarified : (1) a heating region can be controlled by applying a electromagnetic wave with a static magnetic field to a magnetic nanoparticles, (2) a heating region can be measured noninvasively by using the phase change information with temperature in a cavity resonator, (3) the image resolution and detection sensitivity on a molecular imaging for the cancer can be improved.

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  • 集束・焦点状高周波電界を利用した がん治療・診断システムの研究

    2006.6 - 2009.5

    (独)新エネルギー・産業技術総合開発機構  産業技術研究助成事業

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    Authorship:Principal investigator  Grant type:Competitive

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  • PASによる非侵襲血糖測定器のための光マイクロホンの開発

    2006.4 - 2009.3

    基盤研究 (C) 

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  • ユビキタスハンディMRIの基礎研究

    2006.4 - 2008.3

    挑戦的萌芽研究 

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  • Development of a optical microphone using photoacoustic spectroscopyfor non-invasive glucose measurement

    Grant number:18500373  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    WADAMORI Naoki, ISHIHARA Yasutoshi

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    Grant amount:\4140000 ( Direct Cost: \3600000 、 Indirect Cost:\540000 )

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  • ユビキタス・ハンディMRIの基礎研究

    Grant number:18659344  2006 - 2007

    日本学術振興会  科学研究費助成事業 萌芽研究  萌芽研究

    石原 康利

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    Grant amount:\3300000 ( Direct Cost: \3300000 )

    本萌芽研究では、ベッドサイド診断、あるいは、ネットワーク接続によるユビキタス診断を可能とするハンディ型MRI (Magnetic Resonance Imaging)装置の実現を目指し、MRI装置の超小型化に必要な装置構成の検討、再構成アルゴリズムの提案を目的としている。
    平成19年度は、信号対雑音比(SNR: signal-to-noise ratio)の観点から、画像データの収集に必要な静磁場強度が0.1[T]以上であることを示すとともに、磁場均一性を1[ppm]以下にするために、複数の永久磁石(残留磁束密度0.7[T]、直径10[mm]、高さ10[mm])をマトリクス配置(7行×7列=合計49個)する必要のあることを明らかにした。また、ネオジム永久磁石を用いた磁場分布計測を行い、所望とする静磁場分布を形成できる可能性を確認した。さらに、このようにして得られた静磁場下において再構成される画像の評価を行った。その結果、20×20[mm]のFOV (field of view)内に配置した10×10[mm]の方形ファントムの画像を再構成できることを確認した。しかし、急激な磁場不均一性を示す領域では、磁場分布に基づく画像歪の補正が良好に行えないことも明らかになった。
    本研究によって、磁気回路(ヨーク)を付随しない構成でも、ネオジム等の希土類磁石を複数配置することで、MRI画像を再構成できる可能性が示されたが、診断に供する画像を得るためには、画像歪の補正法を新たに考案する必要がある。今後、得られた知見を発展させ、実用システムの構築に必要な基盤技術の研究・開発を加速する。

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Teaching Experience

  • 実践医学(分担)

    2019.4 Institution:St.Marianna University School of Medicine

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  • プログラム実習1

    2017.4 Institution:明治大学理工学部

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  • 機械情報数学演習

    2015.4 - 2016.3 Institution:明治大学理工学部

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  • 応用計測工学

    2010.4 Institution:明治大学理工学部

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  • 情報処理1

    2010.4 - 2017.3 Institution:明治大学理工学部

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  • 数値処理演習

    2010.4 - 2016.3 Institution:明治大学理工学部

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  • サイバネティックス工学

    Institution:長岡技術科学大学

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  • 画像応用工学

    Institution:長岡技術科学大学

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  • アナログ回路工学

    Institution:長岡技術科学大学

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  • 電気電子情報数学及び演習

    Institution:長岡技術科学大学

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